158 research outputs found
Geometric properties of a binary non-Pisot inflation and absence of absolutely continuous diffraction
- Publication venue
- 'Institute of Mathematics, Polish Academy of Sciences'
- Publication date
- 13/06/2017
- Field of study
One of the simplest non-Pisot substitution rules is investigated in its geometric version as a tiling with intervals of natural length as prototiles. Via a detailed renormalization analysis of the pair correlation functions, we show that the diffraction measure cannot comprise any absolutely continuous component. This implies that the diffraction, apart from a trivial Bragg peak at the origin, is purely singular continuous. En route, we derive various geometric and algebraic properties of the underlying Delone dynamical system, which we expect to be relevant in other such systems as well
Tilings associated with non-Pisot matrices
- Publication venue
- 'Cellule MathDoc/CEDRAM'
- Publication date
- 01/01/2006
- Field of study
The Political Economy of Natural Resource Use: Lessons for Fisheries Reform
- Author
- Publication venue
- 'World Bank'
- Publication date
- 04/04/2010
- Field of study
This report discusses key lessons drawn from reform experience in the wider natural resource sector that might inform successful reform in fisheries. This report is a compilation of 12 papers prepared by acknowledged international experts in the fields of fisheries and wider natural resource reform which were reviewed at a workshop convened by the Property and Environment Research Center (PERC) in May 2009.The report forms an important initial input into an ongoing enquiry into the political economy of fisheries reform initiated by the World Bank in partnership with the Partnership for African Fisheries (a United Kingdom Department for International Development funded program of the New Partnership for African Development (NEPAD))
Evidence-based Kernels: Fundamental Units of Behavioral Influence
- Author
- A Ankjaer-Jensen
- A Appels
- A Biglan
- A Biglan
- A Biglan
- A Biglan
- A Carlsson
- A Hudson
- A Ridgway
- A Robin
- A Rolider
- A Spirito
- A Tanskanen
- A Theodore
- AA Berlin
- AC Wagenaar
- AD Pellegrini
- AD Pellegrini
- AE Kazdin
- AG White
- AH Crisp
- AJ Abramowitz
- AJ Abramowitz
- AJ Richardson
- AK Bay-Hinitz
- AK Dellatan
- AL Dunn
- AL Dunn
- AL Stoll
- AL Stoll
- AL Stoll
- AM Cevasco
- AM Greca la
- AM Hall
- Anthony Biglan
- AP McCain
- AR Cavalier
- AS Matheson
- AS Olafsdottir
- AT Vazsonyi
- AU Rickel
- AW Todd
- AY Mikami
- B Beersma
- B Cabello
- B Egeland
- B Krevor
- B Larsson
- B Law
- B Nemets
- BC Barmann
- BC Barmann
- BC Etzel
- BC McCarty
- BD Winn
- BF Walsh
- BK Martens
- BL Burke
- BR Flay
- BS Cox
- C Choenarom
- C Conyers
- C Conyers
- C Harding
- C Heap
- C Hughes
- C Lonnecker
- C Ostrower
- C Pechmann
- C Pechmann
- C Pechmann
- C Pechmann
- C Schwartz
- C Webster-Stratton
- CA Christle
- CA Ferguson
- CB Ferster
- CB Gesch
- CC Piazza
- CD Adams
- CD Furr-Holden
- CH Hitchcock
- CH Hitchcock
- CH Lawshe
- CH Skinner
- CJ Walker
- CL Harris
- CL Melville
- CL Ringwalt
- CL Storr
- CM Robinson
- CM Saunders
- CN Jacklin
- CR Collier
- CR Greenwood
- CR Greenwood
- CS Green
- CS Lieber
- CV Wilson
- D Barnes
- D Ben Shalom
- D Borfitz
- D Brown
- D Burgess
- D DeMartini-Scully
- D Fletcher
- D Hallfors
- D Hallfors
- D Houlihan
- D McDougall
- D Mischoulon
- D Newbern
- D Newbern
- D Paquette
- D Premack
- D Waard de
- DA Wolfe
- DB Lennox
- DB Shabani
- DB Shabani
- DC Grossman
- DD Embry
- DD Embry
- DD Embry
- DD Embry
- DD Embry
- DD Embry
- DD Hallfors
- DE Wolfe
- Dennis D. Embry
- DF Bjorklund
- DF Dansereau
- DF Dansereau
- DH Allsopp
- DH Schunk
- DH Welsh
- DJ Crews
- DJ Flannery
- DJ Howard
- DK Smith
- DL Schilling
- DL Trammel
- DM Browder
- DM Kamps
- DM Koffman
- DO Rudin
- DP Fry
- DS Pine
- DS Wilson
- DW Blick
- E Atlantis
- E Clark
- E Clark
- E Rodrigues
- E Scott
- EG Krug
- EJ Doyne
- EJ Thomas
- EM Rogers
- ES Geller
- ES Petscher
- ET Hartley
- ET Hartley
- F Jorgensen
- F Juarez
- F Lősel
- F Merrett
- F Scafidi
- FE Hoath
- FJ Silva
- FR Blue
- G Diamond
- G Gaskell
- G Perna
- G Zivin
- GA Fabiano
- GD Sideridis
- GJ Anderson
- GJ DuPaul
- GL Cohen
- GL Schilmoeller
- GM Egeland
- GR Mayer
- GR Mayer
- GS Sorock
- GT Taylor
- GW Joe
- GW Joe
- H Aase
- H Blumenfeld
- H Deutsch
- H Farber
- H Jorgenson
- H Lalramnghinglova
- H Marin
- HA Filcheck
- HA Murphy
- HAC Ninness
- HB Andrews
- HC Ninness
- HH Barrish
- HKM Antunes
- HL Peck
- HM Parsons
- HM Parsons
- HS Henderson
- HS Terrace
- HW Thorpe
- HW Thorpe
- IB Helland
- J Backon
- J Bernstein
- J Derzon
- J Gordon
- J Hevel Van
- J Hill
- J Liu
- J McCambridge
- J Merrett
- J Owusu-Bempah
- J Owusu-Bempah
- J Panksepp
- J Szapocznik
- JA Blumenthal
- JB Barker
- JB Hutton
- JC Delquadri
- JD Shannon
- JE Fishbein
- JE Mazur
- JH Derzon
- JH Sumner
- JJ McCarl
- JJ Priya
- JK Fillingham
- JK Luiselli
- JK Porterfield
- JL Lambert
- JM Campbell
- JM DiFilippo
- JM Ducharme
- JM Ducharme
- JM Ducharme
- JM Ducharme
- JM Ducharme
- JM Ducharme
- JM Leibowitz
- JM Richards
- JM Smyth
- JM Standley
- JM Standley
- JR Boyle
- JR Hibbeln
- JR Hibbeln
- JR Hibbeln
- JR Hibbeln
- JR Hibbeln
- JR Hibbeln
- JR Hibbeln
- JR Hibbeln
- JS Downs
- JS Kahn
- JV Roca
- JW Libb
- JW Maag
- JW Wedel
- K Larson
- K Mishima
- K Nakano
- K Resnicow
- K Spindler
- K Steiner
- K Vaddadi
- K-P Sund
- KA Edwards
- KA Maglieri
- KA Rickards-Schlichting
- KD Lakes
- KE McGoey
- KE Robinson
- KK Kellum
- KL Bledsoe
- KM Greenwood
- KM Hume
- KR Harris
- KT Kivlighan
- KV Naveen
- KW Reagles
- L Chassin
- L Kern
- L Maheady
- L Maheady
- L McDonnell
- L Selznick
- LA Jason
- LA Jason
- LA Jason
- LA Jason
- LA Moore
- LA Pawlow
- LA Sisson
- LAR Stein
- LB Zaichkowsky
- LC Sobell
- LD Allen
- LE Arnold
- LE Arnold
- LE Homme
- LE Melchiori
- LE Possell
- LJ Pfiffner
- LM Saari
- LS Robertson
- LS Robertson
- LV Majovski
- M Agathon
- M Agran
- M Bilici
- M Cook
- M Czuchry
- M Czuchry
- M Czuchry
- M Czuchry
- M Dekovic
- M Fava
- M Gonzalez
- M Haag
- M Heffner
- M Hines
- M Lowndes
- M Marchant
- M Marchant
- M Marion
- M O’Reilly
- M Sherif
- M Sherif
- M Sherif
- M Sherif
- M Sidman
- M Taubman
- M Wolery
- M Wolf
- M-P Leblanc
- MA Bray
- MA Clarke
- MA Diego
- MA Woltersdorf
- MB Medland
- MB Stein
- MC Keel
- MC Luciano
- MC Luciano-Soriano
- MC Roberts
- MC Zanarini
- MJ Boulton
- MJ Ford
- MJ Koepp
- MJ McMorrow
- ML Kelley
- ML McGrath
- ML Rock
- MM Acker
- MM Wolf
- MMR Madaus
- MP Freeman
- MP Freeman
- MR Burch
- MR Dadds
- MR Sanders
- MR Sanders
- MR Sanders
- MS Forgatch
- MS Forgatch
- MS Holloway
- MT Hegel
- MT Palermo
- MW Arthur
- MY Mathes
- N Neave
- N Nicol
- N Ram
- N Rusch
- NA Jones
- NC Jackson
- NK McGrath-Hanna
- NM Hunkin
- NM Petry
- NM Petry
- NM Petry
- NM Petry
- NM Petry
- NM Petry
- NM Petry
- NM Petry
- NN Singh
- NN Singh
- NR Sharma
- NS Gordon
- NS Tobler
- OS Elegbeleye
- OS Jarrett
- P Khatri
- P Palmgreen
- PG Mathes
- PJ Krantz
- PJ Schloss
- PL Ellickson
- PM Fischer
- PM Monti
- PM Stecker
- PN Williamson
- PT Norris
- PW Clement
- PW Dowrick
- PW Dowrick
- R Beyth-Marom
- R Feldman
- R Gardner
- R Gupta
- R Hoigaard
- R Houten Van
- R Houten Van
- R Houten Van
- R Houten Van
- R Jarvinen
- R Leclerc
- R McGee
- R Meadow
- R Nordstrom
- R Nordstrom
- R Sandyk
- R Snell
- RA Block
- RA Davis
- RA Hirasing
- RA Rawson
- RB Reamer
- RC Martella
- RD Abbott
- RE Dustman
- RE Glasgow
- RE Glasgow
- RE Glasgow
- RE Hosford
- RF Putnam
- RG Carey
- RG Harrison
- RJ Cowen
- RJ Sampson
- RM Bell
- RM Foxx
- RM Foxx
- RP Liberman
- RP West
- RS Drabman
- RS Morrison
- RS Ragnarsson
- RV Briscoe
- RW Collins
- S Akhondzadeh
- S Akhtar
- S Erkal
- S Ghosh
- S Gudbjarnason
- S Houghton
- S Kubesch
- S Moore
- S Plummer
- S Rajan
- S Roos
- S Scott
- S Sykes
- S Telles
- SA Godfrey
- SA Stage
- SC Bratton
- SC Carr
- SC Duncan
- SC Hayes
- SC Hayes
- SE Rosenkoetter
- SG Ferber
- SG Kellam
- SG Kellam
- SG Stella
- SI Gray
- SJ Haas-Warner de
- SJ Scholer
- SJ Wood
- SJ Wood
- SK Clare
- SK Wurtele
- SM Burn
- SM Colby
- SM Dees
- SM Ludington-Hoe
- SM Shimabukuro
- SM Siviy
- SP Spera
- SR Eisenstein
- SS Leff
- SS Meharg
- SS Meharg
- ST Ennett
- SW Marshall
- SW Twemlow
- T Bellamy
- T Buggey
- T Buggey
- T Buggey
- T Dalton
- T Field
- T Field
- T Field
- T Field
- T Norlander
- T Ogden
- T Reed
- T Suzuki
- TA Manger
- TD Mickleborough
- TF McLaughlin
- TF McLaughlin
- TH Wang
- TH Wasserman
- TJ Kehle
- TJ Knapp
- TK Taylor
- TL St. Pierre
- TL Stawar
- TM Field
- TM Field
- TN Robinson
- TO Lowe
- TS Ball
- TS Watson
- TW Bean
- TW Hosie
- U Pitre
- U Pitre
- U Pitre
- V Anderson
- V Hertz
- V Sanchez
- VG Spencer
- VL Taylor
- VW Cotter
- W Bennett
- WB Davis
- WR Miller
- WS Agras
- WT Phillips
- XP Chen
- Z Wencai
- Publication venue
- Springer US
- Publication date
- 01/01/2008
- Field of study
This paper describes evidence-based kernels, fundamental units of behavioral influence that appear to underlie effective prevention and treatment for children, adults, and families. A kernel is a behavior–influence procedure shown through experimental analysis to affect a specific behavior and that is indivisible in the sense that removing any of its components would render it inert. Existing evidence shows that a variety of kernels can influence behavior in context, and some evidence suggests that frequent use or sufficient use of some kernels may produce longer lasting behavioral shifts. The analysis of kernels could contribute to an empirically based theory of behavioral influence, augment existing prevention or treatment efforts, facilitate the dissemination of effective prevention and treatment practices, clarify the active ingredients in existing interventions, and contribute to efficiently developing interventions that are more effective. Kernels involve one or more of the following mechanisms of behavior influence: reinforcement, altering antecedents, changing verbal relational responding, or changing physiological states directly. The paper describes 52 of these kernels, and details practical, theoretical, and research implications, including calling for a national database of kernels that influence human behavior
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
- Baden M
- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
- Bailey S
- Bair S
- Baker A
- Baker C
- Bakhai A
- Bakker H
- Baksi A
- Baldin Mg
- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
- Bang Sa
- Banker D
- Banker K
- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
- Baron S
- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
- Bayram E
- Beall K
- Beaudry M
- Beauregard La
- Beckett L
- Belejchak P
- Belle Isle J
- Belohlavek J
- Bendelow T
- Bender D
- Benedetti G
- Benjamin S
- Benton J
- Berdoff R
- Berger V
- Bergeron P
- Bergholtz T
- Bergler-Klein J
- Berk M
- Berli Ma
- Bernstein M
- Berra Fc
- Berti S
- Berulfsen A
- Bevilacqua Mt
- Bhadade S
- Bilazarian S
- Bilodeau N
- Binder A
- Binns Y
- Birdane A
- Bisne V
- Bitzer V
- Blagdon M
- Blahey M
- Blankenberg S
- Blazsek Z
- Bloch S
- Blom Kb
- Bluemel J
- Blumberg C
- Blumenthal R
- Bocanera M
- Bodanese L
- Boffetti P
- Bohra P
- Bohula E
- Boivin Mc
- Bolduc H
- Boley K
- Bolognesi Mg
- Bolsmann C
- Boman K
- Bonner J
- Borrayo Na
- Boström På
- Botelho R
- Botta C
- Boudreaux R
- Boulanger K
- Bourgeois S
- Bouvy C
- Bowen L
- Boyarkin M
- Bradley A
- Brady L
- Bramlet D
- Brath H
- Braun P
- Bredlau C
- Brickman T
- Briggs S
- Briké C
- Brodmann M
- Brons S
- Brousalis L
- Brouwer M
- Brown C
- Brown N
- Brown S
- Buchannan C
- Budaj A
- Budassi N
- Budkova J
- Bugan V
- Buhlman S
- Bulashova O
- Bunschoten P
- Burke W
- Burley T
- Burova N
- Burris H
- Burton C
- Burton J
- Burton M
- Burtt D
- Busak L
- Busic N
- Byars W
- Bøen Rh
- C Clavier-Firmin
- C Conradie
- C Contzen
- C Cotes
- C Covert
- C Cuneo
- Caballero-Valiente B
- Cabau Jr
- Calabrese A
- Campanale Eg
- Candusso R
- Cantor W
- CANTOS Trial Group. Krum H
- Capova L
- Carabajal T
- Carr K
- Carrillo J
- Caruso G
- Casala J
- Caso P
- Casoinic F
- Castillo J
- Castillo T
- Cech V
- Cei L
- Cendali G
- Cepinskiene L
- Cerda L
- Cermak O
- Chachalis G
- Chaggar S
- Chambers J
- Chamblee T
- Chang K
- Chang Kc
- Chang Wh
- Charlier F
- Charmarthi B
- Chattin W
- Chauhan D
- Chauhan H
- Chaussé I
- Chavada J
- Chaverra I
- Chaware G
- Chee L
- Chella S
- Chen Cp
- Chen J
- Chen Mh
- Chen Y
- Chen Yc
- Chen Zc
- Cheng Jj
- Cheng S
- Cheng Sm
- Cherlin R
- Cheung D
- Chhabra A
- Chintala P
- Chiodi L
- Choi Aj
- Chou S
- Chouinard G
- Christensen L
- Christenson S
- Chung A
- Churina S
- Cifkova R
- Ciglenecki N
- Cioffi A
- Cislowski D
- Cleveland T
- Clocotan M
- Cmrecnjak J
- Colfer H
- Colhoun H
- Collier D
- Collins R
- Coloma G
- Colquhoun D
- Colvin T
- Coman S
- Commerford P
- Commerford P
- Conrado Y
- Cools F
- Cornel Jh
- Corona V
- Coronel J
- Cosgrove N
- Cosgrove S
- Cosmi F
- Costa Amorim R
- Coufalova Z
- Covell W
- Cox B
- Cox R
- Craig W
- Crandall L
- Crawford G
- Crea F
- Crepps K
- Crocamo A
- Cromer M
- Cruz H
- Cruz H
- Cruz M
- Csala L
- Cucher F
- Cuentas I
- Cuervo A
- Curiac D
- Cymerman K
- Cyprian R
- Czerski T
- D'Amours Dg
- D Dash
- D Dattani
- D Denham
- D Desai
- D Desalle
- D Digangi
- D Dunn
- Da Costa F
- Da Silva A
- Da Silva D Jr
- Da Silva O Jr
- Dahlen G
- Dalseg Am
- Damron M
- Danik J
- Davalos C
- Dave B
- Dave K
- Davidsson K
- Davies M
- Davies N
- Davis B
- Davis M
- Dawkins-Hughes S
- Dawood Sy
- Dayer M
- De Boer P
- De Caterina R
- De Jong C
- De Knijf K
- De Krumbach L
- De Los Milagros Had M
- De Los Rios M
- De Rosa S
- De Vos A
- De Wolf L
- Dean J
- Debnam S
- Decsi K
- Decsi Kl
- Dedek V
- Dedkova S
- Defosse C
- Degennaro N
- Dehning M
- Dela Llana A
- Delfonso F
- Delforge M
- Delgadillo T
- Dellasa M
- Dellborg M
- Dellorso M
- Demidova M
- Den Hartog F
- Denecke C
- Dengler T
- Dermitzakis A
- Deslongchamps F
- Dessalvi Cc
- Destro M
- Dettmer M
- Devasia T
- Deweerdt N
- Dhanak R
- Dhawan M
- Di Biase M
- Diago M
- Diaz M
- Dicken T
- Dickstein K
- Diederich C
- Diederich M
- Diehl R
- Diller P
- Dimattia M
- Dimitrov G
- Diodati J
- Dobariya H
- Dobilas V
- Dodds G
- Doesborg L
- Doggett J
- Dognini Gp
- Doi M
- Dokupilova A
- Dommerholt R
- Donahue K
- Donath M
- Donaubauer T
- Dong X
- Dormidontova G
- Dorogova I
- Dos Santos A
- Dos Santos F
- Dos Santos P
- Doughty A
- Doughty L
- Dovgalevskiy Y
- Dovgolis S
- Dragutksy B
- Dreese M
- Drost I
- Drouin K
- Duchesne L
- Duckert A
- Duda N
- Dudarev M
- Dudhatra N
- Duff J
- Duhan S
- Dunhurst F
- Dussan Ma
- Dutka C
- Dwenger E
- Dzupina A
- Dékány Jn
- E Eleuteri
- E Englmann
- Earl J
- East C
- Eaton C
- Eaves W
- Ebeling K
- Ebrahim I
- Eccleston D
- Echeverria L
- Eder F
- Edgerton L
- Edillo C
- Edwards J
- Edwards T
- Eichinger G
- Einhorn D
- Eki Y
- El Hachem M
- El Hafi S
- Ellenbroek D
- Ellis M
- Emil B
- Endo T
- Engelen W
- Erhard M
- Erickson B
- Ervin W
- Eskridge L
- Espinosa V
- Everett Bm
- F Fedele
- F Fonseca
- F Fucci
- Facello A
- Facello M
- Faghih M
- Fail P
- Falcon D
- Fang C
- Fang Cy
- Farias E
- Fattal P
- Fawson A
- Feitosa G
- Felario Junior Ga
- Felix L
- Feng Y
- Feng Z
- Ferdinand K
- Ferkl R
- Fernandez Aa
- Ferrari V
- Ferrario M
