44 research outputs found
Toward a Coordinated Understanding of Hydro-Biogeochemical Root Functions in Tropical Forests for Application in Vegetation Models
- Author
- Addo-Danso Shalom D.
- Andersen Kelly M.
- Arnaud Marie
- Batterman Sarah A.
- Christoffersen Bradley
- Cordeiro Amanda L.
- Cusack Daniela F.
- Dallstream Caroline
- Dietterich Lee H.
- Fisher Joshua B.
- Fleischer Katrin
- Fortunel Claire
- Fuchslueger Lucia
- Guerrero-RamĂrez Nathaly R.
- Lugli Laynara F.
- McCulloch Lindsay A.
- Ng Jing Cheng
- Norby Richard J.
- Sanchez-Julia Mareli
- Smith-Martin Chris M.
- Toro Laura
- Valverde-Barrantes Oscar J.
- Weemstra Monique
- Wong Michelle Y.
- Wright S. Joseph
- Yaffar Daniela
- Publication venue
- Chapman University Digital Commons
- Publication date
- 28/02/2024
- Field of study
Tropical forest root characteristics and resource acquisition strategies are underrepresented in vegetation and global models, hampering the prediction of forestâclimate feedbacks for these carbon-rich ecosystems. Lowland tropical forests often have globally unique combinations of high taxonomic and functional biodiversity, rainfall seasonality, and strongly weathered infertile soils, giving rise to distinct patterns in root traits and functions compared with higher latitude ecosystems. We provide a roadmap for integrating recent advances in our understanding of tropical forest belowground function into vegetation models, focusing on water and nutrient acquisition. We offer comparisons of recent advances in empirical and model understanding of root characteristics that represent important functional processes in tropical forests. We focus on: (1) fine-root strategies for soil resource exploration, (2) coupling and trade-offs in fine-root water vs nutrient acquisition, and (3) abovegroundâbelowground linkages in plant resource acquisition and use. We suggest avenues for representing these extremely diverse plant communities in computationally manageable and ecologically meaningful groups in models for linked abovegroundâbelowground hydro-nutrient functions. Tropical forests are undergoing warming, shifting rainfall regimes, and exacerbation of soil nutrient scarcity caused by elevated atmospheric CO2. The accurate model representation of tropical forest functions is crucial for understanding the interactions of this biome with the climate
Student Independent Projects Psychology Programs 2014:
- Author
- Publication venue
- Grenfell Campus, Memorial University of Newfoundland
- Publication date
- 01/01/2014
- Field of study
The capstone course, Psychology 4950, in the Bachelor of Arts and Bachelor of Science
psychology degree programs allows students to carry out research on a topic of their choice and
to prepare reports on their findings. This compilation of papers represents the results of their
efforts.
The faculty and staff of the Psychology Program congratulate the members of the Year 2014
course on their accomplishment, and wish them continued succes
Integration of robotic surgery into routine practice and impacts on communication, collaboration, and decision making: A realist process evaluation protocol
- Author
- A Blamey
- A DâAnnibale
- A Healey
- A Jones
- A Oakley
- A Rawlings
- A Smith
- A-S Nyssen
- AH Mirnezami
- Alan Pearman
- Alwyn Kotze
- B Blackwood
- B Lindsay
- B Marchal
- B Marchal
- C Bonell
- C Bonell
- C Heath
- C Pope
- CGL Cao
- D Goodwin
- D Herron
- David Jayne
- Dawn Dowding
- F Collinson
- F Lai
- G Ranmuthugala
- H Garfinkel
- H Mentis
- H Sacks
- HWR Schreuder
- I Goicolea
- J Meehan
- J Rycroft-Malone
- J Rycroft-Malone
- JA Cook
- JL Webster
- JM Schraagen
- Joanne Greenhalgh
- Jon Hindmarsh
- Julie Croft
- K Catchpole
- K Seers
- KR Catchpole
- KR Catchpole
- L Hull
- M Campbell
- M Hammersley
- M Mackenzie
- MA Goldstraw
- Medical Research Council
- MO Eveleigh
- MS Svensson
- MW Dobson
- N Wolff
- NC Campbell
- NSR Implementation Team
- O Sgarbura
- P Craig
- P Koshy
- P McCulloch
- Peter Gardner
- R Byng
- R Byng
- R Emerson
- R Johnson
- R Pawson
- R Pawson
- R Pawson
- Rebecca Randell
- S Bann
- S Jayaraman
- S Lewin
- S McDonald
- S Undre
- T Greenhalgh
- VR Patel
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Background: Robotic surgery offers many potential benefits for patients. While an increasing number of healthcare providers are purchasing surgical robots, there are reports that the technology is failing to be introduced into routine practice. Additionally, in robotic surgery, the surgeon is physically separated from the patient and the rest of the team, with the potential to negatively impact teamwork in the operating theatre. The aim of this study is to ascertain: how and under what circumstances robotic surgery is effectively introduced into routine practice; and how and under what circumstances robotic surgery impacts teamwork, communication and decision making, and subsequent patient outcomes. Methods and design: We will undertake a process evaluation alongside a randomised controlled trial comparing laparoscopic and robotic surgery for the curative treatment of rectal cancer. Realist evaluation provides an overall framework for the study. The study will be in three phases. In Phase I, grey literature will be reviewed to identify stakeholders' theories concerning how robotic surgery becomes embedded into surgical practice and its impacts. These theories will be refined and added to through interviews conducted across English hospitals that are using robotic surgery for rectal cancer resection with staff at different levels of the organisation, along with a review of documentation associated with the introduction of robotic surgery. In Phase II, a multi-site case study will be conducted across four English hospitals to test and refine the candidate theories. Data will be collected using multiple methods: the structured observation tool OTAS (Observational Teamwork Assessment for Surgery); video recordings of operations; ethnographic observation; and interviews. In Phase III, interviews will be conducted at the four case sites with staff representing a range of surgical disciplines, to assess the extent to which the results of Phase II are generalisable and to refine the resulting theories to reflect the experience of a broader range of surgical disciplines. The study will provide (i) guidance to healthcare organisations on factors likely to facilitate successful implementation and integration of robotic surgery, and (ii) guidance on how to ensure effective communication and teamwork when undertaking robotic surgery
The Physics of the B Factories
- Author
- A Abashian
- A. A. Botov
- A. A. Grillo
- A. A. Korol
- A. A. Salnikov
- A. Abashian
- A. Adametz
- A. Agarwal
- A. Anjomshoaa
- A. B. Breon
- A. Bala
- A. Bay
- A. Bondar
- A. Bozek
- A. Buzzo
- A. C. Forti
- A. C. Wren
- A. Calcaterra
- A. Cecchi
- A. Cervelli
- A. Ceseracciu
- A. Chen
- A. Chuvikov
- A. Cotta Ramusino
- A. Crescente
- A. Cunha
- A. D. Bukin
- A. Das
- A. de Lesquen
- A. De Silva
- A. Dorigo
- A. Drutskoy
- A. Dvoretskii
- A. DâOrazio
- A. E. Rubin
- A. Farbin
- A. Fella
- A. Filippi
- A. Frey
- A. G. Denig
- A. Gaidot
- A. Garmash
- A. Gaz
- A. Go
- A. Gordon
- A. GoriĆĄek
- A. Hafner
- A. Hanushevsky
- A. Hasan
- A. Hauke
- A. Hicheur
- A. Höcker
- A. I. Panova
- A. I. Robertson
- A. Igarashi
- A. Ishikawa
- A. J. Bevan
- A. J. Edwards
- A. J. Hart
- A. J. Lankford
- A. J. Lyon
- A. J. Martinez
- A. J. R. Weinstein
- A. J. S. Smith
- A. J. Schwartz
- A. Jawahery
- A. K. McKemey
- A. K. Michael
- A. K. Mohapatra
- A. K. Yarritu
- A. Khan
- A. Khodjamirian
- A. Kibayashi
- A. Kirk
- A. Krasnykh
- A. Kreisel
- A. Kronfeld
- A. Kulikov
- A. Kurup
- A. Kusaka
- A. Kuzmin
- A. Lazzaro
- A. Limosani
- A. Lu
- A. Lusiani
- A. M. Bakich
- A. M. Boyarski
- A. M. Eichenbaum
- A. M. Eisner
- A. M. Gabareen
- A. M. Lutz
- A. M. Merchant
- A. M. Rahimi
- A. M. Ruland
- A. Manabe
- A. Mass
- A. Mathieu
- A. Matyja
- A. Mihalyi
- A. Mohapatra
- A. Moll
- A. Muir
- A. Murakami
- A. N. Yushkov
- A. Novokhatski
- A. Ogawa
- A. Olivas
- A. Oyanguren
- A. P. Onuchin
- A. P. Wagner
- A. Palano
- A. Penzkofer
- A. Perazzo
- A. Perez
- A. Petrella
- A. Petzold
- A. Pich
- A. Pilloni
- A. Poluektov
- A. Pompili
- A. R. Buzykaev
- A. R. Clark
- A. Randle-Conde
- A. Romosan
- A. Roodman
- A. Rossi
- A. Rostomyan
- A. Ryd
- A. Samuel
- A. Santroni
- A. Sarti
- A. Satpathy
- A. Seiden
- A. Sibidanov
- A. Sidorov
- A. Smol
- A. Snyder
- A. Soffer
- A. Soha
- A. Sokolov
- A. Somov
- A. Stocchi
- A. Sugi
- A. Sugiyama
- A. Suzuki
- A. T. Watson
- A. Trunov
- A. Tumanov
- A. V. Gritsan
- A. V. Telnov
- A. Valassi
- A. Vallereau
- A. Vinokurova
- A. Volk
- A. Vossen
- A. W. Borgland
- A. W. Weidemann
- A. Woch
- A. Y. Rakitin
- A. Yamaguchi
- A. Zallo
- A. Zghiche
- A. Zupanc
- A.I. Sekiya
- A.S. Fisher
- Aleksan
- ALEPH CDF, D0, DELPHI, L3, OPAL, SLD and the LEP, Tevatron and SLD Electroweak and Heavy Flavour Working Groups
- B. A. Petersen
- B. A. Schumm
- B. Aubert
- B. Bhuyan
- B. Brau
- B. Broomer
- B. C. K. Casey
- B. C. Shen
- B. C. Wray
- B. Camanzi
- B. Cheng
- B. Claxton
- B. D. Yabsley
- B. Dahmes
- B. Dey
- B. Di Girolamo
- B. Echenard
- B. Foster
- B. Franek
- B. G. Cheon
- B. G. Fulsom
- B. G. Zaslavsky
- B. Golob
- B. H. Kim
- B. Hamilton
- B. Harrop
- B. Hooberman
- B. J. Wogsland
- B. Kronenbitter
- B. L. Hartfiel
- B. Lewandowski
- B. Lindquist
- B. Malaescu
- B. Mayer
- B. Mellado
- B. N. Ratcliff
- B. Oberhof
- B. Pan
- B. R. Ko
- B. Reisert
- B. S. Ahn
- B. Serfass
- B. Shwartz
- B. Spaan
- B. Stugu
- B. T. Meadows
- B. Viaud
- B. W. Drummond
- B. Y. Han
- B. Zhang
- B.V. Grinyov
- Ball Ali
- Bartelt Aleksan
- Bernlochner and Schonherr
- Bigi Benson
- Blok Bigi
- Braaten Bodwin
- Braun Ball
- Buchalla Beneke
- Buchalla Beneke
- Buchalla Beneke
- Buchalla Beneke
- C. A. Chavez
- C. A. Heusch
- C. A. West
- C. Angelini
- C. B. Locke
- C. Beigbeder
- C. Borean
- C. Bozzi
- C. Brew
- C. Buchanan
- C. BĂŒnger
- C. C. Chiang
- C. C. Kuo
- C. C. Peng
- C. C. Wang
- C. C. Young
- C. C. Zhang
- C. Campagnari
- C. Cartaro
- C. Chen
- C. Condurache
- C. Dallapiccola
- C. Davies
- C. De la VaissiĂšre
- C. E. Marker
- C. Fabby
- C. Fanin
- C. Fukunaga
- C. G. West
- C. Gatto
- C. H. Cheng
- C. H. Kim
- C. H. Wang
- C. H. Wu
- C. Hagner
- C. Hast
- C. Hearty
- C. Hee
- C. J. Flacco
- C. J. Schilling
- C. Jacoby
- C. K. Clarke
- C. K. Lae
- C. Kiesling
- C. L. Brown
- C. L. Davis
- C. L. Edgar
- C. L. Hsu
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- C. L. Lim
- C. LeClerc
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- C. P. Shen
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- C. T. Boeheim
- C. T. Day
- C. T. Hoi
- C. T. Potter
- C. Touramanis
- C. Van Hulse
- C. Voci
- C. Voena
- C. VoĂ
- C. W. Everton
- C. W. Park
- C. X. Yu
- C. Z. Yuan
- Ch. de la VaissiĂšre
- Ch. Thiebaux
- Ch. YĂ©che
- Chapovsky Beneke
- Cheung Braaten
- Contino Agashe
- Corazza Bernardini
- Cronin Christenson
- Czyz Rodrigo
- D. A. Bowerman
- D. A. Doll
- D. A. Hopkins
- D. A. Milanes
- D. A. Roberts
- D. A. Sanders
- D. Altenburg
- D. Andreotti
- D. Anipko
- D. Aston
- D. B. MacFarlane
- D. Beiline
- D. Bernard
- D. Bettoni
- D. Boutigny
- D. Breton
- D. C. Williams
- D. Cinabro
- D. Cote
- D. del Re
- D. Derkach
- D. Dujmic
- D. Dutta
- D. E. Azzopardi
- D. E. Hutchcroft
- D. E. Wagoner
- D. Epifanov
- D. Fortin
- D. G. Hitlin
- D. Gamba
- D. H. Kah
- D. H. Wright
- D. Heffernan
- D. Hufnagel
- D. I. Britton
- D. J. Asgeirsson
- D. J. Bard
- D. J. J. Mangeol
- D. J. Jackson
- D. J. Knowles
- D. J. Lange
- D. J. Payne
- D. J. Sherwood
- D. J. Summers
- D. Judd
- D. Kharakh
- D. Kirkby
- D. Kovalskyi
- D. L. Wagner
- D. Lindemann
- D. Liventsev
- D. Lopes Pegna
- D. M. Asner
- D. M. Rodriguez
- D. M. Wright
- D. Marlow
- D. Matvienko
- D. Mohapatra
- D. Monorchio
- D. N. Brown
- D. Nelson
- D. Newman-Coburn
- D. P. Coupal
- D. P. Stoker
- D. Piccolo
- D. R. Johnson
- D. R. Lavin
- D. R. Muller
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- D. S. Bailey
- D. S. Best
- D. S. Chao
- D. S. Smith
- D. S. Yan
- D. Santel
- D. Semmler
- D. Smith
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- D. W. G. S. Leith
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- D. Ćœontar
- Datta Browder
- De Rujula
- Degrassi Ciuchini
- Degrassi Ciuchini
- Dokshitzer Azimov
- Dunietz Aleksan
- DW Sivers
- DâAlesio Bacchetta
- E. A. Antillon
- E. A. Eckhart
- E. A. Kravchenko
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- E. Di Marco
- E. Erdos
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- E. Fioravanti
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- E. I. Rosenberg
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- E. M. Heenan
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- E. Maly
- E. Manoni
- E. Mullin
- E. Nakano
- E. Nedelkovska
- E. O. Olaiya
- E. P. Solodov
- E. Panzenböck
- E. Paoloni
- E. Petigura
- E. Prebys
- E. Prencipe
- E. Robutti
- E. Roussot
- E. S. Swanson
- E. Salvati
- E. Sicard
- E. Soderstrom
- E. Solovieva
- E. Spencer
- E. Stevanato
- E. Torassa
- E. Torrence
- E. Treadwell
- E. Vallazza
- E. W. Thomas
- E. W. Tomassini
- E. W. Varnes
- E. White
- E. Won
- E. Won
- Eidelman Benayoun
- Eidelman Davier
- Eidelman Davier
- Ewerth Bobeth
- F. Anulli
- F. Bellini
- F. Bianchi
- F. Blanc
- F. Bosi
- F. Brochard
- F. Bucci
- F. C. Pastore
- F. C. Porter
- F. Colecchia
- F. Cossutti
- F. Couderc
- F. Dal Corso
- F. Daudo
- F. De Mori
- F. Di Lodovico
- F. Dohou
- F. Evangelisti
- F. F. Wilson
- F. Fabozzi
- F. Fang
- F. Ferrarotto
- F. Ferroni
- F. Forti
- F. Furano
- F. G. OâNeill
- F. Gaede
- F. Galeazzi
- F. Gallo
- F. Gastaldi
- F. Giordano
- F. Haitani
- F. Handa
- F. J. Decker
- F. J. Ronga
- F. Jackson
- F. Jensen
- F. Lanni
- F. Le Diberder
- F. Liu
- F. Mandl
- F. Martinez-Vidal
- F. Morsani
- F. Muheim
- F. Ohno
- F. Palombo
- F. Polci
- F. R. Wappler
- F. Raffaelli
- F. Renga
- F. Safai Tehrani
- F. Salvatore
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- F. U. Bernlochner
- F. Winklmeier
- F. X. Yumiceva
- Fleming Bauer
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- G. B. Mohanty
- G. B. Mohanty
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- G. Bellodi
- G. Benelli
- G. Blaylock
- G. Bonvicini
- G. Brandenburg
- G. Calderini
- G. Casarosa
- G. Castelli
- G. Cavoto
- G. Cerizza
- G. Cibinetto
- G. Cowan
- G. Crane
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- G. D. Lafferty
- G. Dahlinger
- G. De Domenico
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- G. Eigen
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- Gambino Aquila
- GC Branco
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- Giudice DâAmbrosio
- Godfrey Eichten
- Golowich Burdman
- Golowich Burdman
- Golowich Donoghue
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- Grojean Csaki
- Gronau Beneke
- Gronau Chiang
- Grossman Giri
- Grossman Grinstein
- Grossman Gronau
- Grzelinska Czyz
- GĂłmez Dumm
- H. A. Tanaka
- H. Ahmed
- H. Aihara
- H. Atmacan
- H. B. Crawley
- H. B. Li
- H. Briand
- H. Bulten
- H. C. Ha
- H. C. Huang
- H. Cohn
- H. DeStaebler
- H. F. Chen
- H. F. Sung
- H. Farhat
- H. Fujii
- H. Futterschneider
- H. Guler
- H. H. F. Choi
- H. Ha
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- H. Hanada
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- H. Ishino
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- H. J. Hyun
- H. J. Kim
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- H. K. Jang
- H. K. Park
- H. Kagan
- H. Kaji
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- H. Kichimi
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- H. M. Liu
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- H. Neal
- H. Nicholson
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- H. Palka
- H. Park
- H. Quinn
- H. R. Band
- H. R. Khan
- H. S. Ahn
- H. Sagawa
- H. Sahoo
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- H. Sakaue
- H. Schmuecker
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- H. Shibuya
- H. Singh
- H. Staengle
- H. Steininger
- H. Stoeck
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- H. U. Flaecher
- H. W. Kim
- H. W. Shorthouse
- H. W. Wulsin
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- H.-Y. Cheng
- Hashimoto Harada
- He Liu
- Hiller Ali
- I. Adachi
- I. Adam
- I. Bedny
- I. Bingham
- I. Bizjak
- I. Eschrich
- I. Gaponenko
- I. Garzia
- I. Higuchi
- I. I. Bigi
- I. J. Forster
- I. J. R. Aitchison
- I. J. Scott
- I. Jaegle
- I. Kitayama
- I. L. Osipenkov
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- J. A. Kadyk
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- J. Blouw
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
- Author
- Abecasis Goncalo
- Abecasis Gonçalo R.
- Aben Katja K.
- Absher Devin
- Aherrahrou Zouhair
- Ahlqvist Emma
- Ahmadi Kourosh
- Ahmed Nabeel
- Alavere Helene
- Alibrandi Maria T S
- Allayee Hooman
- Almgren Peter
- Altshuler David
- Amin Najaf
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- Andersen Karl
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- Arnold Alice M.
- Aspelund Thor
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- Atwood Larry D.
- Aulchenko Yurii S.
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- Bataille Veronique
- Becker Diane M.
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- Beckmann Jacques S.
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- Bornstein Stefan R.
- Boström Kristina Bengtsson
- Bouatia-Naji Nabila
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- Makrilakis Konstantinos
- Mallick Nadeem
- Mangino Massimo
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- Wright Alan F.
- Wright Benjamin J.
- Wu Guanming
- Xie Weijia
- Xu Jianfeng
- Yang Jian
- Yang Tsun Po
- Ye Shu
- Zabena Carina
- Zaidi Moazzam
- Zaman Khan Shah
- Zeggini Eleftheria
- Zeller Tanja
- Zethelius Björn
- Zgaga Lina
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Ziegler Andreas
- Zillikens M. Carola
- Zitting Paavo
- Zondervan Krina T.
- Ăhrvik John
- Ăstenson Claes Göran
- Publication venue
- Diabetes
- Publication date
- 01/01/2011
- Field of study
OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired ÎČ-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of âŒ2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 Ă 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 Ă 10(-4)), improved ÎČ-cell function (P = 1.1 Ă 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 Ă 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
The Physics of the B Factories
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- Yumiceva F.X.
- Yusa Y.
- Yushkov A.N.
- Yuta H.
- YĂ©che C.
- Zacek V.
- Zain S.B.
- Zallo A.
- Zambito S.
- Zander D.
- Zang S.L.
- Zanin D.
- Zaslavsky B.G.
- Zeng Q.L.
- Zghiche A.
- Zhang B.
- Zhang C.C.
- Zhang J.
- Zhang J.
- Zhang L.
- Zhang L.M.
- Zhang S.Q.
- Zhang Z.P.
- Zhao H.W.
- Zhao M.
- Zhao Z.G.
- Zheng Y.
- Zheng Y.H.
- Zheng Z.P.
- Zhilich V.
- Zhou P.
- Zhu R.Y.
- Zhu Y.S.
- Zhu Z.M.
- Zhulanov V.
- Ziegler T.
- Ziegler V.
- Zioulas G.
- Zisman M.
- Zito M.
- Zupan J.
- Zupanc A.
- Zwahlen N.
- Zyukova O.
- ZĂŒrcher D.
- Ćœivko T.
- Ćœontar D.
- Publication venue
- Springer Verlag
- Publication date
- 29/01/2015
- Field of study
Increasing frailty is associated with higher prevalence and reduced recognition of delirium in older hospitalised inpatients: results of a multi-centre study
- Author
- Aamir Ayesha
- Abdelbadiee Sherif
- Abdullah Saad
- Abiola Oluwatosin O.
- Abras Ahmed
- Abu Emmy
- Abu-Arafeh Hashem
- Achara Amaka
- Adam Muhammad
- Adams Lawrence A. T.
- Adams Phillipa
- Aggarwal Nisha
- Ahmad Asim
- Ahmad Sarah
- Ahmed Bilquis
- Ahmed Hamza
- Ahmed Jabed
- Ahmed Rohan
- Ain Qurrat Ul
- Akintade Olugbenro
- Alareed Ahmad
- Alhadadi Baraa
- Ali Jawad
- Allain Theresa J.
- Allen James
- Alsahab Mustafa
- Amarnani Raj
- Amin Zarah
- Anderson Clementine
- Andrusca Ana
- Annamalai Arunkumar
- Ansell Matthew
- Appiah-Odame Paapa
- Arkle Thomas
- Ashton Caroline
- Astaire Emma
- Austin Keziah
- Babar Laxmi
- Babb Laura
- Bahsoon Farrah
- Baillie Jonathan
- Baldwin Jack B. G.
- Ball Katie
- Bargaoanu Imola
- Barlow Ciaran
- Baron Alexander
- Basker Karthik
- Batho Rachel
- Bazaraa Amr
- Bedi Simran
- Beeley Laura J.
- Beharry Karen
- Behbahani Abolfazl
- Behbahani Ayoub
- Bei Zhao Xiao
- Bell Charlotte
- Bertagne Marc
- Berwick L.
- Beveridge Louise
- Bhakta Shiv
- Bhat Ganapathy
- Bhattacharya Saurav
- Bhatti Jamal
- Bilton Edward
- Blair Mairi
- Bowden Helen
- Bowen Emily
- Bowman Mark A.
- Box Emma
- Bremakumar Sanojan
- Briggs Laura
- Broadhurst Karen
- Brown Harriet
- Browne Marylin
- Bryant Catherine
- Bullock Stuart
- Bultynck Celine
- Burton Jenni K.
- Bygate Rachael
- Byravan Swetha
- Caines Laurence
- Cairns Christopher
- Cameron Ewen
- Campbell Angela
- Capek Eileen
- Carter Sammy
- Cavaliere Chiara
- Chai Chung Sien
- Chamberlain Helen
- Chamboult Aimee-Louise
- Champion Jennifer
- Chapman George
- Cheah Khai L.
- Cheema Anum
- Chevolleau Jasmine
- Chilton Angharad
- Chourot Christian
- Christie Lorna
- Christodoulides Natasha
- Chuter Charlotte
- Clayton Victoria
- Cleaver Sarah L.
- Clements Hollie A.
- Coffey Farah
- Cohen Samuel
- Connell Laura
- Connor Louise
- Cook Alan
- Cooper Freya
- Cooper Olivia
- Copeland Claire
- Cox Natalie
- Cricklow Tamsin
- Croft Paul
- Crofts Jodie
- Cummings Laura
- Cunningham Emma L.
- Currie Hannah
- Cushen Claire
- Dama Sindhoora
- Darko Sandra
- Davies Rhianna
- Davies-Morris Jayne
- Davis Daniel
- De Mucha Pedro Vila
- Deacon Elizabeth
- Debrah Kwasi
- Deosaran Jordanna
- Dhillon Amber
- Doherty Cal
- Dove James
- Dovey Julie
- Drozdowska Bogna
- Durcan Rory
- Durrant Sabrina K.
- Edwards Sarah
- Einarsson Alice
- Elliott Emma
- Elliott Marianne
- Ellis Elizabeth J.
- Enfield-Bance Amy
- Evans Elizabeth
- Evans Jenny
- Evans Olivia
- Evans Sarah
- Faheem Waleed
- Fancourt Sarah
- Farah Rinata
- Faruq Sana
- Fenneley Grace
- Ferguson Eilidh E. C.
- Fergusson Niall
- Ferreira Ana Silva
- Fisken Emma
- Foster Kate
- Fraser Debbie
- Frewen John
- Furmedge Daniel
- Gallagher Michael
- Gaskell Natalie
- Gaunt Victoria
- Gaywood James
- Giblin Eleanor
- Giddings Jane
- Giet Leeying
- Giles Alexis
- Giridharan Kumudhini
- Glasser Martin
- Glasser Martin
- Gluck Ilan
- Goujon Marie
- Govindji Suriti
- Grange Robert
- Greaves Isabel
- Green Jessica
- Gregory Jemma
- Griffiths Eliza
- Grundmann Natalie
- Gui Jonathan
- Gupta Abhishek
- Gurung Sneha
- Hackett Beth
- Haddad Nedaa
- Haley Michael
- Hall Giles
- Hall Susan A.
- Handley Olivia
- Harbinson Alexander
- Harkin Teresa
- Hart Jasmine
- Hayat Yasmeen
- Headlam John
- Healy Roisin
- Henderson Neil
- Henderson Sarah
- Herbert Fiona
- Hindley Esther
- Hodhody Ghazal
- Hoffman Katrin
- Holmes Elizabeth A. M.
- Horner Sarah
- Hornsby Alex
- Horton Robbie
- Houldershaw Katie
- House Shannelle
- Hughes Clare
- Hunt Clare
- Hunt William
- Hunter Elisabeth
- Hussain Ambreen
- Hussain Zainab
- Ibanichuka Jacqueline
- Ikhwan Wan Idoracaera C.
- Ingamells Nathan
- Iqbal Shoaib
- Irvine James
- Irwin Sophie J.
- Iwu Chioma
- Jackson Peter
- Jackson Peter
- Jackson Thomas A.
- Jacques Holly
- Jagdeo Sarah
- Jakupaj Adriana
- Janagal Sureena
- Jatti Puja
- Jay Emma
- Jelley Benjamin
- Jenkin Rodric
- Jewell Emilia
- Jones Howell T.
- Jones Karen
- Jones Laura
- Jones Polly
- Kabia Angela
- Kadir Ismail
- Kalyaani Vickneswaran
- Kantczak Ada
- Katz-Summercorn Charles
- Kay Aaron
- Kearney Matthew
- Kelly Dominic
- Khalid Abdullah B.
- Khambay Ethan
- Khan Ali
- Khan Asma
- Khizar Bushra
- Khor Ming
- Kiani Mahum
- King Rachel
- Kirrane Kimberley
- Konda Nagarjun
- Koshedo Sejlo
- Krishan Anjli
- Kuek Dorothy K. C.
- Kumar Anusha
- Kumbun Gary
- Kunaselan Lleika
- Lai Jo
- Large Jamie
- Laud Rose
- Layton Georgia R.
- Le Poideven Andre
- Leah Eleanor
- Lee Helena
- Lee Tammy
- Leishman Felicity
- Lewis Anna
- Lim Su Kwan
- Lim Vee Han
- Livesey Joanna
- Lochlainn Mary Ni
- Lonsdale-Eccles Elizabeth
- Love Ryan
- Lowes Olivia
- Lucocq James E.
- Lyon Emily
- MacCuish Annabel Hentall
- Macdonald Fiona E.
- Macharouthu Ajay
- Mackenzie Eilidh R.
- Macrae Victoria
- Madden Katy F.
- Magill Laura
- Mahmood Al Wakkass
- Majid Zeinab
- Makin Stephen
- Mani Shama
- Marshall John
- Masoli Jane
- Matheswaran Yathu
- Matthews Natasha R.
- Matthews Stephanie A.
- Mayor Kara
- Mazzoleni Antonella
- McCauley Hannah
- McClean Adam
- McClelland Sarah B.
- McCluskey Heather J.
- McCluskey Lauren
- McCormack Roisin
- McCormack Vincent
- McCready Jack
- McCulloch Alison
- McDonald Helen
- McErlean Catherine M.
- McGonigal Gerry
- McKay Siobhan
- McKeown William
- McNicholas Emily
- McQuillan Alex
- McShane David
- Menezes Reema
- Meyer Caitlin
- Miller Christopher J.
- Miller Hazel
- Millichamp Katie
- Millner Helen
- Mills Sam
- Mishra Pranav
- Mishra Rajeev
- Mitchell Oliver
- Mithrakumar Pryankaran
- Moad Mohammad
- Mohammedseid-Nurhussien Awolkhier
- Moore Emily
- Moore Kirsty
- Moorey Hannah
- Morgan Bethan
- Morgan Hannah
- Morrison Kirty
- Morrow Abbie
- Morrow Olivia
- Mosley Alice
- Mukundan Maya
- Mullarkey Emma
- Mumtaz Emma
- Murphy-Ackroyd Emily
- Murray Adam A.
- Murthy Seema
- Mustafa Zeeshan
- Naeem Fariha
- Nagumantry Shonit
- Naish George
- Nandra Taran
- Naqvi Huma
- Nashed Nader
- Ng Liji
- Ngan Esther E. Y.
- Nicholls Isabelle
- Nightingale Peter
- Nneamaka Asiodu
- Noble Jane
- Norman Emma
- Nwabufor Philip
- Nynaes Olga
- Obi Ijeoma T.
- Offer Megan
- Ofoche Gladys
- Ostrowski Caroline
- Oâshea Kate
- Page Valerie
- Pailing Adam
- Pang Norman
- Parkinson Megan
- Parry Frances
- Parry Sarah
- Patel Minal D.
- Patel Riana
- Patterson Katherine
- Peck George
- Pendleton Hannah
- Perry Rita
- Pettler Sophie
- Pinkney Thomas
- Pope Leo
- Porter Lucy
- Porter-Bent Sasha
- Poynton Jack
- Prasad Vishnu
- Prendergast Emma L.
- Pullen Rosamund
- Pyc Wioletta
- Quinn Sinead
- Quinn Terrence
- Radoja Stephanie
- Rai Nisha
- Ramakrishna Sharan
- Rashid Shayan
- Rayner Helen
- Raza Mahrukh
- Reay Anna
- Reidm James
- Rice Caroline
- Richardson Sarah
- Rickard Frances
- Rimmer Lucy
- Robinson Hannah J.
- Robson Richard
- Ronan Lindsay
- Rose Emily C.
- Ross Anekea
- Rutter Steve
- Ryan Aidan
- Sahnan Kapil
- Saliu David
- Sami Fadi
- Sampson Elizabeth L.
- San Moe Su Su
- Sarma Dhruv
- Satharasinghe Lahiru
- Scarlett Danielle
- Scott Deborah
- Sehmbi Gurpreet
- Sen Michael
- Seymour Elaine
- Shah Hussun-Ara
- Shahid Muhammad
- Shakeel Sohail
- Shaw Megan E.
- Shepherd Alison
- Sloan Gerrard W.
- Smith Abigail
- Smith Gemma M.
- Smith Nina
- Speed James
- Sprosen Charles
- Stambollouian Katharine
- Stapley Simon M.
- Stirling Adam
- Stratton Emma
- Straughan Jacqui
- Studley Mark
- Subhan Zahid
- Sundara Srividya
- Swietoslawski Adam
- Syed Nihaad
- Tan Felicia
- Tantam Kate
- Taranu Roxana
- Taylor Abigail
- Taylor Emily
- Taylor Jemima
- Taylor Joanne
- Taylor-Rowan Martin
- Tencheva Ani
- Tetlow Simon
- Thake Miriam
- Thayabaran Darmiga
- Thomas Philip
- Thyn Thyn
- Timperley Alex
- Tinson Guy
- Todd Oliver
- Torsney Kelli
- Traill Philippa K.
- Treml Jonathan
- Tse Connie
- Tumi Ebrahiem
- Turton Sophie
- Tyagi Bhavyas
- Usmani Kasim
- Valentine Janine
- Vardon Henry
- Varghese Jessel
- Vasudev Ashish
- Vedutla Tarunya
- Velusamy Karthika
- Venkat Shabnam
- Virk Jasmine
- Visvaratnam Parrthiepan
- Wahballa Afnan
- Walker Amy
- Walter Amy
- Waraich Hana
- Warwicker Sarah
- Watson Hannah
- Watt Nicola
- Webb Hannah
- Welch Carly
- Wheeler Alice
- Whyte Lindsay
- Wilcockson James
- Wilkes Claire
- Williamson Emily
- Williamson Katherine
- Willott Ruth
- Wilson Daisy
- Wilson Daisy
- Wilson Darcy S.
- Wilson Faye
- Wilson Joseph B.
- Wilson Michael S. J.
- Winearls Stuart
- Wong Li
- Wong Ting W.
- Woodman Hannah
- Woodward Beth L.
- Wrathall Abigail
- Wright Emily
- Wright Sophie
- Wu Chenxian
- Wu Edward
- Wynne Luke
- Yap Zhi Jiun
- Young Lesley J.
- Yule Ollie
- Yunus Aayenah
- Publication venue
- Springer
- Publication date
- 01/04/2023
- Field of study
Purpose:
Delirium is a neuropsychiatric disorder delineated by an acute change in cognition, attention, and consciousness. It is common, particularly in older adults, but poorly recognised. Frailty is the accumulation of deficits conferring an increased risk of adverse outcomes. We set out to determine how severity of frailty, as measured using the CFS, affected delirium rates, and recognition in hospitalised older people in the United Kingdom.
Methods:
Adults over 65 years were included in an observational multi-centre audit across UK hospitals, two prospective rounds, and one retrospective note review. Clinical Frailty Scale (CFS), delirium status, and 30-day outcomes were recorded.
Results:
The overall prevalence of delirium was 16.3% (483). Patients with delirium were more frail than patients without delirium (median CFS 6 vs 4). The risk of delirium was greater with increasing frailty [OR 2.9 (1.8â4.6) in CFS 4 vs 1â3; OR 12.4 (6.2â24.5) in CFS 8 vs 1â3]. Higher CFS was associated with reduced recognition of delirium (OR of 0.7 (0.3â1.9) in CFS 4 compared to 0.2 (0.1â0.7) in CFS 8). These risks were both independent of age and dementia.
Conclusion:
We have demonstrated an incremental increase in risk of delirium with increasing frailty. This has important clinical implications, suggesting that frailty may provide a more nuanced measure of vulnerability to delirium and poor outcomes. However, the most frail patients are least likely to have their delirium diagnosed and there is a significant lack of research into the underlying pathophysiology of both of these common geriatric syndromes
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro CarĂ Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Bentley Andrew
- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bharaj Kiranjit
- Bhattarai Bina
- Bhattarai Binita
- Bhonagiri Deepak
- Biddie Simon
- Bigas Judit
- Bihari Shailesh
- Bin Hasan Mohd Shahnaz
- Bindels Manon
- Binnie Alexandra
- Biradar Vishwanath
- Birch Catherine
- Birch Janine
- Birch Sophie
- Birchall Kathrine
- Birkinshaw Isobel
- Black Ethel
- Blackledge Bethany
- Blakemore Hayley
- Blanck Wendy
- Bland Yvonne
- Blank Elisabeth
- Bleasdale John
- Bloomfield Jack
- Bloos Frank
- Board Jasmin
- Boardman Melanie
- Boari Gianluca
- Bocher Simon
- Bociek Aneta
- Boivin Anne-Helene
- Boivin Anne-HĂ©lĂšne
- Bojunga Jörg
- Bomken Charlotte
- Bonaccorso Allesandra
- Bongaerts Katherine
- Bonner Stephen
- Bonten Marc J. M.
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Bothma Pieter
- Boudineau Michel
- Boulanger Marie-Claude
- Boumahni Dounia
- Bouman Angela
- Bounab Rania
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Boutin Mireille
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte A.
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- Brakké Karen
- Brant Emily
- Brasselet Aurélie
- Breen Patrick
- Bremmer Pamela
- Brend Morwenna
- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Bridges Sarah
- Brieger Klaus-Gerd
- Brightling Chris
- Brimfield Lutece
- Brittain Michael
- Britton Kate
- Brochard Laurent
- Brodbeck Andreas
- Brohi Farooq
- Brooks Nicole
- Brown Cynthia
- Brown Julia
- Brown Louise
- Brown Nerissa
- Brown Zarah
- Brugman Curt
- Brunetta Enrico
- Brunkhorst Frank M.
- Brunskill Nigel
- Bryan-Morris Kayla
- Bryden Emma
- Budd Joanna
- Buehner Ulrike
- Buhay Megan
- Buhr Heidi
- Burbee Dylan
- Burda Dorota
- Burgess Richard
- Burke David
- Burke Tara
- Burkey Jason
- Burnish Rachel
- Burns Dean
- Burns Karen
- Burrell Aidan
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler Magdalena
- Butler Susan
- Buxton Meredith
- Buzgau Adrian
- Byrne Kathleen
- Byrne Rahim
- Cabrelli Louise
- Cabreros Leilani
- Cairns Tom
- Calfee Carolyn
- Callahan Jean-Christophe
- Cambalova Lenka
- Campbell Andrew
- Campbell Bridget
- Campbell Debbie
- Campbell Hilary
- Campbell Lewis
- Campbell Marion
- Campbell Ryan
- Campion Alexandra
- Campisi Josie
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
- Carmichael Samantha
- Carmona Rosario
- Carn Vanessa
- Carpio Lillian
- Carr Zoe
- Carr-Wilkinson Joanne
- Carrier François
- Carrier Marc
- Carter Angus
- Carter Brittney
- Carter David
- Carter Jay
- Carter Michael
- Casali Sherry
- Casey Ruth
- Casey Siobhan
- Castelain Vincent
- Castle James
- Cathcart Susanne
- Catorze Nuno José Teodoro Amaro dos Santos
- Cattelan Jessy
- Cavayas Alexandros
- Cawley Kathryn
- Cecconi Maurizio
- Centofanti John
- Chambers Emma
- Champanerkar Shreekant
- Chan Carmen
- Chan Charles
- Chan Peter
- Chapman Rachel
- Chapman Susan
- Charles Bethan
- Charles Walton
- Charlewood Richard
- Charlton Sam
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Jonathan
- Chen Lixian
- Chen Yan
- Cheng Allen C.
- Cherian Shiney
- Chhablani Manish
- Chin Teri
- Chudeau Nicolas
- Chukkambotla Sri
- Ciccarelli Michele
- Cirstea Emanuel
- Clair Bernard
- Clark Amy
- Clark Michele
- Clark Richard
- Clark Sarah
- Clarke Frances
- Clarke Jennifer
- Claxton Andrew
- Cleary Joanne
- Clement Ian
- Clere-Jehl Raphael
- Clermont Giles
- Clermont Gilles
- Clinton Alison
- Cloutier Ăve
- Cockrell Maeve
- Codreanu Daniel
- Coetzee Samantha
- Coghlan Phoebe
- Cole Jade
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Amy
- Collins Daniel
- Collins Emma
- Collins Joanne
- Collins Ărin
- Collis Matthew
- Combaux Daniele
- Commons Robert
- Comp Susan
- Concha Pablo
- Connolly Karen
- Constantini Elena
- Constantino-Occhipinti Claudia
- Contou Damien
- Convery Karen
- Conway Robert
- Conzelmann Nadine
- Cook Deborah
- Cook Tim
- Cooke Jill
- Cooke Justin
- Cooper Jamie
- Cooper Josh
- Cooper Lauren
- Cooper Melanie
- Cooper Nichola
- Corbett Sarah
- Corcoran Ele
- Corcoran Kathleen
- Cornell Sarah
- Cornell Thomas
- Cort Jon
- Costerousse Olivier
- Couillard-ChĂ©nard Ămilie
- Courtin Laura
- Coutts Amanda
- Couture Lourie
- Cove Matthew
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craddock Richard
- Craner Michelle
- Craven Thomas
- Crawshaw Sarah
- Creagh-Brown Ben
- Creange Vanessa
- Cremer Olaf
- Crisp Nikki
- Croft Maria
- Csabi Peter
- Cudlipp Joanna
- Cuesta Jeronimo
- Cuffaro Raffaele
- Curley Gerard
- Currie Andrew
- Cusack Rebecca
- Cuthbertson Brian
- Cutler Sean
- CĂĄrcel Sheila
- CĂŽtĂ© Ămilie
- D?Amato Fabiola
- D?Aragon Frédérick
- Daebis Admad
- Daher Rana
- Dale Katie
- Daley Jessica
- Dalton James
- Daly James
- Daly Zoe
- Daneman Nick
- Dark Paul
- Darnell Robert
- Darreau Cedric
- Daugherty Jason
- Davey Miriam
- Davidson Neil
- Davies Ellie
- Davies Gwyneth
- Davies Jennifer
- Davies Louisa
- Davies Michelle
- Davies Rhys
- Dawson Laura Ann
- Dawvda Ashlish
- Day Christopher
- Da Rocha Joana
- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
- de Jonge Evert
- De Keulenaer Bart
- de la Torre Cisneros Julian
- de Man Angelique
- De Neef Mark
- De Smeytere Anouska
- Deacon Bethan
- Dean Steven
- Dean Tessa
- Dearden Joy
- Dechert William
- Declercq Pierre-Louis
- Degracia Anna
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Dell Abbie
- del Prado Michael
- Demetriou Carrie
- Dempster Debra
- Denham Lynn
- Denmade Craig
- Dent Martin
- Depante Maria
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
- Dheke Krishan
- Di Lucca Giuseppe
- Dias Priya
- Dice Julie
- Digby Stephen
- Diridis Kristina
- Distler Michael
- Dobell-Brown Kelsey
- Doble Patricia
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- Doherty Kaleigh
- Doherty Ronan
- Doi Yohei
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- Donadee Chenell
- Donaldson Kate
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- Donnelly Adrian
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- Donnison Phil
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- Duric Natalie
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- Dushianthan Ahilanandan
- Dyas Sarah
- Eapen Beena
- Eastgate Christine
- Ebenezer R
- Edmunds Natasha
- Edwards Alexandra
- Efford Georgia
- Egreteau Pierre
- Ehrmann Stephan
- Eichenauer Dennis
- Eisenbeis Simone
- Ekhérian Jean-Michel
- El-Khawas Khaled
- Elender Corinna
- Elgendy Ahmad
- Elhassan Munzir
- Ellervee Anneli
- Ellis Chiara
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- Elsefi Tarek
- Eltayeb Ayaa
- Elvira Evangeline
- England Jenna
- Englert Sarah
- English Shane
- Epelmanž Slava
- Eroglu Ege
- Estcourt Lise J.
- Estensen Kristen
- Evans Amy
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- Evans Debra
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- Everitt Robert
- Evers Mirjam
- Evetts George
- Ewalds Esther
- Ezekowitz Justin
- Fagan Laura
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- Farahi Neda
- Fareed Komal
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- Fartoukh Muriel
- Faulkner Beverley
- Faulkner Maria
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- Featherstone Peter
- Felton Tim
- Fennessy Gerard
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- Ferguson Susan
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- Fernåndez de Pinedo Artaraz Ziortza
- Ferreira Ricardo Manuel Castro
- Ferrier Janet
- Ferringer Cindy
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- Godement Mathieu
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- Goebeler M.E.
