As crianças com autismo na escola : um olhar inclusivo

Trabalho de conclusão de curso (graduação)—Universidade de Brasília, Faculdade de Educação, 2017.O presente ensaio tem como objetivo problematizar a inclusão, o autismo e as crianças com autismo na escola, tendo como questão norteadora: “Quais aspectos refletem na inclusão das crianças com autismo na escola?”. Foram considerados a importância do conceito de autismo que habita no imaginário cultural das pessoas, os dispositivos de aprendizagem utilizados pelos professores, os dispositivos legais que embasam os direitos das crianças com Transtorno do Espectro Autista e consequentemente os caminhos que estas podem seguir a partir da perspectiva legal. Esses conceitos exercem influência no cotidiano escolar das crianças, evidenciando a necessidade da vivência da inclusão na escola. A inclusão se configura como uma prática que vai além das fronteiras do discurso teórico e, com isso, a problemática da exclusão disfarçada de inclusão também é alvo das discussões deste ensaio. Dessa forma, considerados o direito à infância e a singularidade da crianças com autismo, este trabalho propõe uma educação que reconheça o sujeito com autismo, por meio de uma aprendizagem significativa que englobe respeito, amor, ludicidade, prazer, sabor, autonomia e união.This essay aims to problematize inclusion, autism and the child with autism in school, considering the guiding question: “What aspects influence the inclusion of children with autism in school?”. It is considered the importance of the concept of autism that inhabits the cultural imaginary of people, the learning devices used by teachers, the legal devices that base the rights of children with Autism Spectrum Disorder and consequently the ways that can follow from a legal perspective. These concepts exert an influence on children's daily school life, evidencing the need to live inclusion in school. Inclusion is constituted as a practice that goes beyond the boundaries of theoretical discourse and, based on that, the disguised exclusion of inclusion is also the subject of the discussions in this essay. In this way, considering the right to childhood and the singularity of the child with autism, this work proposes an education that recognizes the subject with autism, through meaningful learning that encompasses respect, love, playfulness, pleasure, flavor, autonomy and unity

COVID-19 outcomes in people living with HIV: Peering through the waves

Objective: To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection. Methods: This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to 4:1). They were compared using the Chi-Square or Fisher's Exact tests for categorical variables and the Wilcoxon for numerical variables. Results: Throughout the study, 17,101 COVID-19 patients were hospitalized, and 130 (0.76%) of those were infected with HIV. The median age was 54 (IQR: 43.0;64.0) years in 2020 and 53 (IQR: 46.0;63.5) years in 2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In 2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9% vs. 17.7%; p = 0.049), but there was no difference in mortality between groups in 2021 (25.0% vs. 25.1%; p > 0.999). Conclusions: Our results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in 2021, when the mortality rate is similar to the control group

Gestão de pessoas em ONGs

-Este livro apresenta as principais ferramentas da gestão de pessoas, destacando como podem ser aplicadas á realidade das organizações não-governamentais. Fruto de uma pesquisa realizada em diversas ONGs, apresenta soluções práticas ara os desafios relacionados ao gerenciamento das equipes desse tipo de organização. Dada a complexidade que caracteriza o trabalho das ONGs, faz-se necessário o desenvolvimento de ações mais efetivas visando a seleção, o desenvolvimento, a motivação e o entrosamento dos empregados e voluntários, o que pode ser beneficiado pelo conhecimento das técnicas de gestão expostas na obra. Tem como público-alvo gestores de ONGs, estudiosos do terceiro setor e estudantes de administração e demais ciências relacionadas à gestão social e ao gerenciamento de pessoas

AI is a viable alternative to high throughput screening: a 318-target study

: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery

Photovoltaic energy: a key player towards a sustainable energy mix

International audienceThe energetic issues are on the top of the political agenda in many countries, for environmental reasons, for its driving role in all the economic sectors, as well as for the energetic independency concerns. This problematic is stressed by the increasing weight of renewable intermittent power sources in the global mix. In particular, due to its high potential and the strong national policy support it beneficiated, solar photovoltaic energy is now a key player in the world energy mutation and the way it is integrated into the global mix should be carefully performed.To deeply understand the way the solar energy can penetrate and transform the forthcoming energy framework, we adopted a three-level strategy to provide some answers to the following questions: i/ how can we situate the photovoltaic power role in future energy mixes?; ii/due to its main drawback, intermittency, could we provide an optimal design of a system combining storage devices?; iii/ what is the efficiency of the incentive policies that are or have been implemented to accelerate its deployment?That is why, in a first part, the peculiar position of the solar photovoltaic energy in the energy mix is analyzed. After recalling the general issue of future global energetic mixes, we propose a brief description of the different photovoltaic technologies and their promising evolutions in terms of technical improvements and cost reductions. Then, we describe the fast growing photovoltaic market and its consequences both on the electricity mix and the industry sector.In the second part we investigate the problematic of integrating such intermittent energy in the electricity mix, by developing a multi-criteria optimization methodology which simulates a system composed of photovoltaic panels and storage devices. Applications on a real case in the Cirque de Mafate (L’île de la Réunion, France) are provided to illustrate the interest of our method.Finally, we question the efficiency of different public supports to the photovoltaic technologies in the most relevant countries. We focus on correlating the installed power capacity with the spent public money and the electricity prices.In these works, we put into relief the necessity to consider energy issues through the prism of technical basis. Indeed, solutions that cannot be efficient should not be implemented in the system. However, a solely technical treatment of energy challenges is obviously insufficient, since energy is core point for the economy, for the citizen and so for the politician. Such a combined approach needs to remain anchored on concrete data close to the reality of the technical devices and keeping in mind the financial feasibility of the proposed solutions, when designing a new energy landscape and thus a new societal model

ABC-SPH risk score for in-hospital mortality in COVID-19 patients : development, external validation and comparison with other available scores

The majority of available scores to assess mortality risk of coronavirus disease 2019 (COVID-19) patients in the emergency department have high risk of bias. Therefore, this cohort aimed to develop and validate a score at hospital admission for predicting in-hospital mortality in COVID-19 patients and to compare this score with other existing ones. Consecutive patients (≥ 18 years) with confirmed COVID-19 admitted to the participating hospitals were included. Logistic regression analysis was performed to develop a prediction model for in-hospital mortality, based on the 3978 patients admitted between March-July, 2020. The model was validated in the 1054 patients admitted during August-September, as well as in an external cohort of 474 Spanish patients. Median (25-75th percentile) age of the model-derivation cohort was 60 (48-72) years, and in-hospital mortality was 20.3%. The validation cohorts had similar age distribution and in-hospital mortality. Seven significant variables were included in the risk score: age, blood urea nitrogen, number of comorbidities, C-reactive protein, SpO/FiO ratio, platelet count, and heart rate. The model had high discriminatory value (AUROC 0.844, 95% CI 0.829-0.859), which was confirmed in the Brazilian (0.859 [95% CI 0.833-0.885]) and Spanish (0.894 [95% CI 0.870-0.919]) validation cohorts, and displayed better discrimination ability than other existing scores. It is implemented in a freely available online risk calculator (https://abc2sph.com/). An easy-to-use rapid scoring system based on characteristics of COVID-19 patients commonly available at hospital presentation was designed and validated for early stratification of in-hospital mortality risk of patients with COVID-19

ABC₂-SPH risk score for in-hospital mortality in COVID-19 patients

Objectives: The majority of available scores to assess mortality risk of coronavirus disease 2019 (COVID-19) patients in the emergency department have high risk of bias. Therefore, this cohort aimed to develop and validate a score at hospital admission for predicting in-hospital mortality in COVID-19 patients and to compare this score with other existing ones. Methods: Consecutive patients (≥ 18 years) with confirmed COVID-19 admitted to the participating hospitals were included. Logistic regression analysis was performed to develop a prediction model for in-hospital mortality, based on the 3978 patients admitted between March–July, 2020. The model was validated in the 1054 patients admitted during August–September, as well as in an external cohort of 474 Spanish patients. Results: Median (25–75th percentile) age of the model-derivation cohort was 60 (48–72) years, and in-hospital mortality was 20.3%. The validation cohorts had similar age distribution and in-hospital mortality. Seven significant variables were included in the risk score: age, blood urea nitrogen, number of comorbidities, C-reactive protein, SpO2/FiO2 ratio, platelet count, and heart rate. The model had high discriminatory value (AUROC 0.844, 95% CI 0.829–0.859), which was confirmed in the Brazilian (0.859 [95% CI 0.833–0.885]) and Spanish (0.894 [95% CI 0.870–0.919]) validation cohorts, and displayed better discrimination ability than other existing scores. It is implemented in a freely available online risk calculator (https://abc2sph.com/). Conclusions: An easy-to-use rapid scoring system based on characteristics of COVID-19 patients commonly available at hospital presentation was designed and validated for early stratification of in-hospital mortality risk of patients with COVID-19.</p

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved

NEOTROPICAL CARNIVORES: a data set on carnivore distribution in the Neotropics

Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyonidae; and Ursidae. Herein, we include published and unpublished data on native terrestrial Neotropical carnivores (Canidae; Felidae; Mephitidae; Mustelidae; Procyonidae; and Ursidae). NEOTROPICAL CARNIVORES is a publicly available data set that includes 99,605 data entries from 35,511 unique georeferenced coordinates. Detection/non-detection and quantitative data were obtained from 1818 to 2018 by researchers, governmental agencies, non-governmental organizations, and private consultants. Data were collected using several methods including camera trapping, museum collections, roadkill, line transect, and opportunistic records. Literature (peer-reviewed and grey literature) from Portuguese, Spanish and English were incorporated in this compilation. Most of the data set consists of detection data entries (n = 79,343; 79.7%) but also includes non-detection data (n = 20,262; 20.3%). Of those, 43.3% also include count data (n = 43,151). The information available in NEOTROPICAL CARNIVORES will contribute to macroecological, ecological, and conservation questions in multiple spatio-temporal perspectives. As carnivores play key roles in trophic interactions, a better understanding of their distribution and habitat requirements are essential to establish conservation management plans and safeguard the future ecological health of Neotropical ecosystems. Our data paper, combined with other large-scale data sets, has great potential to clarify species distribution and related ecological processes within the Neotropics. There are no copyright restrictions and no restriction for using data from this data paper, as long as the data paper is cited as the source of the information used. We also request that users inform us of how they intend to use the data

Diminishing benefits of urban living for children and adolescents’ growth and development

Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified