22 research outputs found
Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies
- Author
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- Zincircioglu C.
- Zogheib E. H.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality. Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42\ub74% vs 44\ub72%; absolute difference \u20131\ub769 [\u20139\ub758 to 6\ub711] p=0\ub767; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5\u20138] vs 6 [5\u20138] cm H2O; p=0\ub70011). ICU mortality was higher in MICs than in HICs (30\ub75% vs 19\ub79%; p=0\ub70004; adjusted effect 16\ub741% [95% CI 9\ub752\u201323\ub752]; p<0\ub70001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0\ub780 [95% CI 0\ub775\u20130\ub786]; p<0\ub70001). Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status. Funding: No funding
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017
- Author
- Abbasalizad-Farhangi Mahdieh
- Abbasi Masoumeh
- Abbastabar Hedayat
- Abdelalim Ahmed
- Abdoli Amir
- Abdollahi Mohammad
- Abdollahpour Ibrahim
- Abdulkader Rizwan Suliankatchi
- Abebe Nebiyu Dereje
- Abebo Teshome Abuka
- Abegaz Kedir Hussein
- Abolhassani Hassan
- Abreu Lucas Guimarães
- Abrigo Michael R. M.
- Abushouk Abdelrahman I.
- Accrombessi Manfred Mario Kokou
- Acharya Dilaram
- Adabi Maryam
- Adebiyi Akindele Olupelumi
- Adedeji Isaac Akinkunmi
- Adekanmbi Victor
- Adema Bereket Duko
- Adeoye Abiodun Moshood
- Adetokunboh Olatunji O.
- Adham Davoud
- Aduroja Posi Emmanuel
- Advani Shailesh M.
- Afarideh Mohsen
- Afshin Ashkan
- Aghaali Mohammad
- Agrawal Anurag
- Ahmad Tauseef
- Ahmadi Keivan
- Ahmadi Sepideh
- Ahmed Muktar Beshir
- Ahmed Rushdia
- Ajumobi Olufemi
- Akal Chalachew Genet
- Akalu Temesgen Yihunie
- Akinyemiju Tomi
- Akombi Blessing
- Al-Aly Ziyad
- Al-Mekhlafi Hesham M.
- Al-Raddadi Rajaa M.
- Alam Samiah
- Alamene Genet Melak
- Alanzi Turki M.
- Alema Niguse Meles
- Ali Beriwan Abdulqadir
- Ali Muhammad
- Alijanzadeh Mehran
- Alinia Cyrus
- Alipour Vahid
- Alizade Hesam
- Aljunid Syed Mohamed
- Almasi Afshin
- Almasi-Hashiani Amir
- Altirkawi Khalid
- Alvis-Guzman Nelson
- Alvis-Zakzuk Nelson J.
- Amare Azmeraw T.
- Amegah Adeladza Kofi
- Amini Saeed
- Amiri Fatemeh
- Amit Arianna Maever Loreche
- Anber Nahla Hamed
- Andrei Catalina Liliana
- Ansari Fereshteh
- Ansari-Moghaddam Alireza
- Anteneh Zelalem Alamrew
- Antonio Carl Abelardo T.
- Antriyandarti Ernoiz
- Anvari Davood
- Anwer Razique
- Appiah Seth Christopher Yaw
- Arab-Zozani Morteza
- Arabloo Jalal
- Araya Ephrem Mebrahtu
- Arefi Zohreh
- Aremu Olatunde
- Arnedo Carlos Alberto Marrugo
- Arzani Afsaneh
- Asadi-Aliabadi Mehran
- Asadi-Pooya Ali A.
- Asante Kwaku Oppong
- Asgari Samaneh
- Asghari Babak
- Ashagre Alebachew Fasil
- Asrat Anemaw A.
- Ataeinia Bahar
- Atalay Hagos Tasew
- Atnafu Desta Debalkie
- Atout Maha Moh’d Wahbi
- Ausloos Marcel
- Avokpaho Euripide F. G. A.
- Awasthi Ashish
- Ayanore Martin Amogre
- Aynalem Yared A. Asmare
- Azadmehr Abbas
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- Balakrishnan Senthilkumar
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- Bali Ayele Geleto
- Banach Maciej
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- Baradaran-Seyed Zahra
- Baraki Adhanom Gebreegziabher
- Barboza Miguel A.
- Barua Lingkan
- Basaleem Huda
- Basu Sanjay
- Bayati Mohsen
- Bayih Mulat Tirfie
- Baynes Habtamu Wondifraw
- Bedi Neeraj
- Behzadifar Masoud
- Behzadifar Meysam
- Bekele Yibeltal Alemu
- Bennett Derrick A.
- Berbada Dessalegn Ajema
- Berhe Abadi Kidanemariam
- Berhe Kidanemaryam
- Berman Adam E.
- Bernstein Robert S.
- Bhageerathy Reshmi
- Bhandari Dinesh
- Bharadwaj Pankaj
- Bhattacharjee Natalia V.
- Bhattacharyya Krittika
- Bijani Ali
- Bikbov Boris
- Bilano Ver
- Bililign Nigus
- Birara Setognal
- Birhane Minuye Biniam Biniam
- Birhanu Minyichil
- Biswas Raaj Kishore
- Bitew Zebenay Workneh
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- Cicuttini Flavia M.
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- Demoz Gebre Teklemariam
- Denova-Gutiérrez Edgar
- Deribe Kebede
- Desai Rupak
- Desalegn Beruk Berhanu
- Desalew Assefa
- Deshpande Aniruddha
- Dey Sagnik
- Dharmaratne Samath Dhamminda
- Dhillon Preeti
- Dhimal Meghnath
- Dhungana Govinda Prasad
- Diaz Daniel
- Dinsa Girmaye Deye
- Dipeolu Isaac Oluwafemi
- Djalalinia Shirin
- Do Hoa Thi
- Do Huyen Phuc
- Doku Paul Narh
- Dorostkar Fariba
- Doshmangir Leila
- Dubey Manisha
- Dunachie Susanna J.
- Duncan Bruce B.
- Durães Andre R.
- Dávila-Cervantes Claudio
- Earl Lucas
- Eftekhari Aziz
- El Razek Hassan Magdy Abd
- El Razek Muhammed Magdy Abd
- El Sayed Zaki Maysaa
- El Sayed Iman
- El Tantawi Maha
- El-Jaafary Shaimaa I.
- El-Khatib Ziad
- El-Sherbiny Yasser Mohamed
- Elbarazi Iffat
- Elemineh Demelash Abewa
- Elsharkawy Aisha
- Elyazar Iqbal R. F.
- Emamian Mohammad Hassan
- Enany Shymaa
- Endalew Daniel Adane
- Endalifer Melese Linger
- Eskandari Khalil
- Eskandarieh Sharareh
- Esmaeilnejad Saman
- Esteghamati Alireza
- Etemadi Arash
- Etisso Atkilt Esaiyas
- Fanzo Jessica
- Farahmand Mohammad
- Faraj Anwar
- Farashi Sajjad
- Fareed Mohammad
- Farioli Andrea
- Faro Andre
- Farzadfar Farshad
- Farzam Hossein
- Fatima Syeda Sadia
- Fattahi Nazir
- Fauk Nelsensius Klau
- Fazaeli Ali Akbar
- Fentahun Netsanet
- Ferede Tomas Y.
- Fereshtehnejad Seyed-Mohammad
- Fernandes Eduarda
- Fernandes João C.
- Feyissa Garumma Tolu
- Filip Irina
- Fischer Florian
- Flohr Carsten
- Foigt Nataliya A.
- Folayan Morenike Oluwatoyin
- Fomenkov Artem Alekseevich
- Forooshani Zahra Sadat Dibaji
- Foroutan Masoud
- Francis Joel Msafiri
- Fukumoto Takeshi
- Förster Jana
- Gayesa Reta Tsegaye
- Geberemariyam Biniyam Sahiledengle
- Gebrehiwot Tsegaye Tewelde
- Gebremariam Hadush
- Gebremariam Kidane Tadesse
- Gebremedhin Ketema Bizuwork Bizuwork
- Gebremeskel Gebreamlak Gebremedhn
- Gebreslassie Assefa Ayalew Ayalew
- Gebretsadik Gebretsadkan G. G.
- Gedefaw Getnet Azeze
- Geramo Yilma Chisha Dea
- Gesesew Hailay Abrha
- Geta Birhanu
- Getenet Agegnehu Bante
- Gezae Kebede Embaye
- Ghaffarifar Fatemeh
- Ghafourifard Mansour
- Ghajar Alireza
- Ghajarzadeh Mahsa
- Ghashghaee Ahmad
- Ghiasvand Hesam
- Gholamian Asadollah
- Gilani Syed Amir
- Gill Tiffany K.
- Ginawi Ibrahim Abdelmageed
- Goli Srinivas
- Gomes Nelson G. M.
