IMPACT OF GERANIOL ON CYCLOPHOSPHAMIDE PROVOKED CARDIOTOXIC PROPERTIES–AN IN VIVO STUDY

Objective: Toxicity profiles of diverse anti-neoplastic drugs are extensively documented in past decades and the protective role of natural products against such toxic drugs plays a vital role in the evolution of chemoprevention. Globally, Cyclophosphamide (CYP) is used as an anticancer drug, but now it has been limited due to its acute and chronic cardio toxicity. Hence the present study was designed to investigate the protective role of Geraniol (GOH) against CYP induced cardio toxicity.Methods: The activity of serum marker enzymes and lipoprotein fractions, cardiac marker enzymes and lipid profiles as well as antioxidant status was done using standard procedures in vivo. In addition, optimum dosage of GOH was determined as obtained by the levels of serum marker enzymes for tissue damage and the pathological changes were assessed by histology.Results: Administration of CYP to rats results in hoisted levels of marker enzymes (in both serum and heart tissue) and reduced levels of antioxidants. GOH (200 mg/kg body weight) restrained the elevation of marker enzymes (in both serum and heart tissue) and augmented the levels of antioxidants. Moreover, histological observations added proofs to the protective role of GOH against cardiac damage.Conclusion: CYP administered pathological changes were attenuated by the oral treatment of GOH at a dose of 200 mg/kg body weight of rat and suggests that the cardioprotective effects could be related to up regulation of antioxidant mechanism. Conclusive outcome from our findings suggests that GOH might be a potential chemo preventive agent in attenuating drug induced cardio toxicity.Â

Potentials of immunonutrition in wound healing : a review

A delayed wound healing process can lead to detrimental complications in chronic wound patients such as tissue necrosis and systemic infections. Application of immunonutrition (IN) in experimental animal models and chronic wound patients has shown promising and improved wound healing processes. IN restores the supply of essential nutrients that are critical for cell growth and tissue repair in the wounded subjects. Several commonly found nutrients in IN formulations include polyunsaturated fatty acids (PUFAs), essential amino acids, trace elements such as zinc and vitamins. Recently, some studies suggested the use of traditionally used herbs like curcumin in IN recipes due to its efficient wound healing properties. The roles and functions of IN in wound healing encompass recruitment of white blood cells, platelets and fibroblasts into the wounded area during the coagulation and inflammation phases, enhancement of fibroblast proliferation, collagen synthesis and neovascularization in the proliferation phase; and lastly, regulation of tissue re-epithelization for wound closure and recovery. In this review, the roles and functions of individual nutrients were deliberately discussed alongside their mechanisms of action in wound healing. This aims to provide a more holistic insight into the potentials of those nutrients when used as part of IN for major wound patients. Despite its remarkable effects in wound healing, several criteria should be considered in an IN formulation: the type and severity of wounds, administration timing and mode of administration, and concoction of immune-boosting nutrients in order to ensure the optimal wound healing effects

Pulp treatment for extensive decay in primary teeth

International audienceIn children, dental caries (tooth decay) is among the most prevalent chronic diseases worldwide. Pulp interventions are indicated for extensive tooth decay. Depending on the severity of the disease, three pulp treatment techniques are available: direct pulp capping, pulpotomy and pulpectomy. After treatment, the cavity is filled with a medicament. Materials commonly used include mineral trioxide aggregate (MTA), calcium hydroxide, formocresol or ferric sulphate.This is an update of a Cochrane Review published in 2014 when insufficient evidence was found to clearly identify one superior pulpotomy medicament and technique