132 research outputs found
Active Inhibition of Plasma Cell Development in Resting B Cells by Microphthalmia-associated Transcription Factor
B cell terminal differentiation involves development into an antibody-secreting plasma cell, reflecting the concerted activation of proplasma cell transcriptional regulators, such as Blimp-1, IRF-4, and Xbp-1. Here, we show that the microphthalmia-associated transcription factor (Mitf) is highly expressed in naive B cells, where it antagonizes the process of terminal differentiation through the repression of IRF-4. Defective Mitf activity results in spontaneous B cell activation, antibody secretion, and autoantibody production. Conversely, ectopic Mitf expression suppresses the expression of IRF-4, the plasma cell marker CD138, and antibody secretion. Thus, Mitf regulates B cell homeostasis by suppressing the antibody-secreting fate
SH2D1A Regulates T-dependent Humoral Autoimmunity
The signaling lymphocytic activation molecule (SLAM)/CD150 family includes a family of chromosome 1âencoded cell surface molecules with costimulatory functions mediated in part by the adaptor protein SH2D1A (SLAM-associated protein, SAP). Deficiency in SH2D1A protects mice from an experimental model of lupus, including the development of hypergammaglobulinemia, autoantibodies including antiâdouble stranded DNA, and renal disease. This protection did not reflect grossly defective T or B cell function per se because SH2D1A-deficient mice were susceptible to experimental autoimmune encephalomyelitis, a T cellâdependent disease, and they were capable of mounting normal T-independent antigen-specific immunoglobulin responses. Instead, T-dependent antibody responses were impaired in SH2D1A-deficient mice, reflecting defective germinal center formation. These findings demonstrate a specific role for the SLAMâSH2D1A system in the regulation of T-dependent humoral immune responses, implicating members of the CD150âSH2D1A family as targets in the pathogenesis and therapy of antibody-mediated autoimmune and allergic diseases
Adaptive Optics Imaging Survey of Luminous Infrared Galaxies
We present high resolution imaging observations of a sample of previously
unidentified far-infrared galaxies at z < 0.3. The objects were selected by
cross-correlating the IRAS Faint Source Catalog with the VLA FIRST catalog and
the HST Guide Star Catalog to allow for adaptive optics observations. We found
two new ULIGs (with L_FIR equal to or greater than 10^{12} L_sun) and 19 new
LIGs (with L_FIR equal to or greater than 10^{11} L_sun). Twenty of the
galaxies in the sample were imaged with either the Lick or Keck adaptive optics
systems in H or K'. Galaxy morphologies were determined using the two
dimensional fitting program GALFIT and the residuals examined to look for
interesting structure. The morphologies reveal that at least 30% are involved
in tidal interactions, with 20% being clear mergers. An additional 50% show
signs of possible interaction. Line ratios were used to determine powering
mechanism; of the 17 objects in the sample showing clear emission lines - four
are active galactic nuclei and seven are starburst galaxies. The rest exhibit a
combination of both phenomena.Comment: 29 pages, 8 figures, accepted for publication in A
Barred Galaxies in the Coma Cluster
We use ACS data from the HST Treasury survey of the Coma cluster (z~0.02) to
study the properties of barred galaxies in the Coma core, the densest
environment in the nearby Universe. This study provides a complementary data
point for studies of barred galaxies as a function of redshift and environment.
From ~470 cluster members brighter than M_I = -11 mag, we select a sample of
46 disk galaxies (S0--Im) based on visual classification. The sample is
dominated by S0s for which we find an optical bar fraction of 47+/-11% through
ellipse fitting and visual inspection. Among the bars in the core of the Coma
cluster, we do not find any very large (a_bar > 2 kpc) bars. Comparison to
other studies reveals that while the optical bar fraction for S0s shows only a
modest variation across low-to-intermediate density environments (field to
intermediate-density clusters), it can be higher by up to a factor of ~2 in the
very high-density environment of the rich Coma cluster core.Comment: Proceedings of the Bash symposium, to appear in the Astronomical
Society of the Pacific Conference Series, eds. L. Stanford, L. Hao, Y. Mao,
J. Gree
Evolution of the Color-Magnitude Relation in Galaxy Clusters at z ~1 from the ACS Intermediate Redshift Cluster Survey
We apply detailed observations of the Color-Magnitude Relation (CMR) with the
ACS/HST to study galaxy evolution in eight clusters at z~1. The early-type red
sequence is well defined and elliptical and lenticular galaxies lie on similar
CMRs. We analyze CMR parameters as a function of redshift, galaxy properties
and cluster mass. For bright galaxies (M_B < -21mag), the CMR scatter of the
elliptical population in cluster cores is smaller than that of the S0
population, although the two become similar at faint magnitudes. While the
bright S0 population consistently shows larger scatter than the ellipticals,
the scatter of the latter increases in the peripheral cluster regions. If we
interpret these results as due to age differences, bright elliptical galaxies
in cluster cores are on average older than S0 galaxies and peripheral
elliptical galaxies (by about 0.5Gyr). CMR zero point, slope, and scatter in
the (U-B)_z=0 rest-frame show no significant evolution out to redshift z~1.3
nor significant dependence on cluster mass. Two of our clusters display CMR
zero points that are redder (by ~2sigma) than the average (U-B)_z=0 of our
sample. We also analyze the fraction of morphological early-type and late-type
galaxies on the red sequence. We find that, while in the majority of the
clusters most (80% to 90%) of the CMR population is composed of early-type
galaxies, in the highest redshift, low mass cluster of our sample, the CMR
late-type/early-type fractions are similar (~50%), with most of the late-type
population composed of galaxies classified as S0/a. This trend is not
correlated with the cluster's X-ray luminosity, nor with its velocity
dispersion, and could be a real evolution with redshift.Comment: ApJ, in press, 27 pages, 22 figure
Stellar Masses of Lyman Break Galaxies, Lyman Alpha Emitters and Radio Galaxies in Overdense Regions at z=4-6
We present new information on galaxies in the vicinity of luminous radio
galaxies and quasars at z=4,5,6. These fields were previously found to contain
overdensities of Lyman Break Galaxies (LBGs) or spectroscopic Lyman alpha
emitters. We use HST and Spitzer data to infer stellar masses, and contrast our
results with large samples of LBGs in more average environments as probed by
the Great Observatories Origins Deep Survey (GOODS). The following results were
obtained. First, LBGs in both overdense regions and in the field at z=4-5 lie
on a very similar sequence in a z'-[3.6] versus [3.6] color-magnitude diagram.
This is interpreted as a sequence in stellar mass (log[M*/Msun] = 9-11) in
which galaxies become increasingly red due to dust and age as their star
formation rate (SFR) increases. Second, the two radio galaxies are among the
most massive objects (log[M*/Msun]~11) known to exist at z~4-5, and are
extremely rare based on the low number density of such objects as estimated
from the ~25x larger area GOODS survey. We suggest that the presence of these
massive galaxies and supermassive black holes has been boosted through rapid
accretion of gas or merging inside overdense regions. Third, the total stellar
mass found in the z=4 ``proto-cluster'' TN1338 accounts for <30% of the stellar
mass on the cluster red sequence expected to have formed at z>4, based on a
comparison with the massive X-ray cluster Cl1252 at z=1.2. Although future
near-infrared observations should determine whether any massive galaxies are
currently being missed, one possible explanation for this mass difference is
that TN1338 evolves into a smaller cluster than Cl1252. This raises the
interesting question of whether the most massive protocluster regions at z>4
remain yet to be discovered.Comment: The Astrophysical Journal, In Press (17 pages, 7 figures
The Galaxy Structure-Redshift Relationship
There exists a gradual, but persistent, evolutionary effect in the galaxy
population such that galaxy structure and morphology change with redshift. This
galaxy structure-redshift relationship is such that an increasingly large
fraction of all bright and massive galaxies at redshifts 2 < z < 3 are
morphologically peculiar at wavelengths from rest-frame ultraviolet to
rest-frame optical. There are however examples of morphologically selected
spirals and ellipticals at all redshifts up to z ~ 3. At lower redshift, the
bright galaxy population smoothly transforms into normal ellipticals and
spirals. The rate of this transformation strongly depends on redshift, with the
swiftest evolution occurring between 1 < z < 2. This review characterizes the
galaxy structure-redshift relationship, discusses its various physical causes,
and how these are revealing the mechanisms responsible for galaxy formation.Comment: 20 pages, 8 figures. Invited Review to appear in "Penetrating Bars
Through Masks of Cosmic Dust: The Hubble Tuning Fork Strikes A New Note", ed.
