Disablist Propaganda: Evil on One Hand, and a Hook for the Other

Despite its publication by J.M. Barrie in 1904, Peter and Wendy has attracted very little critical attention. Perhaps the story is so beloved for its adventure-packed plot, and sweet message about a boy who never grows old, that even scholars have trouble criticizing it—despite its obvious calls for analysis as film and literary adaptations continue to appear. However, most concerning is an apparent gap in the analysis of the story’s disabled villain, Captain Hook, through a modern Disability Studies lens. The following textual analysis of Captain Hook will serve to call attention to the way his disability plays into his role as the villain—for both the reader and the characters in Peter and Wendy—as well as to reassign the inherent complexity of a disabled villain to Captain Hook, who seems to devolve with each adaptation. Theorists do acknowledge that Hook is not the first of his kind—that is, he is not the archetype for such a villainous depiction. Melville’s Ahab and Dickens’ Captain Cuttle, for example, are considered by some to have influenced Barrie’s Captain Hook. Regardless of which fictional character was actually the first, there is a pattern of using disabled bodies as an avenue through which to incite fear and, ultimately, make the main character look “good” by comparison. There are many factors at play here that then become essential to examining Captain Hook from a Disability Studies perspective: a Victorian Era influence, effeminate traits, and the lingering implications of such a portrayal

The Boy from 6B: How Only Murders in the Building Created Groundbreaking Television

Non-disabled actors continue to be cast over disabled actors to portray disabled characters, and disabled storylines are told from an able-bodied perspective. This paper explores how Only Murders in the Building set an example for approaching projects featuring disabled actors and roles while maintaining a complex storyline in the episode titled The Boy from 6B (2021). Analyzing this episode through the lens of the classical idea of anmut shows how it subverted the typical viewing experience of watching a storyline that features disabled characters from an able-bodied perspective. Anmut, as a rhetorical concept, recognizes that the value of physical characteristics is socially constructed; a body can be just as desirable in one cultural setting as it can be undesirable in another. To illustrate this point, anmut creates the space for reconsidering disability by bringing social reactions and underlying assumptions about the human body and physical diversity to the forefront. Only Murders utilized this concept in “The Boy from 6B” by casting a deaf actor to play a deaf character and placing the viewer in the character’s world by removing their sense of hearing and their reliance on sound. The result is a more powerful connection between the viewer and the disabled character. Further, when compared to the movie Music (2020), directed by singer Sia—which features a disabled protagonist—Only Murders stands out by reattributing complexity to a community that is often portrayed reductively and by asking the audience to step, for thirty-one minutes, out of their abled body

Analysis of shared heritability in common disorders of the brain

ience, this issue p. eaap8757 Structured Abstract INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed study of phenotypes with different ages of onset, severity, and presentation poses a considerable challenge. Recently developed heritability methods allow us to accurately measure correlation of genome-wide common variant risk between two phenotypes from pools of different individuals and assess how connected they, or at least their genetic risks, are on the genomic level. We used genome-wide association data for 265,218 patients and 784,643 control participants, as well as 17 phenotypes from a total of 1,191,588 individuals, to quantify the degree of overlap for genetic risk factors of 25 common brain disorders. RATIONALE Over the past century, the classification of brain disorders has evolved to reflect the medical and scientific communities' assessments of the presumed root causes of clinical phenomena such as behavioral change, loss of motor function, or alterations of consciousness. Directly observable phenomena (such as the presence of emboli, protein tangles, or unusual electrical activity patterns) generally define and separate neurological disorders from psychiatric disorders. Understanding the genetic underpinnings and categorical distinctions for brain disorders and related phenotypes may inform the search for their biological mechanisms. RESULTS Common variant risk for psychiatric disorders was shown to correlate significantly, especially among attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder (MDD), and schizophrenia. By contrast, neurological disorders appear more distinct from one another and from the psychiatric disorders, except for migraine, which was significantly correlated to ADHD, MDD, and Tourette syndrome. We demonstrate that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine. We also identify significant genetic sharing between disorders and early life cognitive measures (e.g., years of education and college attainment) in the general population, demonstrating positive correlation with several psychiatric disorders (e.g., anorexia nervosa and bipolar disorder) and negative correlation with several neurological phenotypes (e.g., Alzheimer's disease and ischemic stroke), even though the latter are considered to result from specific processes that occur later in life. Extensive simulations were also performed to inform how statistical power, diagnostic misclassification, and phenotypic heterogeneity influence genetic correlations. CONCLUSION The high degree of genetic correlation among many of the psychiatric disorders adds further evidence that their current clinical boundaries do not reflect distinct underlying pathogenic processes, at least on the genetic level. This suggests a deeply interconnected nature for psychiatric disorders, in contrast to neurological disorders, and underscores the need to refine psychiatric diagnostics. Genetically informed analyses may provide important "scaffolding" to support such restructuring of psychiatric nosology, which likely requires incorporating many levels of information. By contrast, we find limited evidence for widespread common genetic risk sharing among neurological disorders or across neurological and psychiatric disorders. We show that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures. Further study is needed to evaluate whether overlapping genetic contributions to psychiatric pathology may influence treatment choices. Ultimately, such developments may pave the way toward reduced heterogeneity and improved diagnosis and treatment of psychiatric disorders

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Predictors of Neurological Outcome Following Infant Cardiac Surgery Without Deep Hypothermic Circulatory Arrest

The aim of this study is to describe the clinical characteristics, perioperative course and neuroimaging abnormalities of infants with congenital heart disease (CHD) undergoing heart surgery without deep hypothermic circulatory arrest (DHCA) and identify variables associated with neurological outcome. Infants with CHD undergoing open-heart surgery without DHCA between 2009 and 2017 were identified from a cardiac surgery database. Full-term infants \u3c 10 weeks of age at the time of surgery who had both a pre- and postoperative brain magnetic resonance imaging exam (MRI) were included. Clinical characteristics and perioperative variables were collected from the electronic medical record. Brain Injury Scores (BIS) were assigned to pre- and postoperative brain MRIs. Variables were examined for association with neurological outcome at 12 months of age or greater. Forty-two infants were enrolled in the study, of whom 69% (n = 29) had a neurological assessment ≥ to 12 months of age. Adverse neurological outcome was associated with longer intensive care unit (ICU) stay (P = 0.003), lengthier mechanical ventilation (P = 0.031), modified Blalock-Taussig (MBT) shunt procedure (P = 0.005) and postoperative seizures (P = 0.005). Total BIS scores did not predict outcome but postoperative infarction and/or intraparenchymal hemorrhage (IPH) was associated with worse outcome by multivariable analysis (P = 0.018). Infants with CHD undergoing open-heart surgery without DHCA are at increased risk of worse neurological outcome when their ICU stay is prolonged, mechanical ventilation is extended, MBT shunt is performed or when postoperative seizures are present. Cerebral infarctions and IPH on postoperative MRI are also associated with worse outcome