Implementación de un Sistema de Gestión Ambiental en la Institución Educativa Rural Niña del Carmen, sede La Providencia, municipio el Paujil, departamento del Caquetá.

En la actualidad podemos evidenciar la constante preocupación de las personas por el cuidado y la conservación del medio ambiente, en ese orden de ideas, poseemos en nuestras manos los instrumentos necesarios para la toma de decisiones y acciones para lograr subsanar esta preocupación; La integración de Sistemas de Gestiones Ambientales es una de las herramientas base para el alcance de objetivos a mediano y largo plazo en la carrera por lograr un mejor uso de los recursos naturales que nos brinda el planeta tierra. La I.E.R. Niña del Carmen, sede La Providencia, ha sido objeto espacial de aplicación del proyecto “Implementación de un Sistema de Gestión Ambiental en la Institución Educativa Rural Niña del Carmen, sede La Providencia, Municipio El Paujil, Departamento del Caquetá.”, con el objetivo de lograr mejorar y fortalecer la educación ambiental de las futuras generaciones, al igual que disminuir el impacto de las actividades realizadas en su calendario educativo, estableciendo puntos ecológicos de recolección de residuos, selección y demarcación de zonas ecológicas protegidas y reforestación de zonas circundantes a cuerpos de agua cercanos a la Institución.Today we can see the constant concern of people for the care and conservation of the environment, in that order of ideas, we possess in our hands the necessary instruments for taking decisions and actions to overcome this concern; The integration of Environmental Management Systems is one of the basic tools for achieving medium and long term goals in the race to achieve a better use of the natural resources that the planet Earth provides. The I.E.R. Niña del Carmen, La Providencia headquarters, has been a space object of project implementation "Implementation of an Environmental Management System in the Rural Educational Institution Niña del Carmen, headquarters of La Providencia, Municipality El paujil, Department of Caquetá." with the aim of improving and strengthening the environmental education of future generations, as well as reducing the impact of the activities carried out on their educational calendar, establishing ecological points for waste collection, selection and demarcation of protected ecological zones and reforestation of areas surrounding bodies of water near the Institution

The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome

Atypical hemolytic uremic syndrome (aHUS) associates with complement dysregulation caused by muta-tions and polymorphisms in complement activators and regulators. However, the reasons why somemutations in complement proteins predispose to aHUS are poorly understood. Here, we have investigatedthe functional consequences of three aHUS-associated mutations in C3, R592W, R161W and I1157T. First,we provide evidence that penetrance and disease severity for these mutations is modulated by inheri-tance of documented “risk” haplotypes as has been observed with mutations in other complement genes.Next, we show that all three mutations markedly reduce the efficiency of factor I-mediated C3b cleavagewhen catalyzed by membrane cofactor protein (MCP), but not when catalyzed by factor H. Biacore anal-ysis showed that each mutant C3b bound sMCP (recombinant soluble MCP; CD46) at reduced affinity,providing a molecular basis for its reduced cofactor activity. Lastly, we show by electron microscopystructural analysis a displacement of the TED domain from the MG ring in C3b in two of the C3 mutantsthat explains these defects in regulation. As a whole our data suggest that aHUS-associated mutations inC3 selectively affect regulation of complement on surfaces and provide a structural framework to predictthe functional consequences of the C3 genetic variants found in patients

Hacia la Sociedad de la Información y el Conocimiento: Informe 2012

Por séptimo año consecutivo el Prosic presenta su informe anual “Hacia la Sociedad de la Información y el Conocimiento en Costa Rica, 2012”, cuyo propósito es aportar cada año nueva información sobre cómo progresan las tecnologías de la información y comunicación en los diferentes sectores de la sociedad. La Web es hoy en día la mayor fuente de información; definitivamente la forma de comunicarnos ha cambiado: la inmediatez del correo electrónico, los SMS, las redes sociales, el microblogging, los datos abiertos entre muchos otros, abren un gran abanico de oportunidades en la interactividad del quehacer diario: trabajo, estudios, investigación, diversión, familia etc. En esta era de la información las nuevas tecnologías están marcando un cambio fundamental en nuestro país; para muchos habitantes de la ciudad, es casi imposible imaginar la vida sin las TIC. La importancia de este Informe anual del Prosic reside, entre otros elementos, en la exploración de dimensiones diversas concernientes a la incorporación de las tecnologías de información y comunicación en la interacción social cotidiana, tanto en el ámbito privado como público, en la educación, en la salud, en la ciencia y la investigación, la ingeniería, la física y en la economía; en fin en todos los sectores de esta sociedad de la información cada vez en mayor convergencia.UCR::Rectoría::Programa Sociedad de la Información y el Conocimiento (PROSIC

Communication Notebook. No.6. Barichara: Between tradition and modernity

Esta colección de Editorial UNAB presenta reflexiones sobre asuntos de actualidad dentro de la comunicación social, escritos por profesores de la Universidad Autónoma de Bucaramanga e invitados especiales a la institución, como aporte al debate sobre este campo del conocimiento, el oficio y la profesión.Prefacio. - 5 Introducción, - 8 Barichara: identidad firme... identidad moldeable. - 13 Barichara: identidad, cultura y símbolos comunicativos. - 71 Desnudando identidades. - 101This collection of Editorial UNAB presents reflections on current issues within social communication, written by professors from the Universidad Autónoma de Bucaramanga UNAB and special guests at the institution, as a contribution to the debate on this field of knowledge, trade and profession

