Unfamiliar territory: alternative landscape reading of disturbed sites’ particularities

In an age when it is becoming increasingly apparent that disturbed sites (or any other sites for that matter) can never be fully managed, nor can their future development be entirely predetermined, this paper looks at disturbed sites’ landscape as a complex and metastable  system. While it deals with disturbed sites in particular, more broadly it aims to encourage a general re-examination of landscape design that relies on the world in harmonious balance and the experience of visual pleasure, which, according to long-established structures, may please or offer timeless experiences but in most cases hold little power and no potential to change, enhance or diminish (our own) bodily capacities to act – to stimulate thought, influence ideas, judgements and desires. In order to explore ways of moving away from the desire for a stable portrayal of ‘the natural’ that often motivates disturbed sites’ immediate ecological remediation and later programmatic transformation, the paper firstly, in order to clarify the understanding of the proposed alternative, imagines landscapes where such an approach is driven to extreme. Next, it places focus on the concept of territory and through the processes behind territory-making argues for a rethinking of the common ways of reading, intervening in and representing complex (in this case disturbed) sites. Alongside this, it proposes a reinterpretation of the notion of place, presents an alternative search for ‘the specific’ and questions what could specificity, once cleared of any ‘essence’, actually stand for. Ideas and concepts developed throughout this paper begin with writings on territory by Deleuze and Guattari on one side, with further elaborations by Bogue, Brighenti, Grosz, and others. On the other side, ideas of post-humanism and new materialism provide a new view on disturbed sites to broaden the conception of territory as a relational, process-driven and open-ended mode of organization. They are accompanied by diagrammatic mappings that describe and analyse a very particular place – Fort de Vaujours, an abandoned uranium-contaminated site near Paris

Unfamiliar territory: alternative landscape reading of disturbed sites’ particularities

In an age when it is becoming increasingly apparent that disturbed sites (or any other sites for that matter) can never be fully managed, nor can their future development be entirely predetermined, this paper looks at disturbed sites’ landscape as a complex and metastable  system. While it deals with disturbed sites in particular, more broadly it aims to encourage a general re-examination of landscape design that relies on the world in harmonious balance and the experience of visual pleasure, which, according to long-established structures, may please or offer timeless experiences but in most cases hold little power and no potential to change, enhance or diminish (our own) bodily capacities to act – to stimulate thought, influence ideas, judgements and desires.In order to explore ways of moving away from the desire for a stable portrayal of ‘the natural’ that often motivates disturbed sites’ immediate ecological remediation and later programmatic transformation, the paper firstly, in order to clarify the understanding of the proposed alternative, imagines landscapes where such an approach is driven to extreme. Next, it places focus on the concept of territory and through the processes behind territory-making argues for a rethinking of the common ways of reading, intervening in and representing complex (in this case disturbed) sites. Alongside this, it proposes a reinterpretation of the notion of place, presents an alternative search for ‘the specific’ and questions what could specificity, once cleared of any ‘essence’, actually stand for.Ideas and concepts developed throughout this paper begin with writings on territory by Deleuze and Guattari on one side, with further elaborations by Bogue, Brighenti, Grosz, and others. On the other side, ideas of post-humanism and new materialism provide a new view on disturbed sites to broaden the conception of territory as a relational, process-driven and open-ended mode of organization. They are accompanied by diagrammatic mappings that describe and analyse a very particular place – Fort de Vaujours, an abandoned uranium-contaminated site near Paris

Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci.

Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a novel genetic pleiotropy-informed conditional False Discovery Rate (FDR) method to identify single nucleotide polymorphisms (SNPs) associated with BMD by leveraging cardiovascular disease (CVD) associated disorders and metabolic traits. By conditioning on SNPs associated with the CVD-related phenotypes, type 1 diabetes, type 2 diabetes, systolic blood pressure, diastolic blood pressure, high density lipoprotein, low density lipoprotein, triglycerides and waist hip ratio, we identified 65 novel independent BMD loci (26 with femoral neck BMD and 47 with lumbar spine BMD) at conditional FDR < 0.01. Many of the loci were confirmed in genetic expression studies. Genes validated at the mRNA levels were characteristic for the osteoblast/osteocyte lineage, Wnt signaling pathway and bone metabolism. The results provide new insight into genetic mechanisms of variability in BMD, and a better understanding of the genetic underpinnings of clinical comorbidity

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

The effect of cardioprotective diet rich with natural antioxidants on chronic inflammation and oxidized LDL during cardiac rehabilitation in patients after acute myocardial infarction

Chronic inflammation, the fundamental pathogenetic process of atherosclerosis, can be modified by pharmacological and non-pharmacological measures as a part of secondary prevention after acute myocardial infarction (AMI). The aim of our study was to determine the effect of diet, rich with natural antioxidants, added to physical activity (as a part of cardiac rehabilitation (CR) program) on inflammatory markers and ox-LDL, a marker of oxidative stress, closely involved in the process of chronic inflammation. 41 male patients after AMI undergoing CR were divided into a diet group (supervised cardioprotective diet throughout the CR), and control group (CR without diet). We measured hsCRP, leucocytes, neutrophils, IL-6, oxLDL, exercise capacity and classic risk factors before and after CR program. Patients from the diet group presented with a significant decline in classic risk factors (BMI, waist circumference, waist to hip ratio, systolic blood pressure, heart rate, blood glucose, total cholesterol, LDL, TAG) and inflammatory markers (hsCRP, leucocytes, neutrophils) compared to control group. Furthermore, when studying nonsmokers, we observed significant decline of oxLDL in the diet group. The addition of cardioprotective diet, rich with natural antioxidants, to physical activity as a part of a CR program, positively modifies not just classic risk factors and exercise capacity, but also diminishes chronic inflammation markers. These effects, and oxLDL decline were most prominent in nonsmoking patients

The effect of cardioprotective diet rich with natural antioxidants on chronic inflammation and oxidized LDL during cardiac rehabilitation in patients after acute myocardial infarction

Background: Chronic inflammation, the fundamental pathogenetic process of atherosclerosis, can be modified by pharmacological and non-pharmacological measures as a part of secondary prevention after acute myocardial infarction (AMI). The aim of our study was to determine the effect of diet, rich with natural antioxidants, added to physical activity (as a part of cardiac rehabilitation (CR) program) on inflammatory markers and ox-LDL, a marker of oxidative stress, closely involved in the process of chronic inflammation. Methods: 41 male patients after AMI undergoing CR were divided into a diet group (supervised cardioprotective diet throughout the CR), and control group (CR without diet). We measured hsCRP, leucocytes, neutrophils, IL-6, oxLDL, exercise capacity and classic risk factors before and after CR program. Results: Patients from the diet group presented with a significant decline in classic risk factors (BMI, waist circumference, waist to hip ratio, systolic blood pressure, heart rate, blood glucose, total cholesterol, LDL, TAG) and inflammatory markers (hsCRP, leucocytes, neutrophils) compared to control group. Furthermore, when studying nonsmokers, we observed significant decline of oxLDL in the diet group. Conclusions: The addition of cardioprotective diet, rich with natural antioxidants, to physical activity as a part of a CR program, positively modifies not just classic risk factors and exercise capacity, but also diminishes chronic inflammation markers. These effects, and oxLDL decline were most prominent in nonsmoking patients

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P &lt; 5 x 10&lt;sup&gt;-8&lt;/sup&gt;)). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P &lt; 5 x 10&lt;sup&gt;-4&lt;/sup&gt;), Bonferroni corrected), of which six reached P &lt; 5 x 10&lt;sup&gt;-8&lt;/sup&gt;, including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility