Applicability of Boussinesq approximation in a turbulent fluid with constant properties

The equations of motion describing buoyant fluids are often simplified using a set of approximations proposed by J. Boussinesq one century ago. To resume, they consist in assuming constant fluid properties, incompressibility and conservation of calories during heat transport. Assuming fulfilment of the first requirement (constant fluid properties), we derive a set of 4 criteria for assessing the validity of the two other requirements in turbulent Rayleigh-B\'enard convection. The first criterion $\alpha \Delta \ll 1$ simply results from the incompressibility condition in the thermal boundary layer ($\alpha$ and $\Delta$ are the thermal expansion coefficient and the temperature difference driving the flow). The 3 other criteria are proportional or quadratic with the density stratification or, equivalently with the temperature difference resulting from the adiabatic gradient across the cell $\Delta_{h}$. Numerical evaluations with air, water and cryogenic helium show that most laboratory experiments are free from such Boussinesq violation as long as the first criterion is fulfilled. In ultra high Rayleigh numbers ($Ra>10^{16}$) experiments in He, one of the stratification criteria, scaling with $\alpha \Delta_{h}$, could be violated. This criterion garanties that pressure fluctuations have a negligible influence both on the density variation and on the heat transfer equation through compression/expansion cycles. Extrapolation to higher $Ra$ suggests that strong violation of Boussinesq approximation could occur in atmospheric convection.Comment: Submitted to Phys.Fluids (oct 2007

Energy cascade and the four-fifths law in superfluid turbulence

The 4/5-law of turbulence, which characterizes the energy cascade from large to small-sized eddies at high Reynolds numbers in classical fluids, is verified experimentally in a superfluid 4He wind tunnel, operated down to 1.56 K and up to R_lambda ~ 1640. The result is corroborated by high-resolution simulations of Landau-Tisza's two-fluid model down to 1.15 K, corresponding to a residual normal fluid concentration below 3 % but with a lower Reynolds number of order R_lambda ~ 100. Although the K\'arm\'an-Howarth equation (including a viscous term) is not valid \emph{a priori} in a superfluid, it is found that it provides an empirical description of the deviation from the ideal 4/5-law at small scales and allows us to identify an effective viscosity for the superfluid, whose value matches the kinematic viscosity of the normal fluid regardless of its concentration.Comment: 6 pages, 7 figure

Evidence of a boundary layer instability at very high Rayleigh number

In 1997, a Rayleigh-B\'enard experiment evidenced a significant increase of the heat transport efficiency for Rayleigh numbers larger than $Ra \sim 10^{12}$ and interpreted this observation as the signature of the Kraichnan's ``Ultime Regime'' of convection. According to Kraichnan's 1962 prediction, the flow boundary layers above the cold and hot plates -in which most of the fluid temperature drop is localized- become unstable for large enough $Ra$ and this instability boosts the heat transport compared to the other turbulent regimes. Using the same convection cell as in the 1997 experiment, we show that the reported heat transport increase is accompanied with enhanced temperature fluctuations of the bottom plate, which was heated at constant power levels. Indeed, for $Ra < 10^{12}$, the bottom plate fluctuations can simply be accounted from those in the bulk of the flow. In particular, they share the same spectral density at low frequencies, as if the bottom plate was following the slow temperature fluctuations of the bulk, modulo a constant temperature drop across the bottom boundary layer. Conversely, to account for the plate's temperature fluctuations at higher $Ra$, we no-longuer can ignore the fluctuations of the temperature drop across the boundary layer. The negative skewness of fluctuations at high $Ra$ supports the picture of a boundary layer instability. These observations provide new evidence that the transition reported in 1997 corresponds to the triggering of the Ultimate Regime of convection.Comment: Submitted for publicatio

Comment on "Turbulent heat transport near critical points: Non-Boussinesq effects" (cond-mat/0601398)

In a recent preprint (cond-mat/0601398), D. Funfschilling and G. Ahlers describe a new effect, that they interpret as non-Boussinesq, in a convection cell working with ethane, near its critical point. They argue that such an effect could have spoiled the Chavanne {\it et al.} (Phys. Rev. Lett. {\bf 79} 3648, 1997) results, and not the Niemela {\it et al.} (Nature, {\bf 404}, 837, 2000) ones, which would explain the differences between these two experiments. We show that:-i)Restricting the Chavanne's data to situations as far from the critical point than the Niemela's one, the same discrepancy remains.-ii)The helium data of Chavanne show no indication of the effect observed by D. Funfschilling and G. Ahlers.Comment: comment on cond-mat/060139

On the triggering of the Ultimate Regime of convection

Rayleigh-B\'enard cells are one of the simplest systems to explore the laws of natural convection in the highly turbulent limit. However, at very high Rayleigh numbers (Ra > 1E12) and for Prandtl numbers of order one, experiments fall into two categories: some evidence a steep enhancement of the heat transfer while others do not. The origin of this apparent disagreement is presently unexplained. This puzzling situation motivated a systematic study of the triggering of the regime with an enhanced heat transfer, originally named the "Ultimate Regime" of convection. High accuracy heat transfer measurements have been conducted in convection cells with various aspect ratios and different specificities, such as altered boundary conditions or obstacles inserted in the flow. The two control parameters, the Rayleigh and Prandtl numbers have been varied independently to disentangle their relative influence. Among other results, it is found that i) most experiments reaching very high $Ra$ are not in disagreement if small differences in Prandtl numbers are taken into account, ii) the transition is not directly triggered by the large scale circulation present in the cell, iii) the sidewall of the cell have a significant influence on the transition. The characteristics of this Ultimate regime are summarized and compared with R. Kraichnan prediction for the asymptotic regime of convection.Comment: 25 pages, 14 figure

Cinacalcet reverses short QT Interval in familial hypocalciuric hypercalcemia type 1

Context: Familial hypocalciuric hypercalcemia type 1 (FHH-1) defines an autosomal dominant disease, related to mutations in the CASR gene, with mild hypercalcemia in most cases. Cases of FHH-1 with a short QT interval have not been reported to date. Objective: Three family members presented with FHH-1 and short QT interval (< 360 ms), a condition that could lead to cardiac arrhythmias, and the effects of cinacalcet, an allosteric modulator of the CaSR, in rectifying the abnormal sensitivity of the mutant CaSR and in correcting the short QT interval were determined. Methods: CASR mutational analysis was performed by next-generation sequencing and functional consequences of the identified CaSR variant (p.Ile555Thr) and effects of cinacalcet were assessed in HEK293 cells expressing wild-type and variant CaSRs. A cinacalcet test consisting of administration of 30 mg cinacalcet (8am) followed by hourly measurement of serum calcium, phosphate, and PTH during 8 hours, and an ECG was performed. Results: The CaSR variant (p.Ile555Thr) was confirmed in all three FHH-1 patients and was shown to be associated with a loss of function that was ameliorated by cinacalcet. Cinacalcet decreased PTH by >50% within two hours, and decreases in serum calcium and increases in serum phosphate occurred within 8 hours, with rectification of the QT interval, which remained normal after 3 months of cinacalcet treatment. Conclusion: Our results indicate that FHH-1 patients should be assessed for a short QT interval, and a cinacalcet test used to select patients who are likely to benefit from this treatment

Recommendations for acquisition, interpretation and reporting of whole body low dose CT in patients with multiple myeloma and other plasma cell disorders: a report of the IMWG Bone Working Group

Whole Body Low Dose CT (WBLDCT) has important advantages as a first-line imaging modality for bone disease assessment in patients with plasma cell disorders and has been included in the 2014 International Myeloma Working Group (IMWG) criteria for multiple myeloma (MM) definition. Nevertheless, standardization guidelines for the optimal use of WBLDCT in MM patients are still lacking, preventing its more widespread use, both in daily practice and clinical trials. The aim of this report by the Bone Group of the IMWG is to provide practical recommendations for the acquisition, interpretation and reporting of WBLDCT in patients with multiple myeloma and other plasma cell disorders

Critical Overview of Loops and Foams

This is a review of the present status of loop and spin foam approaches to quantization of four-dimensional general relativity. It aims at raising various issues which seem to challenge some of the methods and the results often taken as granted in these domains. A particular emphasis is given to the issue of diffeomorphism and local Lorentz symmetries at the quantum level and to the discussion of new spin foam models. We also describe modifications of these two approaches which may overcome their problems and speculate on other promising research directions.Comment: 75 page

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London