The Index to the Library Chronicle

This is a twenty-seven-year (1970-1997) cumulative index to The Library Chronicle. From 1970 to 1989, The Library Chronicle published New Series Numbers 1 through 48. In 1990, the journal began identifying issues by volume and number, beginning with Volume 20. This index includes New Series Numbers 1-48 (1970-1989) and Volumes 20-27 (1990-1997). The index consists of two parts: the Index to Authors of Journal Articles and the Subject Index. All entries are alphabetized word-by-word.Webster, LindaInformatio

Neurodegeneration in ataxia-telangiectasia: Multiple roles of ATM kinase in cellular homeostasis

Ataxia‐telangiectasia (A‐T) is characterized by neuronal degeneration, cancer, diabetes, immune deficiency, and increased sensitivity to ionizing radiation. A‐T is attributed to the deficiency of the protein kinase coded by the ATM (ataxia‐telangiectasia mutated) gene. ATM is a sensor of DNA double‐strand breaks (DSBs) and signals to cell cycle checkpoints and the DNA repair machinery. ATM phosphorylates numerous substrates and activates many cell‐signaling pathways. There has been considerable debate about whether a defective DNA damage response is causative of the neurological aspects of the disease. In proliferating cells, ATM is localized mainly in the nucleus; however, in postmitotic cells such as neurons, ATM is mostly cytoplasmic. Recent studies reveal an increasing number of roles for ATM in the cytoplasm, including activation by oxidative stress. ATM associates with organelles including mitochondria and peroxisomes, both sources of reactive oxygen species (ROS), which have been implicated in neurodegenerative diseases and aging. ATM is also associated with synaptic vesicles and has a role in regulating cellular homeostasis and autophagy. The cytoplasmic roles of ATM provide a new perspective on the neurodegenerative process in A‐T. This review will examine the expanding roles of ATM in cellular homeostasis and relate these functions to the complex A‐T phenotype.Griffith Health, School of MedicineNo Full Tex