Spouse Maintenance according to the Law approved in Iran and England

Cost of maintenances is one of the most important discussions in family law, which contains the essential factors for proper life. In this research, the above subject based on the comparison between the family right in Britain and Iran has been studied. There are many differences and similarities between these two systems, which are taken from habits, religions, and the government points of view in Iran and England. Regarding the criterion of cost of maintenance, some legislators emphasize the wives’ life before marriage while others pay attention to the conditions of life after marriage. In England the rights due to cost of maintenance have been changed noticeably since 1950. Regarding the comparison of cost of maintenance in Iran it is compulsory and it is not an agreement one but in England it is complementary and based on an agreement one. In this research, we can point to some important subjects such as the nature of wife right in cost of maintenance, the special features of cost of maintenance, the wife cost of maintenance after marriage dissolution, confirmation of cost of maintenance and its guaranty. The legislator in Iran’s right system has added some special conditions which, in comparison to other right systems of other countries, are unique

AN ENGINEERING GEOLOGICAL ANATOMY OF THE PADMA RIVER BANK FAILURE AND EROSION, 2018: A CASE STUDY OF NARIA BANK SECTION, BANGLADESH

The Naria town of Bangladesh is developed on the right bank of the Padma River. The bank is an old natural levee of Meghna River. The Holocene-Recent geology of Naria is actively dominated by the fluvial processes of Ganges-Brahmaputra-Meghna River system where the deltaic sediments are characterized as unconsolidated fine sand and silt, covered by thin veneer of clayey silt and loam. The annual volume of water discharge and flow dynamics are dependent on the intensity of the rainfall, runoff and the length of dry winter. Excessive river bank erosion, channel avulsion, renewed submergence of floodplains, and formation of natural levees and channel-bars are due to natural geomorphological processes that impact the area by inevitable ground failures. The geological attributes of ground condition and drastic variations in water levels make the area extremely vulnerable to severe bank failures and erosion. A unique erosion phenomenon prevailing in this part of Bengal delta prompted this study. During Aug-Sept, 2018 a sudden complex attenuation of current, wave and vortex in the Padma water flow caused an extraordinary disaster and made more than 5000 people homeless overnight by devouring away houses including concrete buildings, factories and markets. It is observed that geologically the Padma River remained confined within a width of 5 miles striking NW-SE trend following the margins of older alluvium and Faridpur Trough. The river tends to a meandering pattern consisting of deep vertical trenches along the Naria curvature. The deep trenches form along right bank and render the ground increasingly more vulnerable to subaqueous slope failure due to presence of thick (~200 ft.) alternating cross-bedded silt and micaceous fine sand of very high dilatancy and low angle of friction. The present study identifies some application of technological advancement for developing real-time engineering geological mapping systems for monitoring and managing complex river bank erosion. Large scale 3D engineering geological map coupled with air-borne photogrammetric and radar inferrometry methods can be applied for real-time monitoring and prediction of differential settlements, subaqueous failures and ground movement. The point cloud maps developed using data from these systems can refine engineering geological maps for decision makers and improve the design of protective measure and sustainable engineering structures

Health economics and cost-effective decision making: addressing contemporary challenges and exploring solutions in Pakistan

Health economics plays a vital role in underpinning the healthcare costs and their significant impact on healthcare decisions, particularly in resource-scarce settings such as Pakistan. this article emphasizes the multifaceted cost considerations in healthcare, including both direct treatment costs and often-overlooked indirect expenses like travel, parking, special diets, and lost wages due to illness. The article emphasizes the role of economic evaluations in addressing Pakistan's healthcare challenges, examining cost-effective options and providing a roadmap for a healthier future. An evidences synthesis approach was applied to explore possible solutions to health challenges. In addition to this, expert opinions were taken into account to investigate how economic concept are relevant in decision making for healthcare. The published qualitative data were combined, organized according to research objective and reported in tabular form. Economic concepts and evaluations are found useful in relation to healthcare infrastructure of Pakistan. There are possible economic solutions available to cope with the hurdles of health system. This article advocates the policymakers to prioritize involving health economists in policy formulation and promoting low-cost or cost-effective health interventions, ensuring fair allocation of health budget

Design, synthesis, in vitro antiproliferative effect and in situ molecular docking studies of a series of new benzoquinoline derivatives

Quinoline derivatives have been reported to possess multi-therapeutic potential owing to the manifestations of different pharmacological effects. The current research work describes about the design and synthesis of a series of novel benzoquinoline analogues with an objective to evaluate their antiproliferative structure–activity relationship against colon, breast and hepatocellular cancers. Upon synthesis, all derivatives’ chemical structures were elucidated through FTIR, 1 HNMR and 13CNMR spectroscopic analysis. All derivatives were investigated for their in vitro anti-proliferative property against three different cancer cell lines (viz., colon carcinoma HT29, Caucasian breast adenocarcinoma MCF7, hepatocellular carcinoma HepG2) and a normal non-transformed human foreskin fibroblast Hs27 cell line. All derivatives demonstrated varied degrees of strong anticancer effect against all of the cell lines with the 2-Amino-4-(4-nitrophenyl)-5,6-dihydrobenzo[h]quinoline-3-carbonitrile (CNMP, 2) exhibited the most potent antiproliferative effect viz. LC50 21.23 lM for breast, 8.24 lM for colon, and 26.15 lM for the hepatocellular, respectively. Molecular docking studies against all the the target crystal structures of cancer proteins (1HK7, 3EQM, 3IG7 and 4FM9) revealed significant binding affinities via hydrophobic and H-bonding interactions with all the compounds in conformity with the wet lab results. CNMP showed the highest binding energy of �7.55 in the HT29, �6.9 (both in MCF7 HepG2) kcal/mol. Based on the results obtained from wet lab and dry lab experiments, it can be proposed that CNMP might prove to be a potential lead structure for the design and synthesis of more potent anticancer candidates

Sustained proliferation in cancer: mechanisms and novel therapeutic targets

Proliferation is an important part of cancer development and progression. This is manifest by altered expression and/or activity of cell cycle related proteins. Constitutive activation of many signal transduction pathways also stimulates cell growth. Early steps in tumor development are associated with a fibrogenic response and the development of a hypoxic environment which favors the survival and proliferation of cancer stem cells. Part of the survival strategy of cancer stem cells may manifested by alterations in cell metabolism. Once tumors appear, growth and metastasis may be supported by overproduction of appropriate hormones (in hormonally dependent cancers), by promoting angiogenesis, by undergoing epithelial to mesenchymal transition, by triggering autophagy, and by taking cues from surrounding stromal cells. A number of natural compounds (e.g., curcumin, resveratrol, indole-3-carbinol, brassinin, sulforaphane, epigallocatechin-3-gallate, genistein, ellagitannins, lycopene and quercetin) have been found to inhibit one or more pathways that contribute to proliferation (e.g., hypoxia inducible factor 1, nuclear factor kappa B, phosphoinositide 3 kinase/Akt, insulin-like growth factor receptor 1, Wnt, cell cycle associated proteins, as well as androgen and estrogen receptor signaling). These data, in combination with bioinformatics analyses, will be very important for identifying signaling pathways and molecular targets that may provide early diagnostic markers and/or critical targets for the development of new drugs or drug combinations that block tumor formation and progression

Rickettsial illnesses as important causes of febrile illness in Chittagong, Bangladesh

We conducted a yearlong prospective study of febrile patients admitted to a tertiary referral hospital in Chittagong, Bangladesh, to assess the proportion of patients with rickettsial illnesses and identify the causative pathogens, strain genotypes, and associated seasonality patterns. We diagnosed scrub typhus in 16.8% (70/416) and murine typhus in 5.8% (24/416) of patients; 2 patients had infections attributable to undifferentiated Rickettsia spp. and 2 had DNA sequence-confirmed R. felis infection. Orientia tsutsugamushi genotypes included Karp, Gilliam, Kato, and TA763-like strains, with a prominence of Karp-like strains. Scrub typhus admissions peaked in a biphasic pattern before and after the rainy season, whereas murine typhus more frequently occurred before the rainy season. Death occurred in 4% (18/416) of cases; case-fatality rates were 4% each for scrub typhus (3/70) and murine typhus (1/28). Overall, 23.1% (96/416) of patients had evidence of treatable rickettsial illnesses, providing important evidence toward optimizing empirical treatment strategies

