Mechanical and microstructural characterization of MCrAlY coatings produced by laser cladding: The influence of the Ni, Co and Al content

[EN] Laser metal deposition (LMD) and laser cladding (LC) are alternative methods to thermal spraying processes to produce dense, high-quality coatings. In this work, two MCrAlY coatings (M=Ni+Co) have been prepared onto stainless steel substrate using a coaxial LC technique under two different Ni/Co and Al proportions. The mechanical properties were then evaluated with microhardness, nanoindentation, and three-point bending tests. The microstructure and composition of coatings were characterized by X-ray Diffraction (XRD) analysis and Field Emission Electron Microscopy (FESEM) coupled to an Energy Dispersive Spectroscopy (EDS) detector. The study revealed that the ¿/ß phases formed in the MCrAlY coating microstructure result in a lower elastic modulus than the austenitic stainless steel substrate, while an inverse behavior for hardness was observed due the presence of the aluminum-rich ß-phase. Under flexural loads, the failure of coatings showed plasticity and anisotropy characteristics depending on the two laser tracks orientations evaluated.The authors would like to acknowledge the financial support of the Ministry of Science and Innovation of the Government of Spain through research project MAT2011-28492-C03, and the support of the Generalitat Valenciana through ACOMP/2013/114Pereira, JC.; Zambrano, JC.; Rayón, E.; Yañez, A.; Amigó, V. (2018). Mechanical and microstructural characterization of MCrAlY coatings produced by laser cladding: The influence of the Ni, Co and Al content. Surface and Coatings Technology. 338:22-31. https://doi.org/10.1016/j.surfcoat.2018.01.073S223133

Targeting ErbB-2 nuclear localization and function inhibits breast cancer growth and overcomes trastuzumab resistance

Membrane overexpression of ErbB-2/HER2 receptor tyrosine kinase (membrane ErbB-2 (MErbB-2)) has a critical role in breast cancer (BC). We and others have also shown the role of nuclear ErbB-2 (NErbB-2) in BC, whose presence we identified as a poor prognostic factor in MErbB-2-positive tumors. Current anti-ErbB-2 therapies, as with the antibody trastuzumab (Ttzm), target only MErbB-2. Here, we found that blockade of NErbB-2 action abrogates growth of BC cells, sensitive and resistant to Ttzm, in a scenario in which ErbB-2, ErbB-3 and Akt are phosphorylated, and ErbB-2/ErbB-3 dimers are formed. Also, inhibition of NErbB-2 presence suppresses growth of a preclinical BC model resistant to Ttzm. We showed that at the cyclin D1 promoter, ErbB-2 assembles a transcriptional complex with Stat3 (signal transducer and activator of transcription 3) and ErbB-3, another member of the ErbB family, which reveals the first nuclear function of ErbB-2/ErbB-3 dimer. We identified NErbB-2 as the major proliferation driver in Ttzm-resistant BC, and demonstrated that Ttzm inability to disrupt the Stat3/ErbB-2/ErbB-3 complex underlies its failure to inhibit growth. Furthermore, our results in the clinic revealed that nuclear interaction between ErbB-2 and Stat3 correlates with poor overall survival in primary breast tumors. Our findings challenge the paradigm of anti-ErbB-2 drug design and highlight NErbB-2 as a novel target to overcome Ttzm resistance.Fil: Cordo Russo, Rosalia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Béguelin, W.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Díaz Flaqué, María Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Proietti Anastasi, Cecilia Jazmín. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Venturutti, Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Galigniana, Natalia Maricel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Tkach, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Guzmán, P.. Universidad de La Frontera; ChileFil: Roa, J.C.. Universidad de La Frontera; ChileFil: O'Brien, N.A.. David Geffen School of Medicine at UCLA; Estados UnidosFil: Charreau, Eduardo Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Schillaci, Roxana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Elizalde, Patricia Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentin

Variaciones interanuales en las capturas de tiburones pelágicos en el

Pelagic migrating sharks are by-caught incidentally in longline fisheries. Some of these species have been catalogued as threatened or vulnerable by several Regional Fisheries Organizations and International Conservational NGOs. Alboran Sea is an important area for pelagic migrating sharks because it is the natural and unique communication way between the Atlantic Ocean and Mediterranean Sea. This area is considered by several authors as a hot-spot of Climate Oscillation, such as the North Atlantic Oscillation (NAO) and the Arctic Oscillation (AO). In addition, Alboran Sea is an important fishing ground where the longline fisheries targeting swordfish operates. Recent studies concluded that historical landing of pelagic sharks from harbours of Alboran Sea and Balearic Sea were mediated for atmospheric oscillations. The main aim of the present study was to assess the effect of atmospheric oscillation on the Catch per Unit Effort (CPUE) of vulnerable sharks thresher shark, Alopias vulpinus (Bonnaterre, 1788) and shortfin mako, Isurus oxyrinchus (Rafinesque, 1810) by-caught in the traditional longline fisheries. The atmospheric oscillations tested in this study were the North Atlantic Oscillation (NAO) and the Arctic Oscillation (AO). We found a significant positive correlation between the NAO and AO indexes of the previous year to the CPUE tested.En prens

Análisis preliminar del efecto de las oscilaciones climáticas sobre la condición física de la melva (Auxis rochei) post-reproductora en el Mar de Alborán

The Mediterranean Sea is considered by several authors as a hot-spot of Climate Oscillation, such as the North Atlantic Oscillation (NAO) and the Arctic Oscillation (AO). However, information about the effect of the climate oscillations on the fitness of the species is still scarce. In this context, bullet tuna is an important migratory species with a substantial socio-economical value, whose fisheries might be affected by the effect of certain climatological conditions. In fact, these atmospheric oscillations trigger a chain of hydrodynamic events, leading a change on the timing, destinations, and success of the migratory species in their search for spawning grounds. This study relies on the hypothesis of a correlation between the physical condition of the post-spawning bullet tuna and climate oscillation indexes. For that purpose, 151 individuals of bullet tuna, Auxis rochei, were collected in the traps of Ceuta (Alboran Sea) during three different years, (1983, 1984 and 2014). The physical condition index was calculated, and later statistically correlated with the climate oscillation indexes proposed. Significant differences were found between the physical condition of A. rochei and the average accumulated NAO index. Moreover, for age class 3+ we obtained a significant correlation with atmospheric oscillations.Postprin

Segregación espacial por sexo de la tintorera en el Atlántico Este y

The main aim of present study was to analyze the spatial and temporal trends segregation by sex of blue shark (Prionace glauca) in the Eastern Atlantic and Western Mediterranean Sea from the individual bycatches by Spanish surface longline fleet. Our results indicate significant differences in the use of space between males and females. Thus, in low latitudes, within the observed range, sharks are mixed, but from North 38 degree of latitude tend to segregate. In the case of length, a similar pattern is observed, in low longitude sexes appear overlapped, and while to high longitude tend to appear segregated. All these results suggested segregation by sex in the Mediterranean where sharks are grouped in single-sex schools.Postprin

Search for displaced vertices arising from decays of new heavy particles in 7 TeV pp collisions at ATLAS

We present the results of a search for new, heavy particles that decay at a significant distance from their production point into a final state containing charged hadrons in association with a high-momentum muon. The search is conducted in a pp-collision data sample with a center-of-mass energy of 7 TeV and an integrated luminosity of 33 pb^-1 collected in 2010 by the ATLAS detector operating at the Large Hadron Collider. Production of such particles is expected in various scenarios of physics beyond the standard model. We observe no signal and place limits on the production cross-section of supersymmetric particles in an R-parity-violating scenario as a function of the neutralino lifetime. Limits are presented for different squark and neutralino masses, enabling extension of the limits to a variety of other models.Comment: 8 pages plus author list (20 pages total), 8 figures, 1 table, final version to appear in Physics Letters

Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment

This paper describes an analysis of the angular distribution of W->enu and W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with the ATLAS detector at the LHC in 2010, corresponding to an integrated luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and the missing transverse energy, the W decay angular distribution projected onto the transverse plane is obtained and analysed in terms of helicity fractions f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw > 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour, are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017 +/- 0.030, where the first uncertainties are statistical, and the second include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables, revised author list, matches European Journal of Physics C versio

Observation of a new chi_b state in radiative transitions to Upsilon(1S) and Upsilon(2S) at ATLAS

The chi_b(nP) quarkonium states are produced in proton-proton collisions at the Large Hadron Collider (LHC) at sqrt(s) = 7 TeV and recorded by the ATLAS detector. Using a data sample corresponding to an integrated luminosity of 4.4 fb^-1, these states are reconstructed through their radiative decays to Upsilon(1S,2S) with Upsilon->mu+mu-. In addition to the mass peaks corresponding to the decay modes chi_b(1P,2P)->Upsilon(1S)gamma, a new structure centered at a mass of 10.530+/-0.005 (stat.)+/-0.009 (syst.) GeV is also observed, in both the Upsilon(1S)gamma and Upsilon(2S)gamma decay modes. This is interpreted as the chi_b(3P) system.Comment: 5 pages plus author list (18 pages total), 2 figures, 1 table, corrected author list, matches final version in Physical Review Letter

Measurement of the inclusive isolated prompt photon cross-section in pp collisions at sqrt(s)= 7 TeV using 35 pb-1 of ATLAS data

A measurement of the differential cross-section for the inclusive production of isolated prompt photons in pp collisions at a center-of-mass energy sqrt(s) = 7 TeV is presented. The measurement covers the pseudorapidity ranges |eta|<1.37 and 1.52<=|eta|<2.37 in the transverse energy range 45<=E_T<400GeV. The results are based on an integrated luminosity of 35 pb-1, collected with the ATLAS detector at the LHC. The yields of the signal photons are measured using a data-driven technique, based on the observed distribution of the hadronic energy in a narrow cone around the photon candidate and the photon selection criteria. The results are compared with next-to-leading order perturbative QCD calculations and found to be in good agreement over four orders of magnitude in cross-section.Comment: 7 pages plus author list (18 pages total), 2 figures, 4 tables, final version published in Physics Letters

Reducing heterotic M-theory to five dimensional supergravity on a manifold with boundary

This paper constructs the reduction of heterotic $M$-theory in eleven dimensions to a supergravity model on a manifold with boundary in five dimensions using a Calabi-Yau three-fold. New results are presented for the boundary terms in the action and for the boundary conditions on the bulk fields. Some general features of dualisation on a manifold with boundary are used to explain the origin of some topological terms in the action. The effect of gaugino condensation on the fermion boundary conditions leads to a `twist' in the chirality of the gravitino which can provide an uplifting mechanism in the vacuum energy to cancel the cosmological constant after moduli stabilisation.Comment: 16 pages, RevTe