Resolved Spectroscopy of Gravitationally-Lensed Galaxies: Recovering Coherent Velocity Fields in Sub-Luminous z~2-3 Galaxies

We present spatially-resolved dynamics for six strongly lensed star-forming galaxies at z=1.7-3.1, each enlarged by a linear magnification factor ~8. Using the Keck laser guide star AO system and the OSIRIS integral field unit spectrograph we resolve kinematic and morphological detail in our sample with an unprecedented fidelity, in some cases achieving spatial resolutions of ~100 pc. With one exception our sources have diameters ranging from 1-7 kpc, star formation rates of 2-40 Msun/yr (uncorrected for extinction) and dynamical masses of 10^(9.7-10.3) Msun. With this exquisite resolution we find that four of the six galaxies display coherent velocity fields consistent with a simple rotating disk model, which can only be recovered with the considerably improved spatial resolution and sampling from the combination of adaptive optics and strong gravitational lensing. Our model fits imply ratios for the systemic to random motion, V sin(i)/sigma, ranging from 0.5-1.3 and Toomre disk parameters Q<1. The large fraction of well-ordered velocity fields in our sample is consistent with data analyzed for larger, more luminous sources at this redshift. Our high resolution data further reveal that all six galaxies contain multiple giant star-forming HII regions whose resolved diameters are in the range 300 pc - 1.0 kpc, consistent with the Jeans length expected in the case of dispersion support. The density of star formation in these regions is ~100 times higher than observed in local spirals; such high values are only seen in the most luminous local starbursts. The global dynamics and demographics of star formation in these HII regions suggest that vigorous star formation is primarily governed by gravitational instability in primitive rotating disks.Comment: 18 pages, 8 figures, submitted to MNRA

The SINS survey of z~2 galaxy kinematics: properties of the giant star forming clumps

We have studied the properties of giant star forming clumps in five z~2 star-forming disks with deep SINFONI AO spectroscopy at the ESO VLT. The clumps reside in disk regions where the Toomre Q-parameter is below unity, consistent with their being bound and having formed from gravitational instability. Broad H{\alpha}/[NII] line wings demonstrate that the clumps are launching sites of powerful outflows. The inferred outflow rates are comparable to or exceed the star formation rates, in one case by a factor of eight. Typical clumps may lose a fraction of their original gas by feedback in a few hundred million years, allowing them to migrate into the center. The most active clumps may lose much of their mass and disrupt in the disk. The clumps leave a modest imprint on the gas kinematics. Velocity gradients across the clumps are 10-40 km/s/kpc, similar to the galactic rotation gradients. Given beam smearing and clump sizes, these gradients may be consistent with significant rotational support in typical clumps. Extreme clumps may not be rotationally supported; either they are not virialized, or they are predominantly pressure supported. The velocity dispersion is spatially rather constant and increases only weakly with star formation surface density. The large velocity dispersions may be driven by the release of gravitational energy, either at the outer disk/accreting streams interface, and/or by the clump migration within the disk. Spatial variations in the inferred gas phase oxygen abundance are broadly consistent with inside-out growing disks, and/or with inward migration of the clumps.Comment: accepted Astrophys. Journal, February 9, 201

Analyzing Recent Coronary Heart Disease Mortality Trends in Tunisia between 1997 and 2009.

BACKGROUND: In Tunisia, Cardiovascular Diseases are the leading causes of death (30%), 70% of those are coronary heart disease (CHD) deaths and population studies have demonstrated that major risk factor levels are increasing. OBJECTIVE: To explain recent CHD trends in Tunisia between 1997 and 2009. METHODS: DATA SOURCES: Published and unpublished data were identified by extensive searches, complemented with specifically designed surveys. ANALYSIS: Data were integrated and analyzed using the previously validated IMPACT CHD policy model. Data items included: (i)number of CHD patients in specific groups (including acute coronary syndromes, congestive heart failure and chronic angina)(ii) uptake of specific medical and surgical treatments, and(iii) population trends in major cardiovascular risk factors (smoking, total cholesterol, systolic blood pressure (SBP), body mass index (BMI), diabetes and physical inactivity). RESULTS: CHD mortality rates increased by 11.8% for men and 23.8% for women, resulting in 680 additional CHD deaths in 2009 compared with the 1997 baseline, after adjusting for population change. Almost all (98%) of this rise was explained by risk factor increases, though men and women differed. A large rise in total cholesterol level in men (0.73 mmol/L) generated 440 additional deaths. In women, a fall (-0.43 mmol/L), apparently avoided about 95 deaths. For SBP a rise in men (4 mmHg) generated 270 additional deaths. In women, a 2 mmHg fall avoided 65 deaths. BMI and diabetes increased substantially resulting respectively in 105 and 75 additional deaths. Increased treatment uptake prevented about 450 deaths in 2009. The most important contributions came from secondary prevention following Acute Myocardial Infarction (AMI) (95 fewer deaths), initial AMI treatments (90), antihypertensive medications (80) and unstable angina (75). CONCLUSIONS: Recent trends in CHD mortality mainly reflected increases in major modifiable risk factors, notably SBP and cholesterol, BMI and diabetes. Current prevention strategies are mainly focused on treatments but should become more comprehensive

The impact of working memory load on task execution and online plan adjustment during multitasking in a virtual environment

Three experiments investigated the impact of working memory load on online plan adjustment during a test of multitasking in young, nonexpert, adult participants. Multitasking was assessed using the Edinburgh Virtual Errands Test (EVET). Participants were asked to memorize either good or poor plans for performing multiple errands and were assessed both on task completion and on the extent to which they modified their plans during EVET performance. EVET was performed twice, with and without a secondary task loading a component of working memory. In Experiment 1, articulatory suppression was used to load the phonological loop. In Experiment 2, oral random generation was used to load executive functions. In Experiment 3, spatial working memory was loaded with an auditory spatial localization task. EVET performance for both good- and poor-planning groups was disrupted by random generation and sound localization, but not by articulatory suppression. Additionally, people given a poor plan were able to overcome this initial disadvantage by modifying their plans online. It was concluded that, in addition to executive functions, multiple errands performance draws heavily on spatial, but not verbal, working memory resources but can be successfully completed on the basis of modifying plans online, despite a secondary task load

The Emission-Line Spectra of Major Mergers: Evidence for Shocked Outflows

Using a spectral decomposition technique (Soto & Martin 2012, hereafter Paper I), we investigate the physical origin of the high-velocity emission line gas in a sample of 39 gas-rich, ultraluminous infrared galaxy (ULIRG) mergers. Regions with shock-like excitation were identified in two kinematically distinct regimes, characterized by broad ($\sigma >$ 150 \kms) and narrow linewidths. Here we investigate the physical origin of the high-velocity (broad) emission with shock-like line ratios. Considering the large amount of extinction in these galaxies, the blueshift of the broad emission suggests an origin on the near side of the galaxy and therefore an interpretation as a galactic outflow. The large spatial extent of the broad, shocked emission component is generally inconsistent with an origin in the narrow-line region of a AGN, so we conclude that energy and momentum supplied by the starburst drives these outflows. The new data are used to examine the fraction of the supernova energy radiated by shocks and the mass loss rate in the warm-ionized phase of the wind. We show that the shocks produced by galactic outflows can be recognized in moderately high-resolution, integrated spectra of these nearby, ultraluminous starbursts. The spectral fitting technique introduced in Paper I may therefore be used to improve the accuracy of the physical properties measured for high-redshift galaxies from their (observed frame) infrared spectra.Comment: Submitted to ApJ. 12 Pages, 7 Figures, 1 Table. This is a companion paper to "Gas Excitation in ULIRGS: Maps of Diagnostic Emission-Line Ratios in Space and Velocity" by Soto & Martin 201

ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: A comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas

&lt;b&gt;Objective&lt;/b&gt; &lt;i&gt;ABCB1&lt;/i&gt; encodes the multi-drug efflux pump P-glycoprotein (P-gp) and has been implicated in multi-drug resistance. We comprehensively evaluated this gene and flanking regions for an association with clinical outcome in epithelial ovarian cancer (EOC).&lt;p&gt;&lt;/p&gt; &lt;b&gt;Methods&lt;/b&gt; The best candidates from fine-mapping analysis of 21 &lt;i&gt;ABCB1&lt;/i&gt; SNPs tagging C1236T (rs1128503), G2677T/A (rs2032582), and C3435T (rs1045642) were analysed in 4616 European invasive EOC patients from thirteen Ovarian Cancer Association Consortium (OCAC) studies and The Cancer Genome Atlas (TCGA). Additionally we analysed 1,562 imputed SNPs around ABCB1 in patients receiving cytoreductive surgery and either ‘standard’ first-line paclitaxel–carboplatin chemotherapy (n = 1158) or any first-line chemotherapy regimen (n = 2867). We also evaluated ABCB1 expression in primary tumours from 143 EOC patients.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Result&lt;/b&gt; Fine-mapping revealed that rs1128503, rs2032582, and rs1045642 were the best candidates in optimally debulked patients. However, we observed no significant association between any SNP and either progression-free survival or overall survival in analysis of data from 14 studies. There was a marginal association between rs1128503 and overall survival in patients with nil residual disease (HR 0.88, 95% CI 0.77–1.01; p = 0.07). In contrast, &lt;i&gt;ABCB1&lt;/i&gt; expression in the primary tumour may confer worse prognosis in patients with sub-optimally debulked tumours.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Conclusion&lt;/b&gt; Our study represents the largest analysis of &lt;i&gt;ABCB1&lt;/i&gt; SNPs and EOC progression and survival to date, but has not identified additional signals, or validated reported associations with progression-free survival for rs1128503, rs2032582, and rs1045642. However, we cannot rule out the possibility of a subtle effect of rs1128503, or other SNPs linked to it, on overall survival.&lt;p&gt;&lt;/p&gt

Socioeconomic position across the lifecourse & allostatic load: data from the West of Scotland Twenty-07 cohort study

Background: We examined how socioeconomic position (SEP) across the lifecourse (three critical periods, social mobility and accumulated over time) is associated with allostatic load (a measure of cumulative physiological burden). Methods. Data are from the West of Scotland Twenty-07 Study, with respondents aged 35 (n = 740), 55 (n = 817) and 75 (n = 483). SEP measures representing childhood, the transition to adulthood and adulthood SEP were used. Allostatic load was produced by summing nine binary biomarker scores (1 = in the highest-risk quartile). Linear regressions were used for each of the lifecourse models; with model fits compared using partial F-tests. Results: For those aged 35 and 55, higher SEP was associated with lower allostatic load (no association in the 75-year-olds). The accumulation model (more time spent with higher SEP) had the best model fit in those aged 35 (b = -0.50, 95%CI = -0.68, -0.32, P = 0.002) and 55 (b = -0.31, 95%CI = -0.49, -0.12, P < 0.001). However, the relative contributions of each life-stage differed, with adulthood SEP less strongly associated with allostatic load. Conclusions: Long-term, accumulated higher SEP has been shown to be associated with lower allostatic load (less physiological burden). However, the transition to adulthood may represent a particularly sensitive period for SEP to impact on allostatic load. © 2014 Robertson et al.; licensee BioMed Central Ltd

Effective suckling in relation to naked maternal-infant body contact in the first hour of life: an observation study

Background Best practice guidelines to promote breastfeeding suggest that (i) mothers hold their babies in naked body contact immediately after birth, (ii) babies remain undisturbed for at least one hour and (iii) breastfeeding assistance be offered during this period. Few studies have closely observed the implementation of these guidelines in practice. We sought to evaluate these practices on suckling achievement within the first hour after birth. Methods Observations of seventy-eight mother-baby dyads recorded newborn feeding behaviours, the help received by mothers and birthing room practices each minute, for sixty minutes. Results Duration of naked body contact between mothers and their newborn babies varied widely from 1 to 60 minutes, as did commencement of suckling (range = 10 to 60 minutes). Naked maternal-infant body contact immediately after birth, uninterrupted for at least thirty minutes did not predict effective suckling within the first hour of birth. Newborns were four times more likely to sustain deep rhythmical suckling when their chin made contact with their mother’s breast as they approached the nipple (OR 3.8; CI 1.03 - 14) and if their mothers had given birth previously (OR 6.7; CI 1.35 - 33). Infants who had any naso-oropharyngeal suctioning administered at birth were six times less likely to suckle effectively (OR .176; CI .04 - .9). Conclusion Effective suckling within the first hour of life was associated with a collection of practices including infants positioned so their chin can instinctively nudge the underside of their mother’s breast as they approach to grasp the nipple and attach to suckle. The best type of assistance provided in the birthing room that enables newborns to sustain an effective latch was paying attention to newborn feeding behaviours and not administering naso-oropharyngeal suction routinely

Nanoscale waveguiding methods

While 32 nm lithography technology is on the horizon for integrated circuit (IC) fabrication, matching the pace for miniaturization with optics has been hampered by the diffraction limit. However, development of nanoscale components and guiding methods is burgeoning through advances in fabrication techniques and materials processing. As waveguiding presents the fundamental issue and cornerstone for ultra-high density photonic ICs, we examine the current state of methods in the field. Namely, plasmonic, metal slot and negative dielectric based waveguides as well as a few sub-micrometer techniques such as nanoribbons, high-index contrast and photonic crystals waveguides are investigated in terms of construction, transmission, and limitations. Furthermore, we discuss in detail quantum dot (QD) arrays as a gain-enabled and flexible means to transmit energy through straight paths and sharp bends. Modeling, fabrication and test results are provided and show that the QD waveguide may be effective as an alternate means to transfer light on sub-diffraction dimensions

Measurement of the production of a W boson in association with a charm quark in pp collisions at √s = 7 TeV with the ATLAS detector

The production of a W boson in association with a single charm quark is studied using 4.6 fb−1 of pp collision data at s√ = 7 TeV collected with the ATLAS detector at the Large Hadron Collider. In events in which a W boson decays to an electron or muon, the charm quark is tagged either by its semileptonic decay to a muon or by the presence of a charmed meson. The integrated and differential cross sections as a function of the pseudorapidity of the lepton from the W-boson decay are measured. Results are compared to the predictions of next-to-leading-order QCD calculations obtained from various parton distribution function parameterisations. The ratio of the strange-to-down sea-quark distributions is determined to be 0.96+0.26−0.30 at Q 2 = 1.9 GeV2, which supports the hypothesis of an SU(3)-symmetric composition of the light-quark sea. Additionally, the cross-section ratio σ(W + +c¯¯)/σ(W − + c) is compared to the predictions obtained using parton distribution function parameterisations with different assumptions about the s−s¯¯¯ quark asymmetry