“Palliative care: a right, a necessity” Evaluation of a collaborative project for the dissemination of palliative care in the Balearic Islands

[cat] Es presenta el projecte col·laboratiu de difusió i divulgació de les Cures Pal·liatives dirigit a la ciutadania amb el títol: “Cures Pal·liatives: un dret, una necessitat” que des del Centre Coordinador del programa de Cures Pal·liatives de les Illes Balears (CCPCPIB), conjuntament amb la Societat Balear de Cures Pal·liatives (IllesPal), l’Associació Espanyola Contra el Càncer (AECC), l’associació de voluntaris de cures pal·liatives de les Illes Balears (DIME) i l’associació Ángeles sin Alas, van posar en marxa. L’objectiu de l’esmentat projecte és donar a conèixer l’atenció pal·liativa com un dret i una necessitat que té tota persona que es troba en un procés de final de vida. S’ha estructurat mitjançant sessions a diferents pobles de les illes, dirigits a la ciutadania, amb la participació de representants de les entitats citades. Es presenten els resultats d’aquest programa, amb la conclusió que la satisfacció percebuda dels assistents ha estat molt bona.[eng] A collaborative project to divulge palliative care to the citizen with the title: “Palliative Care: a right, a necessity” was implemented by the Palliative Care Program Coordinating Center of the Balearic Islands, jointly with the Balearic Society of Palliative Care, the Spanish Association Against Cancer, the association of volunteers of palliative care of the Balearic Islands (DIME) and the association Ángeles sin Alas. The aim of this project is to make people to be aware of palliative care as right and necessity that all people have at the end of life. They organized meetings in different Balearic villages, directed at the citizenry, with the participation of representatives of the quoted entities. The results of this program are presented, with the conclusion that the attendee satisfaction has been very hight

Acuity, nurse staffing and workforce, missed care and patient outcomes. A cluster-unit-level descriptive comparison

Aim: To compare patient acuity, nurse staffing and workforce, missed nursing care and patient outcomes among hospital unit-clusters. Background: Relationships among acuity, nurse staffing and workforce, missed nursing care and patient outcomes, are not completely understood. Method: Descriptive design with data from four unit-clusters: medical, surgical, combined and stepdown units. Descriptive statistics were used to compare acuity, nurse staffing coverage, education and expertise, missed nursing care, and selected nurse-sensitive outcomes. Results: Patient acuity in general (medical, surgical and combined) floors is similar to step-down units, with an average of 5.6 required RN hours per patient day. In general wards, available RN hours per patient day reach only 50% of required RN hours to meet patient needs. Workforce measures are comparable among unit-clusters, and average missed nursing care is 21%. Patient outcomes vary among unit-clusters. Conclusion:Patient acuity is similar among unit-clusters, whilst nurse staffing coverage is halved in general wards. While RN education, expertise and missed care are comparable among unitclusters, mortality, skin injuries and risk of family compassion fatigue rates are higher in general wards. Implications for nursing management: Nurse managers play a pivotal role in hustling policy-makers to address structural understaffing in general wards, to maximize patient safety outcomes

Projeto TURARQ - Turismo Arqueológico para Territórios de Baixa Densidade do Médio Tejo

Apresentação do projeto TurArq, que tem como objetivo principal promover o turismo científico e cultural em territórios de baixa densidade do Médio Tejo português (municípios de Abrantes, Constância, Mação, Tomar e Vila Nova da Barquinha), gerando riqueza e novos empregos, apostando no usufruto presencial do património arqueológico e nos meios de divulgação digital. O projeto pretende contribuir para uma gestão patrimonial integrada na região, a fixação de capital humano, a mobilização de recursos dedicados à sua capacitação e a valorização do património existente. Visa ainda promover o desenvolvimento comunitário, a coesão do território e a sua preservação, numa lógica de sustentabilidade.Os autores agradecem ao projeto “Contratação de Recursos Humanos Altamente Qualificados - Territórios do interior - Entidades Não Empresariais do Sistema I&I” (Centro-04-3559-Fse-000158), financiado pelo Fundo Social Europeu e pelo Instituto Politécnico de Tomar. Trabalho financiado por fundos nacionais através da Fundação para a Ciência e Tecnologia (Fct), no âmbito dos projetos Uid/00073//2020 (Cgeo), Uid/05488/2020 (Techn&Art) e Uid/05567/2020 (Ci2)info:eu-repo/semantics/publishedVersio

TET enzymes and DNA hydroxymethylation in neural development and function : how critical are they?

Epigenetic modifications of the genome play important roles in controlling gene transcription thus regulating several molecular and cellular processes. A novel epigenetic modification - 5-hydroxymethylcytosine (5hmC) - has been recently described and attracted a lot of attention due to its possible involvement in the active DNA demethylation mechanism. TET enzymes are dioxygenases capable of oxidizing the methyl group of 5-methylcytosines (5mC) and thus converting 5mC into 5hmC. Although most of the work on TET enzymes and 5hmC has been carried out in embryonic stem (ES) cells, the highest levels of 5hmC occur in the brain and in neurons, pointing to a role for this epigenetic modification in the control of neuronal differentiation, neural plasticity and brain functions. Here we review the most recent advances on the role of TET enzymes and DNA hydroxymethylation in neuronal differentiation and function.We apologize to those researchers whose important work we were not able to cite. We would like to thank all members of the Neurosciences Research Domain (ICVS) for useful discussions, in particular Luisa Pinto and Joao Oliveira for critically reading the manuscript. Our work is funded by the Fundacao para a Ciencia e Tecnologia (FCT, Portugal) and Compete Program with the project reference PTDC/BIA-BCM/121276/2010. C.J. Marques is the recipient of an FCT Investigator Starting Grant

La comunicació com a eina per a la cohesió social contra el racisme i la intolerància

Aquesta publicació és resultat del projecte "La comunicació com a eina per a la cohesió social contra el racisme i la intolerància", finançat pel XXXV Fons de Solidaritat de la Universitat Autònoma de Barcelona (FSXXXV-03). Des de l'enfocament de contribuir a la promoció de societats més igualitàries, justes i democràtiques, l'objectiu general del projecte va ser afavorir el coneixement sobre la comunicació i l'educació per al desenvolupament i el canvi social en els graus de la Facultat de Ciències de la Comunicació de la UAB, oferint a l'alumnat coneixements que els permetin entendre aquesta perspectiva com una àrea d'especialització i una potencial sortida professional

estudos artísticos

Crescer na intervenção e na comunicação é um dos objetivos da Revista Gama, estudos artísticos. Promove-se a comunicação, formal, dentro das regras da comunicação académica, através de textos cuja característica comum é serem escritos por artistas, sobre a obra de outros artistas. Este foi o critério base que inspirou o projeto das iniciativas associadas ao Congresso CSO (criadores sobre outras obras), que já completou seis anos de disseminação. A Revista Gama singularizou-se por convocar artistas e obras que de algum modo estariam esquecidos, desconhecidos, ou ainda pouco divulgados. Obras cuja execução tem raízes em passados mais ou menos recentes, mas que pelo excesso de discursos na contemporaneidade, não obtiveram a divulgação desejada. Este é um propósito de intervenção no conhecimento patrimonial: as obras existem, foram executadas, enriquecem o nosso património, mas há que as fazer funcionar, dar a conhecer, aos outros artistas, aos especialistas, ao grande público. Assim se reuniram neste número 6 da Revista Gama vinte e quatro artigos originais, procurando-se, na sua sequência e articulação, algumas relações de pertinência e afinidade. Olhares sobre arquivos, sobre acervos, sobre coleções, conjuntos muitas vezes fechados e em perigo de esquecimento, ou de incompreensão: uma entrada discreta que se abre para o interior de uma câmara escura, que é um espaço cheio de imagens por revelar.info:eu-repo/semantics/publishedVersio

Global wealth disparities drive adherence to COVID-safe pathways in head and neck cancer surgery

Peer reviewe

Estudos Artísticos

Há um compromisso entre o artista e a sociedade. Não é possível retirar a arte do seu contexto social. Neste projecto, em que se desafiam os criadores a pesquisar a obra de outros criadores, reúnem-se aqueles artigos que melhor demonstram a responsabilidade e a solidariedade entre os criadores e os seus pares sociais. São obras, artistas, projetos, plataformas de intervenção, projetos que enfatizam as relações sociais como suporte. Sob esta temática geral foram reunidos 25 artigos para este número 6 da Revista Croma, em linhas de exploração variadas e mantendo a elevada internacionalização da revista: mais de noventa por cento das publicações são exógenas à Faculdade de Belas-Artes da Universidade de Lisboa ou do CIEBA, a sua unidade de investigação. Este é um indicador procurado e atingido de modo consistente em todos os exemplares publicados até hoje, e que se espera poder afirmar com continuidade. As diferentes perspetivas apresentadas nos variados artigos expõe a obra de autores que exploram dimensões relacionais ou perante as quais o espectador é convocado a deslocar o seu posicionamento, a desassossegar-se. A implicação surge como resultado da articulação expressiva dos recursos mais variados, em constante mistura, exibindo o modo como as dimensões materiais e ideais são fundadoras das diversas propostas. Nesta revista não há indiferença, há diferenças.info:eu-repo/semantics/publishedVersio

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research