The central dogma of biological homochirality: How does chiral information propagate in a prebiotic network?

Biological systems are homochiral, raising the question of how a racemic mixture of prebiotically synthesized biomolecules could attain a homochiral state at the network level. Based on our recent results, we aim to address a related question of how chiral information might have flowed in a prebiotic network. Utilizing the crystallization properties of the central RNA precursor known as ribose-aminooxazoline (RAO), we showed that its homochiral crystals can be obtained from its fully racemic solution on a magnetic mineral surface, due to the chiral-induced spin selectivity (CISS) effect. Moreover, we uncovered a mechanism facilitated by the CISS effect through which chiral molecules, like RAO, can uniformly magnetize such surfaces in a variety of planetary environments in a persistent manner. All this is very tantalizing, because recent experiments with tRNA analogs demonstrate high stereoselectivity in the attachment of L-amino acids to D-ribonucleotides, enabling the transfer of homochirality from RNA to peptides. Therefore the biological homochirality problem may be reduced to ensuring that a single common RNA precursor (e.g. RAO) can be made homochiral. The emergence of homochirality at RAO then allows for the chiral information to propagate through RNA, then to peptides, and ultimately, through enantioselective catalysis, to metabolites. This directionality of the chiral information flow parallels that of the central dogma of molecular biology--the unidirectional transfer of genetic information from nucleic acids to proteins.Comment: 8 pages, 4 figure

Chirality-Induced Magnetization of Magnetite by an RNA Precursor

Life is homochiral and homochirality is a fundamental feature of living systems on Earth. While the exact mechanism that led to homochirality is still not fully understood, any realistic scenario on the origins of life needs to address the emergence of homochirality. In order to impose and maintain chirality in a prebiotic network, an environmental factor functioning as a chiral agent is demanded. Magnetized surfaces are prebiotically plausible chiral agents, shown to be effective in enantioseparation of ribose-aminooxazoline (RAO), a ribonucleic acid (RNA) precursor, due to the chiral-induced spin selectivity (CISS) effect. As such, mechanisms for breaking the magnetic symmetry of magnetic minerals are of the utmost importance. Here we report the avalanche magnetization of magnetite $(Fe_{3}O_{4})$ by the crystallization of enantiopure RAO. The observed breaking of the magnetic symmetry is induced by the chiral molecules due to the CISS effect and spreads out across the magnetic surface like an avalanche, providing a way to uniformly magnetize a magnetic surface without fully covering it. Considered together with our previous results on enantioseparation by crystallization on a magnetic surface, chirality-induced avalanche magnetization paves the way for a cooperative feedback between chiral molecules and magnetic surfaces. With this feedback, a weak natural bias in the net magnetization can be amplified and spin-selective processes can be accommodated on magnetic minerals on a persistent basis.Comment: 19 pages, 6 figure

Dipolar quantum solids emerging in a Hubbard quantum simulator

In quantum mechanical many-body systems, long-range and anisotropic interactions promote rich spatial structure and can lead to quantum frustration, giving rise to a wealth of complex, strongly correlated quantum phases. Long-range interactions play an important role in nature; however, quantum simulations of lattice systems have largely not been able to realize such interactions. A wide range of efforts are underway to explore long-range interacting lattice systems using polar molecules, Rydberg atoms, optical cavities, and magnetic atoms. Here, we realize novel quantum phases in a strongly correlated lattice system with long-range dipolar interactions using ultracold magnetic erbium atoms. As we tune the dipolar interaction to be the dominant energy scale in our system, we observe quantum phase transitions from a superfluid into dipolar quantum solids, which we directly detect using quantum gas microscopy with accordion lattices. Controlling the interaction anisotropy by orienting the dipoles enables us to realize a variety of stripe ordered states. Furthermore, by transitioning non-adiabatically through the strongly correlated regime, we observe the emergence of a range of metastable stripe-ordered states. This work demonstrates that novel strongly correlated quantum phases can be realized using long-range dipolar interaction in optical lattices, opening the door to quantum simulations of a wide range of lattice models with long-range and anisotropic interactions

Calibration of the CMS hadron calorimeters using proton-proton collision data at root s=13 TeV

Methods are presented for calibrating the hadron calorimeter system of theCMSetector at the LHC. The hadron calorimeters of the CMS experiment are sampling calorimeters of brass and scintillator, and are in the form of one central detector and two endcaps. These calorimeters cover pseudorapidities vertical bar eta vertical bar ee data. The energy scale of the outer calorimeters has been determined with test beam data and is confirmed through data with high transverse momentum jets. In this paper, we present the details of the calibration methods and accuracy.Peer reviewe

Azimuthal separation in nearly back-to-back jet topologies in inclusive 2-and 3-jet events in pp collisions at root s=13TeV

A measurement for inclusive 2- and 3-jet events of the azimuthal correlation between the two jets with the largest transverse momenta, Delta phi(12), is presented. The measurement considers events where the two leading jets are nearly collinear ("back-to-back") in the transverse plane and is performed for several ranges of the leading jet transverse momentum. Proton-proton collision data collected with the CMS experiment at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 35.9 fb(-1) are used. Predictions based on calculations using matrix elements at leading-order and next-to-leading-order accuracy in perturbative quantum chromodynamics supplemented with leading-log parton showers and hadronization are generally in agreement with themeasurements. Discrepancies between the measurement and theoretical predictions are as large as 15%, mainly in the region 177 degrees <Delta phi(12) <180 degrees. The 2- and 3-jet measurements are not simultaneously described by any of models.Peer reviewe

Measurement of the t(t)over-barb(b)over-bar production cross section in the all-jet final state in pp collisions at root s=13 TeV

A measurement of the production cross section of top quark pairs in association with two b jets (t (t) over barb (b) over bar) is presented using data collected in proton-proton collisions at root s=13 TeV by the CMS detector at the LHC corresponding to an integrated luminosity of 35.9 fb(-1). The cross section is measured in the all-jet decay channel of the top quark pair by selecting events containing at least eight jets, of which at least two are identified as originating from the hadronization of b quarks. A combination of multivariate analysis techniques is used to reduce the large background from multijet events not containing a top quark pair, and to help discriminate between jets originating from top quark decays and other additional jets. The cross section is determined for the total phase space to be 5.5 +/- 0.3 (stat)(-1.3)(+)(1.6) (syst)pb and also measured for two fiducial t (t) over barb (b) over bar, definitions. The measured cross sections are found to be larger than theoretical predictions by a factor of 1.5-2.4, corresponding to 1-2 standard deviations. (C) 2020 The Author. Published by Elsevier B.V.Peer reviewe

Search for dark matter particles produced in association with a Higgs boson in proton-proton collisions at √s = 13 TeV

© 2020, The Author(s). A search for dark matter (DM) particles is performed using events with a Higgs boson candidate and large missing transverse momentum. The analysis is based on proton- proton collision data at a center-of-mass energy of 13 TeV collected by the CMS experiment at the LHC in 2016, corresponding to an integrated luminosity of 35.9 fb−1. The search is performed in five Higgs boson decay channels: h → b b ¯ , γγ, τ+τ−, W+W−, and ZZ. The results from the individual channels are combined to maximize the sensitivity of the analysis. No significant excess over the expected standard model background is observed in any of the five channels or in their combination. Limits are set on DM production in the context of two simplified models. The results are also interpreted in terms of a spin-independent DM-nucleon scattering cross section and compared to those from direct-detection DM experiments. This is the first search for DM particles produced in association with a Higgs boson decaying to a pair of W or Z bosons, and the first statistical combination based on five Higgs boson decay channels. [Figure not available: see fulltext.].SCOAP

Search for electroweak production of a vector-like T quark using fully hadronic final states

A search is performed for electroweak production of a vector-like top quark partner T of charge 2/3 in association with a top or bottom quark, using proton-proton collision data at s = 13 TeV collected by the CMS experiment at the LHC in 2016. The data sample corresponds to an integrated luminosity of 35.9 fb−1. The search targets T quarks over a wide range of masses and fractional widths, decaying to a top quark and either a Higgs boson or a Z boson in fully hadronic final states. The search is performed using two experimentally distinct signatures that depend on whether or not each quark from the decays of the top quark, Higgs boson, or Z boson produces an individual resolved jet. Jet substructure, b tagging, and kinematic variables are used to identify the top quark and boson jets, and also to suppress the standard model backgrounds. The data are found to be consistent with the expected backgrounds. Upper limits at 95% confidence level are set on the cross sections for T quark-mediated production of tHQq, tZQq, and their sum, where Q is the associated top or bottom heavy quark and q is another associated quark. The limits are given for each search signature for various T quark widths up to 30% of the T quark mass, and are between 2 pb and 20 fb for T quark masses in the range 0.6–2.6 TeV. These results are significantly more sensitive than prior searches for electroweak single production of T → tH and represent the first constraints on T → tZ using hadronic decays of the Z boson with this production mode. [Figure not available: see fulltext.