El coeficiente de arrastre sobre la superficie del mar como función de las características del oleaje

An analysis of the performance of parameterizations for the drag coefficient CD over the ocean is presented. The results were obtained by considering detailed observations from the recent IntOA experiment in which a co-existence of wind sea and swell provides characteristic mixed sea conditions in a wide range of wind speeds. Recent research has advanced our understanding of air-sea fluxes, proposing new functional forms for the drag coefficient, as well as applying wavelength scaling and determining dimensionally consistent expressions for the drag coefficient. Nevertheless, a detailed analysis of the influence of wind sea parameters confirms the need to include the sea state dependence on parameterizing CD for mixed sea conditions. It is also shown that better results are obtained when aerodynamic roughness is considered as a function of wave age and wave steepness, or equivalently if CD is expressed as a function of a characteristic peak frequency defined through the wave momentum spectrum.Se presenta un análisis del desempeño de algunas parametrizaciones del coeficiente de arrastre CD sobre la superficie del mar. Los resultados se obtienen a partir de observaciones detalladas durante el experimento IntOA. En ese experimento la existencia simultánea de oleaje generado localmente y oleaje que proviene de tormentas lejanas, nos brinda características únicas del estado del mar con constituyentes mixtas de oleaje en una gama amplia de velocidades del viento. A través de investigaciones recientes se ha avanzado en el conocimiento de los flujos entre el océano y la atmósfera, al proponer nuevas formas funcionales del coeficiente de arrastre, así como al utilizar expresiones dimensionalmente consistentes que se basan en escalas asociadas a la longitud de onda de las olas. Los resultados de este trabajo confirman la necesidad de incluir la influencia del estado del mar en las parametrizaciones del coeficiente de arrastre, especialmente bajo condiciones mixtas de oleaje. También se demuestra que se obtienen mejores resultados cuando la escala de rugosidad aerodinámica se considera como una función de la edad de la ola y de la pendiente del oleaje local o de forma equivalente, cuando CD se expresa como función de una frecuencia característica asociada al pico espectral que se determina mediante el espectro del momento del oleaje

On the parameterization of the drag coefficient in mixed seas

An analysis of the performance of parameterizations for the drag coefficient CD over the ocean is presented. The results were obtained by considering detailed observations from the recent IntOA experiment in which a co-existence of wind sea and swell provides characteristic mixed sea conditions in a wide range of wind speeds. Recent research has advanced our understanding of air-sea fluxes, proposing new functional forms for the drag coefficient, as well as applying wavelength scaling and determining dimensionally consistent expressions for the drag coefficient. Nevertheless, a detailed analysis of the influence of wind sea parameters confirms the need to include the sea state dependence on parameterizing CD for mixed sea conditions. It is also shown that better results are obtained when aerodynamic roughness is considered as a function of wave age and wave steepness, or equivalently if CD is expressed as a function of a characteristic peak frequency defined through the wave momentum spectrum

A Single Argonaute Gene Participates in Exogenous and Endogenous RNAi and Controls Cellular Functions in the Basal Fungus Mucor circinelloides

The mechanism of RNAi is well described in metazoans where it plays a role in diverse cellular functions. However, although different classes of endogenous small RNAs (esRNAs) have been identified in fungi, their biological roles are poorly described due, in part, to the lack of phenotype of mutants affected in the biogenesis of these esRNAs. Argonaute proteins are one of the key components of the RNAi pathways, in which different members of this protein family participate in the biogenesis of a wide repertoire of esRNAs molecules. Here we identified three argonaute genes of the fungus Mucor circinelloides and investigated their participation in exogenous and endogenous RNAi. We found that only one of the ago genes, ago-1, is involved in RNAi during vegetative growth and is required for both transgene-induced RNA silencing and the accumulation of distinct classes of esRNAs derived from exons (ex-siRNAs). Classes I and II ex-siRNAs bind to Ago-1 to control mRNA accumulation of the target protein coding genes. Class III ex-siRNAs do not specifically bind to Ago-1, but requires this protein for their production, revealing the complexity of the biogenesis pathways of ex-siRNAs. We also show that ago-1 is involved in the response to environmental signals, since vegetative development and autolysis induced by nutritional stress are affected in ago-1(-) M. circinelloides mutants. Our results demonstrate that a single Ago protein participates in the production of different classes of esRNAs that are generated through different pathways. They also highlight the role of ex-siRNAs in the regulation of endogenous genes in fungi and expand the range of biological functions modulated by RNAi

Association between loop diuretic dose changes and outcomes in chronic heart failure: observations from the ESC-EORP Heart Failure Long-Term Registry

[Abstract] Aims. Guidelines recommend down-titration of loop diuretics (LD) once euvolaemia is achieved. In outpatients with heart failure (HF), we investigated LD dose changes in daily cardiology practice, agreement with guideline recommendations, predictors of successful LD down-titration and association between dose changes and outcomes. Methods and results. We included 8130 HF patients from the ESC-EORP Heart Failure Long-Term Registry. Among patients who had dose decreased, successful decrease was defined as the decrease not followed by death, HF hospitalization, New York Heart Association class deterioration, or subsequent increase in LD dose. Mean age was 66±13 years, 71% men, 62% HF with reduced ejection fraction, 19% HF with mid-range ejection fraction, 19% HF with preserved ejection fraction. Median [interquartile range (IQR)] LD dose was 40 (25–80) mg. LD dose was increased in 16%, decreased in 8.3% and unchanged in 76%. Median (IQR) follow-up was 372 (363–419) days. Diuretic dose increase (vs. no change) was associated with HF death [hazard ratio (HR) 1.53, 95% confidence interval (CI) 1.12–2.08; P = 0.008] and nominally with cardiovascular death (HR 1.25, 95% CI 0.96–1.63; P = 0.103). Decrease of diuretic dose (vs. no change) was associated with nominally lower HF (HR 0.59, 95% CI 0.33–1.07; P = 0.083) and cardiovascular mortality (HR 0.62 95% CI 0.38–1.00; P = 0.052). Among patients who had LD dose decreased, systolic blood pressure [odds ratio (OR) 1.11 per 10 mmHg increase, 95% CI 1.01–1.22; P = 0.032], and absence of (i) sleep apnoea (OR 0.24, 95% CI 0.09–0.69; P = 0.008), (ii) peripheral congestion (OR 0.48, 95% CI 0.29–0.80; P = 0.005), and (iii) moderate/severe mitral regurgitation (OR 0.57, 95% CI 0.37–0.87; P = 0.008) were independently associated with successful decrease. Conclusion. Diuretic dose was unchanged in 76% and decreased in 8.3% of outpatients with chronic HF. LD dose increase was associated with worse outcomes, while the LD dose decrease group showed a trend for better outcomes compared with the no-change group. Higher systolic blood pressure, and absence of (i) sleep apnoea, (ii) peripheral congestion, and (iii) moderate/severe mitral regurgitation were independently associated with successful dose decrease

Sex- and age-related differences in the management and outcomes of chronic heart failure: an analysis of patients from the ESC HFA EORP Heart Failure Long-Term Registry

Aims: This study aimed to assess age- and sex-related differences in management and 1-year risk for all-cause mortality and hospitalization in chronic heart failure (HF) patients. Methods and results: Of 16 354 patients included in the European Society of Cardiology Heart Failure Long-Term Registry, 9428 chronic HF patients were analysed [median age: 66 years; 28.5% women; mean left ventricular ejection fraction (LVEF) 37%]. Rates of use of guideline-directed medical therapy (GDMT) were high (angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, beta-blockers and mineralocorticoid receptor antagonists: 85.7%, 88.7% and 58.8%, respectively). Crude GDMT utilization rates were lower in women than in men (all differences: P\ua0 64 0.001), and GDMT use became lower with ageing in both sexes, at baseline and at 1-year follow-up. Sex was not an independent predictor of GDMT prescription; however, age >75 years was a significant predictor of GDMT underutilization. Rates of all-cause mortality were lower in women than in men (7.1% vs. 8.7%; P\ua0=\ua00.015), as were rates of all-cause hospitalization (21.9% vs. 27.3%; P\ua075 years. Conclusions: There was a decline in GDMT use with advanced age in both sexes. Sex was not an independent predictor of GDMT or adverse outcomes. However, age >75 years independently predicted lower GDMT use and higher all-cause mortality in patients with LVEF 6445%

Many Labs 2: Investigating Variation in Replicability Across Samples and Settings

We conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings. Each protocol was administered to approximately half of 125 samples that comprised 15,305 participants from 36 countries and territories. Using the conventional criterion of statistical significance (p < .05), we found that 15 (54%) of the replications provided evidence of a statistically significant effect in the same direction as the original finding. With a strict significance criterion (p < .0001), 14 (50%) of the replications still provided such evidence, a reflection of the extremely highpowered design. Seven (25%) of the replications yielded effect sizes larger than the original ones, and 21 (75%) yielded effect sizes smaller than the original ones. The median comparable Cohen’s ds were 0.60 for the original findings and 0.15 for the replications. The effect sizes were small (< 0.20) in 16 of the replications (57%), and 9 effects (32%) were in the direction opposite the direction of the original effect. Across settings, the Q statistic indicated significant heterogeneity in 11 (39%) of the replication effects, and most of those were among the findings with the largest overall effect sizes; only 1 effect that was near zero in the aggregate showed significant heterogeneity according to this measure. Only 1 effect had a tau value greater than .20, an indication of moderate heterogeneity. Eight others had tau values near or slightly above .10, an indication of slight heterogeneity. Moderation tests indicated that very little heterogeneity was attributable to the order in which the tasks were performed or whether the tasks were administered in lab versus online. Exploratory comparisons revealed little heterogeneity between Western, educated, industrialized, rich, and democratic (WEIRD) cultures and less WEIRD cultures (i.e., cultures with relatively high and low WEIRDness scores, respectively). Cumulatively, variability in the observed effect sizes was attributable more to the effect being studied than to the sample or setting in which it was studied.UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Instituto de Investigaciones Psicológicas (IIP

Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores

A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació

Spectral Partitioning and Identification of Wind Sea and Swell

In this paper, different partitioning techniques and methods to identify wind sea and swell are investigated, addressing both 1D and 2D schemes. Current partitioning techniques depend largely on arbitrary parameterizations to assess if wave systems are significant or spurious. This makes the implementation of automated procedures difficult, if not impossible, to calibrate. To avoid this limitation, for the 2D spectrum, the use of a digital filter is proposed to help the algorithm keep the important features of the spectrum and disregard the noise. For the 1D spectrum, a mechanism oriented to neglect the most likely spurious partitions was found sufficient for detecting relevant spectral features. Regarding the identification of wind sea and swell, it was found that customarily used methods sometimes largely differ from one another. Evidently, methods using 2D spectra and wind information are the most consistent. In reference to 1D identification methods, attention is given to two widely used methods, namely, the steepness method used operationally at the National Data Buoy Center (NDBC) and the Pierson-Moskowitz (PM) spectrum peak method. It was found that the steepness method systematically overestimates swell, while the PM method is more consistent, although it tends to underestimate swell. Consistent results were obtained looking at the ratio between the energy at the spectral peak of a partition and the energy at the peak of a PM spectrum with the same peak frequency. It is found that the use of partitioning gives more consistent identification results using both 1D and 2D spectra.status: publishe

Sunglint images of current gradients at high resolution: Critical angle and directional observing strategy

High-resolution satellite images of the ocean surface in and around the sunglint often provide unique observations of sub-mesoscale upper ocean surface processes. Local anomalies of wind, waves, currents or surfactants appear on the images as local anomalies of brightness. A quantitative interpretation of those brightness anomalies must relate them to slope properties of the wave field, which are to the lowest order described by the mean square slope (mss). The prevailing paradigm for such interpretation is that of the critical zenith angle. It states that, for subcritical zenith view angle, brightness and mss anomalies have opposite signs, and this defines the so-called inversion region. This prevailing paradigm implicitly builds on the assumption that the mss decomposition between upwind and crosswind components is conserved. The mss anomalies are then isotropic and can be reduced to a scalar (i.e. one-dimensional) quantity. In such a case, one single sunglint image would be sufficient to retrieve the mss anomaly. This isotropic case likely applies for surface wave changes induced by varying wind speed or by surfactants. Yet, satellite and airborne observations at multiple view angles recently revealed anisotropic mss anomalies, e.g. with mss increase in the upwind direction and decrease in the crosswind direction. This anisotropic behavior likely characterizes wave modulations by anisotropic surface current gradients. This paper details the expected properties of such anisotropic mss modulations. It is shown that: 1) The classical concept of critical angle does not systematically hold, neither for frontal current shear nor for internal wave divergence. 2) At least two sunglint images at different zenith and azimuth angles are needed to retrieve the mss anomalies, and a single observation is not sufficient. 3) A satellite with radiometers looking at multiple zenith angles is capable of providing a geometry favorable to retrieve mss anomalies. An illustration is discussed with internal waves observed by the Multi-angle Imaging SpectroRadiometer (MISR), where the upwind and crosswind components of the retrieved mss anomalies are anisotropic. Those results provide guidelines to interpret available observations and to help refine strategy for future satellite missions