- Ferraz R
- Ferreira Dos Santos T
- Ferreira-Jardim A
- Fien E
- Filardi Pp
- Filho P
- Fintel D
- Firek C
- Fischer Sm
- Fisher J
- Fitilev S
- Fitz-Patrick D
- Fitzpatrick L
- Flaksa I
- Flather M
- Flezar M
- Fliesser-Goerzer E
- Flores E
- Flores E
- Flores Gs
- Flores H
- Floro T
- Foerster A
- Folkeringa Rj
- Fonseca A
- Fontaine S
- Forgon T
- Forgosh L
- Forker A
- Forster T
- Foster M
- Foucauld J
- Fowler V
- Fox B
- Franco M
- Francoeur L
- Frandsen B
- Frandsen B
- Frankenstein L
- Fratczak M
- Freitas E
- French J
- Frivold G
- Fruchter G
- Fu G
- Fucak E
- Fuchs R
- Fucili A
- Fukuike C
- Fullerton D
- Fulop P
- Fulop T
- Fulwani M
- Furch G
- Furuseth B
- G Gacioch
- G Gosselin
- Gabito A
- Gabor M
- Gabriel J
- Gabrielli D
- Gaeb-Strasas B
- Gamba C
- Ganau A
- Gapon L
- Garas S
- Garcia Duran R
- Garcia Pinna J
- Garcia Rinaldi R
- Garcia F
- Garcia N
- Garcia-Fragoso V
- Garcia-Portela M
- Garner K
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- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati Cristiana
- Abbas Kaja M.
- Abbasi Mohammad
- Abbasi-Kangevari Mohsen
- Abbasifard Mitra
- Abbastabar Hedayat
- Abd El Razek Hassan Magdy
- Abd El Razek Muhammed Magdy
- Abd-Allah Foad
- Abdelalim Ahmed
- Abdollahi Mohammad
- Abdollahpour Ibrahim
- Abdulkader Rizwan Suliankatchi
- Abdullah Kanaan Hamagharib
- Abedi Aidin
- Abedi Parisa
- Abegaz Kedir Hussein
- Abolhassani Hassan
- Abosetugn Akine Eshete
- Aboyans Victor
- Abrams Elissa M.
- Abreu Lucas Guimaraes
- Abrigo Michael R. M.
- Abu Haimed Abdulaziz Khalid
- Abu-Gharbieh Eman
- Abu-Raddad Laith Jamal
- Abualhasan Ahmed
- Abushouk Abdelrahman I.
- Acebedo Alyssa
- Ackerman Ilana N.
- Adabi Maryam
- Adair Tim
- Adamu Abdu A.
- Adebayo Oladimeji M.
- Adedeji Isaac Akinkunmi
- Adekanmbi Victor
- Adelson Jaimie D.
- Adeoye Abiodun Moshood
- Adetokunboh Olatunji O.
- Adham Davoud
- Advani Shailesh M.
- Afarideh Mohsen
- Afshari Mahdi
- Afshin Ashkan
- Agardh Emilie E.
- Agarwal Gina
- Agasthi Pradyumna
- Agesa Kareha M.
- Aghaali Mohammad
- Aghamir Seyed Mohammad Kazem
- Agrawal Anurag
- Ahmad Tauseef
- Ahmadi Alireza
- Ahmadi Keivan
- Ahmadi Mehdi
- Ahmadieh Hamid
- Ahmadpour Ehsan
- Ahmed Muktar Beshir
- Aji Budi
- Akalu Temesgen Yihunie
- Akinyemi Rufus Olusola
- Akinyemiju Tomi
- Akombi Blessing
- Akunna Chisom Joyqueenet
- Al-Aly Ziyad
- Al-Mekhlafi Hesham M.
- Al-Raddadi Rajaa M.
- Alahdab Fares
- Alam Khurshid
- Alam Noore
- Alam Samiah
- Alam Tahiya
- Alanezi Fahad Mashhour
- Alanzi Turki M.
- Albertson Samuel B.
- Alcalde-Rabanal Jacqueline Elizabeth
- Alema Niguse Meles
- Alemu Biresaw Wassihun
- Alemu Yihun Mulugeta
- Alhabib Khalid F.
- Alhassan Robert Kaba
- Ali Muhammad
- Ali Saqib
- Alicandro Gianfranco
- Alijanzadeh Mehran
- Alinia Cyrus
- Alipour Vahid
- Alizade Hesam
- Aljunid Syed Mohamed
- Alla Francois
- Allebeck Peter
- Almadi Majid Abdulrahman Hamad
- Almasi Ali
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- Amul Gianna Gayle Herrera
- Anbesu Etsay Woldu
- Ancuceanu Robert
- Anderlini Deanna
- Anderson Jason A.
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- Androudi Sofia
- Angus Colin
- Anjomshoa Mina
- Ansari Fereshteh
- Ansari Iman
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- Antonazzo Ippazio Cosimo
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- Arabloo Jalal
- Aravkin Aleksandr Y.
- Arba Aseb Arba Kinfe
- Aremu Olatunde
- Ariani Filippo
- Aripov Timur
- Armoon Bahram
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- Atteraya Madhu Sudhan
- Ausloos Floriane
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- Avokpaho Euripide Frinel Gbenato Arthur
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- Aynalem Getie Lake
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- Azari Samad
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- Bin Zaman Sojib
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- Bisignano Catherine
- Biswas Raaj Kishore
- Bitew Helen
- Bjorge Tone
- Bockarie Moses John
- Bohlouli Somayeh
- Bohluli Mehdi
- Bojia Hunduma Amensisa
- Bolla Srinivasa Rao
- Boloor Archith
- Boon-Dooley Alexandra S.
- Borges Guilherme
- Borzi Antonio Maria
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- Braithwaite Dejana
- Brauer Michael
- Brayne Carol
- Breitborde Nicholas J. K.
- Breitner Susanne
- Brenner Hermann
- Breusov Alexey V.
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- Briggs Andrew M.
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- Cai Tianji
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- Camera Luis Alberto
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- Cao Jackie
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- Cardenas Rosario
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- Castelpietra Giulio
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- Chin Ken Lee
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- Cho Daniel Youngwhan
- Choi Jee-Young Jasmine
- Christensen Hanne
- Chu Dinh-Toi
- Chung Michael T.
- Chung Sheng-Chia
- Cicuttini Flavia M.
- Ciobanu Liliana G.
- Cirillo Massimo
- Cislaghi Beniamino
- Classen Thomas Khaled Dwayne
- Cohen Aaron J.
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- Comfort Haley
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- Conti Sara
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- Cortesi Paolo Angelo
- Costa Vera Marisa
- Cousin Ewerton
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- Cummins Steven
- Cunningham Matthew
- D'Amico Emanuele
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- Dahlawi Saad M. A.
- Dai Haijiang
- Dai Hancheng
- Damasceno Albertino Antonio Moura
- Damiani Giovanni
- Dandona Lalit
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- Dangel William James
- Danielsson Anna-Karin
- Dargan Paul I.
- Darshan B. B.
- Darwesh Aso Mohammad
- Daryani Ahmad
- Das Gupta Rajat
- Das Neves Jose
- Das Jai K.
- Dash Aditya Prasad
- Davey Gail
- Davila-Cervantes Claudio Alberto
- Davis Adrian C.
- Davitoiu Dragos Virgil
- Davletov Kairat
- De Leo Diego
- De Neve Jan-Walter
- Dean Frances E.
- DeCleene Nicole K.
- Deen Amanda
- Defo Barthelemy Kuate
- Degenhardt Louisa
- DeLang Marissa
- Dellavalle Robert Paul
- Demeke Feleke Mekonnen
- Demoz Gebre Teklemariam
- Demsie Desalegn Getnet
- Denova-Gutierrez Edgar
- Dereje Nebiyu Dereje
- Deribe Kebede
- Dervenis Nikolaos
- Desai Rupak
- Desalew Assefa
- Dessie Getenet Ayalew
- Deuba Keshab
- Dharmaratne Samath Dhamminda
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- Elyazar Iqbal R. F.
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- Emmons-Bell Sophia
- Erskine Holly E.
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- Esteghamati Sadaf
- Estep Kara
- Etemadi Arash
- Etisso Atkilt Esaiyas
- Ezekannagha Oluchi
- Fanzo Jessica
- Farag Tamer
- Farahmand Mohammad
- Faraj Anwar
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- Farinha Carla Sofia e Sa
- Farioli Andrea
- Faris Pawan Sirwan
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- Gebremeskel Leake G.
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- Gebreslassie Assefa Ayalew Ayalew Ayalew
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- Geramo Yilma Chisha Dea
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- Gesesew Hailay Abrha
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- Ghiasvand Hesam
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- Guimaraes Andre Luiz Sena
- Guimaraes Rafael Alves
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- Gupta Rajeev
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- Yaminfirooz Mousa
- Yano Yuichiro
- Yaya Sanni
- Yazdi-Feyzabadi Vahid
- Yearwood Jamal A.
- Yeheyis Tomas Y.
- Yeshitila Yordanos Gizachew
- Yilgwan Christopher Sabo
- Yilma Mekdes Tigistu
- Yip Paul
- Yonemoto Naohiro
- Yoon Seok-Jun
- York Hunter W.
- Younis Mustafa Z.
- Younker Theodore Patrick
- Yousefi Bahman
- Yousefi Zabihollah
- Yousefifard Mahmoud
- Yousefinezhadi Taraneh
- Yousuf Abdilahi Yousuf
- Yu Chuanhua
- Yu Yong
- Yuan Chun-Wei
- Yuce Deniz
- Yusefzadeh Hasan
- Zadey Siddhesh
- Zahabi Saleh Salehi
- Zaidi Syed Saoud
- Zaki Leila
- Zaki Maysaa El Sayed
- Zakzuk Josefina
- Zamani Mohammad
- Zamanian Maryam
- Zandian Hamed
- Zangeneh Alireza
- Zarafshan Hadi
- Zastrozhin Mikhail Sergeevich
- Zewdie Kaleab Alemayehu
- Zhang Jianrong
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zhao Jeff T.
- Zhao Xiu-Ju George
- Zhao Yingxi
- Zheleva Bistra
- Zheng Peng
- Zhou Maigeng
- Zhu Cong
- Ziapour Arash
- Zimsen Stephanie R. M.
- Zlavog Bianca S.
- Zodpey Sanjay
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and developm nt investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens
Finishing the euchromatic sequence of the human genome
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- Ishibashi Akiko
- Ishikawa Sabine K.
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- Nakato Eriko
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- Okwuonu Geoffrey O.
- Okwuonu Kenneth C.
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- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
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- Zhang Guohua
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- Zhang Haiqing
- Zhang Haiqing
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- Zhang Hongbo
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- Zhang Jingjing
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- Zhang Jiuchun
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- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
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- Zhang Wei
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- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
A incorporação de novas tecnologias nos serviços de saúde: o desafio da análise dos fatores em jogo
- Author
- Arrow KJ
- Arthur WB
- Aubert BA
- Backer TE
- Barnsley J
- Bashshur RL
- Becker C
- Becker MH
- Blume SS
- Brouselle A
- Callon M
- Champagne F
- Coile Jr. RC
- Coleman JS
- Conrad P
- Cosgrove DM
- Dagnino R
- Dearing JW
- Denis JL
- Dirksen CD
- Dopson S
- Doumit G
- Easton D
- Eveland JD
- Evelinda Trindade
- Fendrick MA
- Fennel ML
- Ferguson JH
- Ferlie E
- Fitzgerald L
- Forester J
- Foy R
- Gelijns AC
- Giddens A
- Gladwin J
- Goodman CS
- Gosling AS
- Greenberg D
- Greenhalgh T
- Greer AL
- Greer AL
- Greer AL
- Greer AL
- Grilli R
- Grimshaw JM
- Gustafson DH
- Hagland M
- Hailey D
- Hall GE
- Ham C
- Hofmann B
- House R
- Ikegami N
- Ikegami N
- James AE
- Kaluzny AD
- Kimberly JR
- Locock L
- Lymberis A
- Markham SK
- Matus C
- May C
- McLaughlin CP
- Menon D
- Meyer AD
- Meyer M
- Moore GA
- Muraskas J
- Narin F
- Newhouse JP
- Nystrom PC
- Ogilvie DB
- Oxley H
- Pallas G
- Pedersen T
- Pettigrew AM
- Plsek PE
- Rhydderch M
- Robinson MA
- Roco MC
- Rogers E
- Rogers EM
- Rogers EM
- Rogers EM
- Rydén L
- Schon DA
- Shane S
- Silva PF
- Silverberg G
- Tellioglu H
- Teplensky JD
- Timmermans S
- Trindade E
- Valente TW
- van de Ven AH
- van der Ploeg I
- Wang SS
- Warner KE
- Watts HG
- Wejnert B
- Weller RE
- West E
- Yetton P
- Zahra AS
- Øvretveit J
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
- …