Structural, Vibrational, and Elastic Properties of Yttrium Orthoaluminate Nanoperovskite at High Pressures

"This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Physical Chemistry C, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/page/policy/articlesonrequest/index.html."[EN] The structural and vibrational properties of nanocrystalline yttrium orthoaluminate perovskite (YAlO3) under compression have been experimentally studied. Experimental results have been compared to ab initio simulations of. bulk YAlO3, in the framework of the density functional theory. Furthermore, they have been complemented with an ab initio study of its elastic properties at different pressures. Calculated total and partial phonon density of states have allowed us to understand the contribution of the different atoms and structural units, YO12 dodecahedra and AlO6 octahedra, to the vibrational modes. The calculated infrared-active modes and their pressure dependence are also reported. Finally, the pressure dependences of the, elastic constants and the mechanical stability of the perovskite structure have been analyzed in detail, showing that this phase is mechanically stable until 92 GPa. In fact, experimental results up to 30 GPa show no evidence of any phase transition. A previously proposed possible phase transition in YAlO3 above 80 GPa is also discussed.This research was partially supported by MINECO (MAT2013-46649-C4-2/3/4-P, MAT2015-71070-REDC, and MAT2016-75586-C4-2/3/4-P) and by EU-FEDER funds. M.A.H.-R. thanks MINECO for an FPI grant (BES-2014-068666).Hernández-Rodríguez, M.; Monteseguro, V.; Lozano-Gorrín, A.; Manjón, F.; González-Platas, J.; Rodríguez-Hernández, P.; Muñoz, A.... (2017). Structural, Vibrational, and Elastic Properties of Yttrium Orthoaluminate Nanoperovskite at High Pressures. The Journal of Physical Chemistry C. 121(28):15353-15367. https://doi.org/10.1021/acs.jpcc.7b04245S15353153671212

Experiencia de uso de antimicrobianos en un servicio de hematología en el contexto de un programa de optimización de antibióticos

Poster [PC-356] Introducción: Se implanta un Programa de Optimización de Antibióticos (PROA) en el Servicio de Hematología (SH) de un hospital de tercer nivel, compuesto por un equipo multidisciplinar (Hematología, Farmacia, Infecciosas). Para entender la situación inicial y detectar posibles acciones de mejora, se realizó un análisis del consumo de antimicrobianos (AM). Material y Métodos: Estudio descriptivo, observacional y retrospectivo de utilización de AM en el SH durante el período de 2014 a 2017. Variables recogidas: número de ingresos, número de estancias, dosis diaria definida (DDD)/100 estancias de antimicrobianos (antibióticos y antifúngicos) y DDD/100 estancias por grupo clínico (G1: antibióticos de espectro reducido, G2: empírico en infecciones comunitarias, G3: bacterias Gram (-) resistentes, G4: bacterias gram (+) resistentes, G5: antifúngicos de espectro reducido, G6: antifúngicos de amplio espectro, G7: otros). Fuente de datos: Programa de Gestión Económica. Resultados: El número de ingresos en el SH en los años 2014, 2015, 2016 y 2017 fue de 765, 662, 756 y 572 respectivamente. Las estancias de 6839, 6280, 6547 y 5841, respectivamente. La evolución de las DDD/ 100 estancias de AM fue: 114.73, 100.91, 122.31, 133.04, de las DDD/100 estancias de antibióticos fue: 86, 38, 75, 04, 88, 05, 89, 01 y de las DDD/100 estancias de antifúngicos fue: 28.35, 25.87, 34.27 y 44.03. El G3 es el que más consumo presenta, el meropenem el principio activo más prescrito: 42.38, 33.02, 39.08 y 32.92 (DDD/100 estancias en los cuatro años del estudio). En el grupo G4 el uso de la vancomicina se ha incrementado (DDD/100 estancias 0.22, 0.04, 0.97 y 5.37) y el consumo de daptomicina ha disminuido (DDD/100 estancias 6.95, 7.42, 12.96, 8.69). El G6 ha sido el que más incremento ha presentado en 2017, siendo posaconazol (DDD/100 estancias 6.14, 7.25, 5.33 y 12.49) y anfotericina B liposomal (DDD/100 estancias 3.35, 3.22, 12.82 y 12.49) los más prescritos. Cabe destacar en el Grupo G1 el incremento del uso de sulfametoxazol-trimetroprim con DDD/100 estancias de 1.51, 2.46, 4.33, 6.00. Conclusiones: Se observa un incremento en DDD/100 estancias de los AM en el año 2017, sin embargo, los ingresos han disminuido. Puede ser que el paciente que ingresa sea más complejo. Meropenem es el principio activo más prescrito en el SH. La vancomicina ha incrementado su uso debido a la monitorización de niveles con recomendación posológica por parte del Servicio de Farmacia y como consecuencia, daptomicina ha disminuido. En los antifúngicos, aumenta el consumo de los de amplio espectro. Sulfametoxazol-trimetroprim ha aumentado su consumo como profilaxis en nuevos tratamientos. Se ha detectado variabilidad en sus dosis prescritas, por lo que se desarrollarán protocolos para su homogeneización

Search for the standard model Higgs boson decaying to a bb pair in events with one charged lepton and large missing transverse energy using the full CDF data set

We present a search for the standard model Higgs boson produced in association with a W boson in sqrt(s) = 1.96 TeV p-pbar collision data collected with the CDF II detector at the Tevatron corresponding to an integrated luminosity of 9.45 fb-1. In events consistent with the decay of the Higgs boson to a bottom-quark pair and the W boson to an electron or muon and a neutrino, we set 95% credibility level upper limits on the WH production cross section times the H->bb branching ratio as a function of Higgs boson mass. At a Higgs boson mass of 125 GeV/c2 we observe (expect) a limit of 4.9 (2.8) times the standard model value.Comment: Submitted to Phys. Rev. Lett (v2 contains clarifications suggested by PRL

Search for the standard model Higgs boson decaying to a bbˉb\bar{b} pair in events with no charged leptons and large missing transverse energy using the full CDF data set

We report on a search for the standard model Higgs boson produced in association with a vector boson in the full data set of proton-antiproton collisions at $\sqrt{s} = 1.96$ TeV recorded by the CDF II detector at the Tevatron, corresponding to an integrated luminosity of 9.45 fb$^{-1}$. We consider events having no identified charged lepton, a transverse energy imbalance, and two or three jets, of which at least one is consistent with originating from the decay of a $b$ quark. We place 95% credibility level upper limits on the production cross section times standard model branching fraction for several mass hypotheses between 90 and $150 \mathrm{GeV}/c^2$. For a Higgs boson mass of $125 \mathrm{GeV}/c^2$, the observed (expected) limit is 6.7 (3.6) times the standard model prediction.Comment: Accepted by Phys. Rev. Let

Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC

The uncertainty on the calorimeter energy response to jets of particles is derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the calorimeter response to single isolated charged hadrons is measured and compared to the Monte Carlo simulation using proton-proton collisions at centre-of-mass energies of sqrt(s) = 900 GeV and 7 TeV collected during 2009 and 2010. Then, using the decay of K_s and Lambda particles, the calorimeter response to specific types of particles (positively and negatively charged pions, protons, and anti-protons) is measured and compared to the Monte Carlo predictions. Finally, the jet energy scale uncertainty is determined by propagating the response uncertainty for single charged and neutral particles to jets. The response uncertainty is 2-5% for central isolated hadrons and 1-3% for the final calorimeter jet energy scale.Comment: 24 pages plus author list (36 pages total), 23 figures, 1 table, submitted to European Physical Journal

Search for the standard model Higgs boson decaying to a bb pair in events with two oppositely-charged leptons using the full CDF data set

We present a search for the standard model Higgs boson produced in association with a Z boson in data collected with the CDF II detector at the Tevatron, corresponding to an integrated luminosity of 9.45/fb. In events consistent with the decay of the Higgs boson to a bottom-quark pair and the Z boson to electron or muon pairs, we set 95% credibility level upper limits on the ZH production cross section times the H -> bb branching ratio as a function of Higgs boson mass. At a Higgs boson mass of 125 GeV/c^2 we observe (expect) a limit of 7.1 (3.9) times the standard model value.Comment: To be submitted to Phys. Rev. Let

Standalone vertex finding in the ATLAS muon spectrometer

A dedicated reconstruction algorithm to find decay vertices in the ATLAS muon spectrometer is presented. The algorithm searches the region just upstream of or inside the muon spectrometer volume for multi-particle vertices that originate from the decay of particles with long decay paths. The performance of the algorithm is evaluated using both a sample of simulated Higgs boson events, in which the Higgs boson decays to long-lived neutral particles that in turn decay to bbar b final states, and pp collision data at √s = 7 TeV collected with the ATLAS detector at the LHC during 2011

Measurements of Higgs boson production and couplings in diboson final states with the ATLAS detector at the LHC

Measurements are presented of production properties and couplings of the recently discovered Higgs boson using the decays into boson pairs, H →γ γ, H → Z Z∗ →4l and H →W W∗ →lνlν. The results are based on the complete pp collision data sample recorded by the ATLAS experiment at the CERN Large Hadron Collider at centre-of-mass energies of √s = 7 TeV and √s = 8 TeV, corresponding to an integrated luminosity of about 25 fb−1. Evidence for Higgs boson production through vector-boson fusion is reported. Results of combined fits probing Higgs boson couplings to fermions and bosons, as well as anomalous contributions to loop-induced production and decay modes, are presented. All measurements are consistent with expectations for the Standard Model Higgs boson

Non Linear Programming (NLP) Formulation for Quantitative Modeling of Protein Signal Transduction Pathways

Modeling of signal transduction pathways plays a major role in understanding cells' function and predicting cellular response. Mathematical formalisms based on a logic formalism are relatively simple but can describe how signals propagate from one protein to the next and have led to the construction of models that simulate the cells response to environmental or other perturbations. Constrained fuzzy logic was recently introduced to train models to cell specific data to result in quantitative pathway models of the specific cellular behavior. There are two major issues in this pathway optimization: i) excessive CPU time requirements and ii) loosely constrained optimization problem due to lack of data with respect to large signaling pathways. Herein, we address both issues: the former by reformulating the pathway optimization as a regular nonlinear optimization problem; and the latter by enhanced algorithms to pre/post-process the signaling network to remove parts that cannot be identified given the experimental conditions. As a case study, we tackle the construction of cell type specific pathways in normal and transformed hepatocytes using medium and large-scale functional phosphoproteomic datasets. The proposed Non Linear Programming (NLP) formulation allows for fast optimization of signaling topologies by combining the versatile nature of logic modeling with state of the art optimization algorithms.National Institutes of Health (U.S.) (Grant P50-GM068762)National Institutes of Health (U.S.) (Grant R24-DK090963)United States. Army Research Office (Grant W911NF-09-0001)German Research Foundation (Grant GSC 111