C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation

C3 glomerulopathies (C3G) are a group of severe renal diseases with distinct patterns of glomerular inflammation and C3 deposition caused by complement dysregulation. Here we report the identification of a familial C3G-associated genomic mutation in the gene complement factor H–related 1 (CFHR1), which encodes FHR1. The mutation resulted in the duplication of the N-terminal short consensus repeats (SCRs) that are conserved in FHR2 and FHR5. We determined that native FHR1, FHR2, and FHR5 circulate in plasma as homo- and hetero-oligomeric complexes, the formation of which is likely mediated by the conserved N-terminal domain. In mutant FHR1, duplication of the N-terminal domain resulted in the formation of unusually large multimeric FHR complexes that exhibited increased avidity for the FHR1 ligands C3b, iC3b, and C3dg and enhanced competition with complement factor H (FH) in surface plasmon resonance (SPR) studies and hemolytic assays. These data revealed that FHR1, FHR2, and FHR5 organize a combinatorial repertoire of oligomeric complexes and demonstrated that changes in FHR oligomerization influence the regulation of complement activation. In summary, our identification and characterization of a unique CFHR1 mutation provides insights into the biology of the FHRs and contributes to our understanding of the pathogenic mechanisms underlying C3G

Predictive Power of the "Trigger Tool" for the detection of adverse events in general surgery: a multicenter observational validation study

Background In spite of the global implementation of standardized surgical safety checklists and evidence-based practices, general surgery remains associated with a high residual risk of preventable perioperative complications and adverse events. This study was designed to validate the hypothesis that a new “Trigger Tool” represents a sensitive predictor of adverse events in general surgery. Methods An observational multicenter validation study was performed among 31 hospitals in Spain. The previously described “Trigger Tool” based on 40 specific triggers was applied to validate the predictive power of predicting adverse events in the perioperative care of surgical patients. A prediction model was used by means of a binary logistic regression analysis. Results The prevalence of adverse events among a total of 1,132 surgical cases included in this study was 31.53%. The “Trigger Tool” had a sensitivity and specificity of 86.27% and 79.55% respectively for predicting these adverse events. A total of 12 selected triggers of overall 40 triggers were identified for optimizing the predictive power of the “Trigger Tool”. Conclusions The “Trigger Tool” has a high predictive capacity for predicting adverse events in surgical procedures. We recommend a revision of the original 40 triggers to 12 selected triggers to optimize the predictive power of this tool, which will have to be validated in future studies

Natural History of MYH7-Related Dilated Cardiomyopathy

BACKGROUND Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are poorly described. OBJECTIVES We sought to determine the phenotype and prognosis of MYH7-related DCM. We also evaluated the influence of variant location on phenotypic expression. METHODS We studied clinical data from 147 individuals with DCM-causing MYH7 variants (47.6% female; 35.6 +/- 19.2 years) recruited from 29 international centers. RESULTS At initial evaluation, 106 (72.1%) patients had DCM (left ventricular ejection fraction: 34.5% +/- 11.7%). Median follow-up was 4.5 years (IQR: 1.7-8.0 years), and 23.7% of carriers who were initially phenotype-negative developed DCM. Phenotypic expression by 40 and 60 years was 46% and 88%, respectively, with 18 patients (16%) first diagnosed at <18 years of age. Thirty-six percent of patients with DCM met imaging criteria for LV noncompaction. During follow-up, 28% showed left ventricular reverse remodeling. Incidence of adverse cardiac events among patients with DCM at 5 years was 11.6%, with 5 (4.6%) deaths caused by end-stage heart failure (ESHF) and 5 patients (4.6%) requiring heart transplantation. The major ventricular arrhythmia rate was low (1.0% and 2.1% at 5 years in patients with DCM and in those with LVEF of <= 35%, respectively). ESHF and major ventricular arrhythmia were significantly lower compared with LMNA-related DCM and similar to DCM caused by TTN truncating variants. CONCLUSIONS MYH7-related DCM is characterized by early age of onset, high phenotypic expression, low left ventricular reverse remodeling, and frequent progression to ESHF. Heart failure complications predominate over ventricular arrhythmias, which are rare. (C) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation

Predicting attitudinal and behavioral responses to COVID-19 pandemic using machine learning

At the beginning of 2020, COVID-19 became a global problem. Despite all the efforts to emphasize the relevance of preventive measures, not everyone adhered to them. Thus, learning more about the characteristics determining attitudinal and behavioral responses to the pandemic is crucial to improving future interventions. In this study, we applied machine learning on the multinational data collected by the International Collaboration on the Social and Moral Psychology of COVID-19 (N = 51,404) to test the predictive efficacy of constructs from social, moral, cognitive, and personality psychology, as well as socio-demographic factors, in the attitudinal and behavioral responses to the pandemic. The results point to several valuable insights. Internalized moral identity provided the most consistent predictive contribution—individuals perceiving moral traits as central to their self-concept reported higher adherence to preventive measures. Similar results were found for morality as cooperation, symbolized moral identity, self-control, open-mindedness, and collective narcissism, while the inverse relationship was evident for the endorsement of conspiracy theories. However, we also found a non-neglible variability in the explained variance and predictive contributions with respect to macro-level factors such as the pandemic stage or cultural region. Overall, the results underscore the importance of morality-related and contextual factors in understanding adherence to public health recommendations during the pandemic.Peer reviewe

National identity predicts public health support during a global pandemic (vol 13, 517, 2022) : National identity predicts public health support during a global pandemic (Nature Communications, (2022), 13, 1, (517), 10.1038/s41467-021-27668-9)

Publisher Copyright: © The Author(s) 2022.In this article the author name ‘Agustin Ibanez’ was incorrectly written as ‘Augustin Ibanez’. The original article has been corrected.Peer reviewe

National identity predicts public health support during a global pandemic.

Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = -0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics