67 research outputs found

    Seroepidemiology and Carriage of Diphtheria in Epidemic-Prone Area and Implications for Vaccination Policy, Vietnam

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    In 2019, a community-based, cross-sectional carriage survey and a seroprevalence survey of 1,216 persons 1–55 years of age were conducted in rural Vietnam to investigate the mechanism of diphtheria outbreaks. Seroprevalence was further compared with that of an urban area that had no cases reported for the past decade. Carriage prevalence was 1.4%. The highest prevalence, 4.5%, was observed for children 1–5 years of age. Twenty-seven asymptomatic Coerynebacterium diphtheriae carriers were identified; 9 carriers had tox gene–bearing strains, and 3 had nontoxigenic tox gene–bearing strains. Child malnutrition was associated with low levels of diphtheria toxoid IgG, which might have subsequently increased child carriage prevalence. Different immunity patterns in the 2 populations suggested that the low immunity among children caused by low vaccination coverage increased transmission, resulting in symptomatic infections at school-going age, when vaccine-induced immunity waned most. A school-entry booster dose and improved infant vaccination coverage are recommended to control transmissions

    Fermion Masses and Mixing in Intersecting Branes Scenarios

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    We study the structure of Yukawa couplings in intersecting D6-branes wrapping a factorizable 6-torus compact space T^6. Models with MSSM-like spectrum are analyzed and found to fail in predicting the quark mass spectrum because of the way in which the family structure for the left-handed, right-handed quarks and, eventually, the Higgses is `factorized' among the different tori. In order to circumvent this, we present a model with three supersymmetric Higgs doublets which satisfies the anomaly cancellation condition in a more natural way than the previous models, where quarks were not treated universally regarding their branes assignments, or some particular branes were singled out being invariant under orientifold projection. In our model, the family structures for the left, right quarks, left leptons and the Higgses arise from one of the tori and can naturally lead to universal strength Yukawa couplings which accommodate the quark mass hierarchy and the mixing angles.Comment: 21 pages, latex, matches the Phys. Rev. D versio

    Associations of autozygosity with a broad range of human phenotypes

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    In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (F-ROH) for >1.4 million individuals, we show that F-ROH is significantly associated (p <0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: F-ROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44-66%] in the odds of having children. Finally, the effects of F-ROH are confirmed within full-sibling pairs, where the variation in F-ROH is independent of all environmental confounding.Peer reviewe

    Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits : A Multi-Ethnic Meta-Analysis of 45,891 Individuals

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    J. Kaprio, S. Ripatti ja M.-L. Lokki työryhmien jäseniä.Peer reviewe

    The Physics of the B Factories

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    A fast algorithm for modeling multiple bubbles dynamics

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    10.1016/j.jcp.2005.12.009Journal of Computational Physics2162430-453JCTP

    Nitrogen-doped carbon coated nanodiamonds for electrocatalytic applications

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    Nitrogen-doped carbon hybridized nanodiamond (N-doped C@ND) materials have been developed and used as an electrocatalytic for oxygen reduction reactions (ORRs). The polymerized ionic liquids are employed to modify NDs and then subjected to thermal annealing at 600 °C, resulting in a high concentration of N-doped (9.33 at.%) carbon frameworks attached on the ND surface. This N-doped C@ND material provides a highly active mesoporous structure (4 nm pore) with a high surface area (366 m² g⁻¹) and allows for enhancement of catalytic performance compared to pure NDs. The N-doped C layers altered the electroneutrality of NDs, creating favourable charged sites for oxygen adsorption, thus weakening the O–O bond strength to facilitate ORR activity. Having a predominant four-electron transfer pathway with a total electron transfer number of 3.44–3.88 in the potential region of 0.1–0.8 V(RHF), the N-doped C@ND-based catalyst materials performed well as a catalyst for the ORR in the alkaline medium. This affordable material and simple process will find potential application in clean energy generation and storage, durable fuel cells and metal–air batteries.Tran Van Hung, Ramesh Karunagaran, Tran Thanh Tung, Nam Nguyen Dang, Sang Xuan Nguyen, and Dusan Losi

    Insight into microstructure and dynamics of network forming liquid from the analysis based on shell–core particles

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    Large models of silica melt have been produced at 3500 K and pressures of 0, 5, 10, 15, 20, 25, 30 and 45 GPa by molecular dynamics simulation. New topological analysis is performed based on shell–core particles. The simulation shows that although the fraction of different types of basic units varies strongly, the topology of those units remains almost constant under pressure. The O-particles contain from 2 to 14 O and Si-particles have 1 or 2 Si. The clusters of particles (CP) include Si-clusters and O-clusters which occupy micro-regions with pure compositions and contain up to 8 Si and 106 O, respectively. The densification is realized by two ways: (i) increasing density of atoms in shell and core of particles; (ii) increasing number of small O-particles in expense of large ones. The simulation also reveals particles and CP which are stable for long times. Strong chemical bonds between core and shell atoms prevent those particles and CP from breaking apart. During about one nanosecond the solid-like atoms are non-uniformly distributed in the space where they gather instead in rigid Si–O subnets, stable particles and clusters of stable particles. We find that the dynamics heterogeneity observed at low pressure is originated from the small rate of bond-breaking events and non-uniform spatial distribution of these events

    A review and notes on the phylogenetic relationship of the centipede genus Otostigmus Porat, 1876 (Chilopoda: Scolopendromorpha: Scolopendridae) from Vietnam

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    Vu, Ha T., Nguyen, Hung D., Le, Son X., Eguchi, Katsuyuki, Nguyen, Anh D., Tran, Binh T.T. (2020): A review and notes on the phylogenetic relationship of the centipede genus Otostigmus Porat, 1876 (Chilopoda: Scolopendromorpha: Scolopendridae) from Vietnam. Zootaxa 4808 (3): 401-438, DOI: 10.11646/zootaxa.4808.3.
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