Micropropagation and conservation of selected endangered anticancer medicinal plants from the Western Ghats of India

Globally, cancer is a constant battle which severely affects the human population. The major limitations of the anticancer drugs are the deleterious side effects on the quality of life. Plants play a vital role in curing many diseases with minimal or no side effects. Phytocompounds derived from various medicinal plants serve as the best source of drugs to treat cancer. The global demand for phytomedicines is mostly reached by the medicinal herbs from the tropical nations of the world even though many plant species are threatened with extinction. India is one of the mega diverse countries of the world due to its ecological habitats, latitudinal variation, and diverse climatic range. Western Ghats of India is one of the most important depositories of endemic herbs. It is found along the stretch of south western part of India and constitutes rain forest with more than 4000 diverse medicinal plant species. In recent times, many of these therapeutically valued herbs have become endangered and are being included under the red-listed plant category in this region. Due to a sharp rise in the demand for plant-based products, this rich collection is diminishing at an alarming rate that eventually triggered dangerous to biodiversity. Thus, conservation of the endangered medicinal plants has become a matter of importance. The conservation by using only in situ approaches may not be sufficient enough to safeguard such a huge bio-resource of endangered medicinal plants. Hence, the use of biotechnological methods would be vital to complement the ex vitro protection programs and help to reestablish endangered plant species. In this backdrop, the key tools of biotechnology that could assist plant conservation were developed in terms of in vitro regeneration, seed banking, DNA storage, pollen storage, germplasm storage, gene bank (field gene banking), tissue bank, and cryopreservation. In this chapter, an attempt has been made to critically review major endangered medicinal plants that possess anticancer compounds and their conservation aspects by integrating various biotechnological tool

The global, regional, and national burden of stomach cancer in 195 countries, 1990-2017 : a systematic analysis for the Global Burden of Disease study 2017

Background: Stomach cancer is a major health problem in many countries. Understanding the current burden of stomach cancer and the differential trends across various locations is essential for formulating effective preventive strategies. We report on the incidence, mortality, and disability-adjusted life-years (DALYs) due to stomach cancer in 195 countries and territories from 21 regions between 1990 and 2017. Methods: Estimates from GBD 2017 were used to analyse the incidence, mortality, and DALYs due to stomach cancer at the global, regional, and national levels. The rates were standardised to the GBD world population and reported per 100 000 population as age-standardised incidence rates, age-standardised death rates, and age-standardised DALY rates. All estimates were generated with 95% uncertainty intervals (UIs). Findings: In 2017, more than 1·22 million (95% UI 1·19–1·25) incident cases of stomach cancer occurred worldwide, and nearly 865 000 people (848 000–885 000) died of stomach cancer, contributing to 19·1 million (18·7–19·6) DALYs. The highest age-standardised incidence rates in 2017 were seen in the high-income Asia Pacific (29·5, 28·2–31·0 per 100 000 population) and east Asia (28·6, 27·3–30·0 per 100 000 population) regions, with nearly half of the global incident cases occurring in China. Compared with 1990, in 2017 more than 356 000 more incident cases of stomach cancer were estimated, leading to nearly 96 000 more deaths. Despite the increase in absolute numbers, the worldwide age-standardised rates of stomach cancer (incidence, deaths, and DALYs) have declined since 1990. The drop in the disease burden was associated with improved Socio-demographic Index. Globally, 38·2% (21·1–57·8) of the age-standardised DALYs were attributable to high-sodium diet in both sexes combined, and 24·5% (20·0–28·9) of the age-standardised DALYs were attributable to smoking in males. Interpretation: Our findings provide insight into the changing burden of stomach cancer, which is useful in planning local strategies and monitoring their progress. To this end, specific local strategies should be tailored to each country's risk factor profile. Beyond the current decline in age-standardised incidence and death rates, a decrease in the absolute number of cases and deaths will be possible if the burden in east Asia, where currently almost half of the incident cases and deaths occur, is further reduced. Funding: Bill & Melinda Gates Foundation