54 research outputs found
The IPBES Conceptual Framework - connecting nature and people
- Author
- Adem Bilgin
- Alfred Apau Oteng-Yeboah
- Ali Moustafa Mokhtar Fouda
- Amanda Driver
- Anantha Duraiappah
- András Báldi
- Ann Bartuska
- Anne Larigauderie
- Asamblea Constituyente de la República del Ecuador
- Ash
- Bateman
- Belinda Reyers
- Berkes
- Berta Martin-Lopez
- Biggs
- Blumetti
- Bojie Fu
- Borrini-Feyerabend
- Brashares
- Brondizio
- Brondízio
- Callicot
- Callistus Akosim
- Carlos Joly
- Carmel Mbizvo
- Carpenter
- Carsten Nesshover
- Cash
- Chan
- Chan
- Chapin
- Costanza
- Daw
- Dedy Darnaedi
- Diana Zlatanova
- Diego Pacheco
- Duraiappah
- Duraiappah
- Duraiappah
- Díaz
- Díaz
- Edgar Selvin Pérez
- Eduardo Brondizio
- Edward Amankwah
- Ernstson
- Estado Plurinacional de Bolivia
- Eva Roth
- Faith
- Floyd Homer
- Food and Agricultural Organization of the United Nations (FAO)
- Food and Agricultural Organization of the United Nations (FAO)
- Gabor Bartus
- Gabriela Lichtenstein
- Gallai
- Garmendia
- Gemedo Dalle
- Georgina M Mace
- Gunay Erpul
- György Pataki
- Gómez-Baggethun
- Görg
- Hajjar
- Harini Nagendra
- Haripriya Gundimeda
- Harold A Mooney
- Heather Tallis
- Henrik Moller
- Hill
- Hoffman
- Iaccarino
- Ivar Andreas Baste
- Jax
- Jay Ram Adhikari
- Jean Bruno Mikissa
- Jean Paul Metzger
- Jennifer Rubis
- Jorge Caillaux
- Julia Carabias
- Kai MA Chan
- Kallis
- Kazuhiko Takeuchi
- Kubiszewski
- Kumar
- L Anathea Brooks
- Larigauderie
- Leemans
- Loh
- Luck
- MacDonald
- Mace
- Mace
- Madhu Verma
- Maffi
- Maria Schultz
- Marie Roué
- Mark Lonsdale
- Markus Fischer
- Martín-López
- Mauser
- Max-Neef
- McGinnis
- Mehrasa Mehrdadi
- Michiko Okumura
- Millennium Ecosystem Assessment
- Nalini Sharma
- National Academy of Sciences USA
- Neville Ash
- Ormsby
- Osamu Saito
- Pablo Escobar-Eyzaguirre
- Pacheco
- Pascual
- Pascual
- Paul Leadley
- Peggy Smith
- Perrings
- Peter Mumby
- Philip Lyver
- Pierre Failler
- Piotr Matczak
- Potts
- Ramnath
- Randolph Thaman
- Rashad Allahverdiyev
- Rashid Sumaila
- Reid
- Reyers
- Robert John Scholes
- Robert Watson
- Rogers
- Rosemary Hill
- Russell
- Sagoff
- Salvatore Arico
- Sandra Díaz
- Sandra Lavorel
- Scholes
- Sebsebe Demissew
- Shapiro
- Sharer
- Shizuka Hashimoto
- Spangenberg
- Spencer Thomas
- Stanley T Asah
- Sutherland
- Takeuchi
- Tengö
- Tetsukazu Yahara
- Thaman
- Thaman
- Thaman
- Thomas Koetz
- Unai Pascual
- UNEP
- Vellekoop
- Viviana Elsa Figueroa
- Wadzanayi Mandivenyi
- Wegner
- William Armand Mala
- Wilson
- World Bank
- Yahara
- Youn Yeo-Chang
- Yousef Al-Hafedh
- Zakri Abdul Hamid
- Zemede Asfaw
- Zimmerer
- Zimmerer
- Östrom
- Östrom
- Östrom
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
The first public product of the Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES) is its Conceptual Framework. This conceptual and analytical tool, presented here in detail, will underpin all IPBES functions and provide structure and comparability to the syntheses that IPBES will produce at different spatial scales, on different themes, and in different regions. Salient innovative aspects of the IPBES Conceptual Framework are its transparent and participatory construction process and its explicit consideration of diverse scientific disciplines, stakeholders, and knowledge systems, including indigenous and local knowledge. Because the focus on co-construction of integrative knowledge is shared by an increasing number of initiatives worldwide, this framework should be useful beyond IPBES, for the wider research and knowledge-policy communities working on the links between nature and people, such as natural, social and engineering scientists, policy-makers at different levels, and decision-makers in different sectors of society
Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel
- Author
- A. Reghan Foley
- Aarno Palotie
- Aaron Day-Williams
- Aaron Isaacs
- Adam Shaw
- Alastair Kent
- Alexandros Onoufriadis
- Alireza Moayyeri
- Allan Daly
- Ana M. Valdes
- Andrew G. McKechanie
- Andrew M. McIntosh
- Andrew McQuillin
- Anette Varbo
- Angela Matchan
- Anja Kolb-Kokocinski
- Anne Tybjaerg-Hansen
- Anthony M. Vandersteen
- Antoinette Amuzu
- Antonio Ciampi
- Audrey E. Hendricks
- Beate St Pourcain
- Bryan Howie
- Børge G. Nordestgaard
- Carl A. Anderson
- Carol Smee
- Catherine Cosgrove
- Celia Greenwood
- ChangJiang Xu
- Cheryl K. Ridout
- Chris Boustred
- Chris Joyce
- Christopher S. Franklin
- Claudia Langenberg
- Cordelia Langford
- Cornelia M. van Duijn
- Crispian Wilson
- Daniel G. MacArthur
- Daniel Geschwind
- Daniel Lawson
- Daniela Toniolo
- David A. Collier
- David B. Savage
- David Curtis
- David K. Jackson
- David M. Evans
- David R. Fitzpatrick
- David Skuse
- David St Clair
- Dawn Muddyman
- Deborah Hart
- Detelina Grozeva
- Dinu Antony
- Douglas Blackwood
- Eleanor Wheeler
- Eleftheria Zeggini
- Elena Bochukova
- Elisabeth M. van Leeuwen
- Elisabetta Trabetti
- Elizabeth Stevens
- Eva Serra
- Ewan Birney
- Farrah Khawaja
- Felicity Payne
- Feng Zhang
- Francesco Muntoni
- Gabriela Surdulescu
- Gail Clement
- Gaëlle Marenne
- Genevieve Lachance
- George Davey Smith
- George Dedoussis
- Gerome Breen
- Gianluigi Zaza
- Giovanni Gambaro
- Giovanni Malerba
- Graham R. S. Ritchie
- Guangbiao Wang
- Guy Coates
- Hannah M. Mitchison
- Hashem A. Shihab
- Heather Griffin
- Hong Lin
- Hou-Feng Zheng
- Hugh Gurling
- Hywel J. Williams
- I. Sadaf Farooqi
- Iain Mathieson
- Ian Dunham
- Ian N. M. Day
- Inês Barroso
- Ioanna Tachmazidou
- Irene Lee
- J. Brent Richards
- Jaana Suvisaari
- James Floyd
- James Morris
- James T. R. Walters
- Jamie Bentham
- Jane Kaye
- Jaspal S. Kooner
- Jeffrey C. Barrett
- Jeremy R. Parr
- Jian Yang
- Jian'an Luan
- Jianping Sun
- Jie Huang
- Jieqin Liang
- Jim Stalker
- Jing Tian
- John C. Chambers
- John Maslen
- John P. Kemp
- John R. B. Perry
- Jon Johnson
- Jonathan Marchini
- Josine L. Min
- Jouko Lönnqvist
- Juan Pablo Casas
- Julia Keogh
- Jun Wang
- Kalliope Panoutsopoulou
- Karen Kennedy
- Karim Oualkacha
- Karola Rehnström
- Kate Northstone
- Kathleen A. Williamson
- Keren Carss
- Kerrin S. Small
- Kim Wong
- Kirsten Ward
- Klaudia Walter
- Konrad J. Karczewski
- Krishna Chatterjee
- Lavinia Paternoster
- Liren Huang
- Lorraine Southam
- Louise Gallagher
- Louise V. Wain
- Lu Chen
- Lucy Crooks
- Lucy Raymond
- Luis R. Lopes
- Lydia Quaye
- Marcus E. Kleber
- Margarida Lopes
- Margriet van Kogelenberg
- Marianne Benn
- Marta Futema
- Martin Bobrow
- Martin D. Tobin
- María Soler Artigas
- Massimiliano Cocca
- Massimo Mangino
- Matthew E. Hurles
- Matthias Geihs
- Mattia Calissano
- Michael A. Quail
- Michael C. O'Donovan
- Michael J. Owen
- Michela Traglia
- Miriam Schmidts
- Monkol Lek
- Muhammad Ayub
- Nadia Schoenmakers
- Nicholas J. Timpson
- Nick Craddock
- Nicola Migone
- Nicola Roberts
- Nicole Soranzo
- null null
- Olivera Spasic-Boskovic
- Olli Pietilainen
- Paolo Gasparini
- Parthiban Vijayarangakannan
- Patrick F. Bolton
- Paul Flicek
- Peter Clapham
- Peter Ellis
- Peter Holmans
- Peter M. Visscher
- Peter McGuffin
- Peter Scambler
- Peter Whincup
- Petr Danecek
- Petros Syrris
- Phil Beales
- Pingbo Zhang
- Pirro Hysi
- Rachel L. Robinson
- Rebecca Bounds
- Rebecca C. Pollitt
- Richard Anney
- Richard Durbin
- Richard H. Scott
- Richard Morris
- Robert A. Scott
- Robert K. Semple
- Rohan Taylor
- Rosemary Ekong
- Rui Li
- Ruth Charlton
- Ryan Liu
- Saeed Al Turki
- Sally I. Sharp
- Sarah Curran
- Sarah Edkins
- Sarah Metrustry
- Scott G. Wilson
- Sebahattin Cirak
- Senduran Bala
- Shane McCarthy
- Shoumo Bhattacharya
- So-Youn Shin
- Stephan Schiffels
- Stephen O'Rahilly
- Steve E. Humphries
- Stewart J. Payne
- Sue Povey
- Susan Ring
- Tamieka Whyte
- Thomas Down
- Thomas Keane
- Tiina Paunio
- Tim Hubbard
- Timothy D. Spector
- Tom R. Gaunt
- Tony Cox
- Valentina Iotchkova
- Victoria Parker
- Vincent Plagnol
- Weihua Zhang
- Winfried März
- Xiaosen Guo
- Xueqin Guo
- Yalda Jamshidi
- Yasin Memari
- Yingrui Li
- Yu Wang
- Yuanping Du
- Publication venue
- NATURE PUBLISHING GROUP
- Publication date
- 01/01/2015
- Field of study
Imputing genotypes from reference panels created by whole-genome sequencing (WGS) provides a cost-effective strategy for augmenting the single-nucleotide polymorphism (SNP) content of genome-wide arrays. The UK10K Cohorts project has generated a data set of 3,781 whole genomes sequenced at low depth (average 7x), aiming to exhaustively characterize genetic variation down to 0.1% minor allele frequency in the British population. Here we demonstrate the value of this resource for improving imputation accuracy at rare and low-frequency variants in both a UK and an Italian population. We show that large increases in imputation accuracy can be achieved by re-phasing WGS reference panels after initial genotype calling. We also present a method for combining WGS panels to improve variant coverage and downstream imputation accuracy, which we illustrate by integrating 7,562 WGS haplotypes from the UK10K project with 2,184 haplotypes from the 1000 Genomes Project. Finally, we introduce a novel approximation that maintains speed without sacrificing imputation accuracy for rare variants
Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa
- Author
- Abramovic L
- Adams HHH
- Adan R
- Agartz I
- Alfredsson L
- Alhusaini S
- Almasy L
- Ames D
- Andersson M
- Ando T
- Andreassen O
- Andreassen OA
- Anttila V
- Arepalli S
- Arias-Vasquez A
- Aribisala BS
- Armstrong NJ
- Aschauer H
- Ashbrook DG
- Assareh AA
- Athanasiu L
- Baker J
- Barrett J
- Bastin ME
- Batury V-L
- Becker JT
- Bencko V
- Bergen A
- Bernard M
- Berrettini W
- Birgegard A
- Bis JC
- Blangero J
- Bohlken MM
- Boks MP
- Boni C
- Boomsma DI
- Bralten J
- Brandt H
- Breen G
- Brodaty H
- Brouwer RM
- Brown AA
- Brunner HG
- Buckner RL
- Buitelaar JK
- Bulayeva KB
- Bulik CM
- Bulik CM
- Bulik-Sullivan B
- Burghardt R
- Cahn W
- Calhoun VD
- Cannon DM
- Carlberg L
- Carless MA
- Cassina M
- Cavalleri GL
- Chakravarty MM
- Chauhan G
- Chen Q
- Cheung J
- Ching CRK
- Cichon CCS
- Cichon S
- Clementi M
- Cohen-Woods S
- Coleman J
- Cone R
- Cookson MR
- Corvin A
- Courtet P
- Crawford S
- Crespo-Facorro B
- Crow S
- Crowley J
- Cuellar-Partida G
- Curran JE
- Czisch M
- Dale AM
- Danner U
- Davies GE
- Davis O
- de Geus EJC
- de Zubicaray GI
- de Zwaan M
- Deary IJ
- Dedoussis G
- Degortes D
- Delanty N
- Den Braber A
- Depondt C
- DeSocio J
- Desrivieres S
- Dick D
- Dikeos D
- Dillman A
- Dina C
- Ding B
- Djurovic S
- Dmitrzak-Weglarz M
- Docampo E
- Donohoe G
- Drevets WC
- Duggirala R
- Duncan L
- Dyer TD
- Ebling M
- Egberts K
- Ehrlich S
- Ehrlich S
- Ehrlich S
- Erk S
- Escaramis G
- Esko T
- Espeseth T
- Espeseth T
- Estivill X
- Favaro A
- Fedko IO
- Fernandez G
- Fernandez-Aranda F
- Ferrucci L
- Fichter M
- Finan C
- Fischer K
- Fischl B
- Fisher SE
- Floyd J
- Focker M
- Foretova L
- Foroud TM
- Forzan M
- Fox C
- Fox PT
- Francks C
- Franke B
- Franklin C
- Fukunaga M
- Gallinger VGS
- Gambaro G
- Gaspar H
- Gibbs JR
- Giddaluru S
- Giegling I
- Glahn DC
- Goldman AL
- Goldstein J
- Gollub RL
- Gonidakis F
- Goring HHH
- Gorwood P
- Grabe HJ
- Gratacos M
- Green RC
- Greve D
- Grimm O
- Gruber O
- Guadalupe T
- Gudnason V
- Guelfi S
- Guillaume S
- Guo Y
- Hager R
- Hakobjan MMH
- Hakonarson H
- Halmi K
- Hansell NK
- Hardy J
- Harrison R
- Hartberg CB
- Hartman CA
- Hashimoto R
- Hass J
- Hatzikotoulas K
- Haukvik UK
- Hauser J
- Hebebrand J
- Hegenscheid K
- Heinz A
- Heister AJGAM
- Helder S
- Hendriks J
- Herms S
- Hernandez DG
- Hernandez MCV
- Herpertz-Dahlmann B
- Herzog W
- Heslenfeld DJ
- Hibar D
- Hibar DP
- Hilliard C
- Hinney A
- Ho B-C
- Hoekstra PJ
- Hoffmann W
- Hohn D
- Holmes AJ
- Holsboer F
- Homuth G
- Hoogman M
- Hosten N
- Hottenga J-J
- Huckins L
- Hudson J
- Huemer J
- Ikeda M
- Ikram MA
- Imgart H
- Inoko H
- Jack CR
- Jahanshad N
- Jahanshad N
- Jamain SJS
- Janout V
- Janowitz D
- Jenkinson M
- Jia T
- Jimenez-Murcia S
- Johnson C
- Johnson R
- Jonsson EG
- Jordan J
- Julia A
- Jureus A
- Kahn RS
- Kalsi G
- Kaminska D
- Kanai R
- Kaplan A
- Kaprio J
- Karhunen L
- Karwautz A
- Kas M
- Kasperaviciute D
- Kaye W
- Keil M
- Kennedy J
- Kennedy M
- Kent JW
- Keski-Rahkonen A
- Kiezebrink K
- Kim S
- Kim Y-R
- Klareskog L
- Klein M
- Kloszewska I
- Klump K
- Knudsen GP
- Kochunov P
- Koeleman B
- Koubek D
- Kraemer B
- Kwok JB
- La Via M
- Landen M
- Launer LJ
- Lawrie SM
- Le Hellard S
- Le Hellard S
- Leboyer M
- Lee PH
- Levitan R
- Li D
- Lichtenstein P
- Liewald DCM
- Lilenfeld L
- Lissowska J
- Liu X
- Longo DL
- Longstreth WT
- Loohuis LMO
- Lopez LM
- Lovestone S
- Lu L
- Luciano M
- Lundervold A
- Macare C
- Magistretti P
- Maj M
- Makkinje RRR
- Mannik K
- Marsal S
- Martin N
- Martin NG
- Matarin M
- Mather KA
- Mattay VS
- Mattheisen M
- Mattingsdal M
- Mazoyer B
- McDevitt S
- McDonald C
- McGuffin P
- McIntosh AM
- Mckay DR
- McMahon FJ
- McMahon KL
- Mecocci P
- Medland SE
- Meisenzahl E
- Melle I
- Merl E
- Metspalu A
- Meulenbelt I
- Meyer-Lindenberg A
- Micali N
- Milaneschi Y
- Mitchell J
- Mitchell K
- Mohnke S
- Monteleone AM
- Monteleone P
- Montgomery G
- Montgomery GW
- Morris DW
- Mortensen P
- Mostert JC
- Mueller T
- Mueller-Myhsok B
- Muhleisen TW
- Munn-Chernoff M
- Naber MAM
- Nacmias B
- Nalls MA
- Nauck M
- Navratilova M
- Needham M
- Nho K
- Nichols TE
- Nilsson I
- Nilsson LG
- Norring C
- Nothen MM
- Ntalla I
- Nugent AC
- Nyberg L
- Nyquist P
- O'Toole J
- Ohi K
- Olvera RL
- Ophoff R
- Ophoff RA
- Palotie A
- Pandolfo M
- Pantel J
- Papezova H
- Papmeyer M
- Paus T
- Pausova Z
- Penninx BWJH
- Perez-Iglesias R
- Perica VB
- Pike GB
- Pinto RPD
- Pol HEH
- Potkin SG
- Putz B
- Rabionet R
- Raevuori A
- Rajewski A
- Ramasamy A
- Ramoz N
- Rayner NW
- Reichborn-Kjennerud T
- Reinvang I
- Renteria ME
- Reppermund S
- Ricca V
- Rietschel M
- Ripatti S
- Ripke S
- Risacher SL
- Ritschel F
- Roberts M
- Roffman JL
- Roiz-Santianez R
- Romanczuk-Seiferth N
- Rose EJ
- Rosen GD
- Rotondo A
- Rujescu D
- Rujescu D
- Rybakowski F
- Ryten M
- Sachdev PS
- Salami A
- Samann PG
- Santonastaso P
- Satizabal CL
- Saykin AJ
- Scherag A
- Scherer S
- Schmaal L
- Schmidt H
- Schmidt R
- Schmidt U
- Schnell K
- Schofield PR
- Schork AJ
- Schork N
- Schosser A
- Schumann G
- Scott L
- Seiler S
- Seitz J
- Seitz J
- Seshadri S
- Shen L
- Shin J
- Simmons A
- Singleton A
- Sisodiya SM
- Slachtova L
- Sladek R
- Slagboom PE
- Slof-Op't Landt M
- Slopien A
- Smith C
- Smith T
- Smoller JW
- Soininen H
- Soranzo N
- Sorbi S
- Southam L
- Sprooten E
- Steen V
- Steen VM
- Stein JL
- Strengman E
- Strike LT
- Strober M
- Sussmann JE
- Szatkiewicz J
- Szeszenia-Dabrowska N
- Tachmazidou I
- Tenconi E
- Teumer A
- Thalamuthu A
- Thompson PM
- Thompson PM
- Thornton L
- Toga AW
- Toro R
- Tortorella A
- Tozzi F
- Trabzuni D
- Traynor BJ
- Treasure J
- Troncoso J
- Tschop M
- Tsitsika A
- Turner JA
- Tziouvas K
- van Bokhoven H
- van der Brug M
- van der Lee SJ
- van der Marel SSL
- van der Wee NJA
- van Donkelaar MMJ
- van Duijn CM
- van Eijk KR
- van Elburg A
- van Furth E
- van Haren NEM
- van Hulzen KJE
- van Tol M-J
- van't Ent D
- Veltman DJ
- Vinke LN
- Volzke H
- Wade T
- Wagner G
- Walter H
- Walters R
- Walters RK
- Walton E
- Walton E
- Walton E
- Wardlaw JM
- Wassink TH
- Watson H
- Weale ME
- Weinberger DR
- Weiner MW
- Wen W
- Westlye LT
- Westman E
- Whelan CD
- White T
- Wichmann H-E
- Widen E
- Williams RW
- Winkler AM
- Wittfeld K
- Woldehawariat G
- Wolf C
- Woodside DB
- Wright MJ
- Xue L
- Yanek LR
- Yanovski J
- Yao S
- Yilmaz Z
- Yilmaz Z
- Zerwas S
- Zielke RH
- Zipfel S
- Zonderman AB
- Zwiers MP
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/07/2019
- Field of study
In MRI scans of patients with anorexia nervosa (AN), reductions in brain volume are often apparent. However, it is unknown whether such brain abnormalities are influenced by genetic determinants that partially overlap with those underlying AN. Here, we used a battery of methods (LD score regression, genetic risk scores, sign test, SNP effect concordance analysis, and Mendelian randomization) to investigate the genetic covariation between subcortical brain volumes and risk for AN based on summary measures retrieved from genome-wide association studies of regional brain volumes (ENIGMA consortium, n = 13,170) and genetic risk for AN (PGC-ED consortium, n = 14,477). Genetic correlations ranged from − 0.10 to 0.23 (all p > 0.05). There were some signs of an inverse concordance between greater thalamus volume and risk for AN (permuted p = 0.009, 95% CI: [0.005, 0.017]). A genetic variant in the vicinity of ZW10, a gene involved in cell division, and neurotransmitter and immune system relevant genes, in particular DRD2, was significantly associated with AN only after conditioning on its association with caudate volume (pFDR = 0.025). Another genetic variant linked to LRRC4C, important in axonal and synaptic development, reached significance after conditioning on hippocampal volume (pFDR = 0.021). In this comprehensive set of analyses and based on the largest available sample sizes to date, there was weak evidence for associations between risk for AN and risk for abnormal subcortical brain volumes at a global level (that is, common variant genetic architecture), but suggestive evidence for effects of single genetic markers. Highly powered multimodal brain- and disorder-related genome-wide studies are needed to further dissect the shared genetic influences on brain structure and risk for AN
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
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- Benke J
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- Hitchens Matthew Edward
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- Kovar Christie L.
- Krawczyk Marie-Claude
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- Kremmidiotis Gabriel
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- Kube Michael
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- Lightning Julia
- Lim Meng K.
- Lindblad-Toh Kerstin
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- Lovell Jamie
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- Lu Lingfeng
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- Lu Yue
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- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
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- Murayama Yuji
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- Williams Gabrielle A.
- Williams Leanne
- Williamson Angela L.
- Williamson Helen
- Wills Patricia L.
- Wills Richard
- Wilmer Tamsin
- Wilming Laurens
- Wilson Brian
- Wilson Gareth
- Wilson Margaret
- Wilson Nyree
- Wilson Piers
- Wilson Richard K.
- Wilson Siobhan
- Wilson Steve
- Wilson Wendy
- Wincker Patrick
- Window Philip
- Winster Jenny
- Winzar Claire
- Witt James
- Wleczyk Regina
- Wobus Fred
- Woessner Jeffrey
- Wohldmann Patty
- Wollard Jessica
- Womack Andrew W.
- Wong Benjamin
- Wong Gane K-S
- Wood Diane
- Wood Emma
- Wood Joe
- Wooden Hailey S.
- Wooden Steven H.
- Woodeson Sharon
- Woodfine Kathryn
- Woodmansey Rebecca
- Woods Eric
- Woodwark Cara
- Wooster Richard
- Worley Kim Carlyle
- Woyke Tanja
- Wray Matthew
- Wray Paul
- Wright Charmain
- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension
- Author
- Acary Souza Bulle Oliveira
- Adam Hart
- Adife Veske
- Aditya Kumar
- Aikaterini Dimitriou
- Akihiro Mukaino
- Akiko Kanzaki
- Akiyuki Uzawa
- Akshay Shah
- Alan Ross Berger
- Albert Hietala
- Alberta Locatelli
- Alejandra Dalila Garcia
- Alejandro Tobon Gonzalez
- Alessandro Filla
- Alex Fondaw
- Alexandre Guerreiro
- Alexandre Guerreiro
- Ali Malekniazi
- Aline de Cassia Santos
- Alzira Alves de Siqueira Carvalho
- Amaiak Chilingaryan
- Amanda Anderson
- Amelia Evoli
- Amna Shah
- Amy Saklad
- Amy Woodall
- Ana Carolina Amaral de Andrade
- Ana Lazaro
- Ana Paula Macagnan
- Ana Paula Melo
- Andrea Corse
- Andrea Kelley
- Andrea Swenson
- Angela Ardoin
- Angela Campanella
- Angela Marsili
- Angela Micheels
- Angiola Fasanaro
- Anh Tran
- Anita Mogensen
- Ann D'Hont
- Anna Gonzalez
- Anne Cooley
- Anne Mette Ostergaard Autzen
- Anneke van der Kooi
- Annelies Depreitere
- Annelies Vanhee
- Anthony Amato
- Antonella Di Pasquale
- Antonella Di Pasquale
- April McVey
- Arshira Seddigh
- Arzu Meherremova
- Ashley Mallon
- Aya Mizugami
- Ayse Kutlu
- Baki Dogan
- Barbara Lokaitis
- Barbora Kurkova
- Bengu Balkan
- Benison Keung
- Benjamin Brooks
- Beth DiSanzo
- Betsy Mosmiller
- Booth H. D. E.
- Brajesh Agrawal
- Brian Droker
- Brian Minton
- Brigitta Szabadosne
- Brittany Harvey
- Bruno Bezerra Rosa
- Bryan Kim
- Byoung Joon Kim
- Byung-Jo Kim
- Can Ebru Bekircan-Kurt
- Cansu Semiz
- Carlo Antozzi
- Carlos Casasnovas
- Carol Herbert
- Carolina Miranda
- Caroline Schotte
- Cecile Phan
- Celal Tuga
- Chae Won Shin
- Chafic Karam
- Chafic Karam
- Chang Nyoung Lee
- Charlene Hafer-Macko
- Charlotte Smetcoren
- Christian Homedes-Pedret
- Christopher Nance
- Claire Brown
- Clara Schommer
- Claudio Gabriel Mazia
- Colleen Pineda
- Craig Donahue
- Cristiani Fernanda Butinhao
- Csilla Rozsa
- Cynthia Bodkin
- Cynthia Carter
- Da Yoon Koh
- Dae Lim Koo
- Dai Matsuse
- Daiane da Cruz Pacheco
- Daisuke Yamamoto
- Dallas Forshew
- Daniel Ambrosio
- Daniel Dicapua
- Danielle Sheldon
- Dave Watling
- David Feder
- Debbie Davies
- Debora Dada Martineli Torres
- Dennis Jeffery
- Derrick Blackmore
- Diana Dimitrova
- Diego Lopergolo
- Donna Carnes
- Doreen Ho
- Délphine Mahieu
- Edina Varga
- Elaine Weiner
- Elena Bravver
- Elena Cortes Vicente
- Elena Giacomelli
- Eliana Reyes
- Elisabet Arribas-Ibar
- Elizabeth Watt
- Emanuela Onesti
- Emiko Tsuda
- Enrico Marano
- Eri Kobayashi
- Erica Nogueira Coelho
- Eriko Higuchi
- Eriko Miyawaki
- Eun Bi Hwang
- Eun Bin Cho
- Eun Haw Choi
- Exuperio Diez Tejedor
- Ezgi Yilmaz
- Fabio Barroso
- Faisal Sohail
- Fatima Maqsood
- Fernanda Carrara
- Fernanda Troili
- Filiz Muharrem
- Fiona Norwood
- Floyd Jones
- Francesco Saccà
- Francisco Javier Rodriguez de Rivera
- Frank Lin
- Fredrik Piehl
- Fujita K. P.
- Fumie Meguro
- Gabor Lovas
- Gabor Lovasamela César
- Gabriel Paiva
- Gabrielle Rico
- Gal Maier
- Gedeonne Jakab
- Gedeonne Jakab
- Giannis Sokratous
- Giorgia Camera
- Giorgia Puorro
- Giovanni Antonini
- Girija Sadalage
- Gisela Gili
- Gonzalo Mazuela
- Gonzalo Vidal
- Graziela Pinto
- Gulmohor Roy
- Gulsah Becerikli
- Gulsah Orsel
- Gustavo Duran
- Guy Van den Abeele
- Gyorgyi Szabo
- H James Jones
- Ha Young Shin
- Ha-Neul Jeong
- Hakan Cavus
- Harpreet Kaur
- Heena Olalde
- Heike Arndt
- Henning Andersen
- Henrique Mohr
- Hidekazu Suzuki
- Hirokazu Shiraishi
- Hiroyuki Murai
- Hisako Kobayashi
- Hong Vu
- Hoo Nam Kang
- Howard J. F.
- Hui Gong
- Huned Patwa
- Hung Youl Seok
- Husnu Efendi
- HyeJin Ra
- HyeLim Lee
- Hyung Seok Lee
- Iandra Souza
- Igor Dias Brockhausen
- Ihsan Sengun
- Ikuko Kamegamori
- Ikuko Yasuda
- Irene Yang
- Isabel Illa
- Ivana Jurajdova
- Iveta Novakova
- Jaana Eriksson
- Jae-Sung Lim
- Jaimin Shah
- Jakit Gollogly
- James Gilchrist
- Jan De Bleecker
- Jan Vynckier
- Jana Junkerova
- Jane Distad
- Jane Pedersen
- Janice Massey
- Jasmine Hewlett
- Jaya Trivedi
- Jayashri Srinivasan
- Jeffery Statland
- Jeffrey Guptill
- Jeffrey Narayan
- Jeffrey Rosenfeld
- Jenna Seelbach
- Jeri Sieren
- Jerry Locheke
- Ji Ye Hwang
- JiEun Lee
- Jinmyoung Seok
- JinWoo Jung
- Jiri Pitha
- Joan Højgaard
- Joan Nye
- Joanne Nemeth
- John Kincaid
- John Kissel
- John Loor
- John Vissing
- Jonathan Katz
- Jonathan McKinnon
- Jordan Jara
- Jordana Gonçalves Geraldo
- Jordi Diaz-Manera
- Josef Bednarik
- Josep Gamez Carbonell
- Joseph Chad Hoyle
- Ju-Hong Min
- Judit Matolcsi
- Juha-Pekka Erälinna
- Julie Agriesti
- Julie Khoury
- Julie Steele
- Juliet Saba
- Jun Kawamata
- Justin Kwan
- JuYoung Kwon
- Kaitlyn McKenna
- Kaori Osakada
- Kaori Uwasa
- Kara Patrick
- Karan Alcon
- Karen Callison
- Karen Zakalik
- Katarina Reguliova
- Kate Beck
- Katherine Amato
- Kathryn Johns
- Kathy de Koning
- Katrien De Mey
- Katsuhisa Masaki
- Kazumi Futono
- Kazumi Takada
- Keiko Kikutake
- Kelley Emmons
- Kendrick Henderson
- Kenichi Tsukita
- Kenkichi Nozaki
- Kerry Naunton
- Kevin Daniels
- Khema Sharma
- Kimberly Robeson
- Kimiaki Utsugisawa
- Koichi Narikawa
- Krishna Polaka
- Kristen Roe
- Kristin Huynh
- Lara Katzin
- Laszlo Vecsei
- Laura Diez Porras
- Laura Echevarria
- Laura Fionda
- Laura Fionda
- Laura Golden
- Laura Haar
- Laura Herbelin
- Lauren Wheeler
- Laurie Gutmann
- Lena Bjarbo
- Lesly Welsh
- Liang Lu
- Liene Duarte Silva
- Linda Wagemaekers
- Lindsay Zilliox
- Lisa Hobson-Webb
- Lisa Smith
- Livia Dezsi
- Lorenzo Maggi
- Lorraine Dishman
- Lotte Vinge
- Louisa Mezache
- Lucas Eduardo Pazetto
- Luciana Ferreira
- Luciana Renata Cubas Volpe
- Luciana Souza Duca
- Ludwig Gutmann
- Luis Antonio Querol Gutiérrez
- Luiz Augusto da Silva
- Luiz Otavio Maia Gonçalves
- Maeda Yasuko
- Magda Chmelikova
- Maki Jingu
- Makoto Samukawa
- Mamatha Pasnoor
- Manisha Chopra
- Mantegazza R.
- Marcela Silva
- Marcela Wolfova
- Marcelo Annes
- Marcelo Chaves
- Marcelo Rugiero
- Marek Cierny
- Marguerite Engel
- Maria Antonia Alberti Aguilo
- Maria da Penha Ananias Morita
- Maria Gabriele
- Maria Gori
- Maria Pasanisi
- Maria Salvado Figueras
- Maria Sastre
- Marianne de Visser
- Mariela Bettini
- Marina Pozo
- Martin Bilsker
- Mary Varghese
- Maryanne Burdette
- Masahiro Mori
- Masakatsu Motomura
- Masaki Saitoh
- Masako Tsurumaru
- Masanori Takahashi
- Masayuki Nakamori
- Matteo Garibaldi
- Maureen Walsh
- Maurer Pereira Martins
- Maurizio Inghilleri
- Maurício AndréGheller Friedrich
- Mayuko Noshiro
- Mazen Dimachkie
- Megan Kramer
- Megumi Koga
- Meinoshin Okumura
- Melanie Glenn
- Melinda Horvath
- Michael Benatar
- Michael Hehir
- Michael Pulley
- Michael Weiss
- Michaela Tyblova
- Michal Vytopil
- Miguel Wilken
- Mihoko Takada
- Miju Shin
- Mikko Laaksonen
- Mireya Fernandez-Fournier
- Mireya Fernandez-Fournier
- Miri Kim
- Miriam Freimer
- Misa Shimpo
- MiSong Choi
- Miwako Sato
- Miyuki Morikawa
- Mohamed Kazamel
- Mohamed Mahdi-Rogers
- Mohammad Alsharabati
- Mohammed Salajegheh
- Mohammed Sanjak
- Mollie Vanderhook
- Mona Elsayed
- Monika Konyane
- Muppidi S.
- Murat Terzi
- Murilo Santos Engel
- Musa Kazim Onar
- Muzeyyen Ugur
- Nadia Sattar
- Namie Taichi
- Namita Goyal
- Nanna Witting
- Naoki Kawaguchi
- Naoko Ishiyama
- Natalia Julia Palacios
- Natalia Prando
- Natália Assis
- Naya McKinnon
- Nazire Pinar Acar
- Neelam Goyal
- Nicholas Silvestri
- Nicholas Ventura
- Nicolas Vandenbussche
- Nicole Jenci
- Nicole Kressin
- Nivedita Jerath
- Nuria Vidal
- O'Brien F. L.
- Ohito Tano
- Olga Zapletalova
- Olivier Stevens
- Olli Oksaranta
- Ozlem Tun
- Paolo Emilio Alboini
- Patricia Padilla
- Patrícia Fernandes
- Pedro Lopez Ruiz
- Petra Tilkin
- Philip Van Damme
- Pilar Gomez Salcedo
- Pilar Sune
- Pinar Ozcelik
- Pravin Torane
- Pravin Torane
- Raffaele Iorio
- Ratna Bhavaraju-Sanka
- Rebecca Traub
- Rebekah Garcia
- Rekha Pillai
- Renata Martins Ribeiro
- Ricardo Rojas Garcia
- Richard Barohn
- Richard Nowak
- Rikako Kurihara
- Rikki Roderus
- Riley Snook
- Robert Miller
- Robert Pascuzzi
- Rosana Rocha
- Rudy Mercelis
- Rumi Takeyama
- Rup Tandan
- Sabrina Pol
- Sachiko Kamakura
- Said Beydoun
- Saiju Jacob
- Salma Akhter
- Sanaz Karimi
- Sandi Mumfrey-Thomas
- Sandra Guingrich
- SangAe Park
- Sara-Claude Michon
- Sarada Sakamuri
- Sarah Plevka
- Sarah Verjans
- Scott Cunningham
- Seda Aydinlik
- Sedat Sen
- Seiko Yoshida
- Seung Min Kim
- Sevim Erdem-Ozdamar
- Shachie Aranke
- Shannon Lucy
- Sharmeen Alam
- Sharon Chelnick
- Sharon Downing
- Sharon Nations
- Shin Hisahara
- Shirley Paulose
- Shirli Toska
- Shizuka Asada
- Shoko Amamoto
- Shuichiro Suzuki
- Shun Shimohama
- Shun Shimohama
- Shunsuke Yoshimura
- Sien Van Daele
- Silvia Bonanno
- Sivakumar Sathasivam
- So-Hyun Ahn
- Soichiro Funaka
- Sonia Garcia
- Stanislav Vohanka
- Stanislava Toncrova
- Stefania Morino
- Stephanie Kohlrus
- Stephanie Scala
- Steve Hopkins
- Susan Strom
- Susanne Krogh
- Tahseen Mozaffar
- Taira Uehara
- Takashi Hayashi
- Takashi Murahara
- Takuya Matsushita
- Tamar Gibson
- Tamires Cristina Gomes da Silva
- Taylor Darnell
- Teiichiro Miyazaki
- Teresa Costabile
- Terry McClain
- Terry McClain
- Tessa Marburger
- Tetsuya Akiyama
- Tetsuya Kanai
- Thabata Veiga
- Thomas Arnold
- Thomas Cochrane
- Thomas Harbo
- Tierney Scott
- Tina Liu
- Tiyonnoh Cash
- Tomihiro Imai
- Tomihiro Imai
- Tomohiro Kawamura
- Tomoko Tsuda
- Tomomi Kobashikawa
- Tomoya Hasuike
- Tomás Augusto Suriane Fialho
- Tuan Vu
- Tugce Kirbas Cavdar
- Tulio Bertorini
- Tuula Harrison
- Valentina D'Amato
- Valentina Velez Santamaria
- Valeria Cavalcante Lino
- Valerie Young
- Veena Mathew
- Vern Juel
- Victor Doan
- Vinay Chaudhry
- Vittorio Frasca
- Vittorio Frasca
- Waqar Waheed
- Wiendl H.
- Wladimir Pinto
- Wolfe G. I.
- Yagmur Caliskan
- Yasmeen Shabbir
- Yasmeen Shabbir
- Yasushi Suzuki
- Ye Liu
- Yoko Ishiyama
- Yoko Kaneko
- Yong Seo Koo
- Yool-Hee Kim
- Yoon-Ho Hong
- Yoshiko Sano
- Yuen T So
- Yuka Saito
- Yukiko Ozawa
- Yuko Fujii
- Yumi Yamashita
- Yumiko Nakamura
- Yunxia Wang
- Yuriko Nagane
- Yusuke Fukuda
- Zaeem Siddiqi
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2021
- Field of study
OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. METHODS: Patients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study. RESULTS: A total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1-4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected. CONCLUSION: Eculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population. CLINICALTRIALSGOV IDENTIFIER: REGAIN, NCT01997229; REGAIN open-label extension, NCT02301624. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo
Minimal Symptom Expression' in Patients With Acetylcholine Receptor Antibody-Positive Refractory Generalized Myasthenia Gravis Treated With Eculizumab
- Author
- Agrawal Brajesh
- Agriesti Julie
- Ahn So-Hyun
- Akhter Salma
- Akiyama Tetsuya
- Alam Sharmeen
- Alcon Karan
- Alsharabati Mohammad
- Alves de Siqueira Carvalho Alzira
- Amamoto Shoko
- Amato Anthony
- Amato Katherine
- Ambrosio Daniel
- Andersen Henning
- Anderson Amanda
- Andoin Angela
- André Gheller Friedrich Maurício
- Annes Marcelo
- Antonia Alberti Aguilo Maria
- Antonini Giovanni
- Antonio Querol Gutiérrez Luis
- Antozzi Carlo
- Aranke Shachie
- Arndt Heike
- Arnold Thomas
- Arribas-Ibar Elisabet
- Asada Shizuka
- Assis Natália
- Augusto da Silva Luiz
- Augusto Suriane Fialho Tomás
- Aydinlik Seda
- Balkan Bengu
- Barohn Richard
- Barroso Fabio
- Becerikli Gulsah
- Beck Kate
- Bednarik Josef
- Benatar Michael
- Bertorini Tulio
- Bettini Mariela
- Beydoun Said
- Bezerra Rosa Bruno
- Bhavaraju-Sanka Ratna
- Bi Hwang Eun
- Bilsker Martin
- Bin Cho Eun
- Bjarbo Lena
- Blackmore Derrick
- Bodkin Cynthia
- Bonanno Silvia
- Bravver Elena
- Brooks Benjamin
- Brown Claire
- Burdette Maryanne
- Caliskan Yagmur
- Callison Karen
- Camera Giorgia
- Campanella Angela
- Carnes Donna
- Carolina Amaral de Andrade Ana
- Carrara Fernanda
- Carter Cynthia
- Casasnovas Carlos
- Cash Tiyonnoh
- Cavalcante Lino Valeria
- Cavus Hakan
- Chad Hoyle Joseph
- Chaudhry Vinay
- Chaves Marcelo
- Chelnick Sharon
- Chilingaryan Amaiak
- Chmelikova Magda
- Choi MiSong
- Chopra Manisha
- Cierny Marek
- Cochrane Thomas
- Cooley Anne
- Corse Andrea
- Cortes Vicente Elena
- Costabile Teresa
- Cristina Gomes da Silva Tamires
- Cunningham Scott
- César Pamela
- D'Amato Valentina
- D'Hont Ann
- da Cruz Pacheco Daiane
- da Penha Ananias Morita Maria
- Dada Martineli Torres Debora
- Dalila Garcia Alejandra
- Daniels Kevin
- Darnell Taylor
- Davies Debbie
- De Bleecker Jan
- de Cassia Santos Aline
- de Koning Kathy
- De Mey Katrien
- de Visser Marianne
- Depreitere Annelies
- Dezsi Livia
- Di Pasquale Antonella
- Dias Brockhausen Igor
- Diaz-Manera Jordi
- Dicapua Daniel
- Diez Porras Laura
- Diez Tejedor Exuperio
- Dimachkie Mazen
- Dimitriou Aikaterini
- Dimitrova Diana
- DiSanzo Beth
- Dishman Lorraine
- Distad Jane
- Doan Victor
- Dogan Baki
- Donahue Craig
- Downing Sharon
- Droker Brian
- Duarte Silva Liene
- Duran Gustavo
- Ebru Bekircan-Kurt Can
- Echevarria Laura
- Eduardo Pazetto Lucas
- Efendi Husnu
- Elsayed Mona
- Emilio Alboini Paolo
- Emmons Kelley
- Engel Marguerite
- Erdem-Ozdamar Sevim
- Eriksson Jaana
- Erälinna Juha-Pekka
- Evoli Amelia
- Fasanaro Angiola
- Feder David
- Fernanda Butinhao Cristiani
- Fernandes Patrícia
- Fernandez-Fournier Mireya
- Fernandez-Fournier Mireya
- Ferreira Luciana
- Filla Alessandro
- Fionda Laura
- Fionda Laura
- Fondaw Alex
- Forshew Dallas
- Frasca Vittorio
- Frasca Vittorio
- Freimer Miriam
- Fujii Yuko
- Fukuda Yusuke
- Funaka Soichiro
- Futono Kazumi
- Gabriel Mazia Claudio
- Gabriele Maria
- Gamez Carbonell Josep
- Garcia Rebekah
- Garcia Sonia
- Garibaldi Matteo
- Giacomelli Elena
- Gibson Tamar
- Gilchrist James
- Gili Gisela
- Glenn Melanie
- Golden Laura
- Gollogly Jakit
- Gomez Salcedo Pilar
- Gong Hui
- Gonzalez Anna
- Gonçalves Geraldo Jordana
- Gori Maria Cristina
- Goyal Namita
- Goyal Neelam
- Guerreiro Alexandre
- Guinrich Sandra
- Guptill Jeffrey
- Gutmann Laurie
- Gutmann Ludwig
- Haar Laura
- Hafer-Macko Charlene
- Harbo Thomas
- Harrison Tuula
- Hart Adam
- Harvey Brittany
- Hasuike Tomoya
- Haw Choi Eun
- Hayashi Takashi
- Hehir Michael
- Henderson Kendrick
- Herbelin Laura
- Herbert Carol
- Hewlett Jasmine
- Hietala Albert
- Higuchi Eriko
- Hisahara Shin
- Ho Doreen
- Hobson-Webb Lisa
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- Previous
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- Shabbir Yasmeen
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- Sune Pilar
- Suzuki Hidekazu
- Suzuki Shuichiro
- Suzuki Yasushi
- Swenson Andrea
- Szabadosne Brigitta
- Szabo Gyorgyi
- T So Yuen
- Taichi Namie
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- Takahashi Masanori
- Takeyama Rumi
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- Ugur Muzeyyen
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- Van Damme Philip
- Van den Abeele Guy
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- Wang Yunxia
- Watling Dave
- Watt Elizabeth
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- Weiss Michael
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- Wheeler Lauren
- Wilken Miguel
- Witting Nanna
- Wolfe Gil
- Wolfova Marcela
- Won Shin Chae
- Woodall Amy
- Yamamoto Daisuke
- Yamashita Yumi
- Yang Irene
- Yasuda Ikuko
- Ye Hwang Ji
- Yilmaz Ezgi
- Yoon Koh Da
- Yoshida Seiko
- Yoshida Seiko
- Yoshimura Shunsuke
- Youl Seok Hung
- Young Shin Ha
- Young Valerie
- Zakalik Karen
- Zapletalova Olga
- Zilliox Lindsay
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
The efficacy and tolerability of eculizumab were assessed in REGAIN, a 26-week, phase 3, randomized, double-blind, placebo-controlled study in anti-acetylcholine receptor antibody-positive (AChR+) refractory generalized myasthenia gravis (gMG), and its open-label extension
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
- Author
- Abdellaoui Abdel
- Abramova Liliya
- Adams Mark
- Adams Mark J.
- Adan Roger A. H.
- Adolfsson Rolf
- Adolfsson Rolf
- Adorjan Kristina
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Aguayo Samuel
- Ahuja Sunil
- Air Tracy M.
- Air Tracy M.
- Al Eissa Mariam
- Albani Diego
- Alda Martin
- Alda Martin
- Alfredsson Lars
- Alfredsson Lars
- Alfredsson Lars
- Alliey-Rodriguez Ney
- Als Thomas D.
- Andlauer Till F. M.
- Ando Tetsuya
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Anjorin Adebayo
- Antilla Verneri
- Antoniou Anastasia
- Appadurai Vivek
- Argyres Dean P.
- Arolt Volker
- Artigas Maria Soler
- Aschauer Harald
- Ashley-Koch Allison E.
- Aslan Mihaela
- Awasthi Swapnil
- Awasthi Swapnil
- Awasthi Swapnil
- Azevedo M. Helena
- Babadjanova Gulja
- Bacanu Silviu-Alin
- Backlund Lena
- Baek Ji Hyun
- Baker Jessica H.
- Ballas Zuhair
- Bass Nicholas
- Bass Nicholas
- Bau Claiton H. D.
- Bauer Michael
- Baune Bernhard T.
- Baune Bernhard T.
- Baune Bernhard T.
- Beckham Jean
- Beckham Jean
- Beckham Jean C.
- Beekman Aartjan T. F.
- Beins Eva C.
- Bellivier Frank
- Bellivier Frank
- Bencko Vladimir
- Bengesser Susanne
- Bergen Andrew W.
- Bergen Andrew W.
- Bergen Sarah E.
- Berger Klaus
- Berger Klaus
- Berrettini Wade H.
- Berrettini Wade H.
- Berrettini Wade H.
- Bhushan Sujata
- Biernacka Joanna M.
- Biernacka Joanna M.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Binder Elisabeth B.
- Binder Elisabeth B.
- Birgegård Andreas
- Birner Armin
- Blackwood Douglas H. R.
- Boden Joseph M.
- Boehm Ilka
- Boehnke Michael
- Boehnke Michael
- Bohus Martin
- Bohus Martin
- Boks Marco P.
- Boks Marco P.
- Boni Claudette
- Boomsma Dorret I.
- Bosch Rosa
- Bosch Rosa
- Boyko Edward
- Braff David L.
- Brandt Harry
- Brandt Harry
- Breeling James
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Brewer Jessica V.
- Brophy Mary T.
- Brum Murielle
- Brumpton Ben M.
- Brunkhorst-Kanaan Nathalie
- Bryant Richard
- Bryois Julien
- Bryois Julien
- Bryois Julien
- Budde Monika
- Budde Monika
- Buehren Katharina
- Bulik Cynthia M.
- Bulik Cynthia M.
- Burghardt Roland
- Buttenschøn Henriette N.
- Bybjerg-Grauholm Jonas
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M.
- Byrne Enda M.
- Bækvad-Hansen Marie
- Bækvad-Hansen Marie
- Bøen Erlend
- Børglum Anders D.
- Børglum Anders D.
- Børglum Anders D.
- Børte Sigrid
- Cahn Wiepke
- Cai Na
- Cairns Murray
- Campos Adrian I.
- Carlberg Laura
- Carr Vaughan J.
- Carter Bruce W.
- Casas Miguel
- Casas Miquel
- Cassina Matteo
- Castelao Enrique
- Castelao Enrique
- Catts Stanley
- Cervantes Pablo
- Cervilla Jorge A.
- Chang Kyong-Mi
- Chang Xiao
- Charney Alexander W.
- Chaumette Boris
- Chen Hsi-Chung
- Chen Wei J.
- Cho Kelly
- Cho Kelly
- Christensen Jane Hvarregaard
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Clarke Toni-Kim
- Clarke Toni-Kim
- Clementi Maurizio
- Cohen David
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Colodro-Conde Lucía
- Cone Roger D.
- Connor Todd
- Constans Joseph
- Coombes Brandon
- Coon Hilary
- Corvin Aiden
- Corvin Aiden
- Courtet Philippe
- Couvy-Duchesne Baptiste
- Craddock Nicholas
- Craddock Nicholas
- Craddock Nick
- Craig David
- Crawford Gregory E.
- Crawford Steven
- Crawford Steven
- Crivelli Silvia
- Crow Scott
- Crow Scott
- Crowley James J.
- Cruceanu Cristiana
- Cuellar-Barboza Alfredo
- Cunningham Julie
- Curtis David
- Czerski Piotr M.
- Dahmen Norbert
- Dale Anders M.
- Dalkner Nina
- Danner Unna N.
- Dannlowski Udo
- Dannlowski Udo
- David Friederike S.
- Davies Gail
- Davis Oliver S. P.
- de Geus E. J. C.
- de Zwaan Martina
- Dedoussis George
- Degenhardt Franziska
- Degenhardt Franziska
- Degenhardt Franziska
- Degortes Daniela
- Dellitalia Louis
- Demontis Ditte
- Dennis Michelle F.
- Depaulo J. Raymond
- DePaulo J. Raymond
- der Auwera Sandra Van
- Derks Eske M.
- DeSocio Janiece E.
- Di Florio Arianna
- DiBlasi Emily
- Dick Danielle M.
- Dietl Lydie
- Dikeos Dimitris
- Dikeos Dimitris
- Dina Christian
- Direk Nese
- Djurovic Srdjan
- Djurovic Srdjan
- Dmitrzak-Weglarz Monika
- Do Nhan
- Dobbyn Amanda L.
- Docherty Anna R.
- Dolan Conor V.
- Domenici Enrico
- Domschke Katharina
- Douzenis Athanassios
- Drange Ole Kristian
- Duncan Laramie E.
- Dunn Erin C.
- Duriez Philibert
- Edenberg Howard J.
- Edenberg Howard J.
- Edwards Alexis C.
- Egberts Karin
- Ehrlich Stefan
- Eley Thalia C.
- Elvsåshagen Torbjørn
- Erlangsen Annette
- Escaramís Geòrgia
- Escott-Price Valentina
- Escott-Price Valentina
- Esko Tõnu
- Esko Tõnu
- Esko Tõnu
- Esko Tõnu
- Espeseth Thomas
- Estivill Xavier
- Etain Bruno
- Fanous Ayman H.
- Farmer Anne
- Favaro Angela
- Fayad Joseph
- Ferentinos Panagiotis
- Fernández-Aranda Fernando
- Fernández-Aranda Fernando
- Ferrier I. Nicol
- Fichter Manfred M.
- Fichter Manfred M.
- Finucane Hilary K.
- Fiorentino Alessia
- Fischer Krista
- Florez Hermes
- Floyd James A. B.
- Foo Jerome C.
- Foo Jerome C.
- Foretova Lenka
- Foroud Tatiana M.
- Forstner Andreas J.
- Forstner Andreas J.
- Forstner Andreas J.
- Forstner Andreas J.
- Forty Liz
- Forzan Monica
- Frank Josef
- Frank Josef
- Frank Josef
- Franklin Christopher S.
- Frei Oleksandr
- Freimer Nelson B.
- Frisén Louise
- Frye Mark
- Frye Mark
- Fullerton Janice M.
- Fullerton Janice M.
- Föcker Manuel
- Gaddy Melinda
- Gade Katrin
- Galfalvy Hanga
- Gallinger Steven
- Gallinger Steven
- Gambaro Giovanni
- Gandal Michael
- Gandal Michael J.
- Gappy Saib
- Garnham Julie
- Gaspar Héléna A.
- Gaspar Héléna A.
- Gatt Justine M.
- Gawlik Micha
- Gaziano J. Michael
- Gaziano J. Michael
- Gejman Pablo V.
- Gelernter Joel
- Gelernter Joel
- Gershon Elliot S.
- Gibson Gretchen
- Giegling Ina
- Giegling Ina
- Gill Michael
- Giuranna Johanna
- Giusti-Rodríquez Paola
- Gizer Ian R.
- Glatt Stephen J.
- Godschalk Michael
- Goes Fernando S.
- Goes Fernando S.
- Gonidakis Fragiskos
- Gordon Scott
- Gordon Scott D.
- Gordon Scott D.
- Gordon-Smith Katherine
- Gorwood Philip
- Gorwood Philip
- Grabe Hans J.
- Grabe Hans J.
- Greco Jennifer
- Green Melissa J.
- Green Melissa J.
- Greenwood Tiffany A.
- Grevet Eugenio H.
- Grigoroiu-Serbanescu Maria
- Grigoroiu-Serbanescu Maria
- Grove Jakob
- Grove Jakob
- Grove Jakob
- Guillaume Sébastien
- Guo Yiran
- Guo Yiran
- Gupta Samir
- Gutierrez Blanca
- Gutierrez Salvador
- Guzman-Parra Jose
- Guzman-Parra José
- Ha Kyooseob
- Hafferty Jonathan D.
- Hagenaars Saskia P.
- Hakonarson Hakon
- Hakonarson Hakon
- Hall Lynsey S.
- Halmi Katherine A.
- Halmi Katherine A.
- Hamilton Steven P.
- Hamilton Steven P.
- Hammer Kimberly
- Hamner Mark
- Hamshere Marian L.
- Hanscombe Ken B.
- Hansen Christine Søholm
- Hansen Christine Søholm
- Hansen Thomas F.
- Haraldsson Magnus
- Harley John
- Hartmann Annette
- Harvey Phillip D.
- Hassan Kiadeh Farnush Farhadi
- Hatzikotoulas Konstantinos
- Hauser Elizabeth
- Hauser Elizabeth R.
- Hauser Joanna
- Hauser Joanna
- Hauser Joanna
- Hauser Michael A.
- Hautzinger Martin
- Hayward Caroline
- Heath Andrew C.
- Hebebrand Johannes
- Heilbronner Urs
- Heilmann-Heimbach Stefanie
- Helder Sietske G.
- Hellgren Dennis
- Henders Anjali K.
- Henskens Frans
- Herms Stefan
- Herms Stefan
- Herms Stefan
- Herpertz-Dahlmann Beate
- Herzog Wolfgang
- Hickie Ian B.
- Hillert Jan
- Hinney Anke
- Hishimoto Akitoyo
- Hoffmann Per
- Hoffmann Per
- Hoffmann Per
- Holmans Peter A.
- Homuth Georg
- Hong Kyung Sue
- Horn Carsten
- Horwood L. John
- Hottenga Jouke-Jan
- Hougaard David M.
- Hougaard David M.
- Hougaard David M.
- Howard David M.
- Huang Grant
- Huckins Laura
- Huckins Laura M.
- Hudson James I.
- Huffman Jennifer E.
- Hultman Christina M.
- Humphries Donald E.
- Hung Adriana
- HUNT All-In Psychiatry
- Huq Mostaqul
- Hurley Robin
- Hveem Kristian
- Hwu Hai-Gwo
- Hübel Christopher
- Ikeda Masashi
- Imgart Hartmut
- Inoko Hidetoshi
- Iruvanti Pran
- Ising Marcus
- Ising Marcus
- Ivins Douglas
- Iwata Nakao
- Jablensky Assen V.
- Jacobson Daniel
- Jacono Frank
- Jain Sonia
- Jamain Stéphane
- Jamain Stéphane
- Janout Vladimir
- Jansen Rick
- Jhala Darshana
- Jiménez-Murcia Susana
- Jiménez-Murcia Susana
- Johnson Craig
- Johnson Craig
- Johnson Jessica S.
- Jones Ian
- Jones Ian
- Jones Ian
- Jones Lisa A.
- Jones Lisa A.
- Jones Lisa A.
- Jonsson Lina
- Jordan Jennifer
- Jorgenson Eric
- Julià Antonio
- Jungkunz Martin
- Kahn René S.
- Kahn René S.
- Kalman Janos L.
- Kalsi Gursharan
- Kamatani Yoichiro
- Kaminsky Laurence
- Kaminská Deborah
- Kamitaki Nolan
- Kang JooEun
- Kaplan Allan S.
- Kaplan Allan S.
- Kaprio Jaakko
- Karhunen Leila
- Karwautz Andreas
- Kas Martien J. H.
- Kay Yang Jessica Mei
- Kaye Walter H.
- Kaye Walter H.
- Keel Pamela K.
- Kelsoe John R.
- Kelsoe John R.
- Kendler Kenneth S.
- Kendler Kenneth S.
- Kennedy James L.
- Kennedy James L.
- Kennedy James L.
- Kennedy Martin A.
- Keski-Rahkonen Anna
- Kessler Ronald C.
- Kiezebrink Kirsty
- Kim Minsoo
- Kim Minsoo
- Kim Youl-Ri
- Kimbrel Nathan A.
- Kinlay Scott
- Kirk Katherine M.
- Kirov George
- Kittel-Schneider Sarah
- Klareskog Lars
- Klein Jon
- Kloiber Stefan
- Kloiber Stefan
- Klump Kelly L.
- Klump Kelly L.
- Knowles James A.
- Knowles James A.
- Knudsen Gun Peggy S.
- Koenen Karestan C.
- Kogevinas Manolis
- Kogevinas Manolis
- Kohane Isaac S.
- Konte Bettina
- Koromina Maria
- Kraft Julia
- Kranz Thorsten M.
- Kranzler Henry R.
- Kranzler Henry R.
- Krebs Kristi
- Krebs Marie-Odile
- Kretzschmar Warren W.
- Kubo Michiaki
- Kuo Po-Hsiu
- Kupka Ralph
- Kushner Steven A.
- Kutalik Zoltán
- Landén Mikael
- Landén Mikael
- Landén Mikael
- Larsen Janne T.
- Lavebratt Catharina
- Lawrence Jacob
- Lawrence Jacob
- Le Hellard Stephanie
- Leber Markus
- Leboyer Marion
- Leboyer Marion
- Lee Heon-Jeong
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- Levinson Douglas F.
- Levinson Douglas F.
- Levy Shawn E.
- Lewis Cathryn M.
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- Li Dong
- Li Dong
- Li Qingqin S.
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- Li Yihan
- Liangpunsakul Suthat
- Liao Calwing
- Liao Calwing
- Liao Shih-Cheng
- Lichtenstein Paul
- Lichy Jack
- Lieb Klaus
- Lieb Klaus
- Lilenfeld Lisa
- Lilenfeld Lisa
- Lin Bochao Danae
- Lind Penelope A.
- Lindquist Jennifer H.
- Lissowska Jolanta
- Lissowska Jolanta
- Lissowska Jolanta
- Liu Chih-Min
- Lochner Christine
- Lori Adriana
- Loughland Carmel
- Lucae Susanne
- Lucae Susanne
- Lucae Susanne
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- Lundervold Astri
- Luykx Jurjen
- MacIntyre Donald J.
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- Magnusson Sigurdur H.
- Maier Robert M.
- Maier Wolfgang
- Maier Wolfgang
- Maihofer Adam
- Maj Mario
- Malaspina Dolores
- Mann J. John
- Mannik Katrin
- Maratou Eirini
- Marchini Jonathan
- Marsal Sara
- Marshall Christian R.
- Marshall Christian R.
- Martin Nicholas G.
- Martin Nicholas G.
- Martin Nicholas G.
- Martin Nicholas G.
- Martinez Elisa Docampo
- Martinsson Lina
- Mastorides Stephen
- Mathew Roy
- Mathews Carol A.
- Mattheisen Manuel
- Mattheisen Manuel
- Mattheisen Manuel
- Mattingsdal Morten
- Mattocks Kristin
- Mayora Monica Gratacos
- Mayoral Fermin
- Mayoral Fermin
- Mbarek Hamdi
- McArdle Rachel
- McDevitt Sara
- McElroy Susan L.
- McElroy Susan L.
- McGrath Patrick
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- McGregor Nathaniel W.
- McGuffin Peter
- McGuffin Peter
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- McMahon Benjamin
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- McQuillin Andrew
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- Medland Sarah E.
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- Mehta Divya
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- Melle Ingrid
- Melle Ingrid
- Metspalu Andres
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- Meyer Paul
- Micali Nadia
- Michie Patricia
- Middeldorp Christel M.
- Mihailov Evelin
- Milaneschi Yuri
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- Pyarajan Saiju
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- Ramos-Quiroga Josep Antoni
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- Ratcliffe Nora
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- Reif Andreas
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- Richarte Vanesa
- Rietschel Marcella
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- Rietschel Marcella
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- Ripke Stephan
- Ripke Stephan
- Ripke Stephan
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- Ritschel Franziska
- Rivas Fabio
- Rivera Margarita
- Rivera Margarita
- Rivera Margarita
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- Roberts Gloria
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- Robey Brooks
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- Rujescu Dan
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- Rybakowski Filip
- Saito Takeo
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- Schall Ulrich
- Schalling Martin
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- Schmahl Christian
- Schmidt Ulrike
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- Schott Björn H.
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- Schulte Eva C.
- Schulze Thomas G.
- Schulze Thomas G.
- Schulze Thomas G.
- Schwarze Cornelia E.
- Scott Laura J.
- Scott Laura J.
- Scott Rodney J.
- Seitz Jochen
- Selva Luis E.
- Senner Fanny
- Serretti Alessandro
- Serretti Alessandro
- Servatius Richard
- Shabalin Andrey
- Shannon Weickert Cynthia
- Sharma Satish
- Sharp Sally
- Shayan Shahpoor
- Shen Ling
- Sherman Scott
- Shi Jianxin
- Shi Jianxin
- Shilling Paul D.
- Shyn Stanley I.
- Shyn Stanley I.
- Sigurdsson Engilbert
- Sigurdsson Engilbert
- Sinnamon Grant C. B.
- Sirignano Lea
- Sirignano Lea
- Sklar Pamela
- Slachtova Lenka
- Slagboom P. Eline
- Slaney Claire
- Slof-Op ‘t Landt Margarita C. T.
- Sloofman Laura G.
- Slopien Agnieszka
- Smeland Olav B.
- Smeland Olav B.
- Smit Johannes H.
- Smith Daniel J.
- Smith Daniel J.
- Smith Daniel J.
- Smoller Jordan W.
- Smoller Jordan W.
- Smoller Jordan W.
- Sobell Janet L.
- Sokolowski Marcus
- Soler Artigas María
- Sonuga-Barke Edmund J. S.
- Soranzo Nicole
- Sorbi Sandro
- Southam Lorraine
- Spalletta Gianfranco
- Spijker Anne T.
- Sriram Peruvemba
- Stahl Eli A.
- Stahl Eli A.
- Stapley Todd
- Starnawska Anna
- Steen Vidar W.
- Stefansson Hreinn
- Stefansson Hreinn
- Stefansson Kari
- Stefansson Kari
- Stein Dan J.
- Stein Murray B.
- Steinberg Stacy
- Steinberg Stacy
- Stephens Brady
- Stordal Eystein
- Strauss John S.
- Strauss John S.
- Streit Fabian
- Streit Fabian
- Streit Fabian
- Streit Fabian
- Striker Robert
- Strober Michael
- Strober Michael
- Strohmaier Jana
- Strollo Patrick
- Stuber Garret D.
- Su Mei-Hsin
- Sullivan Patrick F.
- Sullivan Patrick F.
- Sullivan Patrick F.
- Sun Yan
- Szatkiewicz Jin P.
- Sánchez-Mora Cristina
- Sánchez-Mora Cristina
- Tachmazidou Ioanna
- Tandon Neeraj
- Tansey Katherine E.
- Teismann Henning
- Tenconi Elena
- Terao Chikashi
- Teumer Alexander
- Thompson Wesley
- Thomson Pippa A.
- Thorgeirsson Thorgeir E.
- Thorgeirsson Thorgeir E.
- Thornton Laura M.
- Thornton Laura M.
- Tiemeier Henning
- Toma Claudio
- Tooney Paul
- Tortorella Alfonso
- Tozzi Federica
- Traylor Matthew
- Treasure Janet
- Treasure Janet
- Treutlein Jens
- Treutlein Jens
- Trubetskoy Vassily
- Trubetskoy Vassily
- Trzaskowski Maciej
- Trzaskowski Maciej
- Tsao Philip
- Tsao Philip S.
- Tsao Philip S.
- Tsao Philip S.
- Tsermpini Evangelia-Eirini
- Tsitsika Artemis
- Tsuang Ming T.
- Turecki Gustavo
- Turecki Gustavo
- Tyszkiewicz-Nwafor Marta
- Tziouvas Konstantinos
- Uher Rudolf
- Uitterlinden André G.
- Umbricht Daniel
- Ursano Robert J.
- Vaaler Arne E.
- Van der Auwera Sandra
- van Elburg Annemarie A.
- van Furth Eric F.
- van Hemert Albert M.
- Vawter Marquis P.
- Vedder Helmut
- Vieta Eduard
- Viktorin Alexander
- Vilar-Ribó Laura
- Villareal Gerardo
- Vincent John B.
- Vincent John B.
- Visscher Peter M.
- Völzke Henry
- Völzke Henry
- Wade Tracey D.
- Wagner Gudrun
- Waldman Irwin D.
- Wallbom Agnes
- Walters James T. R.
- Walters James T. R.
- Walton Esther
- Wang Yunpeng
- Ware Erin B.
- Wasserman Danuta
- Watson Hunna J.
- Watson Hunna J.
- Webb Bradley T.
- Weickert Cynthia Shannon
- Weickert Thomas W.
- Weickert Thomas W.
- Weinsheimer Shantel Marie
- Weissman Myrna M.
- Weissman Myrna M.
- Wellmann Jürgen
- Werge Thomas
- Werge Thomas
- Werge Thomas
- Werge Thomas
- Whitbourne Stacey B.
- Whiteman David C.
- Whiteman David C.
- Whittle Jeffrey
- Whooley Mary
- Wichmann H. Erich
- Widen Elisabeth
- Willemsen Gonneke
- Williams Leanne M.
- Willour Virginia
- Wilson Peter
- Winsvold Bendik S.
- Witt Stephanie H.
- Witt Stephanie H.
- Witt Stephanie H.
- Witt Stephanie H.
- Won Hong-Hee
- Woodside D. Blake
- Woodside D. Blake
- Wray Naomi R.
- Wray Naomi R.
- Wray Naomi R.
- Wu Yang
- Xi Hualin S.
- Xi Simon
- Xu Junzhe
- Xu Wei
- Yang Jian
- Yao Shuyang
- Yeh Shing Shing
- Yilmaz Zeynep
- Yilmaz Zeynep
- Young Allan H.
- Young Hannah
- Zablocki Clement J.
- Zai Clement C.
- Zandi Peter P.
- Zeggini Eleftheria
- Zerwas Stephanie
- Zhang Futao
- Zhao Hongyu
- Zhou Hang
- Zillich Lea
- Zillich Lea
- Zipfel Stephan
- Zwart John-Anker
- Świątkowska Beata
- Świątkowska Beata
- Świątkowska Beata
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
Associations between Attention-Deficit/Hyperactivity Disorder and various eating disorders: A Swedish nationwide population study using multiple genetically informative approaches
- Author
- Adan Roger
- Alfredsson Lars
- Almqvist Catrina
- Ando Tetsuya
- Andreassen Ole
- Aschauer Harald
- Baker Jessica
- Barrett Jeffrey
- Bencko Vladimir
- Bergen Andrew
- Berrettini Wade
- Birgegård Andreas
- Boni Claudette
- Boraska Perica Vesna
- Brandt Harry
- Breen Gerome
- Bulik Cynthia
- Burghardt Roland
- Carlberg Laura
- Cassina Matteo
- Cesta Carolyn
- Cichon Laura
- Clementi Maurizio
- Cohen-Woods Sarah
- Coleman Joni
- Cone Roger
- Courtet Philippe
- Crawford Steven
- Crow Scott
- Crowley James
- Danner Unna
- Davis Oliver
- de Zwaan Martina
- Dedoussis George
- Degortes Daniela
- DeSocio Janiece
- Dick Danielle
- Dikeos Dimitris
- Dina Christian
- Ding Bo
- Dmitrzak-Weglarz Monika
- Docampo Elisa
- Egberts Karin
- Ehrlich Stefan
- Escaramís Geòrgia
- Esko Tõnu
- Espeseth Thomas
- Estivill Xavier
- Favaro Angela
- Fernández-Aranda Fernando
- Fichter Manfred
- Finan Chris
- Fischer Krista
- Floyd James
- Foretova Lenka
- Forzan Monica
- Franklin Christopher
- Föcker Manuel
- Gallinger Steven
- Gambaro Giovanni
- Gaspar Héléna
- Giegling Ina
- Gonidakis Fragiskos
- Gorwood Philip
- Gratacos Monica
- Guillaume Sébastien
- Guo Yiran
- Hakonarson Hakon
- Halmi Katherine
- Hatzikotoulas Konstantinos
- Hauser Joanna
- Hebebrand Johannes
- Helder Sietske
- Hendriks Judith
- Herms Stefan
- Herpertz-Dahlmann Beate
- Herzog Wolfgang
- Hilliard Christopher
- Hinney Anke
- Huckins Laura
- Hudson James
- Huemer Julia
- Hübel Christopher
- Imgart Hartmut
- Inoko Hidetoshi
- Janout Vladimir
- Jiménez-Murcia Susana
- Johnson Craig
- Jordan Jenny
- Julià Antonio
- Juréus Anders
- Kalsi Gursharan
- Kaminska Debora
- Kaplan Allan
- Kaprio Jaakko
- Karhunen Leila
- Karwautz Andreas
- Kas Martien
- Kaye Walter
- Kennedy James
- Kennedy Martin
- Keski-Rahkonen Anna
- Kiezebrink Kirsty
- Kim Youl-Ri
- Klareskog Lars
- Klump Kelly
- Knudsen Gun Peggy
- Koeleman Bobby
- Koubek Doris
- Kuja-Halkola Ralf
- La Via Maria
- Landén Mikael
- Larsson Henrik
- Le Hellard Stephanie
- Leboyer Marion
- Levitan Robert
- Li Dong
- Lichtenstein Paul
- Lilenfeld Lisa
- Lissowska Jolanta
- Litchtenstein Paul
- Lu Yi
- Lundervold Astri
- Magistretti Pierre
- Magnusson Patrik
- Maj Mario
- Mannik Katrin
- Marsal Sara
- Martin Joanna
- Martin Nicholas
- Mattingsdal Morten
- McDevitt Sara
- McGuffin Peter
- Merl Elisabeth
- Metspalu Andres
- Meulenbelt Ingrid
- Micali Nadia
- Mitchell James
- Mitchell Karen
- Monteleone Alessio Maria
- Monteleone Palmiero
- Mortensen Preben
- Munn-Chernoff Melissa
- Nacmias Benedetta
- Navratilova Marie
- Nilsson Ida
- Norring Claes
- Ntalla Ioanna
- Ophoff Roel
- O’Toole Julie
- Palotie Aarno
- Pantel Jacques
- Papezova Hana
- Parker Richard
- Pinto Dalila
- Rabionet Raquel
- Raevuori Anu
- Rajewski Andrzej
- Ramoz Nicolas
- Rayner N. William
- Reichborn-Kjennerud Ted
- Ricca Valdo
- Ripatti Samuli
- Ripke Stephan
- Ritschel Franziska
- Roberts Marion
- Rotondo Alessandro
- Rujescu Dan
- Rybakowski Filip
- Santonastaso Paolo
- Scherag André
- Scherer Stephen
- Schmidt Ulrike
- Schork Nicholas
- Schosser Alexandra
- Scott Laura
- Seitz Jochen
- Slachtova Lenka
- Sladek Robert
- Slagboom P. Eline
- Slof-Op’t Landt Margarita
- Slopien Agnieszka
- Smith Tosha
- Soranzo Nicole
- Sorbi Sandro
- Southam Lorraine
- Steen Vidar
- Strengman Eric
- Strober Michael
- Sullivan Patrick
- Szatkiewicz Jin
- Szeszenia-Dabrowska Neonila
- Tachmazidou Ioanna
- Tenconi Elena
- Thornton Laura
- Tortorella Alfonso
- Tozzi Federica
- Treasure Janet
- Tsitsika Artemis
- Tziouvas Konstantinos
- van Elburg Annemarie
- van Furth Eric
- Wade Tracey
- Wagner Gudrun
- Walton Esther
- Watson Hunna
- Wichmann H-Erich
- Widen Elisabeth
- Woodside D. Blake
- Yao Shuyang
- Yao Shuyang
- Yilmaz Zeynep
- Zeggini Eleftheria
- Zerwas Stephanie
- Zipfel Stephan
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/10/2019
- Field of study
Background Although attention-deficit hyperactivity/impulsivity disorder (ADHD) and eating disorders (EDs) frequently co-occur, little is known about the shared etiology. In this study we comprehensively investigated the genetic association between ADHD and various EDs, including anorexia nervosa (AN) and other EDs (OED, including bulimia nervosa [BN]). Methods We applied different genetically informative designs to register-based information of a Swedish nationwide population (N=3,550,118). We first examined the familial co-aggregation of clinically diagnosed ADHD and EDs across multiple types of relatives. We then applied quantitative genetic modeling in full-sisters and maternal half-sisters to estimate the genetic correlations between ADHD and EDs. We further tested the associations between ADHD polygenic risk scores (PRS) and ED symptoms, and between AN PRS and ADHD symptoms, in a genotyped population-based sample (N=13,472). Results Increased risk of all types of EDs was found in individuals with ADHD (any ED: OR [95% CI]=3.97 [3.81-4.14], AN: 2.68 [2.15-2.86], OED: 4.66 [4.47-4.87], BN: 5.01 [4.63-5.41]) and their relatives compared to individuals without ADHD and their relatives. The magnitude of the associations reduced as the degree of relatedness decreased, suggesting shared familial liability between ADHD and EDs. Quantitative genetic models revealed stronger genetic correlation of ADHD with OED (0.37 [0.31-0.42]) than with AN (0.14 [0.05-0.22]). ADHD PRS correlated positively with ED symptom measures overall and sub-scales “drive for thinness” and “body dissatisfaction”, despite small effect sizes. Conclusions We observed stronger genetic association with ADHD for non-AN EDs than AN, highlighting specific genetic correlation beyond a general genetic factor across psychiatric disorders
Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa
- Author
- Abramovic Lucija
- Adams Hieab HH
- Adan Roger
- Agartz Ingrid
- Alfredsson Lars
- Alhusaini Saud
- Almasy Laura
- Ames David
- Andersson Micael
- Ando Tetsuya
- Andreassen Ole
- Andreassen Ole A
- Anttila Verneri
- Arepalli Sampath
- Arias-Vasquez Alejandro
- Aribisala Benjamin S
- Armstrong Nicola J
- Aschauer Harald
- Ashbrook David G
- Assareh Amelia A
- Athanasiu Lavinia
- Baker Jessica
- Barrett Jeffrey
- Bastin Mark E
- Batury V-L
- Becker James T
- Bencko Vladimir
- Bergen Andrew
- Bernard Manon
- Berrettini Wade
- Birgegard Andreas
- Bis Joshua C
- Blangero John
- Bohlken Marc M
- Boks Marco P
- Boni Claudette
- Boomsma Dorret I
- Bralten Janita
- Brandt Harry
- Breen Gerome
- Brodaty Henry
- Brouwer Rachel M
- Brown Andrew A
- Brunner Han G
- Buckner Randy L
- Buitelaar Jan K
- Bulayeva Kazima B
- Bulik CM
- Bulik Cynthia M
- Bulik-Sullivan Brendan
- Burghardt Roland
- Cahn Wiepke
- Calhoun Vince D
- Cannon Dara M
- Carlberg Laura
- Carless Melanie A
- Cassina Matteo
- Cavalleri Gianpiero L
- Chakravarty M Mallar
- Chauhan Ganesh
- Chen Qiang
- Cheung J
- Ching Christopher RK
- Cichon Carolyn Cesta Sven
- Cichon Sven
- Clementi Maurizio
- Cohen-Woods Sarah
- Coleman Joni
- Cone Roger
- Cookson Mark R
- Corvin Aiden
- Courtet Philippe
- Crawford Steven
- Crespo-Facorro Benedicto
- Crow Scott
- Crowley Jim
- Cuellar-Partida Gabriel
- Curran Joanne E
- Czisch Michael
- Dale Anders M
- Danner Unna
- Davies Gareth E
- Davis Oliver
- de Geus Eco JC
- de Zubicaray Greig I
- de Zwaan Martina
- Deary Ian J
- Dedoussis George
- Degortes Daniela
- Delanty Norman
- Den Braber Anouk
- Depondt Chantal
- DeSocio Janiece
- Desrivieres Sylvane
- Dick Danielle
- Dikeos Dimitris
- Dillman Allissa
- Dina Christian
- Ding Bo
- Djurovic Srdjan
- Dmitrzak-Weglarz Monika
- Docampo Elisa
- Donohoe Gary
- Drevets Wayne C
- Duggirala Ravi
- Duncan Laramie
- Dyer Thomas D
- Ebling Maritza
- Egberts Karin
- Ehrlich Stefan
- Ehrlich Stefan
- Ehrlich Stefan
- Erk Susanne
- Escaramis Georgia
- Esko Tonu
- Espeseth Thomas
- Espeseth Thomas
- Estivill Xavier
- Favaro Angela
- Fedko Iryna O
- Fernandez Guillen
- Fernandez-Aranda Fernando
- Ferrucci Luigi
- Fichter Manfred
- Finan Chris
- Fischer Krista
- Fischl Bruce
- Fisher Simon E
- Floyd James
- Focker Manuel
- Foretova Lenka
- Foroud Tatiana M
- Forzan Monica
- Fox Caroline
- Fox Peter T
- Francks Clyde
- Franke Barbara
- Franklin Christopher
- Fukunaga Masaki
- Gallinger Valerie Gaborieau Steven
- Gambaro Giovanni
- Gaspar Helena
- Gibbs J Raphael
- Giddaluru Sudheer
- Giegling Ina
- Glahn David C
- Goldman Aaron L
- Goldstein Jackie
- Gollub Randy L
- Gonidakis Fragiskos
- Goring Harald HH
- Gorwood Philip
- Grabe Hans J
- Gratacos Monica
- Green Robert C
- Greve Douglas
- Grimm Oliver
- Grp ENIGMA Genetics Working
- Gruber Oliver
- Guadalupe Tulio
- Gudnason Vilmundur
- Guelfi Sebastian
- Guillaume Sebastien
- Guo Yiran
- Hager Reinmar
- Hakobjan Marina MH
- Hakonarson Hakon
- Halmi Katherine
- Hansell Narelle K
- Hardy John
- Harrison Rebecca
- Hartberg Cecilie B
- Hartman Catharina A
- Hashimoto Ryota
- Hass Johanna
- Hatzikotoulas Konstantinos
- Haukvik Unn K
- Hauser Joanna
- Hebebrand Johannes
- Hegenscheid Katrin
- Heinz Andreas
- Heister Angelien JGAM
- Helder Sietske
- Hendriks Judith
- Herms Stefan
- Hernandez Dena G
- Hernandez Maria C Valdes
- Herpertz-Dahlmann Beate
- Herzog Wolfgang
- Heslenfeld Dirk J
- Hibar D
- Hibar Derrek P
- Hilliard Christopher
- Hinney Anke
- Ho Beng-Choon
- Hoekstra Pieter J
- Hoffmann Wolfgang
- Hohn David
- Holmes Avram J
- Holsboer Florian
- Homuth Georg
- Hoogman Martine
- Hosten Norbert
- Hottenga Jouke-Jan
- Huckins Laura
- Hudson James
- Huemer Julia
- Ikeda Masashi
- Ikram M Arfan
- Imgart Hartmut
- Inoko Hidetoshi
- Jahanshad N
- Jahanshad Neda
- Jamain Sigrid Jall Stephane
- Janout Vladimir
- Janowitz Deborah
- Jenkinson Mark
- Jia Tianye
- Jimenez-Murcia Susana
- Johnson Craig
- Johnson Robert
- Jonsson Erik G
- Jordan Jenny
- Jr Jack Clifford R
- Jr Kent Jack W
- Julia Antonio
- Jureus Anders
- Kahn Rene S
- Kalsi Gursharan
- Kaminska Debora
- Kanai Ryota
- Kaplan Allan
- Kaprio Jaakko
- Karhunen Leila
- Karwautz Andreas
- Kas Martien
- Kasperaviciute Dalia
- Kaye Walter
- Keil Maria
- Kennedy James
- Kennedy Martin
- Keski-Rahkonen Anna
- Kiezebrink Kirsty
- Kim Sungeun
- Kim Youl-Ri
- Klareskog Lars
- Klein Marieke
- Kloszewska Iwona
- Klump Kelly
- Knudsen Gun Peggy
- Kochunov Peter
- Koeleman Bobby
- Koubek Doris
- Kraemer Bernd
- Kwok John B
- La Via Maria
- Landen Mikael
- Launer Lenore J
- Lawrie Stephen M
- Le Hellard Stephanie
- Le Hellard Stephanie
- Leboyer Marion
- Lee Phil H
- Levitan Robert
- Li Dong
- Lichtenstein Paul
- Liewald David CM
- Lilenfeld Lisa
- Lissowska Jolanta
- Liu Xinmin
- Longo Dan L
- Longstreth WT
- Loohuis Loes M Olde
- Lopez Lorna M
- Lovestone Simon
- Lu Lu
- Luciano Michelle
- Lundervold Astri
- Luting Xue
- Macare Christine
- Magistretti Pierre
- Maj Mario
- Makkinje Remco RR
- Mannik Katrin
- Marsal Sara
- Martin Nicholas
- Martin Nicholas G
- Matarin Mar
- Mather Karen A
- Mattay Venkata S
- Mattheisen Manuel
- Mattingsdal Morten
- Mazoyer Bernard
- McDevitt Sara
- McDonald Colm
- McGuffin Peter
- McIntosh Andrew M
- Mckay David R
- McMahon Francis J
- McMahon Katie L
- Mecocci Patrizia
- Medland Sarah E
- Meisenzahl Eva
- Melle Ingrid
- Merl Elisabeth
- Metspalu Andres
- Meulenbelt Ingrid
- Meyer-Lindenberg Andreas
- Micali Nadia
- Milaneschi Yuri
- Mitchell James
- Mitchell Karen
- Mohnke Sebastian
- Monteleone Alessio Maria
- Monteleone Palmiero
- Montgomery Grant
- Montgomery Grant W
- Morris Derek W
- Mortensen Preben
- Mostert Jeanette C
- Mueller Timo
- Mueller-Myhsok Bertram
- Muhleisen Thomas W
- Munn-Chernoff Melissa
- Naber Marlies AM
- Nacmias Benedetta
- Nalls Michael A
- Nauck Matthias
- Navratilova Marie
- Needham Margaret
- Nho Kwangsik
- Nichols Thomas E
- Nilsson Ida
- Nilsson Lars G
- Norring Claes
- Nothen Markus M
- Ntalla Ioanna
- Nugent Allison C
- Nyberg Lars
- Nyquist Paul
- O'Toole Julie
- Ohi Kazutaka
- Olvera Rene L
- Ophoff Roel
- Ophoff Roel A
- Palotie Aarno
- Pandolfo Massimo
- Pantel Jacques
- Papezova Hana
- Papmeyer Martina
- Paus Tomas
- Pausova Zdenka
- Penninx Brenda WJH
- Perez-Iglesias Rocio
- Perica Vesna Boraska
- PGC-ED
- Pike G Bruce
- Pinto Richard Parker Dalila
- Pol Hilleke E Hulshoff
- Potkin Steven G
- Putz Benno
- Rabionet Raquel
- Raevuori Anu
- Rajewski Andrzej
- Ramasamy Adaikalavan
- Ramoz Nicolas
- Rayner N William
- Reichborn-Kjennerud Ted
- Reinvang Ivar
- Renteria Miguel E
- Reppermund Simone
- Ricca Valdo
- Rietschel Marcella
- Ripatti Samuli
- Ripke Stephan
- Risacher Shannon L
- Ritschel Franziska
- Roberts Marion
- Roffman Joshua L
- Roiz-Santianez Roberto
- Romanczuk-Seiferth Nina
- Rose Emma J
- Rosen Glenn D
- Rotondo Alessandro
- Rujescu Dan
- Rujescu Dan
- Rybakowski Filip
- Ryten Mina
- Sachdev Perminder S
- Salami Alireza
- Samann Philipp G
- Santonastaso Paolo
- Satizabal Claudia L
- Saykin Andrew J
- Scherag Andre
- Scherer Stephen
- Schmaal Lianne
- Schmidt Helena
- Schmidt Reinhold
- Schmidt Ulrike
- Schnell Knut
- Schofield Peter R
- Schork Andrew J
- Schork Nicholas
- Schosser Alexandra
- Schumann Gunter
- Scott Laura
- Seiler Stephan
- Seitz J
- Seitz Jochen
- Seshadri Sudha
- Shen Li
- Shin Jean
- Simmons Andrew
- Singleton Andrew
- Sisodiya Sanjay M
- Slachtova Lenka
- Sladek Robert
- Slagboom P Eline
- Slof-Op't Landt Margarita
- Slopien Agnieszka
- Smith Colin
- Smith Tosha
- Smoller Jordan W
- Soininen Hilkka
- Soranzo Nicole
- Sorbi Sandro
- Southam Lorraine
- Sprooten Emma
- Steen Vidar
- Steen Vidar M
- Stein Jason L
- Strengman Eric
- Strike Lachlan T
- Strober Michael
- Sussmann Jessika E
- Szatkiewicz Jin
- Szeszenia-Dabrowska Neonila
- Tachmazidou Ioanna
- Tenconi Elena
- Teumer Alexander
- Thalamuthu Anbupalam
- Thompson Paul M
- Thompson PM
- Thornton Laura
- Toga Arthur W
- Toro Roberto
- Tortorella Alfonso
- Tozzi Federica
- Trabzuni Daniah
- Traynor Bryan J
- Treasure Janet
- Troncoso Juan
- Tschop Matthias
- Tsitsika Artemis
- Turner Jessica A
- Tziouvas Konstantinos
- van Bokhoven Hans
- van der Brug Marcel
- van der Lee Sven J
- van der Marel Saskia SL
- van der Wee Nic JA
- van Donkelaar Marjolein MJ
- van Duijn Cornelia M
- van Eijk Kristel R
- van Elburg Annemarie
- van Furth Eric
- van Haren Neeltje EM
- van Hulzen Kimm JE
- van Tol Marie-Jose
- van't Ent Dennis
- Veltman Dick J
- Vinke Louis N
- Volzke Henry
- Wade Tracey
- Wagner Gudrun
- Walter Henrik
- Walters Raymond
- Walters Raymond K
- Walton E
- Walton Esther
- Walton Esther
- Wardlaw Joanna M
- Wassink Thomas H
- Watson Hunna
- Weale Michael E
- Weinberger Daniel R
- Weiner Michael W
- Wen Wei
- Westlye Lars T
- Westman Eric
- Whelan Christopher D
- White Tonya
- Wichmann H-Erich
- Widen Elisabeth
- Williams Robert W
- Winkler Anderson M
- Wittfeld Katharina
- Woldehawariat Girma
- Wolf Christiane
- Woodside D Blake
- Wright Margaret J
- Yanek Lisa R
- Yanovski Jack
- Yao Shuyang
- Yilmaz Z
- Yilmaz Zeynep
- Zerwas Stephanie
- Zielke Ronald H
- Zipfel Stephan
- Zonderman Alan B
- Zwiers Marcel P
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/07/2019
- Field of study
Occupied
- Author
- Publication venue
- DigitalCommons@University of Nebraska - Lincoln
- Publication date
- 29/08/2019
- Field of study
Our bodies are home to more microbes than human cells. The balance of helpful to harmful microbes in our bodies can make us sick or healthy. The Biology of Human project focuses on helping people understand themselves by exploring scientific principles that underlie modern research in human biology. Biology of Human is an alliance of science educators, artists, science writers, and biomedical researchers working to increase public understanding about viruses and infectious disease. In this comic, Daniel and Miguel find themselves in the world of the microbes, where they meet the Roid (Bacteroides), Longo biffi (Bifidobacterium longum), E. coli (Escherichia coli), Strep Sally (Streptococcus salivarius), and Candi (Candida albicans). There are about 100 trillion life forms living inside us. Every human being contains a whole universe of organisms, all living together. To keep our human cells happy, we have to keep our microbes in balance. That’s how we stay healthy.https://digitalcommons.unl.edu/zeabook/1076/thumbnail.jp
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