613 research outputs found
Mediators of cardiovascular risk in diabetes mellitus
Cardiovascular risk assessment in patients with diabetes mellitus (DM) remains challenging. Risk scores to predict cardiovascular risk are widely used, but are developed in the general population and tend to underestimate the cardiovascular risk of DM patients. Risk scores developed in diabetic populations to estimate cardiovascular risk have demonstrated good calibration and discriminations indices. However, external validation is still needed. A recent meta-analysis showed that the predictive ability of these scores developed in diabetic populations is not superior to those scores developed in general population. Accordingly, the additional use of other biomarkers or imaging tools seems a good alternative to better risk stratify diabetic patients. This thesis evaluates the application and performance of non-invasive cardiac imaging tests for cardiovascular risk assessment and management of DM patients. Identification of new markers of CAD derived from non-invasive cardiac imaging might result in a broader applicability of cardiovascular risk assessment. Non-invasive cardiac imaging tests might evaluate target organ damage as well as the presence, severity and extent of subclinical atherosclerosis preceding overt clinical CAD. Thus, high-risk patients for CAD can be identified and further decision making of each DM patient can be tailored in order to improve the clinical outcomes at long-term follow-upAmgen B.V. Astellas Pharma B.V. Bayer Healthcare Biotronik Nederland B.V. Daiichi Sankyo Nederland B.V. Novo Nordisk B.V. Pfizer B.V. Servier Nederland Farma B.V. Toshiba Medical Systems NederlandUBL - phd migration 201
The choleretic action of genebile in a dog
A procedure for cannulating the bile duct of the dog is described. An intramuscular injection of Genebile increased the bile
flow rate. A possible mechanism for this increase is suggested.http://www.jsava.co.zaam2020Anatomy and Physiolog
Different value of coronary calcium score to predict obstructive coronary artery disease in patients with and without moderate chronic kidney disease.
published_or_final_versio
Resonance fluorescence of a trapped three-level atom
We investigate theoretically the spectrum of resonance fluorescence of a
harmonically trapped atom, whose internal transitions are --shaped and
driven at two-photon resonance by a pair of lasers, which cool the
center--of--mass motion. For this configuration, photons are scattered only due
to the mechanical effects of the quantum interaction between light and atom. We
study the spectrum of emission in the final stage of laser--cooling, when the
atomic center-of-mass dynamics is quantum mechanical and the size of the wave
packet is much smaller than the laser wavelength (Lamb--Dicke limit). We use
the spectral decomposition of the Liouville operator of the master equation for
the atomic density matrix and apply second order perturbation theory. We find
that the spectrum of resonance fluorescence is composed by two narrow sidebands
-- the Stokes and anti-Stokes components of the scattered light -- while all
other signals are in general orders of magnitude smaller. For very low
temperatures, however, the Mollow--type inelastic component of the spectrum
becomes visible. This exhibits novel features which allow further insight into
the quantum dynamics of the system. We provide a physical model that interprets
our results and discuss how one can recover temperature and cooling rate of the
atom from the spectrum. The behaviour of the considered system is compared with
the resonance fluorescence of a trapped atom whose internal transition consists
of two-levels.Comment: 11 pages, 4 Figure
Motional effects of single trapped atomic/ionic qubit
We investigate theoretical decoherence effects of the motional degrees of
freedom of a single trapped atomic/ionic electronically coded qubit. For single
bit rotations from a resonant running wave laser field excitation, we found the
achievable fidelity to be determined by a single parameter characterized by the
motional states. Our quantitative results provide a useful realistic view for
current experimental efforts in quantum information and computing.Comment: 3 fig
Encoded Recoupling and Decoupling: An Alternative to Quantum Error Correcting Codes, Applied to Trapped Ion Quantum Computation
A recently developed theory for eliminating decoherence and design
constraints in quantum computers, ``encoded recoupling and decoupling'', is
shown to be fully compatible with a promising proposal for an architecture
enabling scalable ion-trap quantum computation [D. Kielpinski et al., Nature
417, 709 (2002)]. Logical qubits are encoded into pairs of ions. Logic gates
are implemented using the Sorensen-Molmer (SM) scheme applied to pairs of ions
at a time. The encoding offers continuous protection against collective
dephasing. Decoupling pulses, that are also implemented using the SM scheme
directly to the encoded qubits, are capable of further reducing various other
sources of qubit decoherence, such as due to differential dephasing and due to
decohered vibrational modes. The feasibility of using the relatively slow SM
pulses in a decoupling scheme quenching the latter source of decoherence
follows from the observed 1/f spectrum of the vibrational bath.Comment: 12 pages, no figure
The evolution of galaxy groups and of galaxies therein
Properties of groups of galaxies depend sensitively on the algorithm for
group selection, and even the most recent catalogs of groups built from
redshift-space selection should suffer from projections and infalling galaxies.
The cosmo-dynamical evolution of groups from initial Hubble expansion to
collapse and virialization leads to a fundamental track (FT) in
virial-theorem-M/L vs crossing time. The increased rates of mergers, both
direct and after dynamical friction, in groups relative to clusters, explain
the higher fraction of elliptical galaxies at given local number density in
X-ray selected groups, relative to clusters, even when the hierarchical
evolution of groups is considered. Galaxies falling into groups and clusters
should later travel outwards to typically 2 virial radii, which is somewhat
less than the outermost radius where observed galaxy star formation
efficiencies are enhanced relative to field galaxies of same morphological
type. An ongoing analysis of the internal kinematics of X-ray selected groups
suggests that the radial profiles of line of sight velocity dispersion are
consistent with isotropic NFW distributions for the total mass density, with
higher (lower) concentrations than LambdaCDM predictions in groups of high
(low) mass. The critical mass, at M200 ~ 10^13 M_sun is consistent with
possible breaks in the X-ray luminosity-temperature and Fundamental Plane
relations. The internal kinematics of groups indicate that the M-T relation of
groups should agree with that extrapolated from clusters with no break at the
group scale. The analyses of observed velocity dispersion profiles and of the
FT both suggest that low velocity dispersion groups (compact and loose, X-ray
emitting or undetected) are quite contaminated by chance projections.Comment: Invited review, ESO workshop "Groups of Galaxies in the Nearby
Universe", held in Santiago, Chile, 5-9 December 2005, ed. I. Saviane, V.
Ivanov & J. Borissova, 16 page
Active Galactic Nuclei at the Crossroads of Astrophysics
Over the last five decades, AGN studies have produced a number of spectacular
examples of synergies and multifaceted approaches in astrophysics. The field of
AGN research now spans the entire spectral range and covers more than twelve
orders of magnitude in the spatial and temporal domains. The next generation of
astrophysical facilities will open up new possibilities for AGN studies,
especially in the areas of high-resolution and high-fidelity imaging and
spectroscopy of nuclear regions in the X-ray, optical, and radio bands. These
studies will address in detail a number of critical issues in AGN research such
as processes in the immediate vicinity of supermassive black holes, physical
conditions of broad-line and narrow-line regions, formation and evolution of
accretion disks and relativistic outflows, and the connection between nuclear
activity and galaxy evolution.Comment: 16 pages, 5 figures; review contribution; "Exploring the Cosmic
Frontier: Astrophysical Instruments for the 21st Century", ESO Astrophysical
Symposia Serie
Performance of gastrointestinal pathologists within a national digital review panel for Barrett's oesophagus in the Netherlands: Results of 80 prospective biopsy reviews
Aims: The histopathological diagnosis of low-grade dysplasia (LGD) in Barrett's oesophagus (BO) is associated with poor interobserver agreement and guidelines dictate expert review. To facilitate nationwide expert review in the Netherlands, a web-based digital review panel has been set up, which currently consists of eight 'core' pathologists. The aim of this study was to evaluate if other pathologists from the Dutch BO expert centres qualify for the expert panel by assessing their performance in 80 consecutive LGD reviews submitted to the panel. Methods: Pathologists independently assessed digital slides in two phases. Both phases consisted of 40 cases, with a group discussion after phase I. For all cases, a previous consensus diagnosis made by five core pathologists was available, which was used as reference. The following criteria were used: (1) percentage of 'indefinite for dysplasia' diagnoses, (2) percentage agreement with consensus diagnosis and (3) proportion of cases with a consensus diagnosis of dysplasia underdiagnosed as non-dysplastic. Benchmarks were based on scores of the core pathologists. Results: After phase I, 1/7 pathologists met the benchmark scor
Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector
A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results
- …