Organised crime, corruption and the movement of people across borders in the new enlarged EU: A case study of Estonia, Finland and the UK

The project reported here is a three-country project, Estonia, Finland and the UK. It is funded by the European Commission AGIS Programme, The Directorate General Justice, Freedom and Security. It investigates the issues of corruption by organised crime in relation to border controls and immigration using as a case study the Finnish-Russian and the Estonian-Russian border. It also considers the methods of facilitation of people across borders, the role of crime groups and networks as well as organised crime and the relationship between illegal facilitation and exploitation in the labour market. The aim of the research was to investigate whether at border points there was evidence of corruption of officials in order to facilitate people across the border illegally. The issue of organised crime was identified as an important factor in understanding how people might be moved across borders illegally. If there was evidence of organised crime it would suggest that transnational networks between organised crime groups might exist and that there are strategic forms of communication between the organised crime groups in order to facilitate the maximisation of profit through the movement of people. If such an influence of organised crime in ‘immigration crime’ were to be discovered then it would indicate that EU borders are porous and therefore readily exploited by organised crime groups. In Finland, particular attention was given to the issues concerning the ‘Development Plan of Border Guards’ and the planned cooperation in relation to Organised Crime and Combating Corruption. The contention was that the EU border with Russia is ‘weak’ and vulnerable to corruption at different levels: systemic, institutional and individual. Our argument was that corruption is used to maintain the flow of people across the border illegitimately by utilising existing legitimate channels. It was the Finnish view that organised crime groups used the Finnish – Russian and the Russian – Estonian borders to bring in illegal immigrants into the EU. Consequently the project was designed to take account of organised immigration crime and so was required to address the issue of human trafficking along with people smuggling and facilitation of people across borders. This raised a number of definitional issues and highlighted the varying perspectives between academic approaches to the problem and those of senior policy makers and operational staff

Swimming with captive dolphins: current debates and post-experience dissonance

Dolphins have widespread contemporary appeal and anthropomorphic social representations of dolphins have fuelled a growing desire in tourist populations to seek interaction with them. This paper is concerned with the staged performance of swim-with-dolphin interaction programmes in aquaria. Qualitative interviews with tourists who have swum with captive dolphins identified their immediate recollections and stressed the grace, size and power of dolphins, but also a belief that the experience was too staged, too short and too expensive. Post-purchase dissonance focused on concerns with the size of enclosures and about captivity, too many tricks, limited interpretation and unfulfilled expectations of a quality interaction

'Sexercise': Working out heterosexuality in Jane Fonda’s fitness books

This is an Author's Accepted Manuscript of an article published in Leisure Studies, 30(2), 237 - 255, 2011, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/02614367.2010.523837.This paper explores the connection between the promotion of heterosexual norms in women’s fitness books written by or in the name of Jane Fonda during the 1980s and the commodification of women’s fitness space in both the public and private spheres. The paper is set in the absence of overt discussions of normative heterosexuality in leisure studies and draws on critical heterosexual scholarship as well as the growing body of work theorising geographies of corporeality and heterosexuality. Using the principles of media discourse analysis, the paper identifies three overlapping characteristics of heterosexuality represented in Jane Fonda’s fitness books, and embodied through the exercise regimes: respectable heterosexual desire, monogamous procreation and domesticity. The paper concludes that the promotion and prescription of exercise for women in the Jane Fonda workout books centred on the reproduction and embodiment of heterosexual corporeality. Set within an emerging commercial landscape of women’s fitness in the 1980s, such exercise practices were significant in the legitimation and institutionalisation of heteronormativity

Genetic epidemiology of motor neuron disease-associated variants in the Scottish population

Genetic understanding of motor neuron disease (MND) has evolved greatly in the past 10 years, including the recent identification of association between MND and variants in TBK1 and NEK1. Our aim was to determine the frequency of pathogenic variants in known MND genes and to assess whether variants in TBK1 and NEK1 contribute to the burden of MND in the Scottish population. SOD1, TARDBP, OPTN, TBK1, and NEK1 were sequenced in 441 cases and 400 controls. In addition to 44 cases known to carry a C9orf72 hexanucleotide repeat expansion, we identified 31 cases and 2 controls that carried a loss-of-function or pathogenic variant. Loss-of-function variants were found in TBK1 in 3 cases and no controls and, separately, in NEK1 in 3 cases and no controls. This study provides an accurate description of the genetic epidemiology of MND in Scotland and provides support for the contribution of both TBK1 and NEK1 to MND susceptibility in the Scottish population

Illegal wildlife trade and the persistence of “plant blindness”

Societal Impact Statement A wide variety of plant species are threatened by illegal wildlife trade (IWT), and yet plants receive scant attention in IWT policy and research, a matter of pressing global concern. This review examines how “plant blindness” manifests within policy and research on IWT, with serious and detrimental effects for biodiversity conservation. We suggest several key points: (a) perhaps with the exception of the illegal timber market, plants are overlooked in IWT policy and research; (b) there is insufficient attention from funding agencies to the presence and persistence of illegal trade in plants; and (c) these absences are at least in part resultant from plant blindness as codified in governmental laws defining the meaning of “wildlife.” Summary This review investigates the ways in which “plant blindness,” first described by Wandersee and Schussler (1999, p. 82) as “the misguided anthropocentric ranking of plants as inferior to animals,” intersects with the contemporary boom in research and policy on illegal wildlife trade (IWT). We argue that plants have been largely ignored within this emerging conservation arena, with serious and detrimental effects for biodiversity conservation. With the exception of the illegal trade in timber, we show that plants are absent from much emerging scholarship, and receive scant attention by US and UK funding agencies often driving global efforts to address illegal wildlife trade, despite the high levels of threat many plants face. Our article concludes by discussing current challenges posed by plant blindness in IWT policy and research, but also suggests reasons for cautious optimism in addressing this critical issue for plant conservation

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist

Safety, immunogenicity, and efficacy of a COVID-19 vaccine (NVX-CoV2373) co-administered with seasonal influenza vaccines: an exploratory substudy of a randomised, observer-blinded, placebo-controlled, phase 3 trial

Background: Safety and immunogenicity of COVID-19 vaccines when co-administered with influenza vaccines have not yet been reported. Methods: A sub-study on influenza vaccine co-administration was conducted as part of the phase 3 randomised trial of NVX-CoV2373’s safety and efficacy; ~400 participants meeting main study entry criteria, with no contraindications to influenza vaccination, were enroled. After randomisation to receive NVX-CoV2373 or placebo, sub-study participants received an open-label influenza vaccine at the same time as the first dose of NVX-CoV2373. Reactogenicity was evaluated for 7 days post-vaccination plus monitoring for unsolicited adverse events (AEs), medically-attended AEs (MAAEs), and serious AEs (SAEs). Vaccine efficacy against COVID-19 was assessed. Findings: Sub-study participants were younger (median age 39; 6.7 % ≥65 years), more racially diverse, and had fewer comorbid conditions than main study participants. Reactogenicity events more common in co-administration group included tenderness (70.1% vs 57.6%) or pain (39.7% vs 29.3%) at injection site, fatigue (27.7% vs 19.4%), and muscle pain (28.3% vs 21.4%). Rates of unsolicited AEs, MAAEs, and SAEs were low and balanced between the two groups. Co-administration resulted in no change to influenza vaccine immune response, while a reduction in antibody responses to the NVX-CoV2373 vaccine was noted. Vaccine efficacy against COVID-19 was 87.5% (95% CI: -0.2, 98.4) in those 18-<65 years in the sub-study while efficacy in the main study was 89.8% (95% CI: 79.7, 95.5).  Interpretation: This is the first study to demonstrate safety, immunogenicity, and efficacy of a COVID-19 vaccine when co-administered with influenza vaccines

Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial

Background: Emergency abdominal surgery is associated with poor patient outcomes. We studied the effectiveness of a national quality improvement (QI) programme to implement a care pathway to improve survival for these patients. Methods: We did a stepped-wedge cluster-randomised trial of patients aged 40 years or older undergoing emergency open major abdominal surgery. Eligible UK National Health Service (NHS) hospitals (those that had an emergency general surgical service, a substantial volume of emergency abdominal surgery cases, and contributed data to the National Emergency Laparotomy Audit) were organised into 15 geographical clusters and commenced the QI programme in a random order, based on a computer-generated random sequence, over an 85-week period with one geographical cluster commencing the intervention every 5 weeks from the second to the 16th time period. Patients were masked to the study group, but it was not possible to mask hospital staff or investigators. The primary outcome measure was mortality within 90 days of surgery. Analyses were done on an intention-to-treat basis. This study is registered with the ISRCTN registry, number ISRCTN80682973. Findings: Treatment took place between March 3, 2014, and Oct 19, 2015. 22 754 patients were assessed for elegibility. Of 15 873 eligible patients from 93 NHS hospitals, primary outcome data were analysed for 8482 patients in the usual care group and 7374 in the QI group. Eight patients in the usual care group and nine patients in the QI group were not included in the analysis because of missing primary outcome data. The primary outcome of 90-day mortality occurred in 1210 (16%) patients in the QI group compared with 1393 (16%) patients in the usual care group (HR 1·11, 0·96–1·28). Interpretation: No survival benefit was observed from this QI programme to implement a care pathway for patients undergoing emergency abdominal surgery. Future QI programmes should ensure that teams have both the time and resources needed to improve patient care. Funding: National Institute for Health Research Health Services and Delivery Research Programme