Impactos de las redes sociales en las lomas del Paraíso en el distrito de Villa María del Triunfo, 2019

El presente trabajo de investigación analiza los impactos de las redes sociales en las lomas del Paraíso en el distrito de Villa María del Triunfo, 2019. La metodología que se empleó es de enfoque cualitativo porque se busca comprender los impactos de las redes sociales, la muestra estuvo conformada por pobladores y visitantes que llegan a las lomas del Paraíso a través de las redes sociales. En cuanto a los resultados, los impactos generados por las redes sociales directas e indirectas han sido frecuentes, debido a que se ha propagado información errónea tales como, fotografías, comentarios y publicaciones que han perjudicado la zona; asimismo, ha generado molestias a la población ya que, son los encargados de realizar el mantenimiento y la protección a las lomas. Finalmente, tiene como conclusión que los impactos de las redes sociales que han sido promocionados por Facebook de manera positiva debido a las publicaciones y fotos de algunos visitantes, ya que, eso lo ha hecho conocido, pero no ven lo que sucede en el lugar porque, las lomas del Paraíso es un espacio frágil y no puede recibir muchos visitantes al día

Seroprevalencia de Toxoplasma gondii en cabras del departamento de Piura, Perú

The aim of this study was to determine the seroprevalence of the Toxoplasma gondii parasite in goats from the department of Piura, Peru. In total, 362 serum samples were evaluated using a commercial indirect ELISA kit, which reveals the presence of IgG anti-T. gondii antibodies. The real seroprevalence was 26.29% (95% CI: 21.74 - 30.84%). The confidence intervals (95% CI) evidenced a significant difference (p<0.05) in the seropositive goats in relation to the altitudinal floor variable (0-500 vs 500-2500 m), while no significant difference was evidenced regarding the age group variable (<1, 1-3 and >3 years). The Odds Ratio (OR) between the sero-reactor animals and the altitudinal floor variable yielded a value of 0.37 (95% CI: 0.20 - 0.69), indicating that the altitude 0-500 m was a protective factor for toxoplasmosis infection in relation to 500-2500 m.El objetivo del presente estudio fue determinar la seroprevalencia del parásito Toxoplasma gondii en cabras del departamento de Piura, Perú. Se evaluaron 362 muestras de suero haciendo uso de un kit comercial de ELISA indirecto, la cual revela presencia de anticuerpos IgG anti-T. gondii. La seroprevalencia real hallada fue de 26.29% (IC 95%: 21.74 - 30.84%). Los intervalos de confianza (IC 95%) evidenciaron diferencia significativa en las cabras seropositivas con relación a la variable piso altitudinal (0-500 vs 500-2500 msnm), mientras que no se evidenció diferencia significativa (p>0.05) respecto a la variable grupo etario (<1, 1-3 y >3 años). El Odds Ratio (OR) entre los animales serorreactores y la variable piso altitudinal arrojó un valor de 0.37 (IC 95%: 0.20 – 0.69), indicando que el piso altitudinal 0-500 msnm fue un factor protector para la infección por toxoplasmosis con relación al piso altitudinal 500-2500 msnm

Planta de producció d'àcid adípic

L'objectiu d'aquest projecte és el disseny d'una planta de producció d'àcid adípic a partir de la oxidació d'una mescla de ciclohexanol-ciclohexanona (KA oil) mitjançant àcid nítric. El projecte ha de complir la legislació vigent a part de ser viable tècnicament i econòmicament.Nota: Aquest document conté originàriament altre material i/o programari només consultable a la Biblioteca de Ciència i Tecnologia

Estudio descriptivo-comparativo de los sistemas de evaluación del desempeño docente, en la modalidad de educación general básica, en los colegios : municipalizados, particulares subvencionado, y particulares pagados de la Comuna de Santiago

Tesis (Magister en Liderazgo de Gestión y Administración Educacional)El presente trabajo es un estudio descriptivo — comparativo de los sistemas de evaluación del desempeño docente que tienen actualmente las escuelas municipalizadas, escuelas subvencionadas y escuelas particulares pagadas en el nivel de educación general básica pertenecientes a la comuna de Santiago. Aplicando una metodología de tipo descriptiva se recolecta la información, se analizan los aspectos más relevantes y se concluye acerca de las principales características observadas. En la actualidad la sociedad busca cada vez con mayor necesidad formas más efectivas de gestionar sus Recursos Humanos con el fin de perfeccionar la gestión de los mismos a tono con las exigencias del mundo de hoy. El concepto de "Evaluación" ha evolucionado de acuerdo a las diferentes orientaciones surgidas en la concepción de la Educación, por tanto el proceso educativo se concibe como una actividad intencionada, planificada y sistemática cuyo fin es producir ciertos cambios en los estudiantes, que son conocidos como objetivos. La evaluación del desempeño profesional del docente es un proceso sistemático de obtención de datos válidos y fiables, con el objetivo de comprobar y valorar el efecto educativo que produce en los alumnos el despliegue de sus capacidades pedagógicas, su emocionalidad, responsabilidad laboral y la naturaleza de sus relaciones interpersonales con alumnos, padres, directivos, colegas y representantes de las instituciones de la comunidad

Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector

A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13  TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139  fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV

Study protocol for the multicentre cohorts of Zika virus infection in pregnant women, infants, and acute clinical cases in Latin America and the Caribbean: The ZIKAlliance consortium

Background: The European Commission (EC) Horizon 2020 (H2020)-funded ZIKAlliance Consortium designed a multicentre study including pregnant women (PW), children (CH) and natural history (NH) cohorts. Clinical sites were selected over a wide geographic range within Latin America and the Caribbean, taking into account the dynamic course of the ZIKV epidemic. Methods: Recruitment to the PW cohort will take place in antenatal care clinics. PW will be enrolled regardless of symptoms and followed over the course of pregnancy, approximately every 4 weeks. PW will be revisited at delivery (or after miscarriage/abortion) to assess birth outcomes, including microcephaly and other congenital abnormalities according to the evolving definition of congenital Zika syndrome (CZS). After birth, children will be followed for 2 years in the CH cohort. Follow-up visits are scheduled at ages 1-3, 4-6, 12, and 24 months to assess neurocognitive and developmental milestones. In addition, a NH cohort for the characterization of symptomatic rash/fever illness was designed, including follow-up to capture persisting health problems. Blood, urine, and other biological materials will be collected, and tested for ZIKV and other relevant arboviral diseases (dengue, chikungunya, yellow fever) using RT-PCR or serological methods. A virtual, decentralized biobank will be created. Reciprocal clinical monitoring has been established between partner sites. Substudies of ZIKV seroprevalence, transmissio

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality