50 research outputs found
Seasonal variation of alkylphenols and bisphenol A in waters and clams from a Spanish-Portuguese river estuary
Compuestos orgánicos en aguas del estuario del Río Miño. Proyecto "TEAM-Miño"
Comunicación presentada al II Congreso Internacional de Ingeniería Civil y Territorio. Agua, Cultura y Sociedad. Vigo, 20 y 21 de Mayo de 2013.Los resultados de este trabajo se engloban en el Marco del proyecto TEAM-Miño “Transferencia de
herramientas para la Evaluación, Ordenación, Gestión y Educación Ambiental en Estuarios” financiado por la
Unión Europea (POCTEP 2007-2013), que pretende desarrollar herramientas comunes para la tipificación y
clasificación del estado ecológico de las masas de agua de transición del sur de Galicia y norte de Portugal, con
la finalidad de colaborar en la implantación de la Directiva Marco del Agua. Se han analizado 19 muestras de
agua recogidas a lo largo del río Miño y sus afluentes. En ellas se han determinado diferentes contaminantes de
amplio interés industrial y ambiental, como hidrocarburos aromáticos policíclicos (HAP), compuestos
organoestánnicos, alquilfenoles y bisfenol A. Salvo excepciones, los niveles encontrados en las muestras no son
elevados (<0,1 μg/L). La mayoría de los HAPs se encuentran por debajo de los límites de cuantificación del
método analítico (MQL), siendo el compuesto mayoritario el naftaleno. Los compuestos organoestánnicos
tampoco han sido detectados. Los alquilfenoles están presentes en todos los puntos muestreados (<MQL-1
μg/L), mientras que el bisfenol A se ha encontrado únicamente en dos de ellos, pero a altas concentraciones (>3
μg/L). En ningún caso las concentraciones medidas superan los límites establecidos en la Directiva
2008/105/CE
Mineral and volatile composition of agua-mel from Portugal
Agua-mel (honey-water) is a typical honey-based product produced by the Portuguese beekeepers, particularly in southern Portugal. Agua-mel was characterized by mineral content and volatiles contents. Mineral content evaluation was performed based on a random sampling of 14 samples from a total of 16 samples provided by local producers. Mineral content showed that potassium predominated in agua-mel samples (1270-4105 mg/kg). The concentration of aluminium in one sample was tenfold higher (5.8 mg/kg) than in the remaining samples (0.3-0.6 mg/kg). Agua-mel volatiles were isolated by hydrodistillation and analysed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) from a subset of eight samples. Cluster analysis showed two poorly correlated clusters (S (corr) < 0.3). Cluster I only sample was dominated by trans-beta-ocimene (19 %), gamma-terpinene (15 %) and 2-furfural (9 %). Cluster II that included the remaining seven samples showed two moderately correlated subclusters (S (corr) < 0.5). The six samples with high correlation from subcluster IIa were dominated by 2-furfural (18-41 %) and benzene acetaldehyde (12-39 %). n-Nonadecane (14 %), n-heneicosane and 2-furfural (both 13 %) were the main components of subcluster IIb sample. Although the presence of some volatile compounds can help in the correlation between agua-mel and honey botanical source, the final product varies largely according to the preparation process even for the same producer, in different years. Agua-mel detailed characterization may assist in bringing added value to this typical Portuguese honey-based product
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality
Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine
[This corrects the article DOI: 10.1186/s13054-016-1208-6.]
Transverse momentum spectra of charged particles in proton-proton collisions at GeV with ALICE at the LHC
The inclusive charged particle transverse momentum distribution is measured
in proton-proton collisions at GeV at the LHC using the ALICE
detector. The measurement is performed in the central pseudorapidity region
over the transverse momentum range GeV/.
The correlation between transverse momentum and particle multiplicity is also
studied. Results are presented for inelastic (INEL) and non-single-diffractive
(NSD) events. The average transverse momentum for is (stat.) (syst.) GeV/ and
\left_{\rm NSD}=0.489\pm0.001 (stat.) (syst.)
GeV/, respectively. The data exhibit a slightly larger than measurements in wider pseudorapidity intervals. The results are
compared to simulations with the Monte Carlo event generators PYTHIA and
PHOJET.Comment: 20 pages, 8 figures, 2 tables, published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/390
Ecotoxicological evaluation of the environmental risk posed by bisphenol A, triclosan, and 4-nonylphenol in coastal waters using early life stages of marine organisms (Isochrysis galbana, Mytilus galloprovincialis, Paracentrotus lividus and Acartia clausi)
En prens
Bioaccumulation of 4-nonylphenol and effects on molecular biomarkers, acetylcholinesterase, glutathione-S-transferase and glutathione peroxidase in Mytilus galloprovincialis mussel gills
Wild marine mussels, Mytilus galloprovincialis showed a moderate bioaccumulation ability when
exposed to waterborne 4-nonylphenol (4-NP), with a bioconcentration factor (BCF) of 6850 L Kg 1 (dry
weight). Kinetic and concentration-response experiments were performed and three enzymatic biomarkers
in mussel gills were measured: Glutathione S-transferase (GST), glutathione peroxidase (GPx)
and acetylcholinesterase (AChE). Exposure of mussels to environmentally relevant concentrations (25
e100 mg L 1) of 4-nonylphenol significantly inhibited the AChE activity and induced the GST and GPx
activities. GST induction was dose dependent whilst GPx activity showed a less consistent pattern, but in
both cases the induction remained after a 10 d depuration period. Mussels seem capable of eliminating 4-
NP from their tissues through a mechanism involving GST inductionVersión del edito
Occurrence of selected endocrine disrupting compounds in Iberian coastal areas and assessment of the environmental risk
The spatial and temporal distribution of selected endocrine disrupting compounds (4-tert-octylphenol, 4-n-octylphenol, 4-n-nonylphenol, nonylphenol, and bisphenol A) in two coastal areas of the Iberian Peninsula (Ria de Vigo and Mar Menor lagoon) were evaluated for the first time. Seawater and sediment samples collected during spring and autumn of 2015 were analysed using greener extraction techniques and liquid chromatography-tandem mass spectrometry. The presence of branched isomers (4-tert-octylphenol and nonylphenol) and bisphenol A in almost all seawater and sediment samples demonstrated their importance as pollutants in the frame of water policy, while no concentrations of linear isomers (4-n-octylphenol and 4-n-nonylphenol) were found. Higher seawater levels were observed in Mar Menor lagoon, especially in spring, associated with wastewater treatment plant effluents and nautical, agricultural and industrial activities. Similar sediment concentrations were measured in both studied areas, being nonylphenol levels five times higher than those measured for the other EDCs. Experimental sediment–water partition coefficients showed a moderate sorption of target compounds to sediments. Risk quotients for water compartment evidenced a moderate risk posed by nonylphenol, considering the worst-case scenario. For sediments, moderate risk related to 4-tert-octylphenol and high risk to nonylphenol were estimated