- Gopalani Sameer Vali
- Goudarzi Houman
- Goulart Alessandra C.
- Govindakarnavar Arunkumar
- Grada Ayman
- Grivna Michal
- Guimarães Rafael Alves
- Guled Rashid Abdi
- Guo Yuming
- Gupta Rahul
- Gupta Rajat Das
- Gupta Rajeev
- Hafezi-Nejad Nima
- Haile Michael Tamene
- Haj-Mirzaian Arvin
- Haj-Mirzaian Arya
- Hall Brian J.
- Halvaei Iman
- Hamadeh Randah R.
- Hamidi Yadollah
- Handiso Demelash Woldeyohannes
- Hankey Graeme J.
- Haririan Hamidreza
- Hariyani Ninuk
- Hasaballah Ahmed I.
- Hasan Md. Mehedi
- Hasankhani Milad
- Hasanpoor Edris
- Hasanzadeh Amir
- Hashemian Maryam
- Hassanipour Soheil
- Hassen Hamid Yimam
- Havmoeller Rasmus
- Hawkes Corinna
- Hay Simon I.
- Hayat Khezar
- Hayelom Desta Haftu
- Heidari Behnam
- Heidari-Soureshjani Reza
- Hendrie Delia
- Henok Andualem
- Henry Nathaniel J.
- Herrero Mario
- Herteliu Claudiu
- Heydarpour Fatemeh
- Hoang Chi Linh
- Hoek Hans W.
- Hole Michael K.
- Holla Ramesh
- Hollerich Gillian
- Hong Sung Hwi
- Hoogar Praveen
- Horino Masako
- Hossain Naznin
- Hosseini Mostafa
- Hosseinzadeh Mehdi
- Hostiuc Mihaela
- Hostiuc Sorin
- Househ Mowafa
- Hsairi Mohamed
- Hu Guoqing
- Huda Tanvir M.
- Humayun Ayesha
- Hwang Bing-Fang
- Ibitoye Segun Emmanuel
- Ilesanmi Olayinka Stephen
- Ilic Milena D.
- Imani-Nasab Mohammad Hasan
- Inbaraj Leeberk Raja
- Iqbal Usman
- Irvani Seyed Sina Naghibi
- Islam Sheikh Mohammed Shariful
- Iwu Chidozie C. D.
- Iwu Chinwe Juliana
- Izadi Neda
- Jaafari Jalil
- Jabbari Seyed Hossein Yahyazadeh
- Jaca Anelisa
- Jadidi-Niaragh Farhad
- Jafarinia Morteza
- Jahani Mohammad Ali
- Jakovljevic Mihajlo
- Jalali Amir
- Jalilian Farzad
- Jayatilleke Achala Upendra
- Jeemon Panniyammakal
- Jehan Fyezah
- Jenabi Ensiyeh
- Jha Ravi Prakash
- Jha Vivekanand
- Ji John S.
- Jia Peng
- John Oommen
- John-Akinola Yetunde O.
- Johnson Kimberly B.
- Jonas Jost B.
- Jose Bruno Piassi Sao
- Joseph Nitin
- Joukar Farahnaz
- Jozwiak Jacek Jerzy
- Jungari Suresh Banayya
- Jürisson Mikk
- Kabir Ali
- Kabir Zubair
- Kafil Hossein Samadi
- Kahsay Amaha
- Kahssay Molla
- Kalani Hamed
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- Kalhor Rohollah
- Kalhori Reza Pourmirza
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- Kanchan Tanuj
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- Karim Mohd A.
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- Karyani Ali Kazemi
- Kasaeian Amir
- Kasahun Gebremicheal Gebreslassie
- Kasaye Habtamu Kebebe
- Kassa Tesfaye Dessale
- Kassaye Hagazi Gebremedhin
- Kassebaum Nicholas J.
- Kengne Andre Pascal
- Ketema Daniel Bekele
- Khader Yousef Saleh
- Khafaie Morteza Abdullatif
- Khaksarian Mojtaba
- Khalid Nauman
- Khalil Ibrahim A.
- Khalilov Rovshan
- Khan Asad
- Khan Ejaz Ahmad
- Khan Md Nuruzzaman
- Khan Mohammad Saud
- Khan Muhammad Shahzeb
- Khaneghah Amin Mousavi
- Khatab Khaled
- Khater Amir
- Khater Mona M.
- Khatib Mahalqua Nazli
- Khayamzadeh Maryam
- Khazaei Mohammad
- Khazaei Salman
- Khazaei-Pool Maryam
- Khodayari Mohammad Taghi
- Khosravi Mohammad Hossein
- Khundkar Roba
- Kiadaliri Ali
- Kianipour Neda
- Kiirithio Daniel N.
- Kim Yun Jin
- Kimokoti Ruth W.
- Kinyoki Damaris K.
- Kisa Adnan
- Kisa Sezer
- Kolola Tufa
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- Lebedev Georgy
- Lee Paul H.
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- Letourneau Ian D.
- Lewycka Sonia
- Leylabadlo Hamed Ebrahimzadeh
- Li Shanshan
- Lim Lee-Ling
- Linn Shai
- Liu Shiwei
- Liu Simin
- Lodha Rakesh
- Longbottom Joshua
- Lopez Jaifred Christian F.
- Lorkowski Stefan
- Macarayan Erlyn Rachelle King
- Madadin Mohammed
- Maghavani Dhaval P.
- Mahasha Phetole Walter
- Mahotra Narayan Bahadur
- Maled Venkatesh
- Maleki Afshin
- Maleki Shokofeh
- Malta Deborah Carvalho
- Manafi Ali
- Manafi Farzad
- Manafi Navid
- Manohar Narendar Dawanu
- Mansour-Ghanaei Fariborz
- Mansouri Borhan
- Mansournia Mohammad Ali
- Mapoma Chabila Christopher
- Marami Dadi
- Marczak Laurie B.
- Martins-Melo Francisco Rogerlândio
- Masaka Anthony
- Massenburg Benjamin Ballard
- Matin Behzad Karami
- Maulik Pallab K.
- Mayala Benjamin K.
- Mazidi Mohsen
- Mehndiratta Man Mohan
- Mehri Freshteh
- Mehta Kala M.
- Meitei Wahengbam Bigyananda
- Mekonnen Fantahun Ayenew
- Mekonnen Teferi
- Meles Gebrekiros Gebremichael
- Meles Hagazi Gebre
- Melese Addisu
- Mendoza Walter
- Menezes Ritesh G.
- Mengesha Meresa Berwo
- Mensah George A.
- Meretoja Tuomo J.
- Mezerji Naser Mohammad Gholi
- Miazgowski Tomasz
- Miller Ted R.
- Mills Edward J.
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- Mir Seyed Mostafa
- Miri Mohammad
- Mirjalali Hamed
- Mirrakhimov Erkin M.
- Mirzaei Hamed
- Mirzaei Maryam
- Mirzaei Roya
- Mirzaei-Alavijeh Mehdi
- Mithra Prasanna
- Moazen Babak
- Moghadam Telma Zahirian
- Mohamadi Efat
- Mohamadi-Bolbanabad Amjad
- Mohammad Dara K.
- Mohammad Karzan Abdulmuhsin
- Mohammad Yousef
- Mohammadian-Hafshejani Abdollah
- Mohammadnia-Afrouzi Mousa
- Mohammadoo-Khorasani Milad
- Mohammadpourhodki Reza
- Mohammed Ammas Siraj
- Mohammed Jemal Abdu
- Mohammed Salahuddin
- Mohammed Shafiu
- Mohebi Farnam
- Mokari Amin
- Mokdad Ali H.
- Montañez Julio Cesar
- Montero-Zamora Pablo A.
- Moodley Yoshan
- Moossavi Maryam
- Moradi Ghobad
- Moradi Masoud
- Moradi Yousef
- Moradi-Joo Mohammad
- Moradi-Lakeh Maziar
- Moradpour Farhad
- Moradzadeh Rahmatollah
- Moraga Paula
- Morrison Shane Douglas
- Mosapour Abbas
- Mosser Jonathan F.
- Mouodi Simin
- Mozaffarian Dariush
- Mueller Ulrich Otto
- Munro Sandra B.
- Murray Christopher J. L.
- Murthy G. V. S.
- Musa Kamarul Imran
- Mustafa Ghulam
- Muthupandian Saravanan
- Nabavizadeh Behnam
- Naderi Mehdi
- Nadkarni Girish N.
- Nagaraja Sharath Burugina
- Nagarajan Ahamarshan Jayaraman
- Naghavi Mohsen
- Naheed Aliya
- Naik Gurudatta
- Najafi Farid
- Nansseu Jobert Richie
- Narayan K. M. Venkat
- Nasab Mostafa Dianati
- Nascimento Bruno Ramos
- Nayak Vinod
- Nazari Javad
- Ndwandwe Duduzile Edith
- Negoi Ionut
- Negoi Ruxandra Irina
- Neve Jan-Walter De
- Ngunjiri Josephine W.
- Nguyen Cuong Tat
- Nguyen Huong Lan Thi
- Nigatu Dabere
- Nigatu Yeshambel T.
- Nikbakhsh Rajan
- Ningrum Dina Nur Anggraini
- Nnaji Chukwudi A.
- Nong Vuong Minh
- Noubiap Jean Jacques
- Nowak Christoph
- Oancea Bogdan
- Ofori-Asenso Richard
- Oghenetega Onome Bright
- Oh In-Hwan
- Oladimeji Olanrewaju
- Oladnabi Morteza
- Olagunju Andrew T.
- Olagunju Tinuke O.
- Olusanya Bolajoko Olubukunola
- Olusanya Jacob Olusegun
- Oluwasanu Mojisola Morenike
- Omer Muktar Omer
- Onwujekwe Obinna E.
- Oren Eyal
- Orisakwe Orish Ebere
- Ortiz Alberto
- Osarenotor Osayomwanbo
- Osgood-Zimmerman Aaron E.
- Owolabi Mayowa Ojo
- P. A. Mahesh
- Padubidri Jagadish Rao
- Pakshir Keyvan
- Pana Adrian
- Panda-Jonas Songhomitra
- Parsian Hadi
- Pashaei Tahereh
- Pasupula Deepak Kumar
- Patel Sangram Kishor
- Pathak Ashish
- Pathak Mona
- Pati Sanghamitra
- Patle Ajay
- Patton George C.
- Paulos Kebreab
- Pepito Veincent Christian Filipino
- Perico Norberto
- Petri William A.
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- Piroozi Bakhtiar
- Pirsaheb Meghdad
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- Pourshams Akram
- Poustchi Hossein
- Prada Sergio I.
- Preotescu Liliana
- Pribadi Dimas Ria Angga
- Quintanilla Beatriz Paulina Ayala
- Rabanal Jacqueline Elizabeth Alcalde
- Rabiee Mohammad
- Rabiee Navid
- Rad Enayatollah Homaie
- Radfar Amir
- Rafiei Alireza
- Rahim Fakher
- Rahimi-Movaghar Vafa
- Rahman Muhammad Aziz
- Rahman Sajjad ur
- Rai Rajesh Kumar
- Rajabpour-Sanati Ali
- Rajati Fatemeh
- Ramezanzadeh Kiana
- Rana Saleem Muhammad
- Ranabhat Chhabi Lal
- Rao Sowmya J.
- Rarani Mostafa Amini
- Rasella Davide
- Rashedi Vahid
- Rastogi Prateek
- Rathi Priya
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- Rezaei Nima
- Rezaeian Shahab
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- Rezapour Aziz
- Riahi Seyed Mohammad
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- Roever Leonardo
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- Saad Anas M.
- Saadatagah Seyedmohammad
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- Sadeghi Ehsan
- Sadeghi Masoumeh
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- Safarpour Hamid
- Sagar Rajesh
- Sahebkar Amirhossein
- Sahraian Mohammad Ali
- Sajadi S. Mohammad
- Salahshoor Mohammad Reza
- Salam Nasir
- Salehi Farkhonde
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- Salimi Yahya
- Salimzadeh Hamideh
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- Seyedmousavi Seyedmojtaba
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- Shafaat Omid
- Shahabi Saeed
- Shaikh Masood Ali
- Shalash Ali S.
- Shams-Beyranvand Mehran
- Shamshirian Amir
- Shamsizadeh Morteza
- Shannawaz Mohammed
- Sharafi Kiomars
- Sharif Mehdi
- Sharma Rajesh
- Shehata Hatem Samir
- Sheikhtaheri Abbas
- Shibuya Kenji
- Shiferaw Wondimeneh Shibabaw
- Shigematsu Mika
- Shin Jae Il
- Shiri Rahman
- Shirkoohi Reza
- Shiue Ivy
- Shuval Kerem
- Siabani Soraya
- Siddiqi Tariq J.
- Sigfusdottir Inga Dora
- Silva Diego Augusto Santos
- Simonetti Biagio
- Singh Ambrish
- Singh Jasvinder A.
- Singh Pankaj Kumar
- Singh Pushpendra
- Singh Virendra
- Sinha Dhirendra Narain
- Sintayehu Yitagesu
- Sisay Malede Mequanent M.
- Soheili Amin
- Soleymani Bija
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- Soltani Shahin
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- Sorrie Muluken Bekele
- Soshnikov Sergey
- Soyiri Ireneous N.
- Spotin Adel
- Sreeramareddy Chandrashekhar T.
- Srivastava Rajni Kant Kant
- Starodubova Antonina
- Sudaryanto Agus
- Sufiyan Mu’awiyyah Babale
- Suleria Hafiz Ansar Rasul
- Sulo Gerhard
- Sunguya Bruno F.
- Syed Zahiruddin Quazi
- Sykes Bryan L.
- Tabarés-Seisdedos Rafael
- Tabuchi Takahiro
- Tadesse Birkneh Tilahun
- Taherkhani Amir
- Tamirat Koku Sisay
- Tassew Segen Gebremeskel
- Taveira Nuno
- Teklehaimanot Berhane Fseha
- Tekulu Gebretsadkan Hintsa
- Temsah Mohamad-Hani
- Terkawi Abdullah Sulieman
- Tessema Zemenu Tadesse
- Thomas Nihal
- Titova Mariya Vladimirovna
- Tlaye Kenean Getaneh
- Tohidinik Hamid Reza
- Tonelli Marcello
- Toroudi Hamidreza Pazoki
- Tovani-Palone Marcos Roberto
- Traini Eugenio
- Tran Khanh Bao
- Tripathi Manjari
- Uddin Riaz
- Ullah Irfan
- Unnikrishnan Bhaskaran
- Upadhyay Era
- Useh Ushotanefe
- Usman Muhammad Shariq
- Uthman Olalekan A.
- Vacante Marco
- Vaezghasemi Masoud
- Valdez Pascual R.
- VanderHeide John
- Varavikova Elena
- Varughese Santosh
- Vasankari Tommi Juhani
- Vasseghian Yasser
- Vecchia Carlo La
- Veisani Yousef
- Venkatesh Srinivasaraghavan
- Venketasubramanian Narayanaswamy
- Verma Madhur
- Vidale Simone
- Violante Francesco S.
- Vlassov Vasily
- Vollmer Sebastian
- Vukovic Rade
- Waheed Yasir
- Wang Haidong
- Wang Yafeng
- Wang Yuan-Pang
- Weldesamuel Girmay Teklay
- Werdecker Andrea
- Wiangkham Taweewat
- Wiens Kirsten E.
- Wijeratne Tissa
- Wolde Haileab Fekadu
- Wondafrash Dawit Zewdu
- Wonde Tewodros Eshete
- Wondmieneh Adam Belay
- Wu Ai-Min
- Xu Gelin
- Yadegar Abbas
- Yadollahpour Ali
- Yamada Tomohide
- Yano Yuichiro
- Yaya Sanni
- Yazdi-Feyzabadi Vahid
- Yeshaneh Alex
- Yeshaw Yigizie
- Yeshitila Yordanos Gizachew
- Yilma Mekdes Tigistu
- Yip Paul
- Yonemoto Naohiro
- Yoon Seok-Jun
- Youm Yoosik
- Younis Mustafa Z.
- Yousefi Zabihollah
- Yousof Hebat-Allah Salah A.
- Yu Chuanhua
- Yusefzadeh Hasan
- Zahabi Saleh Salehi
- Zaki Leila
- Zaman Sojib Bin
- Zamani Mohammad
- Zamanian Maryam
- Zandian Hamed
- Zarafshan Hadi
- Zepro Nejimu Biza
- Zerfu Taddese Alemu
- Zewale Taye Abuhay
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zhao Xiu-Ju
- Zodpey Sanjay
- Zomorodian Kamiar
- Zotor Francis Bruno
- Ärnlöv Johan
- Publication venue
- Nature Research
- Publication date
- 01/01/2020
- Field of study
A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1–70.8) million) to 6.4% (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025. Prevalence of overweight increased from 5.2% (30 (22.8–38.5) million) in 2000 to 6.0% (55.5 (44.8–67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern China, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic
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- Aali Amirali
- Ababneh Hazim S
- Abate Yohannes Habtegiorgis
- Abbafati Cristiana
- Abbasgholizadeh Rouzbeh
- Abbasi-Kangevari Mohsen
- Abbasian Mohammadreza
- Abbastabar Hedayat
- Abd ElHafeez Samar
- Abd-Elsalam Sherief
- Abdelmasseh Michael
- Abdelwahab Ahmed
- Abdollahi Mohammad
- Abdollahifar Mohammad-Amin
- Abdoun Meriem
- Abdulah Deldar Morad
- Abdullahi Auwal
- Abebe Mesfin
- Abebe Samrawit Shawel
- Abedi Aidin
- Abegaz Kedir Hussein
- Abhilash E S
- Abidi Hassan
- Abiodun Olumide
- Aboagye Richard Gyan
- Abolhassani Hassan
- Abolmaali Meysam
- Abouzid Mohamed
- Aboye Girma Beressa
- Abreu Lucas Guimarães
- Abrha Woldu Aberhe
- Abtahi Dariush
- Abu Rumeileh Samir
- Abu-Gharbieh Eman
- Abu-Rmeileh Niveen ME
- Abu-Zaid Ahmed
- Abualruz Hasan
- Abubakar Bilyaminu
- Aburuz Salahdein
- Accrombessi Manfred Mario Kokou
- Adal Tadele Girum
- Adamu Abdu A
- Addo Isaac Yeboah
- Addolorato Giovanni
- Adebiyi Akindele Olupelumi
- Adekanmbi Victor
- Adepoju Abiola Victor
- Adetunji Charles Oluwaseun
- Adetunji Juliana Bunmi
- Adeyeoluwa Temitayo Esther
- Adeyinka Daniel Adedayo
- Adeyomoye Olorunsola Israel
- Admass Biruk Adie Adie
- Adnani Qorinah Estiningtyas Sakilah
- Adra Saryia
- Afolabi Aanuoluwapo Adeyimika
- Afzal Muhammad Sohail
- Afzal Saira
- Agampodi Suneth Buddhika
- Agasthi Pradyumna
- Aggarwal Manik
- Aghamiri Shahin
- Agide Feleke Doyore
- Agodi Antonella
- Agrawal Anurag
- Agyemang-Duah Williams
- Ahinkorah Bright Opoku
- Ahmad Aqeel
- Ahmad Danish
- Ahmad Firdos
- Ahmad Muayyad M
- Ahmad Sajjad
- Ahmad Shahzaib
- Ahmad Tauseef
- Ahmadi Keivan
- Ahmadzade Amir Mahmoud
- Ahmed Ali
- Ahmed Ayman
- Ahmed Haroon
- Ahmed Luai A
- Ahmed Mehrunnisha Sharif
- Ahmed Meqdad Saleh
- Ahmed Muktar Beshir
- Ahmed Syed Anees
- Ajami Marjan
- Aji Budi
- Akara Essona Matatom
- Akbarialiabad Hossein
- Akinosoglou Karolina
- Akinyemiju Tomi
- Akkaif Mohammed Ahmed
- Akyirem Samuel
- Al Hamad Hanadi
- Al Hasan Syed Mahfuz
- Al-Aly Ziyad
- Al-amer Rasmieh Mustafa
- Al-Azzam Sayer
- Al-Gheethi Adel Ali Saeed
- Al-Hanawi Mohammed Khaled
- Al-Marwani Sabah
- Al-Maweri Sadeq Ali Ali
- Al-Mekhlafi Hesham M
- Al-Omari Basem
- Al-Sabah Salman Khalifah
- Al-Tawfiq Jaffar A
- Al-Worafi Yaser Mohammed
- Alahdab Fares
- Alalalmeh Samer O
- Alalwan Tariq A
- Alam Khurshid
- Alam Manjurul
- Alam Noore
- Alanezi Fahad Mashhour
- Alanzi Turki M
- Albakri Almaza
- Albashtawy Mohammed
- AlBataineh Mohammad T
- Alcalde-Rabanal Jacqueline Elizabeth
- Aldawsari Khalifah A
- Aldhaleei Wafa A
- Aldridge Robert W
- Alema Haileselasie Berhane
- Alemayohu Mulubirhan Assefa
- Alemi Sharifullah
- Alemu Yihun Mulugeta
- Alhabib Khalid F
- Alhalaiqa Fadwa Alhalaiqa Naji
- Ali Abid
- Ali Amjad
- Ali Liaqat
- Ali Mohammed Usman
- Ali Rafat
- Ali Shahid
- Ali Syed Shujait Shujait
- Alicandro Gianfranco
- Alif Sheikh Mohammad
- Alikhani Reyhaneh
- Alimohamadi Yousef
- Aliyi Ahmednur Adem
- Aljasir Mohammad A M
- Aljunid Syed Mohamed
- Alla François
- Allebeck Peter
- Almazan Joseph Uy
- Almidani Louay
- Almidani Omar
- Alomari Mahmoud A
- Alonso Jordi
- Alqahtani Jaber S
- Alqalyoobi Shehabaldin
- Alqutaibi Ahmed Yaseen
- Altaany Zaid
- Altaf Awais
- Altirkawi Khalid A
- Aluh Deborah Oyine
- Alvis-Guzman Nelson
- Alwafi Hassan
- Aly Hany
- Aly Safwat
- Alzoubi Karem H
- Amani Reza
- Amare Azmeraw T
- Amegbor Prince M
- Ameyaw Edward Kwabena
- Amin Tarek Tawfik
- Amindarolzarbi Alireza
- Amiri Sohrab
- Amirzade-Iranaq Mohammad Hosein
- Amu Hubert
- Amugsi Dickson A
- Amusa Ganiyu Adeniyi
- Ancuceanu Robert
- Anderlini Deanna
- Anderson David B
- Andrade Pedro Prata
- Andrei Catalina Liliana
- Andrei Tudorel
- Angus Colin
- Anil Abhishek
- Anil Sneha
- Anoushiravani Amir
- Ansari Hossein
- Ansari-Moghaddam Alireza
- Ansariadi Ansariadi
- Antony Catherine M
- Antriyandarti Ernoiz
- Anvari Davood
- Anvari Saeid
- Anwar Saleha
- Anwar Sumadi Lukman
- Anwer Razique
- Anyasodor Anayochukwu Edward
- Aqeel Muhammad
- Arab Juan Pablo
- Arabloo Jalal
- Arafat Mosab
- Aravkin Aleksandr Y
- Areda Demelash
- Aremu Abdulfatai
- Aremu Olatunde
- Ariffin Hany
- Arkew Mesay
- Armocida Benedetta
- Arndt Michael Benjamin
- Arooj Mahwish
- Artamonov Anton A
- Arulappan Judie
- Aruleba Raphael Taiwo
- Arumugam Ashokan
- Asaad Malke
- Asadi-Lari Mohsen
- Asgedom Akeza Awealom
- Asghari-Jafarabadi Mohammad
- Asghariahmadabad Mona
- Ashraf Muhammad
- Aslani Armin
- Astell-Burt Thomas
- Athar Mohammad
- Athari Seyyed Shamsadin
- Atinafu Bantalem Tilaye Tilaye
- Atlaw Habtamu Wondmagegn
- Atorkey Prince
- Atout Maha Moh'd Wahbi
- Atreya Alok
- Aujayeb Avinash
- Ausloos Marcel
- Avan Abolfazl
- Awedew Atalel Fentahun
- Aweke Amlaku Mulat
- Ayala Quintanilla Beatriz Paulina
- Ayatollahi Haleh
- Ayuso-Mateos Jose L
- Ayyoubzadeh Seyed Mohammad
- Azadnajafabad Sina
- Azevedo Rui M S
- Azzam Ahmed Y
- B Darshan B
- Babu Abraham Samuel
- Badar Muhammad
- Badiye Ashish D
- Baghdadi Soroush
- Bagheri Nasser
- Bagherieh Sara
- Bah Sulaiman
- Bahadorikhalili Saeed
- Bahmanziari Najmeh
- Bai Ruhai
- Baig Atif Amin
- Baker Jennifer L
- Bako Abdulaziz T
- Bakshi Ravleen Kaur
- Balakrishnan Senthilkumar
- Balasubramanian Madhan
- Baltatu Ovidiu Constantin
- Bam Kiran
- Banach Maciej
- Bandyopadhyay Soham
- Banik Palash Chandra
- Bansal Hansi
- Bansal Kannu
- Barbic Franca
- Barchitta Martina
- Bardhan Mainak
- Bardideh Erfan
- Barker-Collo Suzanne Lyn
- Barone-Adesi Francesco
- Barqawi Hiba Jawdat
- Barrero Lope H
- Barrow Amadou
- Barteit Sandra
- Barua Lingkan
- Basharat Zarrin
- Bashiri Azadeh
- Basiru Afisu
- Baskaran Pritish
- Basnyat Buddha
- Bassat Quique
- Basso João Diogo
- Basting Ann V L
- Basu Sanjay
- Batra Kavita
- Baune Bernhard T
- Bayati Mohsen
- Bayileyegn Nebiyou Simegnew
- Beaney Thomas
- Bedi Neeraj
- Beghi Massimiliano
- Behboudi Emad
- Behera Priyamadhaba
- Behnoush Amir Hossein
- Behzadifar Masoud
- Beiranvand Maryam
- Bejarano Ramirez Diana Fernanda
- Belay Sefealem Assefa
- Belete Chalie Mulu
- Bell Michelle L
- Bello Muhammad Bashir
- Bello Olorunjuwon Omolaja
- Belo Luis
- Beloukas Apostolos
- Bender Rose Grace
- Bensenor Isabela M
- Beran Azizullah
- Berezvai Zombor
- Berhie Alemshet Yirga
- Berice Betyna N
- Bernstein Robert S
- Bertolacci Gregory J
- Bettencourt Paulo J G
- Beyene Kebede A
- Bhagat Devidas S
- Bhagavathula Akshaya Srikanth
- Bhala Neeraj
- Bhalla Ashish
- Bhandari Dinesh
- Bhangdia Kayleigh
- Bhardwaj Nikha
- Bhardwaj Pankaj
- Bhardwaj Prarthna V
- Bhargava Ashish
- Bhaskar Sonu
- Bhat Vivek
- Bhatti Gurjit Kaur
- Bhatti Jasvinder Singh
- Bhatti Manpreet S
- Bhatti Rajbir
- Bhutta Zulfiqar A
- Bikbov Boris
- Bishai Jessica Devin
- Bisignano Catherine
- Bisulli Francesca
- Biswas Atanu
- Biswas Bijit
- Bitaraf Saeid
- Bitew Bikes Destaw
- Bitra Veera R
- Bjørge Tone
- Boachie Micheal Kofi
- Boampong Mary Sefa
- Bobirca Anca Vasilica
- Bodolica Virginia
- Bodunrin Aadam Olalekan
- Bogale Eyob Ketema
- Bogale Kassawmar Angaw
- Bohlouli Somayeh
- Bolarinwa Obasanjo Afolabi
- Boloor Archith
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- Yao Yao
- Yaribeygi Habib
- Ye Pengpeng
- Yehualashet Sisay Shewasinad
- Yesiltepe Metin
- Yesuf Subah Abderehim
- Yezli Saber
- Yi Siyan
- Yigezu Amanuel
- Yip Paul
- Yismaw Malede Berihun
- Yismaw Yazachew
- Yiğit Arzu
- Yiğit Vahit
- Yon Dong Keon
- Yonemoto Naohiro
- Yoon Seok-Jun
- You Yuyi
- Younis Mustafa Z
- Yousefi Zabihollah
- Yu Chuanhua
- Yu Yong
- Yuh Faith H
- Zadey Siddhesh
- Zadnik Vesna
- Zafari Nima
- Zakham Fathiah
- Zaki Nazar
- Zaman Sojib Bin
- Zamora Nelson
- Zand Ramin
- Zangiabadian Moein
- Zar Heather J
- Zare Iman
- Zarrintan Armin
- Zeariya Mohammed G M
- Zeinali Zahra
- Zhang Haijun
- Zhang Jianrong
- Zhang Jingya
- Zhang Liqun
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zhao Hanqing
- Zhong Chenwen
- Zhou Juexiao
- Zhu Bin
- Zhu Lei
- Ziafati Makan
- Zielińska Magdalena
- Zitoun Osama A
- Zoladl Mohammad
- Zou Zhiyong
- Zuhlke Liesl J
- Zumla Alimuddin
- Zweck Elric
- Zyoud Samer H
- Ärnlöv Johan
- Šekerija Mario
- Publication venue
- Elsevier
- Publication date
- 03/04/2024
- Field of study
BACKGROUND Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mortality rates and life expectancy allow comparisons of the consequences of causes of death globally and over time, providing a nuanced understanding of the effect of these causes on global populations. METHODS The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 cause-of-death analysis estimated mortality and years of life lost (YLLs) from 288 causes of death by age-sex-location-year in 204 countries and territories and 811 subnational locations for each year from 1990 until 2021. The analysis used 56 604 data sources, including data from vital registration and verbal autopsy as well as surveys, censuses, surveillance systems, and cancer registries, among others. As with previous GBD rounds, cause-specific death rates for most causes were estimated using the Cause of Death Ensemble model-a modelling tool developed for GBD to assess the out-of-sample predictive validity of different statistical models and covariate permutations and combine those results to produce cause-specific mortality estimates-with alternative strategies adapted to model causes with insufficient data, substantial changes in reporting over the study period, or unusual epidemiology. YLLs were computed as the product of the number of deaths for each cause-age-sex-location-year and the standard life expectancy at each age. As part of the modelling process, uncertainty intervals (UIs) were generated using the 2·5th and 97·5th percentiles from a 1000-draw distribution for each metric. We decomposed life expectancy by cause of death, location, and year to show cause-specific effects on life expectancy from 1990 to 2021. We also used the coefficient of variation and the fraction of population affected by 90% of deaths to highlight concentrations of mortality. Findings are reported in counts and age-standardised rates. Methodological improvements for cause-of-death estimates in GBD 2021 include the expansion of under-5-years age group to include four new age groups, enhanced methods to account for stochastic variation of sparse data, and the inclusion of COVID-19 and other pandemic-related mortality-which includes excess mortality associated with the pandemic, excluding COVID-19, lower respiratory infections, measles, malaria, and pertussis. For this analysis, 199 new country-years of vital registration cause-of-death data, 5 country-years of surveillance data, 21 country-years of verbal autopsy data, and 94 country-years of other data types were added to those used in previous GBD rounds. FINDINGS The leading causes of age-standardised deaths globally were the same in 2019 as they were in 1990; in descending order, these were, ischaemic heart disease, stroke, chronic obstructive pulmonary disease, and lower respiratory infections. In 2021, however, COVID-19 replaced stroke as the second-leading age-standardised cause of death, with 94·0 deaths (95% UI 89·2-100·0) per 100 000 population. The COVID-19 pandemic shifted the rankings of the leading five causes, lowering stroke to the third-leading and chronic obstructive pulmonary disease to the fourth-leading position. In 2021, the highest age-standardised death rates from COVID-19 occurred in sub-Saharan Africa (271·0 deaths [250·1-290·7] per 100 000 population) and Latin America and the Caribbean (195·4 deaths [182·1-211·4] per 100 000 population). The lowest age-standardised death rates from COVID-19 were in the high-income super-region (48·1 deaths [47·4-48·8] per 100 000 population) and southeast Asia, east Asia, and Oceania (23·2 deaths [16·3-37·2] per 100 000 population). Globally, life expectancy steadily improved between 1990 and 2019 for 18 of the 22 investigated causes. Decomposition of global and regional life expectancy showed the positive effect that reductions in deaths from enteric infections, lower respiratory infections, stroke, and neonatal deaths, among others have contributed to improved survival over the study period. However, a net reduction of 1·6 years occurred in global life expectancy between 2019 and 2021, primarily due to increased death rates from COVID-19 and other pandemic-related mortality. Life expectancy was highly variable between super-regions over the study period, with southeast Asia, east Asia, and Oceania gaining 8·3 years (6·7-9·9) overall, while having the smallest reduction in life expectancy due to COVID-19 (0·4 years). The largest reduction in life expectancy due to COVID-19 occurred in Latin America and the Caribbean (3·6 years). Additionally, 53 of the 288 causes of death were highly concentrated in locations with less than 50% of the global population as of 2021, and these causes of death became progressively more concentrated since 1990, when only 44 causes showed this pattern. The concentration phenomenon is discussed heuristically with respect to enteric and lower respiratory infections, malaria, HIV/AIDS, neonatal disorders, tuberculosis, and measles. INTERPRETATION Long-standing gains in life expectancy and reductions in many of the leading causes of death have been disrupted by the COVID-19 pandemic, the adverse effects of which were spread unevenly among populations. Despite the pandemic, there has been continued progress in combatting several notable causes of death, leading to improved global life expectancy over the study period. Each of the seven GBD super-regions showed an overall improvement from 1990 and 2021, obscuring the negative effect in the years of the pandemic. Additionally, our findings regarding regional variation in causes of death driving increases in life expectancy hold clear policy utility. Analyses of shifting mortality trends reveal that several causes, once widespread globally, are now increasingly concentrated geographically. These changes in mortality concentration, alongside further investigation of changing risks, interventions, and relevant policy, present an important opportunity to deepen our understanding of mortality-reduction strategies. Examining patterns in mortality concentration might reveal areas where successful public health interventions have been implemented. Translating these successes to locations where certain causes of death remain entrenched can inform policies that work to improve life expectancy for people everywhere. FUNDING Bill & Melinda Gates Foundation
Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
- Author
- Abate Yohannes Habtegiorgis
- Abbas Jaffar
- Abbasi Madineh Akram
- Abbasian Mohammadreza
- Abbastabar Hedayat
- Abd-Rabu Rami
- Abdelmasseh Michael
- Abdollahi Mohammad
- Abdollahi Mozhan
- Abdollahifar Mohammad-Amin
- Abdulah Deldar Morad
- Abdullahi Auwal
- Abedi Aidin
- Abedi Vida
- Abeldaño Zuñiga Roberto Ariel
- Abidi Hassan
- Abiodun Olumide
- Aboagye Richard Gyan
- Abolhassani Hassan
- Aboyans Victor
- Abrha Woldu Aberhe
- Abu-Gharbieh Eman
- Abualhasan Ahmed
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- Rahman Md Obaidur
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- Rahman Mosiur
- Rahman Muhammad Aziz
- Rahmani Youshanlouei Hamed
- Rahmani Amir Masoud
- Rahmani Shayan
- Rahmati Masoud
- Raj Moolambally Sheetal
- Rajabpour-Sanati Ali
- Ramadan Hazem
- Ramasamy Shakthi Kumaran
- Ramasubramani Premkumar
- Ramazanu Sheena
- Rancic Nemanja
- Rao Indu Ramachandra
- Rao Sowmya J
- Rapaka Deepthi
- Rashedi Vahid
- Rashid Ahmed Mustafa
- Rashidi Alavijeh Mehran
- Rashidi Mohammad-Mahdi
- Rasouli-Saravani Ashkan
- Rawaf Salman
- Razo Christian
- Redwan Elrashdy Moustafa Mohamed
- Rekabi Bana Atefe
- Remuzzi Giuseppe
- Rezaei Nazila
- Rezaei Negar
- Rezaei Nima
- Rezaeian Mohsen
- Rhee Taeho Gregory
- Riad Abanoub
- Robinson Stephen R
- Rodrigues Mónica
- Rodriguez Jefferson Antonio Buendia
- Roever Leonardo
- Rogowski Emma L B
- Romoli Michele
- Ronfani Luca
- Roy Pramanik Koushik
- Roy Priyanka
- Rubagotti Enrico
- Ruiz Milagros A
- Russ Tom C
- S Sunnerhagen Katharina
- Saad Aly M A
- Saadatian Zahra
- Saber Korosh
- SaberiKamarposhti Morteza
- Sacco Simona
- Saddik Basema
- Sadeghi Erfan
- Sadeghian Saeid
- Saeed Umar
- Saeed Usman
- Safdarian Mahdi
- Safi Sher Zaman
- Sagar Rajesh
- Sagoe Dominic
- Saheb Sharif-Askari Fatemeh
- Saheb Sharif-Askari Narjes
- Sahebkar Amirhossein
- Sahoo Soumya Swaroop
- Sahraian Mohammad Ali
- Sajedi Seyed Aidin
- Sakshaug Joseph W
- Saleh Mohamed A
- Salehi Omran Hossein
- Salem Marwa Rashad
- Salimi Sohrab
- Samadi Kafil Hossein
- Samadzadeh Sara
- Samargandy Saad
- Samodra Yoseph Leonardo
- Samuel Vijaya Paul
- Samy Abdallah M
- Sanadgol Nima
- Sanjeev Rama Krishna
- Sanmarchi Francesco
- Santomauro Damian Francesco
- Santri Ichtiarini Nurullita
- Santric-Milicevic Milena M
- Saravanan Aswini
- Sarveazad Arash
- Satpathy Maheswar
- Saylan Mete
- Sayyah Mehdi
- Scarmeas Nikolaos
- Schiess Nicoline
- Schlaich Markus P
- Schuermans Art
- Schwarzinger Michaël
- Schwebel David C
- Seeher Katrin Maria
- Selvaraj Siddharthan
- Sendekie Ashenafi Kibret
- Sengupta Pallav
- Senthilkumaran Subramanian
- Serban Dragos
- Sergindo Mihretu Tagesse
- Servili Chiara
- Sethi Yashendra
- SeyedAlinaghi SeyedAhmad
- Seylani Allen
- Shabani Mohammad
- Shabany Maryam
- Shafie Mahan
- Shahabi Saeed
- Shahbandi Ataollah
- Shahid Samiah
- Shahraki-Sanavi Fariba
- Shahsavari Hamid R
- Shahwan Moyad Jamal
- Shaikh Masood Ali
- Shaji KS
- Sham Sunder
- Shama Adisu Tafari T
- Shamim Muhammad Aaqib
- Shams-Beyranvand Mehran
- Shamsi Mohammad Anas
- Shanawaz Mohd
- Sharath Medha
- Sharfaei Sadaf
- Sharifan Amin
- Sharma Manoj
- Sharma Rajesh
- Shashamo Bereket Beyene
- Shayan Maryam
- Sheikhi Rahim Ali
- Shekhar Shashank
- Shen Jiabin
- Shenoy Suchitra M
- Shetty Pavanchand H
- Shiferaw Desalegn Shiferaw
- Shigematsu Mika
- Shiri Rahman
- Shittu Aminu
- Shivakumar K M
- Shokri Fereshteh
- Shool Sina
- Shorofi Seyed Afshin
- Shrestha Sunil
- Siankam Tankwanchi Akhenaten Benjamin
- Siddig Emmanuel Edwar
- Sigfusdottir Inga Dora
- Silva João Pedro
- Silva Luís Manuel Lopes Rodrigues
- Sinaei Ehsan
- Singh Balbir Bagicha
- Singh Garima
- Singh Paramdeep
- Singh Surjit
- Sirota Sarah Brooke
- Sivakumar Shravan
- Sohag Abdullah Al Mamun
- Solanki Ranjan
- Soleimani Hamidreza
- Solikhah Solikhah
- Solomon Yerukneh
- Solomon Yonatan
- Song Suhang
- Song Yimeng
- Sotoudeh Houman
- Spartalis Michael
- Stark Benjamin A
- Starnes Joseph R
- Starodubova Antonina V
- Stein Dan J
- Steiner Timothy J
- Steinmetz Jaimie D
- Stovner Lars Jacob
- Suleman Muhammad
- Suliankatchi Abdulkader Rizwan
- Sultana Abida
- Sun Jing
- Sunkersing David
- Sunny Angel
- Susianti Hani
- Swain Chandan Kumar
- Szeto Mindy D
- Tabarés-Seisdedos Rafael
- Tabatabaei Seyyed Mohammad
- Tabatabai Shima
- Tabish Mohammad
- Taheri Majid
- Tahvildari Azin
- Tajbakhsh Ardeshir
- Tampa Mircea
- Tamuzi Jacques JL Lukenze
- Tan Ker-Kan
- Tang Haosu
- Tareke Minale
- Tarigan Ingan Ukur
- Tat Nathan Y
- Tat Vivian Y
- Tavakoli Oliaee Razieh
- Tavangar Seyed Mohammad
- Tavasol Arian
- Tefera Yibekal Manaye
- Tehrani-Banihashemi Arash
- Temesgen Worku Animaw
- Temsah Mohamad-Hani
- Teramoto Masayuki
- Tesfaye Amensisa Hailu
- Tesfaye Edosa Geta
- Tesler Riki
- Thakali Ocean
- Thangaraju Pugazhenthan
- Thapa Rajshree
- Thapar Rekha
- Thomas Nikhil Kenny
- Thrift Amanda G
- Ticoalu Jansje Henny Vera
- Tillawi Tala
- Toghroli Razie
- Tonelli Marcello
- Tovani-Palone Marcos Roberto
- Traini Eugenio
- Tran Nghia Minh
- Tran Ngoc-Ha
- Tran Phu Van
- Tromans Samuel Joseph
- Truelsen Thomas Clement
- Truyen Thien Tan Tri Tai
- Tsatsakis Aristidis
- Tsegay Guesh Mebrahtom
- Tsermpini Evangelia Eirini
- Tualeka Abdul Rohim
- Tufa Derara Girma
- Ubah Chukwudi S
- Udoakang Aniefiok John
- Ulhaq Inam
- Umair Muhammad
- Umakanthan Srikanth
- Umapathi Krishna Kishore
- Unim Brigid
- Unnikrishnan Bhaskaran
- Vaithinathan Asokan Govindaraj
- Vakilian Alireza
- Valadan Tahbaz Sahel
- Valizadeh Rohollah
- Van den Eynde Jef
- Vart Priya
- Varthya Shoban Babu
- Vasankari Tommi Juhani
- Vaziri Siavash
- Vellingiri Balachandar
- Venketasubramanian Narayanaswamy
- Verras Georgios-Ioannis
- Vervoort Dominique
- Villafañe Jorge Hugo
- Villani Leonardo
- Vinueza Veloz Andres Fernando
- Viskadourou Maria
- Vladimirov Sergey Konstantinovitch
- Vlassov Vasily
- Volovat Simona Ruxandra
- Vos Theo
- Vu Loc Tri
- Vujcic Isidora S
- Wagaye Birhanu
- Waheed Yasir
- Wahood Waseem
- Walde Mandaras Tariku
- Wang Fang
- Wang Shu
- Wang Yanzhong
- Wang Yuan-Pang
- Waqas Muhammad
- Waris Abdul
- Weerakoon Kosala Gayan
- Weintraub Robert G
- Weldemariam Abrha Hailay
- Westerman Ronny
- Whisnant Joanna L
- Wickramasinghe Dakshitha Praneeth
- Wickramasinghe Nuwan Darshana
- Willekens Barbara
- Wilner Lauren B
- Winkler Andrea Sylvia
- Wolfe Charles D A
- Wu Ai-Min
- Wulf Hanson Sarah
- Xu Suowen
- Xu Xiaoyue
- Yadollahpour Ali
- Yaghoubi Sajad
- Yahya Galal
- Yamagishi Kazumasa
- Yang Lin
- Yano Yuichiro
- Yao Yao
- Yehualashet Sisay Shewasinad
- Yeshaneh Alex
- Yesiltepe Metin
- Yi Siyan
- Yiğit Arzu
- Yiğit Vahit
- Yon Dong Keon
- Yonemoto Naohiro
- You Yuyi
- Younis Mustafa Z
- Yu Chuanhua
- Yusuf Hadiza
- Zadey Siddhesh
- Zahedi Mohammad
- Zakham Fathiah
- Zaki Nazar
- Zali Alireza
- Zamagni Giulia
- Zand Ramin
- Zandieh Ghazal G Z
- Zangiabadian Moein
- Zarghami Amin
- Zastrozhin Mikhail Sergeevich
- Zeariya Mohammed G M
- Zegeye Zelalem Banjaw
- Zeukeng Francis
- Zhai Chunxia
- Zhang Chen
- Zhang Haijun
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zhao Hanqing
- Zhao Yang
- Zheng Peng
- Zhou Hengxing
- Zhu Bin
- Zhumagaliuly Abzal
- Zielińska Magdalena
- Zikarg Yossef Teshome
- Zoladl Mohammad
- Ärnlöv Johan
- Publication venue
- Elsevier
- Publication date
- 01/04/2024
- Field of study
BackgroundDisorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021.MethodsWe estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined.FindingsGlobally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. Age-standardised rates of deaths per 100 000 people attributed to these conditions decreased from 1990 to 2021 by 33·6% (27·6–38·8), and age-standardised rates of DALYs attributed to these conditions decreased by 27·0% (21·5–32·4). Age-standardised prevalence was almost stable, with a change of 1·5% (0·7–2·4). The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer.InterpretationAs the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed
Factorial design approach to investigate the significance of factors on the fire resistant, compression and adhesion properties of geopolymer binder
- Publication venue
- 'Universiti Malaysia Pahang Publishing'
- Publication date
- 01/01/2020
- Field of study
Despite numerous studies on the factors which influenced the properties of the geopolymer binder have been conducted, the effect of different factors on the properties of geopolymer binder was not well determined. In this research, geopolymer materials were analyzed and profiled using a statistical approach called 2-level fractional factorial design (2-FrFD). The objective is to screen and identify important factors affecting the behaviour of geopolymer binder. MINITAB, a statistical software, was used to design the experiment, analyze data obtained and present the significance value of the factors via chart and plots. The result showed that the curing temperature (V3) did not have a significant effect on the fire resistant properties of the geopolymer binder with the p-value of 0.526. Other factors and interaction were significant with RHA/AA ratio (V2) was the most significant factor with the coefficient value of 135. For the compression strength properties, all factor and interactions were significant (p-value between 0.000 and 0.009) with the RHA/AA ratio (V2) recorded the highly significant factor with the coefficient value of 8.838. For adhesion strength properties, NaOH concentration (V4) and curing time (V5) were found to be insignificant with the p-value of 0.223 and 0.133, respectively. Other factors and interaction were significant curing temperature (V3) was the most significant factor with the coefficient value of 0.287. This result may hugely benefit future researchers, towards producing halal and sustainable polymer, in determining the suitable factors which have a significant effect of the properties (outcome) of the geopolymer binder
Synthesis, Cytotoxic Evaluation, and Molecular Docking Studies of N-(7- hydroxy-4-methyl-2-oxoquinolin-1(2H)-yl)acetamide/benzamide Analogues
- Author
- Abdellatif K.R.A.
- Abdulmalik Bin Saleh Al-Tamimi
- Afzal Hussain
- Afzal O.
- Ahsan M.J.
- Ahsan M.J.
- Aly R.M.
- Bray F.
- DeSantis C.E.
- Ghorab M.M.
- Habibullah Khalilullah
- Heiniger B.
- Kar A.
- Laskowski R.A.
- Li S.
- Lipinski C.A.
- Mohamed Jawed Ahsan
- Mohammed Afroz Bakht
- Mohammed H. Geesi
- Mohd. Zaheen Hassan
- Musiol R.
- Nandakumar A.
- Narayan Murthy Ganta
- Patrick G.L.
- Pawar V.G.
- Ransom M.
- Rupesh Kumar Kumawat
- Salahuddin
- Siegel R.L.
- Surender Singh Jadav
- Thigulla Y.
- Topliss J.G.
- Yassine Riadi
- Publication venue
- 'Bentham Science Publishers Ltd.'
- Publication date
- Field of study
Seawater, biota and sediment partitioning of 137Cs in the east coast of Peninsular Malaysia
- Author
- B Wernsperger
- D Ambe
- D Porcelli
- Dainee Norfardzila Ahmad Tugi
- DJ Rowan
- E Behrens
- F Kasamatsu
- FP Carvalho
- G Gilmore
- GTF Wong
- H Qin
- H Tsukada
- I Valles
- J Carroll
- J Vives i Batlle
- JA Hetherington
- K Misumi
- K Nakata
- K Oguri
- KO Buesseler
- KO Buesseler
- M Chino
- M Kusakabe
- M Manolopoulou
- MA Ashraf
- MC Honda
- Mei-Wo Yii
- Mohamad Noh Sawon
- Mohd Tarmizi Ishak
- Muhammad Izzat Muammar Ramli
- MW Yii
- Nooradilah Abdullah
- Norfaizal Mohamed
- P Børrentzen
- P Grabowski
- QH Fan
- S Otosaka
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- Salahuddin Muhamad
- T Ikäheimonen
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- TJ Yasunari
- V Sanial
- WM Zal U’yun
- WM Zal U’yun
- Y Narimatsu
- Zal U’yun Wan Mahmood
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19
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- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background: We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID-19 cohort, one of the world’s largest international, standardized data sets concerning hospitalized patients. Methods: The data set analysed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. We investigated how symptoms on admission, co-morbidities, risk factors and treatments varied by age, sex and other characteristics. We used Cox regression models to investigate associations between demographics, symptoms, co-morbidities and other factors with risk of death, admission to an intensive care unit (ICU) and invasive mechanical ventilation (IMV). Results: Data were available for 689 572 patients with laboratory-confirmed (91.1%) or clinically diagnosed (8.9%) SARS-CoV-2 infection from 52 countries. Age [adjusted hazard ratio per 10 years 1.49 (95% CI 1.48, 1.49)] and male sex [1.23 (1.21, 1.24)] were associated with a higher risk of death. Rates of admission to an ICU and use of IMV increased with age up to age 60 years then dropped. Symptoms, co-morbidities and treatments varied by age and had varied associations with clinical outcomes. The case-fatality ratio varied by country partly due to differences in the clinical characteristics of recruited patients and was on average 21.5%. Conclusions: Age was the strongest determinant of risk of death, with a ~30-fold difference between the oldest and youngest groups; each of the co-morbidities included was associated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death. The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who have a higher risk of death
Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies
- Author
- Aage Christiansen
- Aaradhana Adhikari
- Aaron Venti
- Aayesha Qadeer
- Abdellatif Benslama
- Abigail Beane
- Abu Hena Mostafa Kamal
- Abul Faiz
- Adam B Schlichting
- Adam Bell Bell
- Adenilton M R Ampinelli
- Aditya Uppalapati
- Adrian Donnelly
- Adriana M Fernandez
- Adrien Robine
- Aftab Akhtar
- Agreta Gecaj-Gashi
- Ahmed Farooq
- Ahmed S Al Jabbary
- Ahmet Dilek
- Ahmet Sukru Denker
- Ai Y Hang
- Aiman Tulaimat
- Akihiro Takaba
- Akinori Uchiyama
- Akira Hirata
- Akm Shamsul Alam
- Akut Aytulun
- Alain Combes
- Alain M Dive
- Alain Mercat
- Alain U Alisasis
- Alan Zazu
- Alastair Rose
- Alberto Deicas
- Alec A Tallet Alfonso
- Alejandro A Saez
- Alejandro Ebeid
- Alejandro G Castro
- Alejandro R Bruhn
- Alek Kumar
- Alessandro Bacuzzi
- Alessandro Protti
- Alessia Mattei
- Alex Mcleod
- Alex Morton
- Alexandra Ceniceros-Barros
- Alexandra J Williams
- Alexandra Marcu
- Alexandra Siqueira Colombo
- Alexandre Biasi Cavalcanti
- Alexandre Biasi Cavalcanti
- Alexandre Chan
- Alexandre Demoule
- Alexandre Guilherme Ribeiro de Carvalho
- Alexandre Molin
- Alexandre Molin
- Alexey I Gritsan
- Alfons Arizmendi
- Aline Ascoli
- Alison Ghosh
- Alistair Nichol
- Alistair Roy Roy
- Alma Cani
- Alvaro Ramirez-Gutierrez
- Amadeu Martinez
- Amanda Cowton
- Amanda Krstevski
- Amanda Maria R R de Oliveira
- Amanda Skinner
- Amanda Whileman
- Amine Ali Zeggwagh
- Amine Ali Zeggwagh
- Amy McInerney
- Ana Carolina P Antônio
- Ana Carolina Peçanha
- Ana G França
- Ana M Araujo
- Ana M Pellicer
- Anais Briquet
- Anand Dongre
- Anatole Harrois
- Anders Aneman
- Anders Larsson
- Andre Japiassu
- Andre Luiz Baptiston Nunes
- Andre Luiz Baptiston Nunes
- Andre Vercueil
- Andrea Coppadoro
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Lombardo
- Andrea N Cracchiolo
- Andrea Tinnirello
- Andreas Barratt-Due
- Andreas W Reske
- Andrej Sribar
- Andrew Bentley
- Andrew Corner
- Andrew Ferguson
- Andrew J Burtenshaw
- Andrey A Gazenkampf
- André Peretti Torelly
- Angela Delsing
- Angela Pinder
- Aniko D Frigyik
- Anil Hormis
- Anil P Hormis
- Anitha Shenoy
- Anna Hunt
- Anna Oscarsson Tibblin
- Anna Rossi
- Anna T Dowling
- Anna Walker
- Anna-Karin Morin
- Anne Adolfsson
- Anne B Guttormsen
- Annop Piriyapatsom
- Antero do Vale Fernandes
- Antoine Pronovost
- Antonino Giarratano
- Antonio Artigas
- Antonio Braschi
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- Antonio G Jimenez
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- Antonio P Nassar Jr
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- Charlotte Downes
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- Cheryl Padilla-Harris
- Chinni Krishna Kasi
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- Christian Schlegel
- Christina Whitehead
- Christine Boyd
- Christine Brown
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- Chunting Wang
- Claine Judy
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- Electra E Stamou
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- Eva O Nagy
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- Frantz Berkelmans
- Frederico Bruzzi Carvalho
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- Giacomo Bellani
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- Giovana Colozza Mecatti
- Giovanna Occhipinti
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- Giulia Crapelli
- Giuseppe Foti
- Giuseppe Melchionda
- Gonzalo Navarro
- Greet Hermans
- Guilherme Schettino
- Guillaume Barberet
- Guillaume Carteaux
- Guillermo Bugedo
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- Gulay Eren
- Gustavo A Plotnikow
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- Güldem Turan
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- Hamidreza Jamaati
- Hanane Ezzouine
- Hannah Crowther
- Hans Kedelv
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- Hasan M Al Dorzi
- Hazel Spencer
- Heather Blaylock
- Hector H Leon Yoshido
- Heera L Mahto
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- Leonardo de Assis Simões
- Leticia Seoane-Quiroga
- Li Ling Tai
- Lia McNamee
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- Lilian Batista Nunes
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- Monica Magret
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- Pamela A Farías
- Paolo Casalena
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- Paulo Fernando G M Marzocchi Tierno
- Pawel Andruszkiewicz
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- Piroska Toth-Tarsoly
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- Pravin Amin
- Priscila Abelha
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- Qiang Xin-Hua
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- Raffaele Caione
- Raghu Seethala
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- Ralph Lohner
- Raman Azad
- Ramesh Unnikrishnan
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- Raphael Cooper
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- Rola F Jaafar
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- Rungsun Bhurayanontachai
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- Sabyasachi Roy
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- Satar Mortaza
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- Savino Spadaro
- Savino Spadaro
- Scott H Beegle
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- Sekine Ryosuke
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- Seyed Mohammadreza Hashemian
- Shailaja Chenna
- Shailesh Bihari
- Shammer Gopal
- Shanaz James
- Shantanu Das
- Shazia Choudry
- Sheeba Suresh
- Sheikh Mohammed Taher
- Shigeki Saito
- Shin Nunomiya
- Shivakumar Iyer
- Shou H Wang
- Shreedhar Kulkarni
- Shu H Qin
- Shuhei Matsumoto
- Shunsuke Takagi
- Sian Birch
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- Siu-Ming Au
- Slaheddine Bouchoucha
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- Stefania Aguirre
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- Sérgio Felix Pinto
- Sílvia Moulin
- T John Trinder
- T Sottiaux
- Tadaaki Takada
- Tai Pham
- Takeshi Ueda
- Tamas Szakmany
- Tananchai Petnak
- Tanja A Treschan
- Tanveer Hussain
- Tao Yu
- Taohidul Majid Taohid
- Tarek Dendane
- Tarikul Hamid
- Tasmin Patel
- Tatjana Simurina
- Teresa Honrubia
- Terri-Ann Sewell
- Tharwat M Aisa
- Theonymfi G Papavasilopoulou
- Thiago Lisboa
- Thomas Baltus
- Thomas C Blakeman
- Thomas Collyer
- Thomas Kander
- Thomas Staudinger
- Thuy Duong Bich
- Théia Forny Wanderley Castellões
- Tiago Macruz
- Tie H Qin
- Tim Wenham
- Tom Hatton
- Tomas P Roser
- Tomaz Mesar
- Tomaz Mesar
- Tommaso Fossali
- Tomoaki Hashida
- Tomofumi Harasawa
- Tomoyuki Nakamura
- Toni E Mckenna
- Toshikazu Abe
- Tracey Evans
- Trevor W Oetting
- Troy S B Rowne
- Tài Pham
- Udomsak Silachamroon
- Ugur Goktas
- Ulysses V A Silva
- Una Poultney
- Unase Buyukkocak
- Upeka Samaranayake
- Ushio Higashijima
- Valeria I Cerrato
- Valerie M Banner-Goodspeed
- Vallish K Bhardwaj
- Vallverdu P Imma
- Valéria Maria Campos Rezende
- Vanessa Linnett
- Vanessa M Sales
- Vanessa Oliveira
- Vania A Brito
- Varsha Kadaba
- Vasilis Ourailogloy
- Venika Manoharan
- Venkatapura J Ramesh
- Veronica Villar
- Vesna Bumbasierevic
- Vesna Bumbasirevic
- Vicente Cés de Souza Dantas
- Vijayanand Palaniswamy
- Vincenzo Pota
- Vincenzo Russotto
- Vincenzo Schiavone
- Viratch Tangsujaritvijit
- Virginie Lemiale
- Visanthi Pinto
- Vivek Kakar
- Vladimir Cerny
- Vlasta Klaric
- Wahid Altaf
- Wajdi Maazouzi
- Wei H Zhu
- Wei Wang
- Weihua Lu
- Wenkui Yu
- Wenwen Li
- Werner Schmid
- William Stigler
- Xavier Wittebole
- Xian Y Zhao
- Xiao B Huang
- Xiao L Li
- Xiaoming Luo
- Xing Y Zhang
- Xinyu Li
- Y A Hasitha Dilhani
- Ya Q Wu
- Yaasen Arabi
- Yan Gao
- Yaseen M Arabi
- Yasuaki Ogino
- Yavuz Orak
- Yen Lam Minh
- Yi Han
- Yimin Li
- Yonghao Xu
- Yoshihiro Yamaji
- Yoshinobu Kameyama
- Youssef Haddad
- Youzhong An
- Yozo Kashiwa
- Yu D Di
- Yuan N Gao
- Yuan Y Li
- Yuanhua Lu
- Yves D Jarquin-Badiola
- Zerrin Demirtürk
- Zhe Zhai
- Zheng L Ye
- Zhenyang He
- Zhou Li-Xin
- Álvaro Réa-Neto
- Ángela Algaba
- Ángela González-Salamanca
- Çiler Zincircioglu
- Érica Aranha Suzumura
- Ênio Rego
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies.
Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality.
Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42·4% vs 44·2%; absolute difference -1·69 [-9·58 to 6·11] p=0·67; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5-8] vs 6 [5-8] cm H2O; p=0·0011). ICU mortality was higher in MICs than in HICs (30·5% vs 19·9%; p=0·0004; adjusted effect 16·41% [95% CI 9·52-23·52]; p<0·0001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0·80 [95% CI 0·75-0·86]; p<0·0001).
Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status
MAPPING LOCAL PATTERNS OF CHILDHOOD OVERWEIGHT AND WASTING IN LOW- AND MIDDLE-INCOME COUNTRIES BETWEEN 2000 AND 2017
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 20/04/2020
- Field of study
A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1–70.8) million) to 6.4% (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025. Prevalence of overweight increased from 5.2% (30 (22.8–38.5) million) in 2000 to 6.0% (55.5 (44.8–67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern China, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic