242 research outputs found
Large excess of heavy nitrogen in both hydrogen cyanide and cyanogen from comet 17P/Holmes
From millimeter and optical observations of the Jupiter-family comet
17P/Holmes performed soon after its huge outburst of October 24, 2007, we
derive 14 N/15N = 139 +/- 26 in HCN, and 14N/15N = 165 +/- 40 in CN,
establishing that HCN has the same non-terrestrial isotopic composition as CN.
The same conclusion is obtained for the long-period comet C/1995 O1 (Hale-Bopp)
after a reanalysis of previously published measurements. These results are
compatible with HCN being the prime parent of CN in cometary atmospheres. The
15N excess relative to the Earth atmospheric value indicates that N-bearing
volatiles in the solar nebula underwent important N isotopic fractionation at
some stage of Solar System formation. HCN molecules never isotopically
equilibrated with the main nitrogen reservoir in the solar nebula before being
incorporated in Oort-cloud and Kuiper-belt comets. The 12C/13C ratios in HCN
and CN are measured to be consistent with the terrestrial value.Comment: Accepted for publication in the Astrophysical Journal (Letters) 4
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Metallicities and dust content of proximate damped Lyman alpha systems in the Sloan Digital Sky Survey
Composite spectra of 85 proximate absorbers (log N(HI)>20 and velocity
difference between the absorption and emission redshift, dv<10,000 km/s) in the
SDSS are used to investigate the trends of metal line strengths with velocity
separation from the QSO. We construct composites in 3 velocity bins: dv<3000
km/s, 30006000 km/s, with further sub-samples to
investigate the metal line dependence on N(HI) and QSO luminosity. Low (e.g.
SiII and FeII) and high ionization (e.g. SiIV and CIV) species alike have
equivalent widths (EWs) that are larger by factors of 1.5 -- 3 in the dv<3000
km/s composite, compared to the dv>6000 km/s spectrum. The EWs show an even
stronger dependence on dv if only the highest neutral hydrogen column density
(log N(HI)>20.7) absorbers are considered. We conclude that PDLAs generally
have higher metallicities than intervening absorbers, with the enhancement
being a function of both dv and N(HI). It is also found that absorbers near
QSOs with lower rest-frame UV luminosities have significantly stronger metal
lines. We speculate that absorbers near to high luminosity QSOs may have had
their star formation prematurely quenched. Finally, we search for the signature
of dust reddening by the PDLAs, based on an analysis of the QSO continuum
slopes relative to a control sample and determine a limit of E(B-V)<0.014 for
an SMC extinction curve. This work provides an empirical motivation for
distinguishing between proximate and intervening DLAs, and establishes a
connection between the QSO environment and galaxy properties at high redshifts.Comment: Accepted for publication in MNRA
New limit on a varying proton-to-electron mass ratio from high resolution optical quasar spectra
Abstract not available
A single intranasal dose of human mesenchymal stem cell-derived extracellular vesicles after traumatic brain injury eases neurogenesis decline, synapse loss, and BDNF-ERK-CREB signaling
An optimal intranasal (IN) dose of human mesenchymal stem cell-derived extracellular vesicles (hMSC-EVs), 90âmin post-traumatic brain injury (TBI), has been reported to prevent the evolution of acute neuroinflammation into chronic neuroinflammation resulting in the alleviation of long-term cognitive and mood impairments. Since hippocampal neurogenesis decline and synapse loss contribute to TBI-induced long-term cognitive and mood dysfunction, this study investigated whether hMSC-EV treatment after TBI can prevent hippocampal neurogenesis decline and synapse loss in the chronic phase of TBI. C57BL6 mice undergoing unilateral controlled cortical impact injury (CCI) received a single IN administration of different doses of EVs or the vehicle at 90âmin post-TBI. Quantifying neurogenesis in the subgranular zone-granule cell layer (SGZ-GCL) through 5âČ-bromodeoxyuridine and neuron-specific nuclear antigen double labeling at ~2 months post-TBI revealed decreased neurogenesis in TBI mice receiving vehicle. However, in TBI mice receiving EVs (12.8 and 25.6âĂâ109 EVs), the extent of neurogenesis was matched to naive control levels. A similar trend of decreased neurogenesis was seen when doublecortin-positive newly generated neurons were quantified in the SGZ-GCL at ~3 months post-TBI. The above doses of EVs treatment after TBI also reduced the loss of pre-and post-synaptic marker proteins in the hippocampus and the somatosensory cortex. Moreover, at 48âh post-treatment, brain-derived neurotrophic factor (BDNF), phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK1/2), and phosphorylated cyclic AMP response-element binding protein (p-CREB) levels were downregulated in TBI mice receiving the vehicle but were closer to naĂŻve control levels in TBI mice receiving above doses of hMSC-EVs. Notably, improved BDNF concentration observed in TBI mice receiving hMSC-EVs in the acute phase was sustained in the chronic phase of TBI. Thus, a single IN dose of hMSC-EVs at 90âmin post-TBI can ease TBI-induced declines in the BDNF-ERK-CREB signaling, hippocampal neurogenesis, and synapses
A High-Velocity Narrow Absorption Line Outflow in the Quasar J212329.46-005052.9
We report on a variable high-velocity narrow absorption line outflow in the
redshift 2.3 quasar J2123-0050. Five distinct outflow systems are detected with
velocity shifts from -9710 to -14,050 km/s and CIV 1548,1551 line widths of
FWHM = 62-164 km/s. These data require five distinct outflow structures with
similar kinematics, physical conditions and characteristic sizes of order
0.01-0.02 pc. The most likely location is ~5 pc from the quasar. The
coordinated line variations in <0.63 yr (rest) are best explained by global
changes in the outflow ionization caused by changes in the quasar's ionizing
flux. The absence of strong X-ray absorption shows that radiative shielding is
not needed to maintain the moderate ionizations and therefore, apparently, it
is not needed to facilitate the radiative acceleration to high speeds. The
kinetic energy yield of this flow is at least two orders of magnitude too low
to be important for feedback to the host galaxy's evolution.Comment: 20 pages. In press with MNRA
New limit on a varying proton-to-electron mass ratio from high-resolution optical quasar spectra
Antiproliferative Effects of DNA Methyltransferase 3B Depletion Are Not Associated with DNA Demethylation
Silencing of genes by hypermethylation contributes to cancer progression and has been shown to occur with increased frequency at specific genomic loci. However, the precise mechanisms underlying the establishment and maintenance of aberrant methylation marks are still elusive. The de novo DNA methyltransferase 3B (DNMT3B) has been suggested to play an important role in the generation of cancer-specific methylation patterns. Previous studies have shown that a reduction of DNMT3B protein levels induces antiproliferative effects in cancer cells that were attributed to the demethylation and reactivation of tumor suppressor genes. However, methylation changes have not been analyzed in detail yet. Using RNA interference we reduced DNMT3B protein levels in colon cancer cell lines. Our results confirm that depletion of DNMT3B specifically reduced the proliferation rate of DNMT3B-overexpressing colon cancer cell lines. However, genome-scale DNA methylation profiling failed to reveal methylation changes at putative DNMT3B target genes, even in the complete absence of DNMT3B. These results show that DNMT3B is dispensable for the maintenance of aberrant DNA methylation patterns in human colon cancer cells and they have important implications for the development of targeted DNA methyltransferase inhibitors as epigenetic cancer drugs
Characterization of the John A. Galt telescope for radio holography with CHIME
The Canadian Hydrogen Intensity Mapping Experiment (CHIME) will measure the
21 cm emission of astrophysical neutral hydrogen to probe large scale structure
at redshifts z=0.8-2.5. However, detecting the 21 cm signal beneath
substantially brighter foregrounds remains a key challenge. Due to the high
dynamic range between 21 cm and foreground emission, an exquisite calibration
of instrument systematics, notably the telescope beam, is required to
successfully filter out the foregrounds. One technique being used to achieve a
high fidelity measurement of the CHIME beam is radio holography, wherein
signals from each of CHIME's analog inputs are correlated with the signal from
a co-located reference antenna, the 26 m John A. Galt telescope, as the 26 m
Galt telescope tracks a bright point source transiting over CHIME. In this work
we present an analysis of several of the Galt telescope's properties. We employ
driftscan measurements of several bright sources, along with background
estimates derived from the 408 MHz Haslam map, to estimate the Galt system
temperature. To determine the Galt telescope's beam shape, we perform and
analyze a raster scan of the bright radio source Cassiopeia A. Finally, we use
early holographic measurements to measure the Galt telescope's geometry with
respect to CHIME for the holographic analysis of the CHIME and Galt
interferometric data set
Defending the genome from the enemy within:mechanisms of retrotransposon suppression in the mouse germline
The viability of any species requires that the genome is kept stable as it is transmitted from generation to generation by the germ cells. One of the challenges to transgenerational genome stability is the potential mutagenic activity of transposable genetic elements, particularly retrotransposons. There are many different types of retrotransposon in mammalian genomes, and these target different points in germline development to amplify and integrate into new genomic locations. Germ cells, and their pluripotent developmental precursors, have evolved a variety of genome defence mechanisms that suppress retrotransposon activity and maintain genome stability across the generations. Here, we review recent advances in understanding how retrotransposon activity is suppressed in the mammalian germline, how genes involved in germline genome defence mechanisms are regulated, and the consequences of mutating these genome defence genes for the developing germline
Observation of associated near-side and away-side long-range correlations in âsNN=5.02ââTeV proton-lead collisions with the ATLAS detector
Two-particle correlations in relative azimuthal angle (ÎÏ) and pseudorapidity (Îη) are measured in âsNN=5.02ââTeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1ââÎŒb-1 of data as a function of transverse momentum (pT) and the transverse energy (ÎŁETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Îη|<5) ânear-sideâ (ÎÏâŒ0) correlation that grows rapidly with increasing ÎŁETPb. A long-range âaway-sideâ (ÎÏâŒÏ) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ÎŁETPb, is found to match the near-side correlation in magnitude, shape (in Îη and ÎÏ) and ÎŁETPb dependence. The resultant ÎÏ correlation is approximately symmetric about Ï/2, and is consistent with a dominant cosâĄ2ÎÏ modulation for all ÎŁETPb ranges and particle pT
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