Surface flux concentrations and spherical alpha-square dynamo

In the presence of strong density stratification, turbulence can lead to a large-scale instability of a horizontal magnetic field if its strength is in a suitable range (within a few percent of the turbulent equipartition value). This instability is related to a suppression of the turbulent pressure so that the turbulence contribution to the mean magnetic pressure becomes negative. This results in the excitation of a negative effective magnetic pressure instability (NEMPI). This instability has so far only been studied for an imposed magnetic field. We want to know how NEMPI works when the mean magnetic field is generated self-consistently by an $\alpha^2$ dynamo, whether it is affected by global spherical geometry, and whether it can influence the properties of the dynamo itself. We adopt the mean-field approach which has previously been shown to provide a realistic description of NEMPI in direct numerical simulations. We assume axisymmetry and solve the mean-field equations with the Pencil-Code for an adiabatic stratification at a total density contrast in the radial direction of approximately 4 orders of magnitude. NEMPI is found to work when the dynamo-generated field is about 4% of the equipartition value, which is achieved through strong $\alpha$ quenching. This instability is excited in the top 5% of the outer radius provided the density contrast across this top layer is at least 10. NEMPI is found to occur at lower latitudes when the mean magnetic field is stronger. For weaker fields, NEMPI can make the dynamo oscillatory with poleward migration. NEMPI is a viable mechanism for producing magnetic flux concentrations in a strongly stratified spherical shell in which a magnetic field is generated by a strongly quenched $\alpha$ effect dynamo.Comment: published in A&

Limitations of Civil Rights of Foreign Nationals in Iran during the Years 1991-2011

The realization of citizens’ rights with the approach of considering the private rights of foreign nationals is one of the most important foundations of civil society in the political system of countries. This issue is placed within the framework of the principles and rules governing each political system and laws and regulations on foreign nationals have been approved in this respect. Islamic Republic of Iran, due to being in the vicinity of a number of countries in crisis such as Iraq and Afghanistan, has been extensively faced with the presence of foreign nationals and has taken steps to organize it. These actions have been influenced by the teachings of Islam and have enjoyed the laws of other countries and international law and Islamic Republic of Iran intends to provide the private rights of citizenship for the foreign nationals living in this country within the framework of the rules and principles of the system by offering a new model. Accordingly, various political and security institutions and organizations are active in this regard and the study of this issue can provide the ground for better identifying the measures taken in the area of the foreign nationals’ private rights of citizenship in the country

Bipolar magnetic spots from dynamos in stratified spherical shell turbulence

Recent work by Mitra et al. (2014) has shown that in strongly stratified forced two-layer turbulence with helicity and corresponding large-scale dynamo action in the lower layer, a magnetic field occurs in the upper layer in the form of sharply bounded bipolar magnetic spots. Here we extend this model to spherical wedge geometry covering the northern hemisphere up to 75{\deg} latitude and an azimuthal extent of 180{\deg}. The kinetic helicity and therefore also the large-scale magnetic field are strongest at low latitudes. For moderately strong stratification, several bipolar spots form that fill eventually the full longitudinal extent. At early times, the polarity of spots reflects the orientation of the underlying azimuthal field, as expected from {\Omega}-shaped flux loops. At late times their tilt changes such that there is a radial field of opposite orientation at different latitudes separated by about 10{\deg}. Our model demonstrates the spontaneous formation of spots of sizes much larger than the pressure scale height. Their tendency to produce filling factors close to unity is argued to be reminiscent of highly active stars. We confirm that strong stratification and strong scale separation are essential ingredients behind magnetic spot formation, which appears to be associated with downflows at larger depths.Comment: 12 pages, 14 figure

ASSOCIATION MAPPING OF MORPHOLOGICAL AND PHYSIOLOGICAL TRAITS OF FLAG LEAF RELATED TO DROUGHT TOLERANCE IN BARLEY

Association mapping has proven to be a powerful approach for dissecting the genetic basis of complex traits. In this study, QTLs controlling flag leaf characteristics under drought stress were detected in a set of 148 modern spring barley cultivars using AM analysis. Flag leaf length (FLL), flag leaf width (FLW), relative water content (RWC), chlorophyll content, and maximum quantum efficiency of PSII (Fv/Fm) which are important in photosynthetic rate, were evaluated under normal irrigation and drought stress conditions at grain filling stage. Population structure was estimated using Structure2.3 and linkage disequilibrium (LD) was estimated by the ‘Full Matrix LD’ using Tassel5.0. Significant marker/trait associations were investigated based on K-Q matrix using Tassel3.0. The analysis of population structure divided the cultivars into two sub-groups. Significant LD values (P < 0.01) between polymorphic sites with regions of high and low LD were observed. A total of 84 significant putative genomic regions were identified, which delineated into 37 QTLs under two water treatments. Two stable QTLs on 2H and 3H were detected for FLL in drought stress treatment. A QTL for FLL were detected on 2H in normal treatment, which alone explained around 11% of phenotypic variance of FLL. This QTL was also associated with the expression of FLW and explained around 7.5% of phenotypic variance. The results suggest that major loci are located on chromosomes 2H, 3H, 4H and 5H involved in the development of flag leaf characteristics and could be used as selection criteria in barley breeding for drought tolerance

Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Background Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels. Methods We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level. Findings In 2019, there were 12·2 million (95% UI 11·0–13·6) incident cases of stroke, 101 million (93·2–111) prevalent cases of stroke, 143 million (133–153) DALYs due to stroke, and 6·55 million (6·00–7·02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11·6% [10·8–12·2] of total deaths) and the third-leading cause of death and disability combined (5·7% [5·1–6·2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70·0% (67·0–73·0), prevalent strokes increased by 85·0% (83·0–88·0), deaths from stroke increased by 43·0% (31·0–55·0), and DALYs due to stroke increased by 32·0% (22·0–42·0). During the same period, age-standardised rates of stroke incidence decreased by 17·0% (15·0–18·0), mortality decreased by 36·0% (31·0–42·0), prevalence decreased by 6·0% (5·0–7·0), and DALYs decreased by 36·0% (31·0–42·0). However, among people younger than 70 years, prevalence rates increased by 22·0% (21·0–24·0) and incidence rates increased by 15·0% (12·0–18·0). In 2019, the age-standardised stroke-related mortality rate was 3·6 (3·5–3·8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3·7 (3·5–3·9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62·4% of all incident strokes in 2019 (7·63 million [6·57–8·96]), while intracerebral haemorrhage constituted 27·9% (3·41 million [2·97–3·91]) and subarachnoid haemorrhage constituted 9·7% (1·18 million [1·01–1·39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79·6 million [67·7–90·8] DALYs or 55·5% [48·2–62·0] of total stroke DALYs), high body-mass index (34·9 million [22·3–48·6] DALYs or 24·3% [15·7–33·2]), high fasting plasma glucose (28·9 million [19·8–41·5] DALYs or 20·2% [13·8–29·1]), ambient particulate matter pollution (28·7 million [23·4–33·4] DALYs or 20·1% [16·6–23·0]), and smoking (25·3 million [22·6–28·2] DALYs or 17·6% [16·4–19·0]). Interpretation The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries.publishedVersio

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and developm nt investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens

Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

Background Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels. Methods We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level. Findings In 2019, there were 12.2 million (95% UI 11.0-13.6) incident cases of stroke, 101 million (93.2-111) prevalent cases of stroke, 143 million (133-153) DALYs due to stroke, and 6.55 million (6.00-7.02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11.6% 10.8-12.2] of total deaths) and the third-leading cause of death and disability combined (5.7% 5.1-6.2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70.0% (67.0-73.0), prevalent strokes increased by 85.0% (83.0-88.0), deaths from stroke increased by 43.0% (31.0-55.0), and DALYs due to stroke increased by 32.0% (22.0-42.0). During the same period, age-standardised rates of stroke incidence decreased by 17.0% (15.0-18.0), mortality decreased by 36.0% (31.0-42.0), prevalence decreased by 6.0% (5.0-7.0), and DALYs decreased by 36.0% (31.0-42.0). However, among people younger than 70 years, prevalence rates increased by 22.0% (21.0-24.0) and incidence rates increased by 15.0% (12.0-18.0). In 2019, the age-standardised stroke-related mortality rate was 3.6 (3.5-3.8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3.7 (3.5-3.9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62.4% of all incident strokes in 2019 (7.63 million 6.57-8.96]), while intracerebral haemorrhage constituted 27.9% (3.41 million 2.97-3.91]) and subarachnoid haemorrhage constituted 9.7% (1.18 million 1.01-1.39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79.6 million 67.7-90.8] DALYs or 55.5% 48.2-62.0] of total stroke DALYs), high body-mass index (34.9 million 22.3-48.6] DALYs or 24.3% 15.7-33.2]), high fasting plasma glucose (28.9 million 19.8-41.5] DALYs or 20.2% 13.8-29.1]), ambient particulate matter pollution (28.7 million 23.4-33.4] DALYs or 20.1% 16.6-23.0]), and smoking (25.3 million 22.6-28.2] DALYs or 17.6% 16.4-19.0]). Interpretation The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries

ASSOCIATION MAPPING OF MORPHOLOGICAL AND PHYSIOLOGICAL TRAITS OF FLAG LEAF RELATED TO DROUGHT TOLERANCE IN BARLEY

Association mapping has proven to be a powerful approach for dissecting the genetic basis of complex traits. In this study, QTLs controlling flag leaf characteristics under drought stress were detected in a set of 148 modern spring barley cultivars using AM analysis. Flag leaf length (FLL), flag leaf width (FLW), relative water content (RWC), chlorophyll content, and maximum quantum efficiency of PSII (Fv/Fm) which are important in photosynthetic rate, were evaluated under normal irrigation and drought stress conditions at grain filling stage. Population structure was estimated using Structure2.3 and linkage disequilibrium (LD) was estimated by the ‘Full Matrix LD’ using Tassel5.0. Significant marker/trait associations were investigated based on K-Q matrix using Tassel3.0. The analysis of population structure divided the cultivars into two sub-groups. Significant LD values (P < 0.01) between polymorphic sites with regions of high and low LD were observed. A total of 84 significant putative genomic regions were identified, which delineated into 37 QTLs under two water treatments. Two stable QTLs on 2H and 3H were detected for FLL in drought stress treatment. A QTL for FLL were detected on 2H in normal treatment, which alone explained around 11% of phenotypic variance of FLL. This QTL was also associated with the expression of FLW and explained around 7.5% of phenotypic variance. The results suggest that major loci are located on chromosomes 2H, 3H, 4H and 5H involved in the development of flag leaf characteristics and could be used as selection criteria in barley breeding for drought tolerance

Hierarchical cluster analysis to identify the homogeneous desertification management units.

Since in most mapping models geometric mean of different criteria are used to determine the desertification intensity, one of the most important issues in desertification studies is understanding the similar areas, which require similar management after determining the desertification intensity map. Two similar classes of desertification intensity may require different management due to differences in the criteria that affect its desertification severity. Therefore, after determining the geomorphological facies as the working units in Sistan plain, we used hierarchical cluster analysis to identify the homogeneous environmental management units (HEMUs) based on indices of MEDALUS model. According to the MEDALUS model, the studied area was divided into two categories namely medium and high desertification classes. Working units (geomorphological facies) are classified into five clusters according to HEMUs analysis based on climate, soil, vegetation, and wind erosion criteria. The first cluster (C11) include six facies with moderate and severe desertification; in all of these units the main effective factor was wind erosion, so they need the same management decisions controlling wind erosion. Two working units (1 and 4) with the same desertification severity were placed in two different clusters due to the main factors affecting each other. The results of the Mann-Whitney test showed that the value of the test statistics was 79. Also, the value of Asymp.Sig was obtained to be 0.018, which is less than 0.025 (two-tailed test), and it can be concluded that the classification of work units in the two models, clustering and desertification, is not equal (P<0.05). So It seems that using cluster analysis to identify the same units, which need the same management decision after preparing the desertification intensity, is necessary