Three Cube

The objective of this project is to create a three-song world fusion/experimental EP with folk songs from three different regions around the world.https://remix.berklee.edu/graduate-studies-production-technology/1091/thumbnail.jp

On the height variation of the E-region cowling conductivity ? effect of charged dust particles

International audienceHeight profiles of the Cowling conductivity in the electrojet region, estimated using the atmospheric parameters given by the existing models like CIRA or MSIS and measured electron density profiles, consistently show the heights of the electrojet current intensity peak to be more than 3 km below those estimated from in-situ measurements using magnetometers on board sounding rockets. Kulkarni and Muralikrishna (2005) attempted to explain this to be due to the effect of neutral dust particles. They reported that neutral dust particles, when they exist in sufficient numbers, can modify the collision parameters, especially in the lower E-region, where dust particles of meteoric origin are known to exist in large numbers, and thereby can modify the Cowling conductivity profile in the electrojet region. This work is extended here to include the effect of charged dust particles. Dust particles can become charged negatively by the attachment of ambient free electrons, and can thus reduce the number density of free electrons especially below the electrojet peak. This can alter the vertical profile of the east-west Hall current driven by the vertical Hall polarization field, thereby causing a net reduction in the electrojet current. Such a decrease in the electrojet current may be observed on the ground magnetograms. This mechanism, as proposed here, can operate only during periods of strong meteor shower activity, when the dust particle density at the assumed deposit height of 103 km can reach extreme values (for example, 5×104 cm?3 of 1-µm diameter dust particles). Such a dense dust layer may even cause a reversal in the normally upward vertical Hall polarization field, within the dust layer, causing a reversal of the electrojet currents below the current peak

Crude Birth Rate and Crude Mortality Rate in India: A Case of Application of Regression in Healthcare

India’s demographic transition in 1950 has led to decline of high birth and mortality rate to 6.5%, a drop of 0.6% in 2016–2017, as per the economic survey (2017–2018). The crude birth rate and crude mortality rate decreases with the occupation. In this study, the statistical parameter, confidence interval indicates the true range of the mean of the crude birth rate and crude mortality rate computed from the observed data in the study. Location and precision of a measure are made available with the confidence interval. In the study, the results for crude birth rate in 1984 were highest, 95% CI = 32.08–39.22, and in 2011, were lowest, 95% CI = 20.68–25.24, and the results for crude mortality rate in 1984 were highest, 95% CI = 32.08–39.22, and in 2011 were lowest, 95% CI = 20.68–25.24. A small standard error implies that the sample mean is a more accurate reflection of the actual population mean. The smallest standard error of crude birth rate is 1.08, and the smallest standard error of crude mortality rate is 0.50

Harnessing Wisdom for Managing Watersheds: Honey Bee Perspective on Innovations, Institutions and Policies for Marginal Environments

Participatory approaches for watershed management are now considered essential for sustainable natural resources management and yet there is very little opportunity for intellectual participation by the people. This requires understanding of the local knowledge systems and their institutional context. In this paper, we provide an overview of the conceptual framework which can facilitate such participation. The full report being published separately includes case studies of farmers’ innovations in natural resources management.

Natural Frequency of Vibrating Foundations on Layered Soil System-An Experimental Investigation

This paper presents model block vibration tests results on two and three layered soil system underlain by rigid layer. Using sand and sawdust in different positions (either at top or at middle or at bottom) and thickness (es) inside a tank, different layered soil bed are prepared and vibration tests are conducted on each prepared bed using Lazan Type oscillator. A large number of response curves (frequency vs. amplitude) are obtained on different layered system. Maximum amplitudes (resonant amplitude) and corresponding frequencies (resonant frequency) are tabulated to study the effect of layering on resonant frequencies. Effects of position and thickness (es) of the layer/layers on natural frequencies are found to be significant, Natural frequency increases significantly due to presence of thin stiff layer at top compared to natural frequency of bottom layer treating it to be half space whereas it decreases significantly due presence of thin soft layer at top. Several other significant observations are made and presented in the paper. Natural frequencies of the soil foundation on different layered soil systems used for the experimental investigations are predicted using static equivalent stiffness of the system and compared with experimental results. Predicted results are found to be in good agreement with the experimental results

The ECG changes in various comorbidities with hypertension and without hypertension

Background: Hypertension is the commonest cardiovascular disorder posing a challenge to the societies in socioeconomic and epidemiologic transition. In India, Cardiovascular Diseases (CVDs) are estimated to be responsible for 1.5 million deaths annually. Indeed, it is estimated that by 2020, CVDs will be the largest cause of mortality and morbidity in India. To present study is designed to evaluate the variation of blood pressure and ECG wave forms among people hypertension with co morbidities (study group) and controls.Methods: The study included 50 people comorbidities with hypertension and 50 controls, each between ages 30-40 years from general population, and also from Medicine outpatient department, KIMS and RF Amalapuram. Detailed history from subjects, blood pressure (sitting position) and electrocardiogram was recorded during resting state in supine position. The ECG results were evaluated for various parameters like heart rate, P wave, PR interval, QRS complex etc.Results: There was significant increase in heart rate, systolic blood pressure as well as diastolic blood pressure in study group when compared to controls. Decrease in PR interval, decrease in QT interval, decrease in QTc interval, decrease in QRS axis in smokers when compared to controls.Conclusions: There was significant increase in heart rate in study group (smokers, diabetic) when compared to controls. There was significant increase in systolic blood pressure as well as diastolic blood pressure in study group (smokers, diabetics) when compared to controls. There was significant decrease in PR interval in smokers when compared to controls. There was significant decrease in QT and QTc interval in smokers when compared to controls

Lamins, laminopathies and disease mechanisms: possible role for proteasomal degradation of key regulatory proteins

Lamins are major structural proteins of the nucleus and are essential for nuclear integrity and organization of nuclear functions. Mutations in the human lamin genes lead to highly degenerative genetic diseases that affect a number of different tissues such as muscle, adipose or neuronal tissues, or cause premature ageing syndromes. New findings on the role of lamins in cellular signalling pathways, as well as in ubiquitin-mediated proteasomal degradation, have given important insights into possible mechanisms of pathogenesis

The Polylogarithm and the Lambert W Functions in Thermoelectrics

In this work, we determine the conditions for the extremum of the figure of merit, theta2, in a degenerate semiconductor for thermoelectric (TE) applications. We study the variation of the function theta2 with respect to the reduced chemical potential mu* using relations involving polylogarithms of both integral and nonintegral orders. We present the relevant equations for the thermopower, thermal, and electrical conductivities that result in optimizing theta2 and obtaining the extremum equations. We discuss the different cases that arise for various values of r, which depends on the type of carrier scattering mechanism present in the semiconductor. We also present the important extremum conditions for theta2 obtained by extremizing the TE power factor and the thermal conductivity separately. In this case, simple functional equations, which lead to solutions in terms of the Lambert W function, result. We also present some solutions for the zeros of the polylogarithms. Our analysis allows for the possibility of considering the reduced chemical potential and the index r of the polylogarithm as complex variables

Method Development and Method Validation for Ramipril and Telmisartan by RP-HPLC in Pharmacentical Dosage form.

The present study from the literature survey conducted, it was found that there are few analytical methods reported for Ramipril and Telmisartan by reverse phase HPLC method alone or in combination with other drugs. Presently the new formulation of Ramipril and Telmisartan is available in market. There are only few methods reported for the determination of Ramipril and Telmisartan in combined pharmaceutical dosage form. So it was felt that there is a need to develop a sensitive analytical method for the simultaneous estimation of Ramipril and Telmisartan in Tablet dosage form available in market. AIM: To develop a sensitive, simple, rapid and accurate analytical method for the simultaneous estimation of Ramipril and Telmisartan in formulations and validation of developed method by using RP-HPLC technique. OBJECTIVE: The scope of developing and validating method is to ensure a suitable strategy for a particular analyte which is more specific, accurate and precise. Here the main focus is drawn to achieve improvement in conditions and standard operating procedures to be followed. To develop a method that is rapid, sensitive and at the same time cost effective. CONCLUSION: From the reported literature, there were few methods established for the determination of Ramipril and Telmisartan in individual and in combination with other drug. It was concluded that there were only few methods reported for the simultaneous estimation of the above selected multi component dosage form, which promote to pursue the present work. The scope and objective of the present work is to develop and validate a new simple RP-HPLC method for simultaneous estimation of Ramipril and Telmisartan in combined dosage form. In simultaneous RP-HPLC method development, Waters 2695 Separations Module with PDA Detector and column used is C8 SB ZORBAX (150 X 4.6mm) column with3.5-micron particle size. Injection volume of 10 μL is injected and eluted with the mobile phase selected after optimization was Phosphate buffer and Acetonitrile in the ratio of 70:30 was found to be ideal. The flow rate was found to be optimized at 1.0 mL/min. Detection was carried out at 230 nm. This system produced symmetric peak shape, good resolution and reasonable retention times of Ramipril and Telmisartan were found to be 2.275 and 4.261 minutes respectively. The Ramipril and Telmisartan showed linearity in the range of 20-60 μg/mL and 160-480 μg/mL respectively. Precision of the developed method was studied under system precision and method precision. The %RSD values for precision was found to be within the acceptable limit, which revealed that the developed method was precise. The developed method was found to be robust. The %RSD value for percentage recovery of Ramipril and Telmisartan was found to be within the acceptance criteria. The results indicate satisfactory accuracy of method for simultaneous estimation of the Ramipril and Telmisartan

Expression of disease-causing lamin A mutants impairs the formation of DNA repair foci

A-type lamins are components of the nuclear lamina. Mutations in the gene encoding lamin A are associated with a range of highly degenerative diseases termed laminopathies. To evaluate sensitivity to DNA damage, GFP-tagged lamin A cDNAs with disease-causing mutations were expressed in HeLa cells. The inner nuclear membrane protein emerin was mislocalised upon expression of the muscular dystrophy mutants G232E, Q294P or R386K, which aberrantly assembled into nuclear aggregates, or upon expression of mutants causing progeria syndromes in vivo (lamin A del50, R471C, R527C and L530P). The ability of cells expressing these mutants to form DNA repair foci comprising phosphorylated H2AX in response to mild doses of cisplatin or UV irradiation was markedly diminished, unlike the nearly normal response of cells expressing wild-type GFP-lamin A or disease-causing H222P and R482L mutants. Interestingly, mutants that impaired the formation of DNA repair foci mislocalised ATR (for 'ataxia telangiectasia-mutated and Rad3-related') kinase, which is a key sensor in the response to DNA damage. Our results suggest that a subset of lamin A mutants might hinder the response of components of the DNA repair machinery to DNA damage by altering interactions with chromatin