Kinematic Performances Comparisons Between Galileo, GPS And Glonass Satellite Positioning Systems

The initial Galileo satellite positioning services, starting from the 15 December 2016, became available with a formal announcement of the European Commission. This was the first step toward the Galileo system Full Operational Capability (FOC) and allowed many researchers to test the new system. The aim of this paper is to show some results of kinematic tests involving a GNSS multi-constellation receiver able to acquire the Galileo Open Service (OS) signal. The acquired data were compared with the outputs obtained by a Mobile Mapping System (MMS) implementing integrated high-performance GPS/INS measurements. Using GrafNav software version 8.80 all the possible operative combinations were tested and analyzed. The results, referred to the performed experimental test, show that the new European system is characterized by a better planimetric performance with respect to the other systems whereas, from an altimetric point of view, the GPS and Glonass systems perform bette

APPLICAZIONI DEL SISTEMA SATELLITARE EUROPEO GALILEO ALLA NAVIGAZIONE TERRESTRE

Lo scopo dell’attività di ricerca è testare le prestazioni del sistema satellitare Galileo nelle applicazioni alla navigazione terrestre, rispetto ai sistemi GNSS GPS e GLONASS, analizzando l’accuratezza nel posizionamento cinematico e le precisioni ottenibili in diverse condizioni operative, confrontando i risultati con quelli ottenuti utilizzando strumentazione geodetica multi-costellazione in differenti configurazioni con le diverse costellazioni attualmente operative. Per verificare il miglioramento delle prestazioni del sistema satellitare Galileo legate all’avanzamento nell’implementazione del sistema, sono state pianificate a partire da dicembre 2019, nell’ambito del primo Grant del Progetto GRC-MS, delle campagne di misura con cadenza trimestrale. Per ogni campagna di misura sono stati svolti rilievi in due ambiti: ambito urbano ed ambito extraurbano. Le campagne di misura sono state condotte utilizzando il veicolo MMS (Mobile Mapping System) del GeoSNaV Lab, Università degli studi di Trieste. Per il posizionamento assoluto, il veicolo è dotato di un sistema POS/LV di Applanix Corporation®, un sistema di posizionamento e orientamento, con posizionamento GNSS integrato dalla tecnologia inerziale per generare soluzioni di posizionamento stabili, affidabili e ripetibili. Per l’acquisizione dei dati GNSS Galileo, GPS e GLONASS, a bordo del veicolo è stato installato un ricevitore GNSS multi-costellazione, e la relativa antenna fissata tra le due antenne GNSS del sistema POS/LV sul tetto del veicolo. Inoltre è stata eseguita l’analisi delle prestazioni raggiungibili da uno smartphone, capace di ricevere segnali GNSS, fissato anch’esso sul tetto del veicolo.The aim of the research activity is to test the performance of the Galileo satellite system in terrestrial navigation applications, compared to the GNSS GPS and GLONASS systems. The kinematic positioning accuracy and the accuracies obtainable in different operating conditions have been analyzed comparing the results with those obtained using multi-constellation geodetic instrumentation in different configurations with the currently operational constellations. To verify the improvement in the performance of the Galileo satellite system related to the progress in the implementation of the system, quarterly measurement campaigns have been planned starting from December 2019, as part of the first Grant of the GRC-MS Project. For each measurement campaign, surveys were carried out in urban and extra-urban areas. The measurement campaigns were conducted using a MMS (Mobile Mapping System) vehicle of the GeoSNaV Lab, University of Trieste. For the absolute positioning, the vehicle is equipped with an Applanix Corporation® POS/LV, positioning and orientation system, integrated by inertial technology to generate stable, reliable, and repeatable positioning solutions for land-based vehicle applications. For the acquisition of Galileo GNSS, GPS and GLONASS data, a multi-constellation GNSS receiver was installed inside the vehicle, and the relative antenna fixed between the two GNSS antennas of the POS/LV system on the roof of the vehicle. Furthermore, an analysis of the performances achievable by a smartphone, capable of receiving GNSS signals, also fixed on the roof of the vehicle, was carried out

Analisi delle prestazioni di rilievi cinematici Galileo con ricevitori GNSS e MMS

La ricerca ha riguardato la definizione, ottimizzazione ed esecuzione di test cinematici con utilizzo di dati interferenziali multi-frequenza acquisiti con ricevitori multi-costellazione e con l’utilizzo di dati GPS, GLONASS, Galileo, in modalità interferenziale differenziale. I dati GNSS sono stati analizzati utilizzando tecniche di acquisizione ed elaborazione dei dati in post-processing mediante confronto con i dati 3D ottenuti da veicolo MMS (Mobile Mapping System) equipaggiato con strumentazione GPS/INS ad alte prestazioni

Kinematic Galileo and GPS Performances in Aerial, Terrestrial, and Maritime Environments

On 15 December 2016, the European Commission (EC) declared the provision of the Galileo Initial Services (IS). This marked a historical milestone in the Galileo program, towards the reaching of its Full Operational Capability. This allows users to navigate with performance-accuracy levels either matching or exceeding those obtained with other GNSS. Under the delegation of the EC, the European Union Agency for the Space Programme (EUSPA) has assumed the role of the Galileo Service Provider. As part of this service provision, the primary mission of the Galileo Reference Centre (GRC) is to provide the EUSPA and the EC with independent means for monitoring and evaluating the performance of the Galileo services, the quality of the signals in space, and the performance of other GNSS. This mission includes significant contributions from cooperating entities in the European Union (EU) Member States (MS), Norway and Switzerland. In particular, for a detailed assessment of the Galileo performance, these contributions include (but are not limited to) periodic dynamic campaigns in three different environments (aerial, terrestrial, and maritime). These campaigns were executed in the frame of the GRC-MS Project and use multi-constellation receivers to compare the navigation performance obtained with different GNSS. The objective of this paper is to present the numerical results obtained from these campaigns, together with several considerations about the experimental setup, the methodology for the estimation of the reference («actual») trajectory, and the reasons for possible performance degradations

Status Report of the DPHEP Study Group: Towards a Global Effort for Sustainable Data Preservation in High Energy Physics

Data from high-energy physics (HEP) experiments are collected with significant financial and human effort and are mostly unique. An inter-experimental study group on HEP data preservation and long-term analysis was convened as a panel of the International Committee for Future Accelerators (ICFA). The group was formed by large collider-based experiments and investigated the technical and organisational aspects of HEP data preservation. An intermediate report was released in November 2009 addressing the general issues of data preservation in HEP. This paper includes and extends the intermediate report. It provides an analysis of the research case for data preservation and a detailed description of the various projects at experiment, laboratory and international levels. In addition, the paper provides a concrete proposal for an international organisation in charge of the data management and policies in high-energy physics

Il progetto Interreg Italia-Slovenia HARMO-DATA: un geoportale per la condivisione di dati territoriali transfrontalieri armonizzati

Il progetto Interreg HARMO-DATA, finanziato nell’ambito del Programma Interreg V-A Italia-Slovenia 2014-2020, è stato avviato ufficialmente a Settembre 2017 e si è concluso il 30 giugno 2019. Il Partenariato era composto da: Geodetski In titut Slovenije, Ljubljana, Slovenia (coordinamento), Geodetska Uprava Republike Slovenije, Igea S.r.l. Ljubljana, Slovenia, Insiel S.p.a. Trieste, GeoSNav Lab - Dipartimento di Ingegneria e Architettura, Università degli Studi di Trieste - Terre S.r.l. Mestre. Hanno partecipato inoltre in qualità di partner associati: Regione Veneto, Regione Friuli Venezia Giulia e Ministero sloveno per l’ambiente ed il territorio. Obiettivo generale del Progetto è stato quello di rafforzare la capacità di cooperazione istituzionale transfrontaliera tra le autorità pubbliche e i responsabili della pianificazione territoriale, promuovendo la creazione di soluzioni condivise per il coordinamento e un’efficace gestione del territorio

IMMU-01. TEM-GBM: AN OPEN-LABEL, PHASE I/IIA DOSE-ESCALATION STUDY EVALUATING THE SAFETY AND EFFICACY OF GENETICALLY MODIFIED TIE-2 EXPRESSING MONOCYTES TO DELIVER IFN-A WITHIN GLIOBLASTOMA TUMOR MICROENVIRONMENT

Abstract Temferon is a macrophage-based treatment relying on ex-vivo transduction of autologous HSPCs to express immune-payloads within the TME. Temferon targets the immune-modulatory molecule IFN-a, to a subset of tumor infiltrating macrophages known as Tie-2 expressing macrophages (TEMs) due to the Tie2 promoter and a post-transcriptional regulation layer represented by miRNA-126 target sequences. As of 31st May 2021, 15-patients received Temferon (D+0) with follow-up of 3 – 693 days. After conditioning neutrophil and platelet engraftment occurred at D+13 and D+13.5, respectively. Temferon-derived differentiated cells, as determined be the number of vector copy per genome, were found within 14 days post treatment and persisted albeit at lower levels up to 18-months. Very low concentrations of IFN-a in the plasma (8.7 pg/ml-D+30) and in the CSF (1.6 pg/ml-D+30) were detected, suggesting tight regulation of transgene expression. Five-deaths occurred at D+322, +340, +402, +478 and +646 due to PD, and one at D+60 due to complications following the conditioning regimen. Eight-patients had progressive disease (range: D-11 to +239) as expected for this tumor type. SAEs include GGT elevation (possibly related to Temferon) and infections, venous thromboembolism, brain abscess, hemiparesis, seizures, anemia and general physical condition deterioration, compatible with ASCT, concomitant medications and PD. Four-patients underwent 2ndsurgery. Recurrent tumors had gene-marked cells and increased expression of ISGs compared to first surgery, indicative of local IFNa release by TEMs. In one patient, a stable lesion had a higher proportion of T cells and TEMs within the myeloid infiltrate and an increased ISGs than in the progressing lesion, detected in the same patient. Tumor-associated clones expanded in the periphery. TME characterization by scRNA and TCR-sequencing is ongoing. To date, Temferon is well tolerated, with no DLTs identified. The results provide initial evidence of Temferon potential to activate the immune system of GBM patients, as predicted by preclinical studies

Observation of Exclusive Gamma Gamma Production in p pbar Collisions at sqrt{s}=1.96 TeV

We have observed exclusive \gamma\gamma production in proton-antiproton collisions at \sqrt{s}=1.96 TeV, using data from 1.11 \pm 0.07 fb^{-1} integrated luminosity taken by the Run II Collider Detector at Fermilab. We selected events with two electromagnetic showers, each with transverse energy E_T > 2.5 GeV and pseudorapidity |\eta| < 1.0, with no other particles detected in -7.4 < \eta < +7.4. The two showers have similar E_T and azimuthal angle separation \Delta\phi \sim \pi; 34 events have two charged particle tracks, consistent with the QED process p \bar{p} to p + e^+e^- + \bar{p} by two-photon exchange, while 43 events have no charged tracks. The number of these events that are exclusive \pi^0\pi^0 is consistent with zero and is < 15 at 95% C.L. The cross section for p\bar{p} to p+\gamma\gamma+\bar{p} with |\eta(\gamma)| < 1.0 and E_T(\gamma) > 2.5$ GeV is 2.48^{+0.40}_{-0.35}(stat)^{+0.40}_{-0.51}(syst) pb.Comment: 7 pages, 4 figure

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms