263 research outputs found
Liderazgo distribuido y capacidad de mejora en centros de educación secundaria
El artículo que presentamos es una aproximación al estudio de las formas de liderazgo de los Institutos de Educación Secundaria. En concreto, busca verificar la presencia de formas de liderazgo distribuido en una muestra de 24 institutos de la provincia de Granada. Aplicando una metodología mixta en la que se combinan guiones de auto-observación y entrevistas semiestructuradas, se llega a concluir que el modelo de liderazgo vigente en la muestra de institutos analizados es un modelo de liderazgo burocrático apoyado en la figura de un director que actúa de manera solitaria. Aunque la muestra utilizada para la estudio es limitada, el artículo promueve una reflexión sobre la necesidad de definir la fi gura del director como elemento clave para dinamizar la capacidad de mejora de los centros de educación secundaria.
The article we submit is an approach to the study of leadership on secondary schools and seeks to verify the presence or absence of distributed leadership arranged in a sample of 24 secondary schools in the Granada province. Applying a mixed methodology in which self-analysis outlines and semi-structured interviews are combined, it comes to the conclusion that the actual leadership model in the analysed secondary schools sample is a bureaucratic one supported by the figure of a director acting on his/her own. Although the sample used for the study is limited, the article encourages the reflection on the need to define the director figure as a key element in order to stimulate secondary schools'' improvement capacity
Şeref madalyası
Taha Toros Arşivi, Dosya No: 34-Safiye-Hüseyin ElbiUnutma İstanbul projesi İstanbul Kalkınma Ajansı'nın 2016 yılı "Yenilikçi ve Yaratıcı İstanbul Mali Destek Programı" kapsamında desteklenmiştir. Proje No: TR10/16/YNY/010
Evaluación de la seguridad de los anticoagulantes orales de acción directa
Objetivo: Comparar la incidencia de hemorragias entre los anticoagulantes orales (ACO) y analizar los factores que influyen en la aparición de hemorragias.
Material y métodos: Estudio observacional, retrospectivo unicéntrico. Tras estudiar la población total en tratamiento con ACO, se analizó a los pacientes en tratamiento con un ACO del sector II de Zaragoza que acudieron al Servicio de Urgencias de Hospital Universitario Miguel Servet de julio a diciembre de 2015 por presentar algún evento. Se registraron datos demográficos, variables clínicas y características del evento hemorrágico. Como factores independientes en la aparición de hemorragias se valoró la dosis, fármacos, el sexo y la edad.
Resultados: Había 9.452 pacientes en tratamiento con ACO, de los cuales 371 presentaron un evento hemorrágico (3, 9%). La frecuencia por ACO fue 4, 1% (311) en pacientes tratados con antagonistas de la vitamina K (AVK), 3, 8% (33) con rivaroxaban, 3, 3% (19) con dabigatran y, por último, con apixaban 2, 1% (8) (p < 0, 05). En el análisis multivariante solo obtuvieron una influencia estadísticamente significativa la selección del anticoagulante y el sexo, en concreto, la dosis de apixaban 2, 5 mg y ser mujer presentaban menor riesgo de hemorragia (OR = 0, 1; IC = 0, 014-0, 71 y OR = 0, 688; IC = 0, 55-0, 85, respectivamente).
Conclusión: Según los datos obtenidos, las mujeres y los pacientes en tratamiento con apixaban presentaban menor riesgo hemorrágico, si bien existen dudas de si este mejor perfil de seguridad está relacionado con una infradosificación, que podría influir en su efectividad. Por lo tanto, estos resultados deben ser analizados con prudencia y se deben realizar más estudios para confirmar estos datos.
Objective: To compare the occurrence of haemorrhages among the different oral anticoagulants (OAC) and to analyse factors that influence it.
Material and methods: Single-centre, observational, retrospective study. After studying the total population treated with OAC, patients who were treated with an OAC from July 2015 to December 2015 in the II Sector of the Zaragoza Hospital, who consulted the Emergency Department of the Miguel Servet University Hospital and presented a haemorrhagic event, were analysed. Patients’ demographic data, clinical variables and data on the haemorrhagic event characteristics were gathered.
Results: There were 9, 452 patients treated with an OAC, 371 (3.9%) of which presented a haemorrhagic event. The frequency per OAC was; 4.1% (311) in patients treated with vitamin K antagonists, 3.8% (33) with rivaroxaban, 3.3% (19) with dabigatran and 2.1% (8) with apixaban. In the multivariate analysis, only the choice of anticoagulant and sex had a statistically significant influence of a lower risk of haemorrhage, in particular the dose of apixaban at 2.5 mg and being female. (OR = 0.1, CI = 0.014-0.71 and OR = 0.688, CI = 0.55-0.85, respectively).
Conclusion: According to the results obtained, females and patients undergoing treatment with apixaban presented lower haemorrhagic risk, although there are doubts about whether this better safety profile is related to underdosing, which could influence its effectiveness. Therefore, these results should be analysed with caution and further studies are needed to confirm this data
Possible contribution of paraquat to the development of Parkinson disease
La enfermedad de Parkinson (PD) es una de las
enfermedades neurodegenerativas más comunes relacionadas con la
edad que afecta a millones de personas en todo el mundo. Existen
pruebas sólidas que apoyan el papel de los radicales libres, estrés
oxidativo, disfunción mitocondrial y agregación de proteínas en el
mecanismo de acción tóxica y muerte neuronal en la PD. Los factores
ambientales, especialmente, los plaguicidas constituyen uno de los
principales grupos de agentes neurotóxicos asociados a la PD. La
toxicidad de los plaguicidas ha sido claramente demostrada, siendo
capaces de alterar una gran variedad de funciones neurológicas. En
particular, existe una fuerte evidencia que sugiere que la exposición a
estas sustancias predispone a ciertas enfermedades
neurodegenerativas (esclerosis lateral amiotrófica, enfermedad de
Huntington, etc.). De hecho, los estudios epidemiológicos han
sugerido una relación entre la exposición a determinados plaguicidas
y la neurodegeneración cerebral. Cabe destacar la relación observada
entre Paraquat (PQ) y la PD en estudios experimentales con roedores
en los que se observan lesiones en la substancia nigra pars compacta.
Sin embargo, los resultados de los estudios epidemiológicos no son
definitivos en este sentido, haciéndose necesario llevar a cabo más
estudios de este tipo, que estén bien diseñados para poder llegar a una
conclusión firme a la hora de relacionar la exposición a PQ y la PD.
En esta revisión se analizan críticamente los estudios que tratan de
relacionar al PQ en el parkinsonismo, con énfasis en los mecanismos
asociados con la inducción de muerte celular neuronal por esta
sustancia.Parkinson's disease (PD) is one of the most
common age related neurodegenerative diseases and affects millions
of people worldwide. Strong evidence supports the role of free
radicals, oxidative stress, mitochondrial dysfunctions and protein
aggregation underlying neuronal death in PD. Environmental factors,
especially pesticides represent one of the main groups of neurotoxic
agents associated with PD. Pesticide toxicity has been clearly
demonstrated to alter a variety of neurological functions. Particularly,
there is strong evidence suggesting that pesticide exposure
predisposes to neurodegenerative diseases (amyotrophic lateral
sclerosis, Huntington's disease, etc.). Indeed, epidemiological data
have suggested a relationship between pesticide exposure and brain
neurodegeneration. Highlighting the observed relationship between
paraquat (PQ) and PD in experimental studies with rodents in which
lesions are seen in the substantia nigra pars compacta. However, the
results of epidemiological studies are not conclusive in this regard, making it necessary to design further epidemiological studies to reach
evidences in linking exposure to PQ and PD. In this paper, we analyze
critically studies attempting to relate the PQ in Parkinsonism, with
emphasis on the mechanisms associated with the induction of
neuronal cell death by this substance
Anisotropic flow of charged hadrons, pions and (anti-)protons measured at high transverse momentum in Pb-Pb collisions at TeV
The elliptic, , triangular, , and quadrangular, , azimuthal
anisotropic flow coefficients are measured for unidentified charged particles,
pions and (anti-)protons in Pb-Pb collisions at TeV
with the ALICE detector at the Large Hadron Collider. Results obtained with the
event plane and four-particle cumulant methods are reported for the
pseudo-rapidity range at different collision centralities and as a
function of transverse momentum, , out to GeV/.
The observed non-zero elliptic and triangular flow depends only weakly on
transverse momentum for GeV/. The small dependence
of the difference between elliptic flow results obtained from the event plane
and four-particle cumulant methods suggests a common origin of flow
fluctuations up to GeV/. The magnitude of the (anti-)proton
elliptic and triangular flow is larger than that of pions out to at least
GeV/ indicating that the particle type dependence persists out
to high .Comment: 16 pages, 5 captioned figures, authors from page 11, published
version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/186
Centrality dependence of charged particle production at large transverse momentum in Pb-Pb collisions at TeV
The inclusive transverse momentum () distributions of primary
charged particles are measured in the pseudo-rapidity range as a
function of event centrality in Pb-Pb collisions at
TeV with ALICE at the LHC. The data are presented in the range
GeV/ for nine centrality intervals from 70-80% to 0-5%.
The Pb-Pb spectra are presented in terms of the nuclear modification factor
using a pp reference spectrum measured at the same collision
energy. We observe that the suppression of high- particles strongly
depends on event centrality. In central collisions (0-5%) the yield is most
suppressed with at -7 GeV/. Above
GeV/, there is a significant rise in the nuclear modification
factor, which reaches for GeV/. In
peripheral collisions (70-80%), the suppression is weaker with almost independently of . The measured nuclear
modification factors are compared to other measurements and model calculations.Comment: 17 pages, 4 captioned figures, 2 tables, authors from page 12,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/284
Measurement of charm production at central rapidity in proton-proton collisions at TeV
The -differential production cross sections of the prompt (B
feed-down subtracted) charmed mesons D, D, and D in the rapidity
range , and for transverse momentum GeV/, were
measured in proton-proton collisions at TeV with the ALICE
detector at the Large Hadron Collider. The analysis exploited the hadronic
decays DK, DK, DD, and their charge conjugates, and was performed on a
nb event sample collected in 2011 with a
minimum-bias trigger. The total charm production cross section at TeV and at 7 TeV was evaluated by extrapolating to the full phase space
the -differential production cross sections at TeV
and our previous measurements at TeV. The results were compared
to existing measurements and to perturbative-QCD calculations. The fraction of
cdbar D mesons produced in a vector state was also determined.Comment: 20 pages, 5 captioned figures, 4 tables, authors from page 15,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/307
Two-pion Bose-Einstein correlations in central Pb-Pb collisions at = 2.76 TeV
The first measurement of two-pion Bose-Einstein correlations in central Pb-Pb
collisions at TeV at the Large Hadron Collider is
presented. We observe a growing trend with energy now not only for the
longitudinal and the outward but also for the sideward pion source radius. The
pion homogeneity volume and the decoupling time are significantly larger than
those measured at RHIC.Comment: 17 pages, 5 captioned figures, 1 table, authors from page 12,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/388
Suppression of charged particle production at large transverse momentum in central Pb-Pb collisions at TeV
Inclusive transverse momentum spectra of primary charged particles in Pb-Pb
collisions at = 2.76 TeV have been measured by the ALICE
Collaboration at the LHC. The data are presented for central and peripheral
collisions, corresponding to 0-5% and 70-80% of the hadronic Pb-Pb cross
section. The measured charged particle spectra in and GeV/ are compared to the expectation in pp collisions at the same
, scaled by the number of underlying nucleon-nucleon
collisions. The comparison is expressed in terms of the nuclear modification
factor . The result indicates only weak medium effects ( 0.7) in peripheral collisions. In central collisions,
reaches a minimum of about 0.14 at -7GeV/ and increases
significantly at larger . The measured suppression of high- particles is stronger than that observed at lower collision energies,
indicating that a very dense medium is formed in central Pb-Pb collisions at
the LHC.Comment: 15 pages, 5 captioned figures, 3 tables, authors from page 10,
published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/98
Particle-yield modification in jet-like azimuthal di-hadron correlations in Pb-Pb collisions at = 2.76 TeV
The yield of charged particles associated with high- trigger
particles ( GeV/) is measured with the ALICE detector in
Pb-Pb collisions at = 2.76 TeV relative to proton-proton
collisions at the same energy. The conditional per-trigger yields are extracted
from the narrow jet-like correlation peaks in azimuthal di-hadron correlations.
In the 5% most central collisions, we observe that the yield of associated
charged particles with transverse momenta GeV/ on the
away-side drops to about 60% of that observed in pp collisions, while on the
near-side a moderate enhancement of 20-30% is found.Comment: 15 pages, 2 captioned figures, 1 table, authors from page 10,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/350
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