834 research outputs found
Anti‐osteoporosis medication dispensing by clinical commissioning groups in England: an ecological study of variability in practice and of the effect of the Covid‐19 pandemic
- Publication venue
- 'Wiley'
- Publication date
- 20/09/2022
- Field of study
Purpose: To investigate whether the rate of Anti‐Osteoporosis Medication (AOM) dispensing was related to prevalence of risk factors and hip fracture incidence in the local population. Methods: The Open Prescribing database was used to analyse dispensed AOM at the level of Clinical Commissioning Groups (CCGs) in England. Male Healthy Life Expectancy (MHLE), Female Healthy Life Expectancy (FHLE), the prevalence of smoking and active adults, the incidence of hip fracture and of alcohol related hospital admissions, and local dispensing of a comparator drug (atorvastatin) were considered as predictor variables. Linear and multilinear regression were performed. Using atorvastatin as a comparator, AOM dispensing was compared after the start of the Covid‐19 pandemic with the same quarter the previous year. Results: Rates of AOM per 1000 people aged over 65 years in a CCG area varied between 379.2 and 1129.1, with a mean of 670.3. Population risk factors were individually related to the amount of AOM dispensed in an area. Collectively, local activity levels in adults (p = 0.042) and local hip fracture incidence (p = 0.003) were significantly negatively correlated with rates of AOM dispensed. Rates of alendronate dispensing fell significantly at the start of the Covid‐19 pandemic (p < 0.001), whilst atorvastatin dispensing rates significantly increased (p < 0.001). Conclusion: Lower rates of AOM dispensing were seen in areas with a higher proportion of active adults and higher incidence of hip fracture. Multidisciplinary services should be developed to address this care gap with consideration given to local population risk factors. Community pharmacists are ideally placed to play a vital role in osteoporosis management
Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis
- Author
- Abd-Allah Foad
- Abdelnour Loay H
- Al Sami Yaqub
- Alkeridy Walid
- Azab Mohammed A
- Babu Heavenna
- Banks Tristan
- Barrios-López José María
- Beach Scott
- Beltrán-Corbellini Álvaro
- Benger Matthew
- Benjamin Laura
- Beretta Simone
- Bernard-Valnet Raphaël
- Biagio Mercuri Nicola
- Bigaut Kévin
- Boso Federica
- Brain Infections Global COVID-Neuro Network Study Group .
- Breville Gautier
- Brew Bruce
- Brito Ferreira Maria Lúcia
- Cabreira Verónica
- Calabresi Paolo
- Cattrall Jonathan WS
- Cavallieri Francesco
- Chandratheva Arvind
- Chinthapalli Krishna
- Cividini Sofia
- Coen Matteo
- Cohen Matthew
- Contini Erika
- Corvol Jean-Christophe
- Costache Oana
- Cysique Lucette
- D'Anna Lucio
- Davies Emma
- Defres Sylviane
- Delorme Cécile
- Dervisevic Samir
- Dhar Shalley
- Diezma-Martín Alba María
- Du Pasquier Renaud
- Elicer Isabel
- Elkady Ahmed
- Enright Noelle
- Escalard Simon
- Eugenín-von Bernhardi Laura
- Fajardo Modol Anna
- Farooq Hamzah
- Fernández Díaz Eva
- Foschi Matteo
- Garazzino Silvia
- García García Sergio
- Giunta Marcello
- Goodwin Lynsey C
- Guekht Alla
- Guijarro-Castro Cristina
- Gunasekaran Kulothungan
- Harkness Kirsty
- Harte Jeffrey
- Hassell Jane
- Hey Samuel
- Heyse Alex
- Hodel Eva Maria
- Hornuss Daniel
- Hosp Jonas
- Huda Saif
- Jain Rajan
- JamaliMoghadamSiahkali Saeidreza
- Jillella Dinesh
- Joseph Albert
- Kahn Lora
- Kaimovsky Igor
- Karthikappallil Dileep
- Kassahun Daniel
- Kaya Yildiz
- Khawaja Ayaz
- Kim Carla Y
- Klok Frederikus A
- Knier Benjamin
- Koh Jasmine
- Lahiri Durjoy
- Lant Suzannah
- Lechien Jérome
- Libri Ilenia
- Liguori Claudio
- Lingor Paul
- Lipunga Gareth
- Lopez Evelyn C
- Lorenz Norbert
- Maggi Pietro
- Mariotto Sara
- Martínez-Poles Javier
- Mason Rachel
- Matos Aline de Moura Brasil
- Meza Roger
- Mhlanga Sithembinkosi
- Michael Benedict D
- Minton Thomas
- Moein Shima T
- Mond Gabrielle
- Morales-Casado Maria Isabel
- Morassi Mauro
- Morrison Hamish
- Nalleballe Krishna
- Nicholson Timothy R
- Nortley Ross
- Oliveira Vanessa
- Padovani Alessandro
- Paterson Ross
- Patrick Kimani N
- Pierantozzi Mariangela
- Pilotto Andrea
- Pincherle Alexander
- Pinto Ashwin
- Poxon Joseph
- Primiano Guido
- Rabas Sophie
- Raith Eamon
- Ravaglia Sabrina
- Rawlinson Rebecca
- Rice Claire
- Rieg Siegbert
- Rocha Ferreira Da Silva Ivan
- Santoro Jonathan
- Sargent Brendan F
- Sarmati Loredana
- Saussez Sven
- Scullen Tyler
- Sejvar James J
- Servidei Serenella
- SeyedAlinaghi SeyedAhmad
- Sharifi-Razavi Athena
- Singh Bhagteshwar
- Soares Cristiane N
- Solomon Tom
- Somasundaran Anushri
- Soothill Germander
- Sztriha Laszlo
- Tamborska Arina
- Tattevin Pierre
- Thakur Kiran T
- Tudur Smith Catrin
- Uginet Marjolaine
- Umapathi Thirugnanam
- Valdoleiros Sofia R
- van Pesch Vincent
- Wagner Dirk
- Webb Glynn
- Werring David J
- Winkler Andrea Sylvia
- Yenkoyan Konstantin
- Yin Rong
- Younas Komal
- Zedde Marialuisa
- Zhang Xin
- Ñancupil Reyes Waleng
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2022
- Field of study
BACKGROUND: Neurological COVID-19 disease has been reported widely, but published studies often lack information on neurological outcomes and prognostic risk factors. We aimed to describe the spectrum of neurological disease in hospitalised COVID-19 patients; characterise clinical outcomes; and investigate factors associated with a poor outcome. METHODS: We conducted an individual patient data (IPD) meta-analysis of hospitalised patients with neurological COVID-19 disease, using standard case definitions. We invited authors of studies from the first pandemic wave, plus clinicians in the Global COVID-Neuro Network with unpublished data, to contribute. We analysed features associated with poor outcome (moderate to severe disability or death, 3 to 6 on the modified Rankin Scale) using multivariable models. RESULTS: We included 83 studies (31 unpublished) providing IPD for 1979 patients with COVID-19 and acute new-onset neurological disease. Encephalopathy (978 [49%] patients) and cerebrovascular events (506 [26%]) were the most common diagnoses. Respiratory and systemic symptoms preceded neurological features in 93% of patients; one third developed neurological disease after hospital admission. A poor outcome was more common in patients with cerebrovascular events (76% [95% CI 67-82]), than encephalopathy (54% [42-65]). Intensive care use was high (38% [35-41]) overall, and also greater in the cerebrovascular patients. In the cerebrovascular, but not encephalopathic patients, risk factors for poor outcome included breathlessness on admission and elevated D-dimer. Overall, 30-day mortality was 30% [27-32]. The hazard of death was comparatively lower for patients in the WHO European region. INTERPRETATION: Neurological COVID-19 disease poses a considerable burden in terms of disease outcomes and use of hospital resources from prolonged intensive care and inpatient admission; preliminary data suggest these may differ according to WHO regions and country income levels. The different risk factors for encephalopathy and stroke suggest different disease mechanisms which may be amenable to intervention, especially in those who develop neurological symptoms after hospital admission
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi Hasan M.
- Al Jabbary Ahmed S.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Abdellatif Benslama Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M.
- Barberet Guillaume
- Baron Rebecca M.
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa M.
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri E.
- Bauer Philippe R.
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H.
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Bellani Giacomo
- Beloncle Francois
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Biondi Rodrigo S.
- Biscione Roberto R.
- Bisso Mariano Carboni
- Black Colin S.
- Blakeman Thomas C.
- Bolon Stefan
- Borello Silvina A.
- Borotto Erika E.
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J.
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito Vania A.
- Brizuela Matias
- Brochard Laurent
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- Broman Lars M.
