Transdiagnostic model of psychological factors and sex differences in depression in a large sample of Ecuador

Background/Objective: depression represents a leading cause of disability and a major contributor to the overall global burden of disease with women systematically reporting a higher prevalence than men. This study aimed to examine the predictive value and relation of three transdiagnostic psychological factors (perceived stress, psychological inflexibility and loneliness) on depression and its sex differences for the general population in a large sample of Ecuador. Method: a non-probabilistic and non-clinical sample of 16.074 people from across Ecuador were online surveyed using a cross-sectional design. The structural equation model was based on scores from standardized questionnaires as measures of depression, psychological perceived stress, psychological inflexibility, and loneliness. Results: women reported significantly higher levels of depression, mediated by differences in perceived stress, psychological inflexibility and loneliness. Perceived stress was the most important predictor of depression and mediated the effect of loneliness on depression. Complementarily, psychological inflexibility partially mediated the effect of perceived stress and loneliness on depression. The overall model accounted for the 78% of the total variance in depression. Conclusions: results of this study provide a novel and robust transdiagnostic model of sex differences on depression and insights on how to design effective programs for preventing depression targeting modifiable transdiagnostic risk factors.The study was funded by the Particular Technical University of Loja (Ecuador) (PROY-INV-PSI2020-2781). Additional funding to P.R. was provided by the European Union— 'NextGenerationEU' through the Grant for the Requalification of the Spanish University System for 2021-2023 at the Public University of Navarra (Resolution 1402/2021)

Revision of the New World Genus Crassomicrodus Ashmead (Hymenoptera, Braconidae, Agathidinae), with an Identification Key to Species

A key to species and descriptions are presented for 14 species of the New World genus Crassomicrodus Ashmead. Seven new species, Crassomicrodus azteca, Crassomicrodus clypealis, Crassomicrodus costaricensis, Crassomicrodus jalisciensis, Crassomicrodus mariae, Crassomicrodus oaxaquensis,and Crassomicrodus olgae are described. Crassomicrodus fenestratus (Viereck) is synonymized with Crassomicrodus nigriceps (Cresson). Crassomicrodus melanopleurus (Ashmead) is recognized as a valid species

Desenho e validação do questionário para avaliação da qualidade percebida na gestão esportiva do futebol feminino

The purpose of this study is to design and validate the creation of the questionnaire for the evaluation of the perceived quality in the sports management of women's soccer. The sampling was intentional for convenience, with a total of 332 soccer players and an age range between 18 and 51 years (M = 20.92; SD = 3.59). Construct validity analyses were carried out using an exploratory factor analysis (EFA) as well as a confirmatory factor analysis (CFA) followed by reliability analysis and extracted mean-variance. The instrument created was the GEDECAFF. The result of the factor analysis showed 36 items divided into 4 factors: (1) Interaction with a coach, (2) Facilities, (3) Personal service, and (4) Institutional; the relevance indicators were adequate, explaining 76.25% of the total variance. The fit and error indices are adequate CFI = .90, TLI = .89, and RMSEA = .07, regarding the χ2/df = 2.17. The results show that Cronbach's Alpha and McDonald's Omega by factors is above .90. In conclusion, the GEDECAFF questionnaire presents the appropriate psychometric properties and meets the needs of the services offered by the different women's soccer clubs, opening an opportunity for continuous improvement in the quality of service in women's soccer.El objetivo del presente trabajo es diseñar y validar la creación del cuestionario de evaluación de la calidad percibida en la gestión deportiva del futbol femenil. El muestreo fue intencional por conveniencia, con un total de 332 jugadoras y un rango de edad de entre los 18 y 51 años (M = 20.92; DE = 3.59). Se llevaron a cabo análisis de validez de constructo por medio de un análisis factorial exploratorio (AFE) así como un análisis factorial confirmatorio (AFC) seguido de análisis de fiabilidad y varianza media extractada. El instrumento creado fue el GEDECAFF. Los resultados de los análisis factoriales mostraron 36 ítems divididos en 4 factores: (1) Interacción con el entrenador, (2) Instalaciones, (3) Servicio de personal e (4) Institucional; los indicadores de pertinencia fueron apropiados y explican el 76.25% de la varianza total. Los índices de ajuste, error y chi cuadrado son adecuados CFI = .90, TLI = .89 y RMSEA = .07, χ2/gl = 2.17. Los resultados muestran que Alfa de Cronbach y Omega de McDonald por factores está por encima de .90. En conclusión, el cuestionario GEDECAFF presenta las propiedades psicométricas satisfactorias y atiende las necesidades de los servicios ofrecidos por los distintos clubes, dando oportunidad a la mejora continua de la calidad del servicio en el futbol femenil.O objetivo deste estudo foi validar a criação do questionário para avaliação da qualidade percebida na gestão desportiva do futebol feminino. A amostra foi intencional por conveniência, com um total de 332 jogadores de futebol e faixa etária entre 18 e 51 anos (M = 20,92; DP = 3,59). As análises de validade de construto foram realizadas por meio de uma análise fatorial exploratória (EFA), bem como uma análise fatorial confirmatória (CFA), seguida de análise de confiabilidade e variância média extraída. O instrumento criado foi o GEDECAFF. Os resultados das análises fatoriais mostraram 36 itens divididos em 4 fatores: (1) Interação com o formador, (2) Instalações, (3) Atendimento Pessoal e (4) Institucional; os indicadores de relevância foram adequados, explicando 76,25% da variância total. Os índices de ajuste e erro são adequados CFI = .90, TLI = .89 e RMSEA = .07, em relação ao χ2/df = 2.17. Os resultados mostram que o Alfa de Cronbach e o ômega do McDonald's por fatores estão acima de 0,90. Em conclusão, o questionário GEDECAFF apresenta as propriedades psicométricas adequadas e atende às necessidades dos serviços oferecidos pelos diferentes clubes de futebol feminino, abrindo uma oportunidade de melhoria contínua na qualidade do serviço no futebol feminino

Predictors of right atrial dilatation and long-term function after right ventricular outflow tract surgical repair: Quantification of restrictive physiology matters

Right diastolic dysfunction; Right atrium function; Restrictive physiologyDisfunción diastólica derecha; Función de la aurícula derecha; Fisiología restrictivaDisfunció diastòlica dreta; Funció de l'aurícula dreta; Fisiologia restrictivaRight ventricular (RV) diastolic dysfunction in patients with a surgically-repaired RV outflow tract (RVOT) obstruction merits further studies. Right atrial (RA) dilation and function may be related to (RV) diastolic dysfunction in this setting. The end-diastolic forward flow (EDFF) in the pulmonary artery (PA) has been suggested as a non-invasive marker of poor RV compliance, however, there is controversy regarding its true significance; EDFF quantification may help elucidate this controversy. Objective to study predictors of RA enlargement and dysfunction in patients with a surgically-repaired RVOT obstruction and its relationship with quantitative EDFF. Methods In 81 consecutive patients (mean age: 37.5 (±7) years), transthoracic echocardiography (Echo) and cardiac magnetic resonance (CMR) were performed. Echo parameters: RA size (indexed RA area (iRAA)), RA function (RA global strain (RAGS)) and maximum EDFF velocity-time integral (VTI-EDFF) obtained during a whole respiratory cycle. CMR-indexed RA area (imRAA) was also obtained. Patients were divided into three groups according to iRAA, imRAA and RAGS; bivariate analysis was performed. A multivariate model was then applied using variables that were found to be statistically significant in the bivariate analysis. Results Upon multivariate analysis, higher VTI-EDFF values and the presence of significant tricuspid regurgitation proved to be independent factors associated with increased iRAA and imRAA and lower RAGS, whereas RV volumes, function and pulmonary regurgitant fraction were not. Conclusion VTI-EDFF linearly correlated with the degree of RA dilation and deformation; EDFF quantification as against qualitative assessment may be considered a non-invasive tool for diastolic RV dysfunction

Germline Mutations in FAN1 Cause Hereditary Colorectal Cancer by Impairing DNA Repair

Identification of genes associated with hereditary cancers facilitates management of patients with family histories of cancer. We performed exome sequencing of DNA from 3 individuals from a family with colorectal cancer who met the Amsterdam criteria for risk of hereditary nonpolyposis colorectal cancer. These individuals had mismatch repair-proficient tumors and each carried nonsense variant in the FANCD2/FANCI-associated nuclease 1 gene (FAN1), which encodes a nuclease involved in DNA inter-strand cross-link repair. We sequenced FAN1 in 176 additional families with histories of colorectal cancer and performed in vitro functional analyses of the mutant forms of FAN1 identified. We detected FAN1 mutations in approximately 3% of families who met the Amsterdam criteria and had mismatch repair-proficient cancers with no previously associated mutations. These findings link colorectal cancer predisposition to the Fanconi anemia DNA repair pathway, supporting the connection between genome integrity and cancer risk

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Funder: Funder: Fundación bancaria ‘La Caixa’ Number: LCF/PR/PR16/51110003 Funder: Grifols SA Number: LCF/PR/PR16/51110003 Funder: European Union/EFPIA Innovative Medicines Initiative Joint Number: 115975 Funder: JPco-fuND FP-829-029 Number: 733051061Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI