New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Le concept d’objet primaire en psychanalyse: origines

National audienc

LaI construction de l'objet en psychanalyse (des origines à la source)

ST ETIENNE-BU Médecine (422182102) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Les sols, nouvelle frontière pour les savoirs et les politiques de l’environnement

Le sol demeure largement vu comme un socle inerte, un arrière-plan pour l’existence biologique et sociale. Ce numéro s’intéresse aux dynamiques de production, négociation, circulation et mobilisation des savoirs sur les sols. Les questions ne se cantonant plus à l’agriculture ou à l’extraction minière, mais s’invitent dans des débats environnementaux, il questionne la façon dont les sols constituent un front de transformation des savoirs et des politiques de l’environnement, autour d’une diversité d’enjeux (des sols vivants aux déchets nucléaires et aux métabolismes urbains). The soil is still widely seen as an inert base, a backdrop for biological and social existence. This issue focuses on the dynamics of production, negotiation, circulation and mobilisation of knowledge about soils. As the issues are no longer confined to agriculture or mining, but are now part of environmental debates, it questions the way in which soils constitute a front for the transformation of knowledge and environmental policies, around a diversity of issues (from living soils to nuclear waste and urban metabolism). El suelo sigue siendo ampliamente considerado como una base inerte, un telón de fondo para la existencia biológica y social. Este número se centra en la dinámica de la producción, la negociación, la circulación y la movilización de los conocimientos sobre los suelos. Como las cuestiones ya no se limitan a la agricultura o la minería, sino que ahora forman parte de los debates sobre el medio ambiente, se cuestiona la forma en que los suelos constituyen un frente para la transformación de los conocimientos y las políticas ambientales, en torno a una diversidad de cuestiones (desde los suelos vivos hasta los desechos nucleares y los metabolismos urbanos)

Psychiatric symptoms and mortality in older adults with major psychiatric disorders: results from a multicenter study

International audienc

Children living with HIV in Europe: do migrants have worse treatment outcomes?

International audienceTo assess the effect of migrant status on treatment outcomes among children living with HIV in Europe

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population