- Brown Samuel M.
- Browne Troy S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns Monique M.
- Buensuseso Juan A.
- Bugedo Guillermo
- Buise Marc P.
- Bulpa Pierre A.
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew J.
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P.
- Careless Jon P.
- Carpentier Dorothée
- Carreño Nicolás G.
- Carteaux Guillaume
- Casalena Paolo
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- Castro Alejandro G.
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- Cazorla-Barranquero Francisca G.
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
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- Cervantes Mavy Ramirez
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon K.
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy Perez
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega Luis M.
- Clarkson Kevin
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- Danin Pierre-Eric
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- Daviaud Fabrice
- Davies Kyle G.
- Dawson Heidi
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- de Gordoa Laura Ortiz-Ruiz
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- de Pablo Raul
- de Prost Nicolas
- Dean Michael N.
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- Dector Dulce
- Dector Dulce M.
- Deicas Alberto
- del Carmen Lorente Maria
- Dellamonica Jean
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- Demirkiran Oktay
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- Shiozaki Kyoko
- Silesky Jimenez Juan I.
- Silesky Juan
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- Stewart Richard
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- Strauch Ulrich
- Sula Hektor
- Sun Renhua
- Surbatovic Maja
- Susana-Temprano
- Suzuki Hiroyuki
- Symmonds Sophie
- Szakmany Tamas
- Sánchez Rocío Manzano
- Sánchez-Ballesteros Jesús
- Søreide Eldar
- Tabhan Edgardo
- Tabhan Edgardo E.
- Tainter Christopher
- Takaba Akihiro
- Takada Tadaaki
- Takagi Shunsuke
- Tallet Alfonso Alec A.
- Tan Beatriz C.
- Tanaka Hiroyuki
- Tang Rui
- Tapponnier Romain
- Tarantino Fabio
- Terzi Nicolas
- Theresa Uhc Mother
- Thibault Sandrine
- Thompson B. Taylor
- Thompson Marlus M.
- Tibblin Anna Oscarsson
- Tinnirello Andrea
- Tiribelli Norberto
- Todeschini Manuel
- Tomescu Dana R.
- Toribio D. Á Cil Parrilla
- Toth-Tarsoly Piroska
- Treanor Nuala
- Trinder T. John
- Trinidad Olivia A.
- Tulaimat Aiman
- Twohey Linda
- Uchiyama Akinori
- Ueda Takeshi
- Ueno Keiko
- Umbrello Michele
- Unnikrishnan Ramesh
- Uppalapati Aditya
- van Haren Frank
- van Haren Frank
- van Wezel Hellen M.
- Vargas Monica P.
- Vascotto Ettore R.
- Vasquez Daniela N.
- Vega Luis D.
- Veljovic Milic
- Venti Aaron
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- Vermassen Joris
- Verstraete Rik
- Villagomez Asisclo
- Villagomez Asisclo J.
- Villamagua Boris G.
- Villar Veronica
- Vinzio Mauricio
- Virgilio Corcoles G.
- Vitale Michela N.
- Volta Carlo A.
- Wang Chunting
- Wang Hua X.
- Wang Shou H.
- Wang Wei
- Warren Jessica
- Watanabe Eizo
- Watt Philip
- Welters Ingeborg D.
- Wenham Tim
- Wessbergh Joanna
- Whitehead Christina
- Willett Emma L.
- Williams Alexandra J.
- Williams Karen E.
- Wise Matt P.
- Wittebole Xavier
- Wong Helen S.
- Woods Paul W.
- Wrathall David W.
- Wrigge Hermann
- Wu Ya Q.
- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L.
- Yeatts Dale J.
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste Luis J.
- Zacharas Giannis A.
- Zacharowski Kai D.
- Zani Gianluca
- Zantua Kim S.
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé O.
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao H.
- Zhu Wei H.
- Zogheib Elie H.
- Ñamendys-Silva Silvio A.
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe
Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC
- Author
- Acharya Shreyasi
- Adamova Dagmar
- Adolfsson Jonatan
- Aggarwal Madan Mohan
- Aglieri Rinella Gianluca
- Agnello Michelangelo
- Agrawal Neelima
- Ahammed Zubayer
- Ahn Sang Un
- Aiola Salvatore
- Akindinov Alexander
- Al-turany Mohammad
- Alam Sk Noor
- Alarcon Do Passo Suaide Alexandre
- Aleksandrov Dmitry
- Alessandro Bruno
- Alfaro Molina Jose Ruben
- Ali Yasir
- ALICE Collaboration
- Alici Andrea
- Alkin Anton
- Alme Johan
- Alt Torsten
- Altenkamper Lucas
- Altsybeev Igor
- Alves Garcia Prado Caio
- Andrei Cristian
- Andreou Dimitra
- Andrews Harry Arthur
- Andronic Anton
- Anguelov Venelin
- Anson Christopher Daniel
- Anticic Tome
- Antinori Federico
- Antonioli Pietro
- Aphecetche Laurent Bernard
- Appelshaeuser Harald
- Araujo Silva Figueredo Marcel
- Arcelli Silvia
- Arnaldi Roberta
- Arnold Oliver Werner
- Arsene Ionut Cristian
- Arslandok Mesut
- Audurier Benjamin
- Augustinus Andre
- Averbeck Ralf Peter
- Azmi Mohd Danish
- Badala Angela
- Baek Yong Wook
- Bagnasco Stefano
- Bailhache Raphaelle Marie
- Bala Renu
- Baldisseri Alberto
- Ball Markus
- Baral Rama Chandra
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- Barbera Roberto
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- Barnafoldi Gergely Gabor
- Barnby Lee Stuart
- Bartalini Paolo
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- Bartsch Esther
- Bashir Butt Jamila
- Bastid Nicole
- Basu Sumit
- Batigne Guillaume
- Batyunya Boris
- Batzing Paul Christoph
- Bautista Guzman Irais
- Bazo Alba Jose Luis
- Bearden Ian Gardner
- Beck Hans
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- Behera Nirbhay Kumar
- Belikov Iouri
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- Blair Justin Thomas
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- Book Julian Heinz
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- Borissov Alexander
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- Botta Elena
- Bourjau Christian
- Bratrud Lars
- Braun-munzinger Peter
- Bregant Marco
- Broker Theo Alexander
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- Castillo Castellanos Javier Ernesto
- Castro Andrew John
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- Ceballos Sanchez Cesar
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- Chang Wan
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- Cho Soyeon
- Chochula Peter
- Chojnacki Marek
- Choudhury Subikash
- Chowdhury Tasnuva
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- Christensen Christian Holm
- Christiansen Peter
- Chujo Tatsuya
- Chung Suh-urk
- Chunhui Zhang
- Cicalo Corrado
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- Ren Xiaowen
- Renfordt Rainer Arno Ernst
- Reshetin Andrey
- Reygers Klaus Johannes
- Riabov Viktor
- Richert Tuva Ora Herenui
- Richter Matthias Rudolph
- Riedler Petra
- Riegler Werner
- Riggi Francesco
- Ristea Catalin-lucian
- Rodriguez Cahuantzi Mario
- Roeed Ketil
- Roehrich Dieter
- Rogochaya Elena
- Rohr David Michael
- Rojas Torres Solangel
- Rokita Przemyslaw Stefan
- Ronchetti Federico
- Rosado Navarro Sebastian
- Rosnet Philippe
- Rossi Andrea
- Rotondi Alberto
- Roukoutakis Filimon
- Roy Christelle Sophie
- Roy Pradip Kumar
- Rubio Montero Antonio Juan
- Rui Rinaldo
- Rumyantsev Boris
- Rustamov Anar
- Ryabinkin Evgeny
- Ryabov Yury
- Rybicki Andrzej
- Saarinen Sampo
- Sadhu Samrangy
- Sadovskiy Sergey
- Safarik Karel
- Saha Sumit Kumar
- Sahlmuller Baldo
- Sahoo Baidyanath
- Sahoo Pragati
- Sahoo Raghunath
- Sahoo Sarita
- Sahu Pradip Kumar
- Saini Jogender
- Sakai Shingo
- Saleh Mohammad Ahmad
- Salzwedel Jai Samuel Nielsen
- Sambyal Sanjeev Singh
- Samsonov Vladimir
- Sanchez Gonzalez Andres
- Sandoval Andres
- Sarkar - Sinha Tinku
- Sarkar Amal
- Sarkar Debojit
- Sarkar Nachiketa
- Sarma Pranjal
- Sas Mike Henry Petrus
- Scapparone Eugenio
- Scarlassara Fernando
- Schaefer Brennan
- Scheid Horst Sebastian
- Schiaua Claudiu Cornel
- Schicker Rainer Martin
- Schmidt Christian Joachim
- Schmidt Hans Rudolf
- Schmidt Marten Ole
- Schmidt Martin
- Schmidt Nicolas Vincent
- Schukraft Jurgen
- Schutz Yves Roland
- Schwarz Kilian Eberhard
- Schweda Kai Oliver
- Scioli Gilda
- Scomparin Enrico
- Sefcik Michal
- Seger Janet Elizabeth
- Sekiguchi Yuko
- Sekihata Daiki
- Selyuzhenkov Ilya
- Senosi Kgotlaesele
- Senyukov Serhiy
- Serradilla Rodriguez Eulogio
- Sett Priyanka
- Sevcenco Adrian
- Shabanov Arseniy
- Shabetai Alexandre
- Shahoyan Ruben
- Shaikh Wadut
- Shangaraev Artem
- Sharma Anjali
- Sharma Ankita
- Sharma Mona
- Sharma Monika
- Sharma Natasha
- Sheikh Ashik Ikbal
- Shigaki Kenta
- Shirinkin Sergey
- Shou Qiye
- Shtejer Diaz Katherin
- Sibiryak Yury
- Siddhanta Sabyasachi
- Sielewicz Krzysztof Marek
- Siemiarczuk Teodor
- Silaeva Svetlana
- Silva De Albuquerque Danilo
- Silvermyr David Olle Rickard
- Simatovic Goran
- Simonetti Giuseppe
- Singaraju Rama Narayana
- Singh Ranbir
- Singhal Vikas
- Sitar Branislav
- Sitta Mario
- Skaali Bernhard
- Slupecki Maciej
- Smirnov Nikolai
- Snellings Raimond
- Snellman Tomas Wilhelm
- Song Jihye
- Song Myunggeun
- Soramel Francesca
- Sorensen Soren Pontoppidan
- Sozzi Federica
- Sputowska Iwona Anna
- Stachel Johanna
- Stan Ionel
- Stankus Paul
- Stenlund Evert Anders
- Stocco Diego
- Storetvedt Maksim Melnik
- Strmen Peter
- Sugitate Toru
- Suire Christophe Pierre
- Suleymanov Mais Kazim Oglu
- Suljic Miljenko
- Sultanov Rishat
- Sumbera Michal
- Sumowidagdo Suharyo
- Suzuki Ken
- Swain Sagarika
- Szabo Alexander
- Szarka Imrich
- Tabassam Uzma
- Takahashi Jun
- Tambave Ganesh Jagannath
- Tanaka Naoto
- Tarhini Mohamad
- Tariq Mohammad
- Tarzila Madalina-gabriela
- Tauro Arturo
- Tejeda Munoz Guillermo
- Telesca Adriana
- Terasaki Kohei
- Terrevoli Cristina
- Teyssier Boris
- Thakur Dhananjaya
- Thakur Sanchari
- Thomas Deepa
- Thoresen Freja
- Tieulent Raphael Noel
- Tikhonov Anatoly
- Timmins Anthony Robert
- Toia Alberica
- Toledo Matuoka Paula Fernanda
- Toppi Marco
- Tripathy Sushanta
- Trogolo Stefano
- Trombetta Giuseppe
- Tropp Lukas
- Trubnikov Victor
- Trzaska Wladyslaw Henryk
- Trzeciak Barbara Antonina
- Tsuji Tomoya
- Tumkin Alexandr
- Turrisi Rosario
- Tveter Trine Spedstad
- Ullaland Kjetil
- Umaka Ejiro Naomi
- Uras Antonio
- Usai Gianluca
- Utrobicic Antonija
- Vala Martin
- Van Der Maarel Jasper
- Van Doremalen Lennart Vincent
- Van Hoorne Jacobus Willem
- Van Leeuwen Marco
- Vanat Tomas
- Vande Vyvre Pierre
- Varga Dezso
- Varga-kofarago Monika
- Vargyas Marton
- Varma Raghava
- Vasileiou Maria
- Vasiliev Andrey
- Vauthier Astrid
- Vazquez Doce Oton
- Vazquez Rueda Omar
- Vechernin Vladimir
- Veen Annelies Marianne
- Velure Arild
- Vercellin Ermanno
- Vergara Limon Sergio
- Vernet Renaud
- Vertesi Robert
- Vickovic Linda
- Vigolo Sonia
- Viinikainen Jussi Samuli
- Vilakazi Zabulon
- Villalobos Baillie Orlando
- Villatoro Tello Abraham
- Vinogradov Alexander
- Vinogradov Leonid
- Virgili Tiziano
- Vislavicius Vytautas
- Vodopyanov Alexander
- Volkl Martin Andreas
- Voloshin Kirill
- Voloshin Sergey
- Volpe Giacomo
- Von Haller Barthelemy
- Vorobyev Ivan
- Voscek Dominik
- Vranic Danilo
- Vrlakova Janka
- Wagner Boris
- Wang Hongkai
- Wang Mengliang
- Watanabe Daisuke
- Watanabe Yosuke
- Weber Michael
- Weber Steffen Georg
- Weiser Dennis Franz
- Wenzel Sandro Christian
- Wessels Johannes Peter
- Westerhoff Uwe
- Whitehead Andile Mothegi
- Wiechula Jens
- Wikne Jon
- Wilk Grzegorz Andrzej
- Wilkinson Jeremy John
- Willems Guido Alexander
- Williams Crispin
- Willsher Emily
- Windelband Bernd Stefan
- Witt William Edward
- Xu Ran
- Yalcin Serpil
- Yamakawa Kosei
- Yang Ping
- Yano Satoshi
- Yin Zhongbao
- Yokoyama Hiroki
- Yoo In-kwon
- Yoon Jin Hee
- Yun Eungyu
- Yurchenko Volodymyr
- Zaccolo Valentina
- Zaman Ali
- Zampolli Chiara
- Zardoshti Nima
- Zarochentsev Andrey
- Zavada Petr
- Zavyalov Nikolay
- Zbroszczyk Hanna Paulina
- Zhalov Mikhail
- Zhang Haitao
- Zhang Xiaoming
- Zhang Yonghong
- Zhang Zuman
- Zhao Chengxin
- Zhigareva Natalia
- Zhou Daicui
- Zhou You
- Zhou Zhuo
- Zhu Hongsheng
- Zhu Jianhui
- Zhu Ya
- Zichichi Antonino
- Zimmermann Markus Bernhard
- Zinovjev Gennady
- Zmeskal Johann
- Zou Shuguang
- Publication venue
- Publication date
- 01/01/2017
- Field of study
Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe
The role and uses of antibodies in COVID-19 infections: a living review
- Author
- Ahern David J.
- Alderson Jennifer
- Almuttaqi Hannah
- Alonzi Dominic S.
- Alrubayyi Aljawharah
- Alsaleh Ghada
- Bart Valentina M. T.
- Bart Valentina M. T.
- Batchelor Vicky
- Bayliss Rebecca
- Berthold Dorothée L.
- Bezbradica Jelena S
- Bharuchq Tehmina
- Borrmann Helene
- Borsa Mariana
- Borst Rowie
- Brun Juliane
- Burnell Stephanie E. A.
- Burnell Stephanie E. A.
- Capitani Lorenzo
- Cavounidis Athena
- Chapman Lucy
- Chauveau Anne
- Cifuentes Liliana
- Codd Amy Susan
- Compeer Ewoud Bernardus
- Coveney Clarissa
- Crespo Alicia Teijeira
- Cross Amy
- Danielli Sara
- Davies Luke C
- Dendrou Calliope A.
- Dimonte Sandra
- Dustin Lynn B.
- Dyer Arthur
- Eléonore Pavillet Clara
- Fielding Ceri
- Fischer Fabian
- Gallimore Awen
- Galloway Sarah
- Gammage Anís
- Gea-Mallorquí Ester
- Godkin Andrew
- Hanna Stephanie Jean
- Heuberger Cornelia
- Hulin-Curtis Sarah
- Issa Fadi
- James Matthews Reginald
- Jones Emma
- Jones Ruth
- Jones Ruth
- Ladell Kristin
- Lauder Sarah N.
- Liddiard Kate
- Ligoxygakis Petros
- Lu Fangfang
- MacLachlan Bruce
- Maleki-Toyserkani Shayda
- Mann Elizabeth H.
- Marzeda Anna M.
- Mazet Julie M.
- Milicic Anita
- Mitchell Emma
- Moon Owen
- Nguyen Van Dien
- O'Hanlon Miriam
- Peppa Dimitra
- Peres Raphael Sanches
- Peter Durairaj Ruban Rex
- Pires Ana
- Pring Eleanor
- Pring Ellie
- Quastel Max
- Quastel Max
- Reed Sophie
- Reed Sophie G.
- Rehwinkel Jan
- Richmond Niamh
- Richter Felix Clemens
- Richter Felix Clemens
- Robinson Alice J. B.
- Rodrigues Patrícia R. S.
- Sabberwal Pragati
- Sami Arvind
- Sattentau Quentin
- Schonfeldova Barbora
- Scourfield D. Oliver
- Scourfield David Oliver
- Selvakumar Tharini A.
- Shepherd Freya R.
- Shorten Cariad
- Simon Anna Katharina
- Smith Adrian L.
- Teijeira Crespo Alicia
- Tellier Michael
- Thornton Emily
- Uhl Lion F. K.
- van Grinsven Erinke
- Wann Angus K. T.
- Williams Richard
- Wilson Joseph D.
- Zhou Dingxi
- Zhu Zihan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2021
- Field of study
Coronavirus disease 2019 has generated a rapidly evolving field of research, with the global scientific community striving for solutions to the current pandemic. Characterizing humoral responses towards SARS-CoV-2, as well as closely related strains, will help determine whether antibodies are central to infection control, and aid the design of therapeutics and vaccine candidates. This review outlines the major aspects of SARS-CoV-2-specific antibody research to date, with a focus on the various prophylactic and therapeutic uses of antibodies to alleviate disease in addition to the potential of cross-reactive therapies and the implications of long-term immunity
T cell phenotypes in COVID-19 - a living review
- Author
- Ahern David J.
- Almuttaqi Hannah
- Alonzi Dominic S.
- Alrubayyi Aljawharah
- Alsaleh Ghada
- Bart Valentina M. T.
- Batchelor Vicky
- Bayliss Rebecca
- Berthold Dorothée L.
- Bezbradica Jelena S.
- Bharuchq Tehmina
- Borrmann Helene
- Borsa Mariana
- Borsa Mariana
- Borst Rowie
- Brun Juliane
- Burnell Stephanie
- Capitani Lorenzo
- Capitani Lorenzo
- Cavounidis Athena
- Chapman Lucy
- Chauveau Anne
- Cifuentes Liliana
- Codd Amy S.
- Codd Amy Susan
- Compeer Ewoud B.
- Compeer Ewoud Bernardus
- Coveney Clarissa
- Crespo Alicia Teijeira
- Cross Amy
- Danielli Sara
- Davies Luke C.
- Dendrou Calliope A.
- Dimonte Sandra
- Dimonte Sandra
- Dustin Lynn B.
- Dyer Arthur
- Eléonore Pavillet Clara
- Fielding Ceri
- Fischer Fabian
- Gallimore Awen
- Gallimore Awen M.
- Galloway Sarah
- Galloway Sarah A.E.
- Gammage Anís
- Gea-Mallorqui Ester
- Gea-Mallorquí Ester
- Godkin Andrew
- Hanna Stephanie J.
- Hanna Stephanie J.
- Heuberger Cornelia
- Hulin-Curtis Sarah
- Issa Fadi
- Jones Emma
- Jones Ruth
- Ladell Kristin
- Ladell Kristin
- Lauder Sarah N.
- Liddiard Kate
- Ligoxygakis Petros
- Lu Fangfang
- MacLachlan Bruce
- Maleki-Toyserkani Shayda
- Mann Elizabeth H.
- Marzeda Anna M.
- Matthews Reginald James
- Mazet Julie M.
- Milicic Anita
- Milicic Anita
- Mitchell Emma
- Moon Owen
- Moon Owen R.
- Nguyen Van Dien
- O'Hanlon Miriam
- Peppa Dimitra
- Peres Raphael Sanches
- Peter Durairaj Ruban Rex
- Pires Ana
- Pring Eleanor
- Quastel Max
- Reed Sophie
- Rehwinkel Jan
- Richmond Niamh
- Richter Felix C.
- Richter Felix Clemens
- Robinson Alice J. B.
- Rodrigues Patrícia R. S.
- Sabberwal Pragati
- Sami Arvind
- Sattentau Quentin
- Schonfeldova Barbora
- Scourfield D. Oliver
- Scourfield David Oliver
- Selvakumar Tharini A.
- Shepherd Freya R.
- Shepherd Freya R.
- Shorten Cariad
- Simon Anna Katharina
- Smith Adrian L.
- Tellier Michael
- Thornton Emily
- Uhl Lion F. K.
- Uhl Lion F. K.
- van Grinsven Erinke
- Wann Angus K. T.
- Williams Richard
- Wilson Joseph D.
- Wilson Joseph D.
- Zhou Dingxi
- Zhu Zihan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2021
- Field of study
COVID-19 is characterized by profound lymphopenia in the peripheral blood, and the remaining T cells display altered phenotypes, characterized by a spectrum of activation and exhaustion. However, antigen-specific T cell responses are emerging as a crucial mechanism for both clearance of the virus and as the most likely route to long-lasting immune memory that would protect against re-infection. Therefore, T cell responses are also of considerable interest in vaccine development. Furthermore, persistent alterations in T cell subset composition and function post-infection have important implications for patients’ long-term immune function. In this review, we examine T cell phenotypes, including those of innate T cells, in both peripheral blood and lungs, and consider how key markers of activation and exhaustion correlate with, and may be able to predict, disease severity. We focus on SARS-CoV-2-specific T cells to elucidate markers that may indicate formation of antigen-specific T cell memory. We also examine peripheral T cell phenotypes in recovery and the likelihood of long-lasting immune disruption. Finally, we discuss T cell phenotypes in the lung as important drivers of both virus clearance and tissue damage. As our knowledge of the adaptive immune response to COVID-19 rapidly evolves, it has become clear that while some areas of the T cell response have been investigated in some detail, others, such as the T cell response in children remain largely unexplored. Therefore, this review will also highlight areas where T cell phenotypes require urgent characterisation
Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis.
- Author
- Abd-Allah Foad
- Abdelnour Loay H
- Al Sami Yaqub
- Alkeridy Walid
- Azab Mohammed A
- Babu Heavenna
- Banks Tristan
- Barrios-López José María
- Beach Scott
- Beltrán-Corbellini Álvaro
- Benger Matthew
- Benjamin Laura
- Beretta Simone
- Bernard-Valnet Raphaël
- Biagio Mercuri Nicola
- Bigaut Kévin
- Boso Federica
- Brain Infections Global COVID-Neuro Network Study Group
- Breville Gautier
- Brew Bruce
- Brito Ferreira Maria Lúcia
- Cabreira Verónica
- Calabresi Paolo
- Cattrall Jonathan WS
- Cavallieri Francesco
- Chandratheva Arvind
- Chinthapalli Krishna
- Cividini Sofia
- Coen Matteo
- Cohen Matthew
- Contini Erika
- Corvol Jean-Christophe
- Costache Oana
- Cysique Lucette
- D'Anna Lucio
- Davies Emma
- Defres Sylviane
- Delorme Cécile
- Dervisevic Samir
- Dhar Shalley
- Diezma-Martín Alba María
- Du Pasquier Renaud
- Elicer Isabel
- Elkady Ahmed
- Enright Noelle
- Escalard Simon
- Eugenín-von Bernhardi Laura
- Fajardo Modol Anna
- Farooq Hamzah
- Fernández Díaz Eva
- Foschi Matteo
- Garazzino Silvia
- García García Sergio
- Giunta Marcello
- Goodwin Lynsey C
- Guekht Alla
- Guijarro-Castro Cristina
- Gunasekaran Kulothungan
- Harkness Kirsty
- Harte Jeffrey
- Hassell Jane
- Hey Samuel
- Heyse Alex
- Hodel Eva Maria
- Hornuss Daniel
- Hosp Jonas
- Huda Saif
- Jain Rajan
- JamaliMoghadamSiahkali Saeidreza
- Jillella Dinesh
- Joseph Albert
- Kahn Lora
- Kaimovsky Igor
- Karthikappallil Dileep
- Kassahun Daniel
- Kaya Yildiz
- Khawaja Ayaz
- Kim Carla Y
- Klok Frederikus A
- Knier Benjamin
- Koh Jasmine
- Lahiri Durjoy
- Lant Suzannah
- Lechien Jérome
- Libri Ilenia
- Liguori Claudio
- Lingor Paul
- Lipunga Gareth
- Lopez Evelyn C
- Lorenz Norbert
- Maggi Pietro
- Mariotto Sara
- Martínez-Poles Javier
- Mason Rachel
- Matos Aline de Moura Brasil
- Meza Roger
- Mhlanga Sithembinkosi
- Michael Benedict D
- Minton Thomas
- Moein Shima T
- Mond Gabrielle
- Morales-Casado Maria Isabel
- Morassi Mauro
- Morrison Hamish
- Nalleballe Krishna
- Nicholson Timothy R
- Nortley Ross
- Oliveira Vanessa
- Padovani Alessandro
- Paterson Ross
- Patrick Kimani N
- Pierantozzi Mariangela
- Pilotto Andrea
- Pincherle Alexander
- Pinto Ashwin
- Poxon Joseph
- Primiano Guido
- Rabas Sophie
- Raith Eamon
- Ravaglia Sabrina
- Rawlinson Rebecca
- Rice Claire
- Rieg Siegbert
- Rocha Ferreira Da Silva Ivan
- Santoro Jonathan
- Sargent Brendan F
- Sarmati Loredana
- Saussez Sven
- Scullen Tyler
- Sejvar James J
- Servidei Serenella
- SeyedAlinaghi SeyedAhmad
- Sharifi-Razavi Athena
- Singh Bhagteshwar
- Soares Cristiane N
- Solomon Tom
- Somasundaran Anushri
- Soothill Germander
- Sztriha Laszlo
- Tamborska Arina
- Tattevin Pierre
- Thakur Kiran T
- Tudur Smith Catrin
- Uginet Marjolaine
- Umapathi Thirugnanam
- Valdoleiros Sofia R
- van Pesch Vincent
- Wagner Dirk
- Webb Glynn
- Werring David J
- Winkler Andrea Sylvia
- Yenkoyan Konstantin
- Yin Rong
- Younas Komal
- Zedde Marialuisa
- Zhang Xin
- Ñancupil Reyes Waleng
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2022
- Field of study
BackgroundNeurological COVID-19 disease has been reported widely, but published studies often lack information on neurological outcomes and prognostic risk factors. We aimed to describe the spectrum of neurological disease in hospitalised COVID-19 patients; characterise clinical outcomes; and investigate factors associated with a poor outcome.MethodsWe conducted an individual patient data (IPD) meta-analysis of hospitalised patients with neurological COVID-19 disease, using standard case definitions. We invited authors of studies from the first pandemic wave, plus clinicians in the Global COVID-Neuro Network with unpublished data, to contribute. We analysed features associated with poor outcome (moderate to severe disability or death, 3 to 6 on the modified Rankin Scale) using multivariable models.ResultsWe included 83 studies (31 unpublished) providing IPD for 1979 patients with COVID-19 and acute new-onset neurological disease. Encephalopathy (978 [49%] patients) and cerebrovascular events (506 [26%]) were the most common diagnoses. Respiratory and systemic symptoms preceded neurological features in 93% of patients; one third developed neurological disease after hospital admission. A poor outcome was more common in patients with cerebrovascular events (76% [95% CI 67-82]), than encephalopathy (54% [42-65]). Intensive care use was high (38% [35-41]) overall, and also greater in the cerebrovascular patients. In the cerebrovascular, but not encephalopathic patients, risk factors for poor outcome included breathlessness on admission and elevated D-dimer. Overall, 30-day mortality was 30% [27-32]. The hazard of death was comparatively lower for patients in the WHO European region.InterpretationNeurological COVID-19 disease poses a considerable burden in terms of disease outcomes and use of hospital resources from prolonged intensive care and inpatient admission; preliminary data suggest these may differ according to WHO regions and country income levels. The different risk factors for encephalopathy and stroke suggest different disease mechanisms which may be amenable to intervention, especially in those who develop neurological symptoms after hospital admission
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Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
- Aves Emma
- Avogadro Prune
- Avramopoulou Lamprini
- Ay Mustafa
- Ay Serap Avcı
- Aya Umeda
- Ayala Maria
- Aydemir Semih
- Aydin Demet Tok
- Azencot Mazal
- Azoia Joao
- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
- Bai Xiaowu
- Baini Matías
- Bakas Apostolos
- Baker Helen
- Baker Nerilee
- Balasubramanian Madhu
- Balbay Abidin Oner
- Balon Sandrine
- Bantar Ana
- Banwarie Preveen
- Bao Guijun
- Baptiste-Savoie Jacqueline
- Barakat-Johnson Michelle
- Barefield Cindy
- Barkas Diane
- Barnes Christopher
- Barone Antonio
- Baronia Arvind
- Barr Louise
- Barreiro Emma Moreno
- Barros Elaine
- Barrowcliffe Suzanne
- Barrueco-Francioni Jesus Emilio
- Bartoli Julio Ricardo
- Baruah Rosaleen
- Bascary Carlos Alejandro
- Baskakov Danil
- Baskoro Windu
- Bastani Styliani
- Baumber Rachel
- Baxter Karen
- Bayraktar Yesim Serife
- Bealer Cheryl
- Bean Sarah
- Becker Cathy
- Becker Delmiro
- Behan Helena
- Beker Tatjana
- Bekos Vasileios
- Belii Adrian
- Belkhair Wesal Ali
- Belskiy Vladislav
- Ben-Hamouda Nawfel
- Ben-Jacob Talia
- Benbenishty Julie
- Bench Suzanne
- Bendelari Valentina
- Benlamin Mohamed
- Berry Gillian
- Bertoletti Fernando Pablo
- Besbes Lamia
- Besbes Lamia Ouanes
- Besch Guillaume
- Bestle Morten
- Beuret Pascal
- Bhakhtiani Lakshay
- Bhargava Vaibhav
- Bi AiPing
- Bianchini Suzana
- Bielskute Egidija
- Bilawicz Jan
- Binda Filipo
- Birgisdottir Hrönn
- Birgisdóttir Hrönn
- Bispo Bruno Miguel
- Biston Patrick
- Bjorgen Hege
- Blackwood Bronagh
- Blanc Agnès
- Blanco Daniel
- Blanco Maria Pilar Sogues
- Blasco Maria Luisa
- Bliksted Inger Abildgaard
- Blondal Asbjorn
- Bloos Frank
- Blot Stijn I.
- Bo Qi
- Bocui Nie
- Boedjawan Naraindath N.
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- von der Osten Ingrid
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- von Lewinski Dirk
- Vosylius Saulius
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- Vymazal Tamas
- Vymazal Tomas
- Wahab Sherliza
- Wahlbom Ewa
- Waibel Hansjoerg
- Wallin Ewa
- Walsh Amy
- Wan Jianhong
- Wan Yan
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- Wang Ying
- Wang Yingli
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- Watts Stacey
- Waweru-Siika Wangari
- Wei Dongfang
- Wei Wei
- Wei Xiyan
- Wei Ying
- Welters Ingeborg D.
- White Joanne
- White Nigel
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- Xia Chun Jie
- Xia Xinhua
- Xiao Lina
- Xiao Min
- Xiao Yan
- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
- Ye Man
- Ye Mei
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- Yeon-Joo Lee
- Yildiz İsmail
- Yilmaz Hakan
- Yin Hai
- Yin Li
- Young Charlotte
- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- 'Organisation for Economic Co-Operation and Development (OECD)'
- Publication date
- 26/02/2021
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
Recommended from our members
Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
- Aves Emma
- Avogadro Prune
- Avramopoulou Lamprini
- Ay Mustafa
- Ay Serap Avcı
- Aya Umeda
- Ayala Maria
- Aydemir Semih
- Aydin Demet Tok
- Azencot Mazal
- Azoia Joao
- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
- Bai Xiaowu
- Baini Matías
- Bakas Apostolos
- Baker Helen
- Baker Nerilee
- Balasubramanian Madhu
- Balbay Abidin Oner
- Balon Sandrine
- Bantar Ana
- Banwarie Preveen
- Bao Guijun
- Baptiste-Savoie Jacqueline
- Barakat-Johnson Michelle
- Barefield Cindy
- Barkas Diane
- Barnes Christopher
- Barone Antonio
- Baronia Arvind
- Barr Louise
- Barreiro Emma Moreno
- Barros Elaine
- Barrowcliffe Suzanne
- Barrueco-Francioni Jesus Emilio
- Bartoli Julio Ricardo
- Baruah Rosaleen
- Bascary Carlos Alejandro
- Baskakov Danil
- Baskoro Windu
- Bastani Styliani
- Baumber Rachel
- Baxter Karen
- Bayraktar Yesim Serife
- Bealer Cheryl
- Bean Sarah
- Becker Cathy
- Becker Delmiro
- Behan Helena
- Beker Tatjana
- Bekos Vasileios
- Belii Adrian
- Belkhair Wesal Ali
- Belskiy Vladislav
- Ben-Hamouda Nawfel
- Ben-Jacob Talia
- Benbenishty Julie
- Bench Suzanne
- Bendelari Valentina
- Benlamin Mohamed
- Berry Gillian
- Bertoletti Fernando Pablo
- Besbes Lamia
- Besbes Lamia Ouanes
- Besch Guillaume
- Bestle Morten
- Beuret Pascal
- Bhakhtiani Lakshay
- Bhargava Vaibhav
- Bi AiPing
- Bianchini Suzana
- Bielskute Egidija
- Bilawicz Jan
- Binda Filipo
- Birgisdottir Hrönn
- Birgisdóttir Hrönn
- Bispo Bruno Miguel
- Biston Patrick
- Bjorgen Hege
- Blackwood Bronagh
- Blanc Agnès
- Blanco Daniel
- Blanco Maria Pilar Sogues
- Blasco Maria Luisa
- Bliksted Inger Abildgaard
- Blondal Asbjorn
- Bloos Frank
- Blot Stijn I.
- Bo Qi
- Bocui Nie
- Boedjawan Naraindath N.
- Bogarin Javier
- Bogoevska-Miteva Zaneta
- Bonaccorso Luciano
- Bongiorno Benjamin
- Bonsignore Pablo Julio Maldonaldo
- Borgognoni Cinzia
- Borin Christophe
- Borkowska Marta
- Bormans Laura
- Boroli Filippo
- Borys Michal
- Boschetto Margherita
- Bossolasco Matteo
- Bota Marc
- Boulanger Carole
- Boulton Karen
- Bowes Bonnie
- Boyer Laetitia
- Bozbay Suha
- Bozena Armanda
- Bratsberg Bjorn
- Bravo Silvina
- Brett Carole
- Brett Stephen
- Brett Stephen J.
- Briva Arturo
- Brizio Elisabetta
- Brizuela Patricia
- Broadhurst Phil
- Brown Wendy
- Browne Troy
- Bruel Cédric
- Bruhn Louise
- Brumwell Sarah
- Bruni Andrea
- Bruno Anna Vita
- Buckley Sarah
- Bull Rhian
- Bumbasirevic Vesna
- Buregeya Egide
- Burns Karen
- Butcher Rand
- Byers Heather
- Bösl Kathrin
- Cabral Dolly Mabel Bordon
- Cabral João
- Cabrita Paula
- Caddell Paul
- Caicedo Nestor
- Calamai Italo
- Calili Duygu Kayar
- Caliskan Gulbahar
- Calleja Pablo Lopez-Arcas
- Calpe Neus
- Calvino-Gunther Silvia
- Campanili Ticiane
- Campbell Elizabeth
- Campos Pierina Arias
- Campos-Perez Margarita
- Camputaro Luis
- Camsooksai Julie
- Canales Julieta
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- Carter Charlotte
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- Clesi Tara
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- Collet Marie
- Collins Amy
- Coman Mary
- Conde Belen Burgos
- Conejo Isabel
- Constantinou Constantina
- Corcoran Ailesh
- Coremans Stefano
- Correia Malcolm C.
- Corso Amalia
- Cortegiani Andrea
- Cortellazi Paolo
- Cosano Rosario
- Cossu Maria
- Costa Humberto
- Cotoia Antonella
- Coyer Fiona
- Craig Geraldine
- Craig Jayne
- Cranmer Karen
- Cranshaw Julius
- Creber Peter
- Crone Petra
- Cui Xia
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- Dagooc Rica
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- Dallaire Julie
- Das Sasidharan Nair Vishnu
- Daubin Cédric
- Davidow Jon
- Davidson Cheryl
- Dawn Frances
- Dayan Meneses
- de Almeida Angelica Olivetto
- de Anda Gilberto Felipe Vazquez
- De Bels David
- de Ceballos José Peral Gutierrez
- De Decker Koen
- De Haan Marina
- de Jesús Ortiz Alberto
- de la Ventana Ana Belén Sánchez
- De lange Dylan
- De Lange Dylan
- de Molina Serrano José Ivan Rodriguez
- De Montmollin Etienne
- De Pablo Ana María
- De Rosa Silvia
- De Sanctis Francesca
- De Schryver Nicolas
- De Wit Irene
- Dean Emiliano
- Debue Anne-Sophie
- Del Bosque Diez Rosa
- del Cotillo Mercedes
- del Mar Diaz Salcedo Maria
- Del Moral Armengol Mario
- Del Rio Cabajo Lorena
- del Rosario Villar Redondo M.
- del Valle Gimenez Graciela
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- Delgado Patricia
- Dellafiore Federica
- Delossantos Shella
- Delve Peter
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- Derbyshire Claire
- Derrick Helen
- Deschepper Mieke
- Deva Shanti Rudra
- Dhaliwal Jasdeep
- Di Gravio Valentina
- Di Risio Alessandro
- Di Yanhong
- Diakaki Chrisi
- Dias Sofia
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- Diaz Monica Garcia
- Dieperink Willem
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- Dikmen Yalim
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- Dimoula Aikaterini
- Dimski Thomas
- Ding Min
- Ding Xinran
- Ding Yajun
- Ding Yanming
- Dlamini-Sserumaga Lomangisi
- Dobric Milena
- Dolenc Simon
- Dolgusevs Mihails
- Domenech Laura Claramunt
- Dong Jingwen
- Dong Yunchun
- Donvito Maria
- Dormans Tom
- Douschan Philipp
- Doyle Deirdre
- Dragoumanis Christos
- Du Guifang
- Duan Huan
- Dugernier Thierry
- Duggal Abhijit
- Dullenkopf Alexander
- Dungca Adonis
- Dunne Lisa
- Duran Karely
- Déserts Marc Danguy des
- D’Ambrosio Francesco
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- Tabah Alexis
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- Taghavi Noushin
- Taibi Maria Rosa
- Taito Shunsuke
- Tak Poon Shing
- Takahashi Kenji
- Talik Imen
- Tallot Mandy
- Tamayo Luis Mario
- Tamme Kadri
- Tan Lei
- Tao Jing
- Tapia Fernando
- Tavares Ana
- Taşdemir Banu
- Teig Magnus
- Tejeda-Huezo Brigitte
- Telleria Vanesa Mercado
- Templeton Mae
- Terry Dorothy
- Tervo-Heikkinen Tarja
- Thankamma Bindu
- Theisen Christian
- Thix Cyril
- Tholioti Thomai
- Thoma Giannoula
- Thomas Beverley
- Thompson Amy
- Thompson Lorraine
- Thomsen Tina Damgaar
- Thorpe Elaine
- Tian Eryun
- Tian Xiao Fang
- Tian Yani
- Tian Zhixia
- Timsit Jean-Francois
- Tingsvik Catarina
- Tirado Celia
- Toellefsen Annette
- Tokareva Ekaterina
- Tokur Murat Emre
- Tole Eunice
- Tomescu Dana
- Tong Jenny May Geok
- Tonkovic Dinko
- Toppin Patrick
- Torlinski Tomasz
- Traina Lidia
- Tranello Francesca Paola
- Tribulev Maksim
- Tridente Ascanio
- Triki Ahmed Ramadan
- Tripathy Swagata
- Trongtrakul Konlawij
- Trongtratul Konlawij
- Trposak Angela
- Trudvang Siw
- Trueman-Dawkins Treiza
- Tsarev Alexander
- Tsikriki Syragoula
- Tsikritsaki Kyriaki
- Tsujimoto Mayumi
- Tubacka Marta
- Tuinstra Binny
- Tuo Lili
- Turan Can
- Turan Sema
- Turc Jean
- Turner Sarah Jane
- Turčan Anton
- Tutillo Diego Rolando Morocho
- Twagirumugabe Theogene
- Twiggs Hilary
- Uba Stella
- Uccelli Francesco
- Udiljak Nikolina
- Ugwu Innocent
- Umek Nejc
- Undar Hasan Nabi
- Vakalos Aristeidis
- Valerio Idália
- Valgolio Emanuel
- Valta Maija
- Valta Maija Anniina
- van Axel Alisha
- Van Cotthem Ilse
- Van de Velde Stijn
- Van Den Berg Lettie
- Van Den Brink Mark
- Van Den Elst Arlette
- van der Kuil Mark
- Van Gulik Laura
- Van Regenmortel Niels
- Van Vliet Peter
- Vanroest Margijske
- Varela Maria
- Vaschetto Rosanna
- Vasquez Alexandra
- Vaughan-Jones Nicola
- Velickovic Jelena
- Veličković Dejan
- Ventour Dale
- Vermeijden Jan Wytze
- Vieira João
- Villa Robert
- Villafuerte Missael Vladimir Espinoza
- Villanueva Ximena
- Villegas Paula
- Viveiros Abel
- Vizcaychipi Marcela
- Vlaovic Janko
- Vochin Ana
- Volta Carlo Alberto
- von der Osten Ingrid
- Von Der Osten Ingrid
- von Lewinski Dirk
- Vosylius Saulius
- Vuković Anita
- Vullum Sylvi
- Vymazal Tamas
- Vymazal Tomas
- Wahab Sherliza
- Wahlbom Ewa
- Waibel Hansjoerg
- Wallin Ewa
- Walsh Amy
- Wan Jianhong
- Wan Yan
- Wang Damei
- Wang Fanglan
- Wang GuoXian
- Wang Hai Yun
- Wang Haiyan
- Wang Jing
- Wang Kefang
- Wang LingLing
- Wang RuiXia
- Wang Shuhui
- Wang Shuo
- Wang Wei
- Wang Wenmei
- Wang Xiaomin
- Wang Yan
- Wang Ying
- Wang Yingli
- Wang Yuping
- Wang Yuxia
- Watts Stacey
- Waweru-Siika Wangari
- Wei Dongfang
- Wei Wei
- Wei Xiyan
- Wei Ying
- Welters Ingeborg D.
- White Joanne
- White Nigel
- Whiteley Simon
- Whitticase Richard
- Wiborg Elisabeth
- Wijnands Patricia
- Wilby Liz
- Williams Anne
- Williams Ged
- Williams Helen
- Williams Karen
- Williams Lynne
- Wilting Rob
- Wise Robert
- Woods Justin
- Wright Kerry
- Wu Juan
- Wu ShiFen
- Wu Xiaojun
- Wu Xiaoying
- Wu Yang
- Wu Yun
- Wu Zijing
- Xhindi Nordian
- Xia Chun Jie
- Xia Xinhua
- Xiao Lina
- Xiao Min
- Xiao Yan
- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
- Ye Man
- Ye Mei
- Yeni Nomhle Princess
- Yeon-Joo Lee
- Yildiz İsmail
- Yilmaz Hakan
- Yin Hai
- Yin Li
- Young Charlotte
- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- Intensive Care Medicine
- Publication date
- 09/04/2021
- Field of study
The original version of this article unfortunately contained a mistake
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Aaron Joffe
- Aaron Mark Hernandez
- Aaron Mark Hernandez
- Abby Lewis
- Abdelhamid Hachimi
- Abdualhamid I Alshrif
- Abel Viveiros
- Abhijit Duggal
- Abidin Oner Balbay
- Achilleas Chovas
- Ade Susanti
- Adi Hadzibegovic
- Adonis Dungca
- Adrian Belii
- Adrian Belii
- Adriana Onelli
- Afolabi Owojuyigbe
- Agnieszka Kubisz-Pudelko
- Agnès Blanc
- Ahmed Ali Aboufray
- Ahmed Elhadi
- Ahmed Ramadan Triki
- Ahmed Subhy Alsheikhly
- Ahmed Zaki
- Ahmet Eroglu
- Aidan O'Shea
- Aikaterini Dimoula
- Aikaterini Efthimiou
- Aikaterini Flevari
- Ailesh Corcoran
- AiPing Bi
- Aiua Ren
- Aizhi Zhang
- Ajitha Rajendran
- Akemi Hirao
- Akira Ohuchi
- Aktham Yaghi
- Ala Khaled
- Alan Sustic
- Alan Sustic
- Alba Riera
- Alban Greca
- Alberto de Jesús Ortiz
- Alberto Peratoner
- Alejandra Aucapina
- Alejandra Azahara Marguello Fernandez
- Alejandro Ibarra
- Aleksandar Šuput
- Aleksandra Gutysz-Wojnicka
- Alessandra Negro
- Alessandro Di Risio
- Alessandro Galazzi
- Alexander Dullenkopf
- Alexander Kiselev
- Alexander Tsarev
- Alexandra Pivkina
- Alexandra Vasquez
- Alexis Tabah
- Ali Kağnıcı
- Alida Moise
- Aline Ramalho
- Alinoy Lavy
- Alisha van Axel
- Alma Cani
- Alvaro Ortega Guerrero
- Amalia Corso
- Amber Markham
- Amelia Ferreira
- Amer Assiri
- Amilcar Garcia
- Amilcar Garcia
- Amit Gupta
- Amit Gupta
- Amy Collins
- Amy Thompson
- Amy Walsh
- Amylkar Garay Reyes
- Amylkar José Garay Reyes
- Ana Alabart Llinas
- Ana Alícia Velarde Pineda
- Ana Bantar
- Ana Belén Curto Polo
- Ana Belén Sánchez de la Ventana
- Ana Diaz
- Ana Diaz
- Ana Isabel Clement
- Ana Laura Gonzalez
- Ana Lucia Vitti Ronchini
- Ana Margarida Feranandes
- Ana María De Pablo
- Ana Pascual-Bielsa
- Ana Tavares
- Ana Vochin
- Ana Wensell Fernández
- Anastasia Spyropoulou
- Anastasio Espejo Cano
- Andeas Stübner
- Andrea Bruni
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Giampaoletti
- Andrea Martonova
- Andrea Martonova
- Andrea McDonnell
- Andrea McLucas
- Andrej Markota
- Andrijan Kartalov
- Andréa Maria Laizner
- Andréa Maria Laizner
- Andréa Maria Laizner
- Ane Stenset
- Angela Trposak
- Angelica Olivetto de Almeida
- Anisette Hoegenhaven
- Anita Alias
- Anita Jans
- Anita Vuković
- Anita-Chrysolyte Kusi-Appiah
- Anja Diers
- Anja Hansen
- Ann-Sofie Malvemyr
- Anna Alexandrou
- Anna Diaz
- Anna Efthymiou
- Anna Kyriakoudi
- Anna Leonova
- Anna Vita Bruno
- Anne Fishman
- Anne Langvad
- Anne Marie Kodal
- Anne Sofie Bomholt Pedersen
- Anne Williams
- Anne-Sophie Debue
- Annette Carey
- Annette Toellefsen
- Anthony Adenekan
- Anthony Radavidson
- Antigoni Karathanou
- Anton Turčan
- Antonella Cotoia
- Antonella Mo
- Antoni Margarit Ribas
- Antonia Liarmakopoulou
- Antonija Petosic
- Antonino Rizzo
- Antonio Abdala
- Antonio Barone
- Antonio Landaverde
- Antonio Manzo
- Antonio Margarit Ribas
- Antony Eneas
- Apostolos Bakas
- Arena Raimondo
- Arif Moghal
- Aristeidis Vakalos
- Arlette Van Den Elst
- Armanda Bozena
- Armando Schmukler
- Armorel Salberg
- Artemis Patsalos
- Arturo Briva
- Arvind Baronia
- Asbjorn Blondal
- Ascanio Tridente
- Ashish K Khanna
- Ashish K Khanna
- Ashish Khanna
- Ashley Szabo Eltorai
- Ashok Sundai Raj
- Ashwaq Ali
- Asmah Zainudin
- Asu Ozgultekin
- Ata Mahmoodpoor
- Athena Lavrentieva
- Attilio Quaini
- Audrey Fioretti
- Audrey Massard
- Auke Reidinga
- Auli Palmu
- Avşar Zerman
- Aya Alabuzidi
- Ayako Noguchi
- Ayça Gümüş
- Azmin Huda Abdul Rahim
- Babangida John Sankey
- Badiola Hilario
- Banu Taşdemir
- Baoke Zhang
- Barbara Garcia
- Barbro Meland
- Bart Ramaker
- Basri Mat Nor
- Battsetseg Baasanjav
- Başar Erdivanli
- Başar Erdivanli
- Beatrice Pastore
- Begoña Zalba-Etayo
- Belen Burgos Conde
- Belinda Guadi-Gosh
- Ben Attwood
- Benjamin Bongiorno
- Benjamin Gerretsen
- Benoît Chinardet
- Berenice Navarro
- Bernardo Panka
- Bernardo Panka
- Bernd Oliver Rose
- Bert Loef
- Betty Star Kampayana
- Beverley Thomas
- Beysim Özcan
- Beysim Özcan
- Bhagyesh Shah
- Biljana Kuzmanovska
- Bindu Thankamma
- Bing Song
- Binny Tuinstra
- Birgitte Fosser Johansen
- Birthe Husted
- Biyan Li
- Bjoern Monsen
- Bjorn Bratsberg
- Bodin Khwannimit
- Bogdan Raitsiou
- Bojan Jovanovic
- Bonnie Bowes
- Boğaç Özserezli
- Bram Kilapong
- Bram Kilapong
- Branislava Stefanovic
- Brian Marsh
- Brigitte Tejeda-Huezo
- Brita Fosser Olsen
- Britt Galaaen
- Britt Sjobo
- Britta Jepsen
- Bronagh Blackwood
- Bruno Miguel Bispo
- Bruno Sousa
- Bruno Sousa
- Brynja Rygvadottir
- Burhan Hadri
- Burhan Hadri
- Byung Ju Kang
- Caihong Hui
- Caiju Song
- Caitriona Cody
- Can Turan
- Carita Löfqvist
- Carlo Alberto Volta
- Carlos Alejandro Bascary
- Carlos Castro Delgado
- Carmel Chapman
- Carmel Georgiev
- Carmen Partera Luque
- Carmen Velasco Guillén
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- Carole Boulanger
- Carole Brett
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- Carolina Palaez
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- Carrie Sona
- Casiano Barrera Groba
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- Catarina Nunes
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- Catherine O'Brien
- Catherine Smith
- Cathy Becker
- Catia Quagliotto
- Cecilia Inés Loudet
- Cecilia Loudet
- Celia Tirado
- Ceri Lynch
- Cesar Aponte
- Cesar Rodriguez Nuñez
- Chaiwut Sawawiboon
- Chaoqun Ma
- Charalampos Martinos
- Charalice Ramiro
- Charikleia Nikolaou
- Charlotte Carter
- Charlotte Young
- Charlotte Young
- Chen Yumei
- Cheng
- Chenghau Mu
- Chengxia Sun
- Cheryl Bealer
- Cheryl Davidson
- Chiara Gatti
- Chiara Megna
- Chiara Megna
- Cho Young-Jae
- Chris Gerome Ellazar
- Chris Smith
- Chrisi Diakaki
- Christian Ferretti
- Christian Frey
- Christian Theisen
- Christiana Chime
- Christine Fiedler
- Christine Sheehan
- Christophe Borin
- Christophe Giacardi
- Christopher Barnes
- Christopher Barnes
- Christopher Palfreeman
- Christopher Potestio
- Christos Christofis
- Christos Dragoumanis
- Chrysanthos Markoulias
- Chrysostomos Katsenos
- Chun Jie Xia
- Chunxia Li
- Cindy Barefield
- Cindy Pillard
- Cintia Valencia Hurtado
- Cinzia Borgognoni
- Claire Derbyshire
- Claire Randell
- Claire Reynolds
- Clara Hurtado
- Clara Santa Rita
- Clare Fielding
- Clare Howcroft
- Claude Sertznig
- Claudia Lizbeth Lopez Nava
- Claudia Martins
- Congcong Liu
- Constantina Constantinou
- Cristal April Jane Aperocho
- Cristian Quiroga
- Cristiana Mota Pinheiro
- Cristina Paños Espinosa
- Cristina Petrisor
- Cui Yuan
- Cynthia Xing
- Cyril Thix
- Cyril Thix
- Cédric Bruel
- Cédric Daubin
- Dagmar Holmquist
- Daira Gonzalez
- Daisy Mehay
- Dale Ventour
- Damei Wang
- Damien O'Connell Rosemary Finn
- Dana Tomescu
- Dana Tomescu
- Danca Lančaričová
- Daniel Blanco
- Daniel Horner
- Daniel Owens
- Daniel Sancho Muriel
- Daniela Alampi
- Daniela Carmen Filipescu
- Danielle Hacking
- Danil Baskakov
- Daria Rabarova
- Dassy Levy
- David De Bels
- David Higgins
- David Perez-Torres
- David Shaw
- Davide Massimo Ghioldi
- Dea Mahanes
- Debbie Noblezada-Uy
- Deborah Jibrin
- DeHong Lei
- Deirdre Doyle
- Dejan Veličković
- Delmiro Becker
- Delphine Ngo
- Demet Tok Aydin
- Detlef Kindgen-Milles
- Devrim Akdağ
- Deyan Cao
- Diana Alvarez
- Diane Barkas
- Dianne Figaro-Barclay
- Dick Nahar
- Diego Rolando Morocho Tutillo
- Dimitra Lepida
- Dimitrios Papadopoulos
- Dinko Tonkovic
- Dirk von Lewinski
- Dmitriy Galishevskiy
- Dmitry Sergeev
- Dolly Mabel Bordon Cabral
- Dominic Carney
- Donaldo S Arteta Arteta
- Dongfang Wei
- Dongliang Lin
- Dongmei Bai
- Dongshu Ni
- Donna Cummings
- Dorel Sandesc
- Dorothee Mueller
- Dorothy Terry
- Drammen Sykehus
- Dritan Muzha
- Dritan Muzha
- Duygu Kayar Calili
- Dylan De Lange
- Dylan De Lange
- Edda Johansen
- Edwin Chapeta
- Egide Buregeya
- Egidija Bielskute
- Eileen Gilder
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- Elaine Barros
- Elaine Thorpe
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- Elisabet Gallart
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- Elisabetta Brizio
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- Elizabeth Maidana
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- Ella Rokosh
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- Elsa Afonso
- Emanuel Valgolio
- Emiliano Dean
- Emilio Maseda
- Emma Aves
- Emma Moreno Barreiro
- Emma Parkin
- Enas Soula
- Eneli Anvelt
- Enora Atchade
- Epaminontas Farmakis
- Erik Roman-Pognuz
- Erika Backlund Jansson
- Eryun Tian
- Esben Straede
- Esteban Milioto
- Estefania Orozco
- Estefanía Prol-Silva
- Estevão Lafuente
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- Eumorfia Kondili
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- Fayez François Abillama
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- Federico Gordo
- Federico Iglesias
- Fei Ouyang
- Feifei Chen
- Feifei Luo
- Feifei Zhang
- Fekri Abroug
- Fengling Yang
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- Fernando Avalos
- Fernando Baccaro
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- Fernando Lipovesty
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- Fethi Gül
- Fidelina Canete
- Filip Naumovski
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- Fiona Coyer
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- Hrönn Birgisdottir
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- Jale Bengi Çelik
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- Jan-Willem Fijen
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- Jane McMullen
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- Janko Vlaovic
- Jarone Lee
- Jasdeep Dhaliwal
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- Xuejuan Liang
- XueLian Liu
- Xuelian Pang
- Xuelian Xu
- Xueping Jiao
- Yajun Ding
- Yakubu H Yakubu
- Yali Zhang
- Yalım Dikmen
- Yalım Dikmen
- Yalim Dikmen
- Yan Gao
- Yan Li
- Yan Liu
- Yan Liu
- Yan Long
- Yan Wan
- Yan Wang
- Yan Xiao
- Yan Xie
- Yan Xu
- Yan Yan
- Yanfei Long
- Yang Lei
- Yang Liu
- Yang Wu
- Yang Xiaoyan
- Yanhong Di
- Yanhua Hao
- Yani Tian
- Yanlan Yao
- Yanling Shen
- Yanman Jian
- Yanmei Gu
- Yanming Ding
- Yann Le Guen
- Yanping Yang
- Yasser Mandourah
- Yenny Cardenas
- Yenny Cardenas
- Yesim Serife Bayraktar
- Yin He
- Ying Cao
- Ying Li
- Ying Liu
- Ying Wang
- Ying Wei
- Ying Zhang
- Yingjuan Zhao
- Yingli Wang
- Yinhua Guo
- Yolanda Mendiara
- YongXia Yang
- Yoshimasa Nishime
- Yoshiro Hayashi
- Youjin Chang
- Youru Jiang
- Youssef Zied Elhechmi
- Ysica Acosta
- Yu Chao
- Yu Han
- Yu Liu
- Yu Liu
- Yue Sun
- Yue Ying Gong
- Yuming Zhou
- Yun Su Sim
- Yun Wu
- Yunchun Dong
- Yunfeng Xiong
- Yupeng Liu
- Yuping Wang
- Yuxia Huo
- Yuxia Wang
- Yuxia Yuan
- Yvan Fleury
- Yvonne Andersen
- Zainab Ateya
- Zaneta Bogoevska-Miteva
- Zeya Shi
- Zhang Zhigang
- ZhangShuangzi Li
- ZhangXia Feng
- Zhaoxia Feng
- Zhaoxing Dai
- Zhenxia Zhang
- Zhihong Chen
- Zhiru Yao
- Zhixia Jiang
- ZhiXia Jiang
- Zhixia Tian
- Zhu Jun Yu
- Zhuqing Li
- Zied Hajjej
- Zijing Wu
- Zsuzsann Ágoston
- Zu Qing Cao
- Zulkifli Zulkifli
- Ângela Lima
- Publication venue
- Intensive Care Medicine
- Publication date
- 29/08/2020
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
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