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- Gordon Anthony C.
- Gosbell Iain
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- Guérin Emmanuelle
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- Göpel Siri
- Habeichi Wadih
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- Haider Nafeesah
- Haider Syeda
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- Hakak Sheeba
- Halden Sandra
- Haldeos Anne
- Hall Alistair S
- Hall Amelia
- Hall Andrew
- Hall Kathryn
- Hall Rebecca
- Hamilton David
- Hamilton-Davies Colin
- Hamlyn Vincent
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- Hammonds Fiona
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- Haniffa Rashan
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- Harrington Kate
- Harris Celia
- Harris Jade
- Harris John
- Harrison David A.
- Harrison Susan
- Harrow Kath
- Hartley Melissa
- Harvala-Simmonds Heli
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- Harvey Daniel
- Harvey James
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- Hegazy Mohamed
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- Hernandez Erik
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- Hey Samuel
- Hickey John
- Hierons Sarah
- Higgins Alisa M.
- Hill Claire
- Hill Dianne
- Hill Helen
- Hilldrith Anette
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- Hin Lui Lok
- Hindle Grace
- Hinrichs Carl
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- Hodge Christopher
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- Hodgson Helen
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- Holland Susan
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- Honda Hitoshi
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- Hormis Anil
- Horner Dan
- Hornsby James
- Horton Michelle
- Horvat Christopher M.
- Howcroft Clare
- Howell Alice
- Hower Martin
- Howie Lucy
- Howle Ryan
- Hoxha Elvira
- Huang David T.
- Hughes Debbie
- Hugill Keith
- Huijbens Danique
- Hullegie Sebastiaan
- Hulley Amanda
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- Hussain Mahwish
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- Hutton Paula
- HĂŒning Vanessa
- Ichihara Nao
- Ijaz Nazia
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- Irving Ben
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- Ivatt Helen
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- Jackson Shane
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- Jacquier Sophie
- Jafarzadeh Mina
- Jagannathan Vijay
- Jain Susan
- James Augustian
- James Christie
- Jan Hassing Robert
- Janin Pierre
- Jarczak Dominik
- Jarman Claire
- Jayakumar Deva
- Jayakumar Devachandran
- Jean-Pierre Eraldi
- Jeblaoui Asma
- Jenkins Samuel
- Jenkins Sarah
- Jenkins Steve
- Jennings Stacey
- Jepson Eleanor
- Jerenec Katja
- Jesty Robert
- Jha Avinash
- Jha Rajeev
- Jhanji Shaman
- Jin Xia
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- Jongebloed Katherine
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- Kamata Kazuhiro
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- Karim Hina
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- Karlikowski Michal
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- Kato Hideaki
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- Kiiski Heikki
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- Kim Edy Y.
- Kimpton Sarah
- King Andrew
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- Kirk Jill
- Kirk Rosemary
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- Kirkham Simon
- Kit Barbara
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- Klein Daniela
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- Kochanek Matthias
- Kochert Erik
- Koelink Maaike
- Koirala Kanchan
- Koirala Sabin
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- Konecny Pam
- Kong Jing
- Koopmans Matty
- Kosa Alma
- Kremling Julius
- KreĂ Gabriele
- Krishnamoorthy S
- Krishnamurthy Vinodh
- Kruger Peter
- Kruisdijk-Gerritsen Arriette
- Kruisselbrink Rebecca
- Kuitunen Anne
- Kumar Anand
- Kumar Nikhil
- Kumar Rohit
- Kummerlen Christine
- Kunishima Hiroyuki
- Kunwar Puja
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- Kurenda Catherine
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- Kwan Yvonne
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- Kyle Laura
- L?Hotellier Sylvie
- Labbe Vincent
- Laffan Mike
- Laffey John
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- Lai Vivian
- Lambert Bridget
- Lamontagne Francois
- Lampro Lamprini
- Landais Michaël
- Landoni Giovanni
- Landsiedel-Mechenbier Elke
- Lang Eva
- Langridge Emma
- Latham Victoria
- Latino Reece
- Laudi Svenja
- Laugs Fabian
- Lavana Jayshree
- Laver Russell D.
- Law Daniel
- Lawler Patrick R.
- Le Basnier Elliot
- Le Guen LenaĂŻg
- Le Loup Guillaume
- Leaf David E.
- Lean Richard
- Leaver Susannah
- Leavis Helen
- Leblond Julie
- Leditschke Anne
- Lee Kelvin
- Lee Stephanie
- Lee Stephen
- Lefevre Montaine
- Leffelaar Evelien
- Lehalleur Adrien
- Lellouche Francois
- Lemaire-Brunel Delphine
- Lembo Rosalba
- Leparco CĂ©cile
- Leroyer Marie-Helene
- Lesona Eden
- Levett Chris
- Lewis Joanne
- Lewis Roger J.
- Lewis Sarah
- LewisProsser Lorraine
- Liao Angela
- Lim Rosario
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- Lindergard Gabriella
- Linnett Vanessa
- Linstrum Kelsey M.
- Litton Ed
- Litton Edward
- Liu Theresa
- Lizotte Patricia
- Lock Stephen
- Lockett Teresa
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- Lomme Kaatje
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- Marin?ek Martin
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- Marroquin Oscar
- Marsden Tracy
- Marsh Emma
- Marshall John C.
- Marshall Lucy
- Marten Nicole
- Martin Elise
- Martin Emma
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- Maynard Victoria
- Mayr Florian
- Mc-Kenzie Josette
- McAdams David
- McArthur Colin J.
- McAuley Daniel F.
- McAuley Julie
- McCallion Edmund
- McCarthy Aine
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- McCracken Phoebe
- McCreary Erin
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- McCullagh Liz
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- McCullough James
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- McGain Forbes
- McGarry Karen
- McGhee Christopher
- McGlothlin Anna
- McGloughlin Steve
- McGlynn Deborah
- McGoldrick Clare
- McGuigan Peter
- McGuinness Shay P.
- McIntyre Joanne
- McIntyre Lauralyn
- McKee Madeleine
- McKenna Shirley
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- McVerry Bryan J.
- McWilliam Stephen
- Medhurst Laura
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- Paramasivam Elankumaran
- Parekh Dhruv
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- Parke Rachael L.
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- Ralston Maximillian
- Ramakrishnan N
- Ramali Mohamed
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- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
The drift time and charge division electronics system for the axial field spectrometer vertex detector
- Publication venue
- 'Elsevier BV'
- Publication date
- 26/03/1980
- Field of study
The drift time and charge division electronics system for the axial field spectrometer vertex detector
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study