Die Entwicklung der Totalkunst in der Wachau.

Schlusswort Zusammenfassend lässt sich sagen, dass das als utopisch geltende Experiment einer Totalkunst durchaus ein realisierbares Projekt sein kann. Die einzelnen Vorreiter einer gesamtkonzeptuellen angelegten Kunst, wie etwa Richard Wagner, Karl Heinz Stockhausen, Hans Jürgen Syberberg, Kurt Schwitters, Heiner Müller oder Joseph Beuys waren Bürger verschiedener Nationen und lebten in unterschiedlichen Jahrhunderten; zielten aber in ihrem Schaffen auf eine scheinbar abhanden gekommene Einheit der Künste – auf eine Urkunst hin. Auf der nationalen Ebene beschäftigen sich die Kooperative K.U.SCH. wie auch zum Teil die Künstlerin, Galeristin und Frauenrechtkämpferin Christa Hauer Fruhmann mit der Verschiebung und Auflösung der Grenzen innerhalb der (österreichischen) Kunst und dem Leben. Zum ersten Mal in der Kunstgeschichte wird die Sehnsucht nach dem Gesamtkunstwerk in der Romantik geweckt. Diese gefühl- und naturbetonte Zeit ist es auch, die zu „Bewusstseinserweiterung in den verschiedensten Richtungen“ führt, wie auch zur „Wiederentdeckung des Dionysischen als schöpferisches Prinzip in der Kunst, zur Erschließung von Mythos und zur Wiedereinsetzung der spielerischen Phantasie in Wiederbelebung der mythischen Spiritualität und nicht zuletzt zur Entdeckung des Unbewussten.“ Das Konventionelle, die selbst erschaffenen Grenzen, sollten abgelegt werden und „das Leben sollte dem Kunstwerk gleichen, das alle sinnlichen, emotionalen und intellektuellen Fähigkeiten des Menschen zu einem Ganzen formt.“ Das Innere eines Menschen – seine innere Natur – sollte sich mit dem Äußeren, der äußeren Natur und Umwelt verbünden. Mitte des 19. Jahrhunderts ist es Wagner, der nicht nur für das Bündnis der Inneren und äußeren Natur eintritt, sondern sich auch für die Vereinigung der einzelnen Kunstgattungen ausspricht. Die folgenden Jahrzehnte gilt der Begriff der Gesamtkunst als ein Monopolunternehmen Wagners. Immer wieder werden Versuche einer Zusammenfassung der Künste und Kunstgattungen unternommen. Einen weiteren Höhepunkt in der Geschichte der Gesamtkunst und der Synästhesien bilden die Dadaisten oder auch die Gründung des Bauhauses. Einen Schritt weiter geht Beuys, Bildhauer, Zeichner, Kunsttheoretiker und Aktionskünstler, indem er bekräftigt, dass jeder Mensch Künstler sei. Mit seinen neuen und kritischen Zugängen und der Ausdehnung des Begriffs Kunst, mit der Schaffung eines erweiterten Kunstbegriffs, nämlich dem einer „sozialen Plastik“ bindet Beuys somit jeden Menschen an die Kunst. Diese Forderung ist allerdings nur bedingt einlösbar. Die Ausdehnung des Skulpturenbegriffs, sein plastischer Wert der Gedanken bei Beuys und die Ausweitung der Kunst in das Soziale, die Gleichberechtigung der Materialen und somit die Wertschätzung des Austausches bei der Kooperative K.U.SCH. und bei Christa Hauer Fruhmann sind in gewisser Weise einem erweiterten Kunstbegriff, nämlich einer Gesamtkunst zuzuordnen. Heutzutage lebt Christa Hauer Fruhmann weiterhin auf Schloss Lengenfeld, und auch wenn sie nicht mehr aktiv schafft, so lebt sie doch in ihrer Arbeit weiter. Die Kooperative K.U.SCH. ist weiterhin überaus aktiv. Außerdem besteht die Kooperative K.U.SCH. seit über einem Jahr nicht mehr aus zwei, sondern aus drei Personen. Gemeinsam mit ihrem Sohn Sito Schwarzenberger setzen sie sich weiterhin kritisch mit der Umwelt und den vorgefundenen Gegenständen auseinander. Durch die Aufnahme Sitos erfolgt eine Wiederbelebung und Aktualisierung ihrer Kunst. (Abb. 34) Sein grafisches Werk ist von großer Experimentierfreude und symbolhaft-utopischen Zügen geprägt, dass mit dem Werk seiner Eltern in einen Dialog tritt. Gemeinsam erarbeiten sie neue Formen und setzen neuartige Kunststoffe in ihren Werken ein. Heutzutage reicht ihr Arbeitsfeld sogar bis nach China , wo sie im Wintersemester 2007/08 Galerieeinladungen gefolgt sind um dort an Einzelausstellungen zu arbeiten. In Beijing stellten sie im November 2007 in Iberia Center for Contemporary Art/Segment Space aus. Der Titel der Ausstellung lief unter dem Namen „DAS GESCHENK DER DESTRUKTION“/„THE GIFT OF DESTRUCTION“. Ihre letzte Ausstellung (im Ausland) fand in Nanjing 2008 im RCM Museum statt und beschäftigte sich mit dem Wert der Wertlosigkeit

Podstawowa opieka zdrowotna nad osobami w wieku podeszłym

Primary health care of elderly peopleNowadays is need for developing grater system-wide support for managing our geriatric population. Improvement of common geriatric syndromes is important (urinary incontinence, falls, depressive symptoms, high risk medications or functional impairment).The new model of geriatric care is needed.  Does this model should wide connected to primary system? Which aspects of primary geriatrics care are important?  Do primary care doctors prepare for better care of geriatric population? Many of those questions still are not resolved. European Union prepared some instruments for care of older and aging population.Increasing hospitalization rate and out patients visit are a big problem in many health care systems. Out patterns of the look at the older population need change. We need to be preparing for new ideas of geriatric care. The voice of patients and their families is importan

Mechanism of collagen biosynthesis up-regulation in cultured leiomyoma cells.

Uterine leiomyoma is the most common tumour in women with a reported incidence of 25-30%. The tumors are benign, composed of smooth muscle cells with variable amount of collagen - rich fibrous tissue. It is well established that accumulation of extracellular matrix in leiomyoma is key feature of tissue fibrosis. However, the pathogenesis of leiomyoma is still unclear. The aim of this study was to evaluate the metabolism of collagen in cultured leiomyoma cells and in control myometrium cells. The effect of estradiol, selective modulators of estrogen receptors (raloxifene, tamoxifen) and estrogen receptor down regulator (ICI 182.780) on collagen biosynthesis (measured by 5-[3H]-proline incorporation assay and measurement of prolidase activity) and collagen degradation (measured by metalloproteinase activity assay) was studied. It was found that collagen biosynthesis is strongly stimulated by low doses of estradiol (5 nM) in leiomyoma cells while it is not changed in control myometrium cells. An increase in estradiol concentration to 10 nM results in drastic decrease of this process both in leiomyoma as well as control cells. Although raloxifene and tamoxifen only slightly affected collagen biosynthesis in control myometrium cells, they significantly inhibited the process in leiomyoma cells. There was no coordinate correlation between collagen biosysignificantly inhibited the process in leiomyoma cells. There was no coordinate correlation between collagen biosynthesis and prolidase activity suggesting that regulation of this process may take place at transcriptional level. Both estrogen and SERMs were found to inhibit MMP-2 in leiomyoma as well as in control myometrium cells. The data suggest that stimulatory action of estrogen on collagen biosynthesis and inhibitory effect on MMP-2 activity in uterine leiomyoma may contribute to accumulation of this protein in ECM of this tissue

Everything you always wanted to know about systemic sclerosis but were afraid to ask: Part 5. Treatment of patients with systemic sclerosis characteristics and treatment recommendations for interstitial lung disease, cardiac involvement, pulmonary arterial hypertension, musculoskeletal, gastrointestinal and renal involvement

Systemic sclerosis (SSc) is a systemic connective tissue disease characterised by disseminated microangiopathy and excessively immune-stimulated fibroblast activity, leading to fibrosis of the skin and internal organs. In the literature, the first report of the disease dates back to 1753 and is attributed to the physician Carlo Curzio of Naples, who described the case of a 17-year-old girl who developed induration of the skin all over her body. The disease is a rare condition, with an estimated 1 in 10 000 people in Poland suffering from SSC. Women predominate among patients, with a 3–4-fold advantage over men. The disease typically has its onset between the ages of 30 and 50. Early detection and treatment of organ complications are key to improving quality of life and reducing mortality in SSc patients. Given the considerable variability of the clinical course, it seems justified to take an individual approach to patients and cooperate with multiple specialists, both at the stage of diagnosis and at the stage of treatment. Treatment is based on what is known as an organ-specific strategy and consists of tailoring pharmacotherapy to the clinical presentation, disease period and organ complications. In addition to pharmacology, the treatment of patients should also include education of the patient and their family, and — if necessary — surgical treatment or other necessary interventions

Everything you always wanted to know about systemic sclerosis but were afraid to ask: Part 5. Vital activity of patients with systemic sclerosis

Systemic sclerosis is an inflammatory connective tissue disease of autoimmune origin, characterized by progressive fibrosis of the skin, internal organs and damage to blood vessels referred to as vasculopathy. Although the most visible symptom of the disease is hardening of the skin, the involvement of internal organs leading to their extreme insufficiency determines the severity of the disease, resulting in a severe course for the patient. The aim of the work is to show how systemic sclerosis affects the patient’s vital activity, with particular emphasis on those activities of everyday life that cause the greatest difficulty. In addition, an attempt was made to determine how the progression of the disease affects the physical and mental sphere of patients with systemic sclerosis The method used to carry out this test is the diagnostic survey method. The paper used a questionnaire that contained 22 questions, including 7 open-ended questions and 2 multiple choice questions. Studies show that systemic sclerosis is a disease that affects the life activity of patients to varying degrees. It penetrates both the physical sphere of the patient, gradually limiting his independence, but also into his mental sphere.Systemic sclerosis is an inflammatory connective tissue disease of autoimmune origin, characterized by progressive fibrosis of the skin, internal organs and damage to blood vessels referred to as vasculopathy. Although the most visible symptom of the disease is hardening of the skin, the involvement of internal organs leading to their extreme insufficiency determines the severity of the disease, resulting in a severe course for the patient. The aim of the work is to show how systemic sclerosis affects the patient's vital activity, with particular emphasis on those activities of everyday life that cause the greatest difficulty. In addition, an attempt was made to determine how the progression of the disease affects the physical and mental sphere of patients with systemic sclerosis The method used to carry out this test is the diagnostic survey method. The paper used a questionnaire that contained 22 questions, including 7 open-ended questions and 2 multiple choice questions. Studies show that systemic sclerosis is a disease that affects the life activity of patients to varying degrees. It penetrates both the physical sphere of the patient, gradually limiting his independence, but also into his mental sphere

Everything you always wanted to know about systemic sclerosis but were afraid to ask: Part 1. Clinical pictures

The authors present the clinical picture of systemic sclerosis including organ and system involvement

Everything you always wanted to know about systemic sclerosis but were afraid to ask: Part 2. Intermediate pathophenotypes: the best pathogenetic background in systemic sclerosis

Systemic sclerosis (SSc, scleroderma) is a chronic systemic connective tissue disease with a complex pathogenesis that is still not fully understood, in the course of which attention is increasingly drawn to the dynamic, sequential pathogenetic mechanisms according to disease stage. An increasing understanding of the diversity of mechanisms underlying this disease, as well as the prevalence of certain pathogenetic elements that depend i.a. on disease stage, will enable more effective therapeutic interventions in the future. Systemic sclerosis can thus be seen as a complex process, where the main players are immune cells, endothelial cells and fibroblasts, and the focal point is probably impaired function and subsequent damage to endothelial cells. Systemic sclerosis is also the final stage of a certain continuum of events, starting with a state of susceptibility to the development of the disease (dependent on genetic conditions and environmental influences), followed by disruption of homeostasis and initiation of pathological processes (e.g. as a result of viral infections), progression of pathological responses (inflammation, endothelial damage, fibrosis) and consequently organ damage. According to most authors, the key event and focal point of the cascade of phenomena is endothelial cell damage, and the mechanisms that lead to this damage are related to the activation of the immune system. There is growing acceptance of the thesis of an autoimmune origin of the disease involving mechanisms of innate and acquired immunity, both cellular and humoral.Systemic sclerosis (SSc, scleroderma) is a chronic systemic connective tissue disease with a complex pathogenesis that is still not fully understood, in the course of which attention is increasingly drawn to the dynamic, sequential pathogenetic mechanisms according to disease stage. An increasing understanding of the diversity of mechanisms underlying this disease, as well as the prevalence of certain pathogenetic elements that depend i.a. on disease stage, will enable more effective therapeutic interventions in the future. Systemic sclerosis can thus be seen as a complex process, where the main players are immune cells, endothelial cells and fibroblasts, and the focal point is probably impaired function and subsequent damage to endothelial cells. Systemic sclerosis is also the final stage of a certain continuum of events, starting with a state of susceptibility to the development of the disease (dependent on genetic conditions and environmental influences), followed by disruption of homeostasis and initiation of pathological processes (e.g. as a result of viral infections), progression of pathological responses (inflammation, endothelial damage, fibrosis) and consequently organ damage. According to most authors, the key event and focal point of the cascade of phenomena is endothelial cell damage, and the mechanisms that lead to this damage are related to the activation of the immune system. There is growing acceptance of the thesis of an autoimmune origin of the disease involving mechanisms of innate and acquired immunity, both cellular and humoral

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements