Does location congruence matter? : A field study on the effects of location-based advertising on perceived ad intrusiveness, relevance & value

We investigate the effect of location-congruent mobile messages on perceived intrusiveness, value, and relevance through a field experiment using the Experience Sampling Method (ESM). We developed a mobile application for undergraduate students, featuring campus news and information concerning class schedules. This application also included daily ads for the University restaurant, which were either location-(semi)congruent or location-incongruent. Immediately after viewing the ads the app presented a short questionnaire to the participants for a period of four weeks, thereby measuring their perceived intrusiveness, relevance and value of these ads. During these four weeks daily ads were sent to 40 students, resulting in 107 responses from 23 participants. The results show that our participants perceived location-(semi)congruent ads as significantly more valuable and relevant, whereas no significant results were found for perceived intrusiveness. By investigating LBA in a field-study based on ESM utilizing participants’ own smartphone devices this study corroborates the presumed effects of location-(semi)congruency on marketing relevant ad perceptions.</p

The interplay between the Rab27A effectors Slp4-a and MyRIP controls hormone-evoked Weibel-Palade body exocytosis.

Weibel-Palade body (WPB) exocytosis underlies hormone-evoked VWF secretion from endothelial cells (ECs). We identify new endogenous components of the WPB: Rab3B, Rab3D, and the Rab27A/Rab3 effector Slp4-a (granuphilin), and determine their role in WPB exocytosis. We show that Rab3B, Rab3D, and Rab27A contribute to Slp4-a localization to WPBs. siRNA knockdown of Slp4-a, MyRIP, Rab3B, Rab3D, Rab27A, or Rab3B/Rab27A, or overexpression of EGFP-Slp4-a or EGFP-MyRIP showed that Slp4-a is a positive and MyRIP a negative regulator of WPB exocytosis and that Rab27A alone mediates these effects. We found that ECs maintain a constant amount of cellular Rab27A irrespective of the WPB pool size and that Rab27A (and Rab3s) cycle between WPBs and a cytosolic pool. The dynamic redistribution of Rab proteins markedly decreased the Rab27A concentration on individual WPBs with increasing WPB number per cell. Despite this, the probability of WPB release was independent of WPB pool size showing that WPB exocytosis is not determined simply by the absolute amount of Rab27A and its effectors on WPBs. Instead, we propose that the probability of release is determined by the fractional occupancy of WPB-Rab27A by Slp4-a and MyRIP, with the balance favoring exocytosis

Antisemitism and anti-Zionism in Iran: the effects of identity, threat, and political trust

Antisemitism and anti-Zionism constitute two important ideological building blocks of the Islamic Republic of Iran. This article is the first to present quantitative empirical survey data elucidating attitudes towards Jews and Israel among an opportunity sample of Iranians. This study examines the correlates of antisemitism and anti-Zionism in Iran with particular attention to the effects of identity, threat, and political trust. Consistent with emerging research into antisemitism and anti-Zionism, there was a positive association between both forms of prejudice, suggesting social psychological overlap between the constructs. Given the pervasiveness of antisemitic and anti-Zionist representations in Iran, there were no significant differences in levels of anti-Zionism or antisemitism on the basis of gender and educational orientations. Political conservatives did manifest greater antisemitism and anti-Zionism than political reformists, although both groups scored high on these scales. There was a significant interaction effect of Iranian national identity and political trust on anti-Zionism, and a significant interaction effect of Muslim religious identity and political trust on antisemitism. Political trust was by far the most powerful predictor of both forms of prejudice, followed by the perception of identity threat. These observations are considered through the lenses of Social Identity Theory and Identity Process Theory from social psychology

IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry

To replicate, viruses must gain access to the host cell's resources. Interferon (IFN) regulates the actions of a large complement of interferon effector genes (IEGs) that prevent viral replication. The interferon inducible transmembrane protein family members, IFITM1, 2 and 3, are IEGs required for inhibition of influenza A virus, dengue virus, and West Nile virus replication in vitro. Here we report that IFN prevents emergence of viral genomes from the endosomal pathway, and that IFITM3 is both necessary and sufficient for this function. Notably, viral pseudoparticles were inhibited from transferring their contents into the host cell cytosol by IFN, and IFITM3 was required and sufficient for this action. We further demonstrate that IFN expands Rab7 and LAMP1-containing structures, and that IFITM3 overexpression is sufficient for this phenotype. Moreover, IFITM3 partially resides in late endosomal and lysosomal structures, placing it in the path of invading viruses. Collectively our data are consistent with the prediction that viruses that fuse in the late endosomes or lysosomes are vulnerable to IFITM3's actions, while viruses that enter at the cell surface or in the early endosomes may avoid inhibition. Multiple viruses enter host cells through the late endocytic pathway, and many of these invaders are attenuated by IFN. Therefore these findings are likely to have significance for the intrinsic immune system's neutralization of a diverse array of threats

Supplement: "Localization and broadband follow-up of the gravitational-wave transient GW150914" (2016, ApJL, 826, L13)

This Supplement provides supporting material for Abbott et al. (2016a). We briefly summarize past electromagnetic (EM) follow-up efforts as well as the organization and policy of the current EM follow-up program. We compare the four probability sky maps produced for the gravitational-wave transient GW150914, and provide additional details of the EM follow-up observations that were performed in the different bands

When size matters: advantages of weighted effect coding in observational studies

Contains fulltext : 166462.pdf (publisher's version ) (Open Access)To include nominal and ordinal variables as predictors in regression models, their categories first have to be transformed into so-called 'dummy variables'. There are many transformations available, and popular is 'dummy coding' in which the estimates represent deviations from a preselected 'reference category'. A way to avoid choosing a reference category is effect coding, where the resulting estimates are deviations from a grand (unweighted) mean. An alternative for effect coding was given by Sweeney and Ulveling in 1972, which provides estimates representing deviations from the sample mean and is especially useful when the data are unbalanced (i.e., categories holding different numbers of observation). Despite its elegancy, this weighted effect coding has been cited only 35 times in the past 40 years, according to Google Scholar citations (more recent references include Hirschberg and Lye 2001 and Gober and Freeman 2005). Furthermore, it did not become a standard option in statistical packages such as SPSS and R. The aim of this paper is to revive weighted effect coding illustrated by recent research on the body mass index (BMI) and to provide easy-to-use syntax for SPSS, R, and Stata on http://www.ru.nl/sociology/mt/wec/downloads. For didactical reasons we apply OLS regression models, but it will be shown that weighted effect coding can be used in any generalized linear model.5 p

A novel method for modelling interaction between categorical variables

Contains fulltext : 168867.pdf (publisher's version ) (Open Access)Sweeney and Ulveling (1972) introduced weighted effect coding, where the estimates for categories of nominal and ordinal variables are deviations from the arithmetic mean, typically from a sample. This somewhat neglected parameterization is preferred over the well-known effect coding (ANOVA) if the data are unbalanced (i.e., when categories hold different numbers of observations) and was recently revived in this journal (te Grotenhuis et al. 2016). In this paper, we show that weighted effect coding can also be applied to regression models with interaction effects. The weighted effect coded interactions represent the additional effects over and above the main effects obtained from the model without these interactions. This is a useful alternative to effect coding when the data are unbalanced as in most observational data. In this contribution, we describe this novel parameterization and provide syntax, data, and examples in SPSS, R, and Stata on http://www.ru.nl/sociology/mt/wec/downloads. For didactical reasons we apply OLS regression models, but weighted effect coded interactions can be used in any generalized linear model. Throughout this text we use the word 'interaction', while other researchers prefer 'moderation'.5 p