Generating asymptotically plane wave spacetimes

In an attempt to study asymptotically plane wave spacetimes which admit an event horizon, we find solutions to vacuum Einstein's equations in arbitrary dimension which have a globally null Killing field and rotational symmetry. We show that while such solutions can be deformed to include ones which are asymptotically plane wave, they do not posses a regular event horizon. If we allow for additional matter, such as in supergravity theories, we show that it is possible to have extremal solutions with globally null Killing field, a regular horizon, and which, in addition, are asymptotically plane wave. In particular, we deform the extremal M2-brane solution in 11-dimensional supergravity so that it behaves asymptotically as a 10-dimensional vacuum plane wave times a real line.Comment: 23 pages, 1 eps figure; harvmac; v2:refs added; v3:minor comments adde

Assessment of genetic diversity among Malnad Gidda, Punganur and Vechur-dwarf cattle breeds of India using microsatellite markers

The genetic diversity among 3 dwarf breeds of cattle in India, viz. Malnad Gidda, Punganur and Vechur were analysed using 12 sets of microsatellite markers. All 11 amplified microsatellite loci were polymorphic with a mean number of alleles of 7.818±1.66 across breeds and in different breeds it ranged from 7.273 in Malnad Gidda to 3.546 in Vechur. The mean polymorphic information content (PIC) value observed and expected heterozygosity values across the population were 0.642, 0.610 and 0.683, respectively. A moderate level of inbreeding was observed with the inbreeding estimates ranging from -0.027 (ILSTS6) to 0.271 (HAUT24). Among the 3 breeds the highest mean number of alleles (7.273), mean PIC value (0.639), observed heterozygosity (0.630) and lower inbreeding estimates at majority of loci were observed in Malnad Gidda cattle indicating high degree of heterozygosity compared to Punganur and Vechur breeds. Even though departure from Hardy Weinberg Equilibrium (HWE) was found in Vechur and Punganur cattle population at majority of the loci, the population combining the 3 breeds was maintained at HWE with respect to most of loci under study. The genetic distance analysis revealed highest genetic distance between Vechur and Punganur (0.331) and lowest between Malnad Gidda and Punganur (0.125)

Checkpoint-Dependent and -Independent Roles of Swi3 in Replication Fork Recovery and Sister Chromatid Cohesion in Fission Yeast

Multiple genome maintenance processes are coordinated at the replication fork to preserve genomic integrity. How eukaryotic cells accomplish such a coordination is unknown. Swi1 and Swi3 form the replication fork protection complex and are involved in various processes including stabilization of replication forks, activation of the Cds1 checkpoint kinase and establishment of sister chromatid cohesion in fission yeast. However, the mechanisms by which the Swi1–Swi3 complex achieves and coordinates these tasks are not well understood. Here, we describe the identification of separation-of-function mutants of Swi3, aimed at dissecting the molecular pathways that require Swi1–Swi3. Unlike swi3 deletion mutants, the separation-of-function mutants were not sensitive to agents that stall replication forks. However, they were highly sensitive to camptothecin that induces replication fork breakage. In addition, these mutants were defective in replication fork regeneration and sister chromatid cohesion. Interestingly, unlike swi3-deleted cell, the separation-of-functions mutants were proficient in the activation of the replication checkpoint, but their fork regeneration defects were more severe than those of checkpoint mutants including cds1Δ, chk1Δ and rad3Δ. These results suggest that, while Swi3 mediates full activation of the replication checkpoint in response to stalled replication forks, Swi3 activates a checkpoint-independent pathway to facilitate recovery of collapsed replication forks and the establishment of sister chromatid cohesion. Thus, our separation-of-function alleles provide new insight into understanding the multiple roles of Swi1-Swi3 in fork protection during DNA replication, and into understanding how replication forks are maintained in response to different genotoxic agents

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Search for heavy resonances decaying to two Higgs bosons in final states containing four b quarks

A search is presented for narrow heavy resonances X decaying into pairs of Higgs bosons (H) in proton-proton collisions collected by the CMS experiment at the LHC at root s = 8 TeV. The data correspond to an integrated luminosity of 19.7 fb(-1). The search considers HH resonances with masses between 1 and 3 TeV, having final states of two b quark pairs. Each Higgs boson is produced with large momentum, and the hadronization products of the pair of b quarks can usually be reconstructed as single large jets. The background from multijet and t (t) over bar events is significantly reduced by applying requirements related to the flavor of the jet, its mass, and its substructure. The signal would be identified as a peak on top of the dijet invariant mass spectrum of the remaining background events. No evidence is observed for such a signal. Upper limits obtained at 95 confidence level for the product of the production cross section and branching fraction sigma(gg -> X) B(X -> HH -> b (b) over barb (b) over bar) range from 10 to 1.5 fb for the mass of X from 1.15 to 2.0 TeV, significantly extending previous searches. For a warped extra dimension theory with amass scale Lambda(R) = 1 TeV, the data exclude radion scalar masses between 1.15 and 1.55 TeV

Search for supersymmetry in events with one lepton and multiple jets in proton-proton collisions at root s=13 TeV

Peer reviewe

Measurement of the top quark mass using charged particles in pp collisions at root s=8 TeV

Peer reviewe