D. Block et a
Data and 2D scaling relations for galaxies in Abell 1689: a hint of size evolution at z~0.2
{abridged} We present imaging and spectroscopy of Abell 1689 (z=0.183) from
GEMINI/GMOS-N and HST/ACS. We measure integrated photometry from the GMOS g'
and r' images (for 531 galaxies) and surface photometry from the HST F625W
image (for 43 galaxies) as well as velocities and velocity dispersions from the
GMOS spectra (for 71 galaxies). We construct the Kormendy relation (KR),
Faber-Jackson relation (FJR) and colour-magnitude relation (CMR) for early-type
galaxies in Abell 1689 using this data and compare them to those of the Coma
cluster. We measure the intrinsic scatter of the CMR in Abell 1689 to be 0.054
\pm 0.004 mag which places degenerate constraints on the ratio of the assembly
timescale to the time available (beta) and the age of the population. Making
the assumption that galaxies in Abell 1689 will evolve into those of Coma over
an interval of 2.26 Gyr breaks this degeneracy and limits beta to be > 0.6 and
the age of the red sequence to be > 5.5 Gyr (formed at z > 0.55). Without
corrections for size evolution but accounting for magnitude cuts and selection
effects, the KR & FJR are inconsistent and disagree at the 2 sigma level
regarding the amount of luminosity evolution in the last 2.26 Gyr. However,
after correcting for size evolution the KR & FJR show similar changes in
luminosity (0.22 \pm 0.11 mag) that are consistent with the passive evolution
of the stellar populations from a single burst of star formation 10.2 \pm 3.3
Gyr ago (z = 1.8+inf-0.9). Thus the changes in the KR, FJR & CMR of Abell 1689
relative to Coma all agree and suggest old galaxy populations with little or no
synchronisation in the star formation histories. Furthermore, the weak evidence
for size evolution in the cluster environment in the last 2.26 Gyr places
interesting constraints on the possible mechanisms at work, favouring
harassment or secular processes over merger scenarios.Comment: Accepted for publication in MNRA
Improved constraints on the expansion rate of the Universe up to z~1.1 from the spectroscopic evolution of cosmic chronometers
We present new improved constraints on the Hubble parameter H(z) in the
redshift range 0.15 < z < 1.1, obtained from the differential spectroscopic
evolution of early-type galaxies as a function of redshift. We extract a large
sample of early-type galaxies (\sim11000) from several spectroscopic surveys,
spanning almost 8 billion years of cosmic lookback time (0.15 < z < 1.42). We
select the most massive, red elliptical galaxies, passively evolving and
without signature of ongoing star formation. Those galaxies can be used as
standard cosmic chronometers, as firstly proposed by Jimenez & Loeb (2002),
whose differential age evolution as a function of cosmic time directly probes
H(z). We analyze the 4000 {\AA} break (D4000) as a function of redshift, use
stellar population synthesis models to theoretically calibrate the dependence
of the differential age evolution on the differential D4000, and estimate the
Hubble parameter taking into account both statistical and systematical errors.
We provide 8 new measurements of H(z) (see Tab. 4), and determine its change in
H(z) to a precision of 5-12% mapping homogeneously the redshift range up to z
\sim 1.1; for the first time, we place a constraint on H(z) at z \neq 0 with a
precision comparable with the one achieved for the Hubble constant (about 5-6%
at z \sim 0.2), and covered a redshift range (0.5 < z < 0.8) which is crucial
to distinguish many different quintessence cosmologies. These measurements have
been tested to best match a \Lambda CDM model, clearly providing a
statistically robust indication that the Universe is undergoing an accelerated
expansion. This method shows the potentiality to open a new avenue in constrain
a variety of alternative cosmologies, especially when future surveys (e.g.
Euclid) will open the possibility to extend it up to z \sim 2.Comment: 34 pages, 15 figures, 6 tables, published in JCAP. It is a companion
to Moresco et al. (2012b, http://arxiv.org/abs/1201.6658) and Jimenez et al.
(2012, http://arxiv.org/abs/1201.3608). The H(z) data can be downloaded at
http://www.physics-astronomy.unibo.it/en/research/areas/astrophysics/cosmology-with-cosmic-chronometer
The Hubble Space Telescope Cluster Supernova Survey: V. Improving the Dark Energy Constraints Above z>1 and Building an Early-Type-Hosted Supernova Sample
We present ACS, NICMOS, and Keck AO-assisted photometry of 20 Type Ia
supernovae SNe Ia from the HST Cluster Supernova Survey. The SNe Ia were
discovered over the redshift interval 0.623 < z < 1.415. Fourteen of these SNe
Ia pass our strict selection cuts and are used in combination with the world's
sample of SNe Ia to derive the best current constraints on dark energy. Ten of
our new SNe Ia are beyond redshift , thereby nearly doubling the
statistical weight of HST-discovered SNe Ia beyond this redshift. Our detailed
analysis corrects for the recently identified correlation between SN Ia
luminosity and host galaxy mass and corrects the NICMOS zeropoint at the count
rates appropriate for very distant SNe Ia. Adding these supernovae improves the
best combined constraint on the dark energy density \rho_{DE}(z) at redshifts
1.0 < z < 1.6 by 18% (including systematic errors). For a LambdaCDM universe,
we find \Omega_\Lambda = 0.724 +0.015/-0.016 (68% CL including systematic
errors). For a flat wCDM model, we measure a constant dark energy
equation-of-state parameter w = -0.985 +0.071/-0.077 (68% CL). Curvature is
constrained to ~0.7% in the owCDM model and to ~2% in a model in which dark
energy is allowed to vary with parameters w_0 and w_a. Tightening further the
constraints on the time evolution of dark energy will require several
improvements, including high-quality multi-passband photometry of a sample of
several dozen z>1 SNe Ia. We describe how such a sample could be efficiently
obtained by targeting cluster fields with WFC3 on HST.Comment: 27 pages, 11 figures. Submitted to ApJ. This first posting includes
updates in response to comments from the referee. See
http://www.supernova.lbl.gov for other papers in the series pertaining to the
HST Cluster SN Survey. The updated supernova Union2.1 compilation of 580 SNe
is available at http://supernova.lbl.gov/Unio
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