Cardiovascular consequences of obstructive sleep apnea syndrome

Uma condição clínica muito comum é SAOS, que está associada a várias doenças cardiovasculares, incluindo hipertensão arterial sistêmica, fibrilação atrial e aterosclerose. A associação entre SAOS e doença cardiovascular não é somente uma consequência da sobreposição de fatores de risco, incluindo obesidade, sedentarismo, ser do sexo masculino e ter idade maior. Existem evidências crescentes de que SAOS contribui de forma independente para o aparecimento e a progressão de várias doenças cardiovasculares. Os mecanismos pelos quais SAOS pode afetar o sistema cardiovascular são múltiplos e incluem a ativação do sistema nervoso simpático, inflamação sistêmica, resistência a insulina e geração de estresse oxidativo. Existem evidências que o tratamento de SAOS com CPAP pode reduzir a pressão arterial, sinais precoces de aterosclerose, risco de recorrência de fibrilação atrial e mortalidade, principalmente por acidente vascular cerebral e infarto agudo do miocárdio, em pacientes com SAOS grave.Obstructive sleep apnea syndrome (OSAS) is a common condition associated with various cardiovascular diseases, including systemic arterial hypertension, atrial fibrillation, and atherosclerosis. The association between OSAS and cardiovascular disease has been related to the overlapping of risk factors, including obesity, having a sedentary lifestyle, being male, and being older. However, there is mounting evidence that OSAS can also independently contribute to the development and progression of various cardiovascular diseases. The mechanisms by which OSAS can affect the cardiovascular system are multiple, including the activation of the sympathetic nervous system, systemic inflammation, insulin resistance, and oxidative stress. There is also evidence that the treatment of OSAS with CPAP can reduce arterial blood pressure, early signs of atherosclerosis, the risk of atrial fibrillation recurrence, and mortality (principally mortality due to stroke or acute myocardial infarction) in patients with severe OSAS

Rings and spirals in barred galaxies. III. Further comparisons and links to observations

In a series of papers, we propose a theory to explain the formation and properties of rings and spirals in barred galaxies. The building blocks of these structures are orbits guided by the manifolds emanating from the unstable Lagrangian points located near the ends of the bar. In this paper, the last of the series, we present more comparisons of our theoretical results to observations and also give new predictions for further comparisons. Our theory provides the right building blocks for the rectangular-like bar outline and for ansae. We consider how our results can be used to give estimates for the pattern speed values, as well as their effect on abundance gradients in barred galaxies. We present the kinematics along the manifold loci, to allow comparisons with the observed kinematics along the ring and spiral loci. We consider gaseous arms and their relations to stellar ones. We discuss several theoretical aspects and stress that the orbits that constitute the building blocks of the spirals and rings are chaotic. They are, nevertheless, spatially well confined by the manifolds and are thus able to outline the relevant structures. Such chaos can be termed `confined chaos' and can play a very important role in understanding the formation and evolution of galaxy structures and in galactic dynamics in general. This work, in agreement with several others, argues convincingly that galactic dynamic studies should not be limited to the study of regular motions and orbits.Comment: 17 pages, 12 figures; accepted in MNRA

The GAPS Programme with HARPS-N at TNG VIII: Observations of the Rossiter-McLaughlin effect and characterisation of the transiting planetary systems HAT-P-36 and WASP-11/HAT-P-10

We determine the true and the projected obliquity of HAT-P-36 and WASP-11/HAT-P-10 systems, respectively, which are both composed of a relatively cool star and a hot-Jupiter planet. Thanks to the high-resolution spectrograph HARPS-N, we observed the Rossiter-McLaughlin effect for both the systems by acquiring precise radial-velocity measurements during planetary transit events. We also present photometric observations comprising six light curves covering five transit events, obtained using three medium-class telescopes and the telescope-defocussing technique. One transit of WASP-11/HAT-P-10 was followed simultaneously from two observatories. The three transit light curves of HAT-P-36b show anomalies that are attributable to starspot complexes on the surface of the parent star, in agreement with the analysis of its spectra that indicate a moderate activity. By analysing the complete HATNet data set of HAT-P-36, we estimated the stellar rotation period by detecting a periodic photometric modulation in the light curve caused by star spots, obtaining Prot=15.3 days, which implies that the inclination of the stellar rotational axis with respect to the line of sight is 65 degree. We used the new spectroscopic and photometric data to revise the main physical parameters and measure the sky-projected misalignment angle of the two systems. We found \lambda=-14 degree for HAT-P-36 and \lambda=7 degree for WASP-11/HAT-P-10, indicating in both cases a good spin-orbit alignment. In the case of HAT-P-36, we also measured its real obliquity, which turned out to be 25 degrees.Comment: 18 pages, 14 figure

Genetic characterization of 12 heterologous microsatellite markers for the giant tropical tree Cariniana legalis (Lecythidaceae)

Twelve microsatellite loci previously developed in the tropical tree Cariniana estrellensis were genetically characterized in Cariniana legalis. Polymorphisms were assessed in 28 C. legalis individuals found between the Pardo and Mogi-Guaçu River basins in the state of São Paulo, Brazil. Of the 12 loci, 10 were polymorphic and exhibited Mendelian inheritance. The allelic richness at each locus ranged from 2-11, with an average of 7 alleles per locus, and the expected heterozygosity ranged from 0.07-0.88. These loci showed a high probability of paternity exclusion. The characteristics of these heterologous microsatellite markers indicate that they are suitable tools for investigating questions concerning population genetics in C. legalis

An ultra-short period rocky super-Earth orbiting the G2-star HD 80653

Ultra-short period (USP) planets are a class of exoplanets with periods shorter than one day. The origin of this sub-population of planets is still unclear, with different formation scenarios highly dependent on the composition of the USP planets. A better understanding of this class of exoplanets will, therefore, require an increase in the sample of such planets that have accurate and precise masses and radii, which also includes estimates of the level of irradiation and information about possible companions. Here we report a detailed characterization of a USP planet around the solar-type star HD 80653 $\equiv$ EP 251279430 using the K2 light curve and 108 precise radial velocities obtained with the HARPS-N spectrograph, installed on the Telescopio Nazionale Galileo. From the K2 C16 data, we found one super-Earth planet ($R_{b}=1.613\pm0.071 R_{\oplus}$) transiting the star on a short-period orbit ($P_{\rm b}=0.719573\pm0.000021$ d). From our radial velocity measurements, we constrained the mass of HD 80653 b to $M_{b}=5.60\pm0.43 M_{\oplus}$. We also detected a clear long-term trend in the radial velocity data. We derived the fundamental stellar parameters and determined a radius of $R_{\star}=1.22\pm0.01 R_{\odot}$ and mass of $M_{\star}=1.18\pm0.04 M_{\odot}$, suggesting that HD 80653, has an age of $2.7\pm1.2$ Gyr. The bulk density ($\rho_{b} = 7.4 \pm 1.1$ g cm$^{-3}$) of the planet is consistent with an Earth-like composition of rock and iron with no thick atmosphere. Our analysis of the K2 photometry also suggests hints of a shallow secondary eclipse with a depth of 8.1$\pm$3.7 ppm. Flux variations along the orbital phase are consistent with zero. The most important contribution might come from the day-side thermal emission from the surface of the planet at $T\sim3480$ K.Includes STFC

The effect of continuous positive airway pressure on blood pressure in patients with obstructive sleep apnea and uncontrolled hypertension : study design and challenges during the COVID-19 pandemic

OBJECTIVES: To describe the MORPHEOS (Morbidity in patients with uncontrolled HTN and OSA) trial, and describe the challenges imposed by the COVID-19 pandemic. METHODS: MORPHEOS is a multicenter (n=6) randomized controlled trial designed to evaluate the blood pressure (BP) lowering effects of treatment with continuous positive airway pressure (CPAP) or placebo (nasal strips) for 6 months in adult patients with uncontrolled hypertension (HTN) and moderate-to-severe obstructive sleep apnea (OSA). Patients using at least one antihypertensive medication were included. Uncontrolled HTN was confirmed by at least one abnormal parameter in the 24-hour ABPM and >= 80% medication adherence evaluated by pill counting after the run-in period. OSA was defined by an apnea-hypopnea index >= 15 events/ hours. The co-primary endpoints are brachial BP (office and ambulatory BP monitoring, ABPM) and central BP. Secondary outcomes include hypertension-mediated organ damage (HMOD) to heart, aorta, eye, and kidney. We pre-specified several sub-studies from this investigation. Visits occur once a week in the first month and once a month thereafter. The programmed sample size was 176 patients but the pandemic prevented this final target. A post-hoc power analysis will be calculated from the final sample. ClinicalTrials.gov: NCT02270658. RESULTS: The first 100 patients are predominantly males (n=69), age: 52±10 years, body mass index: 32.7±3.9 kg/m2 with frequent co-morbidities. CONCLUSIONS: The MORPHEOS trial has a unique study design including a run-in period; pill counting, and detailed analysis of hypertension-mediated organ damage in patients with uncontrolled HTN that will allow clarification of the impact of OSA treatment with CPAP

Opposite-side flavour tagging of B mesons at the LHCb experiment

The calibration and performance of the oppositeside flavour tagging algorithms used for the measurements of time-dependent asymmetries at the LHCb experiment are described. The algorithms have been developed using simulated events and optimized and calibrated with B + →J/ψK +, B0 →J/ψK ∗0 and B0 →D ∗− μ + νμ decay modes with 0.37 fb−1 of data collected in pp collisions at √ s = 7 TeV during the 2011 physics run. The oppositeside tagging power is determined in the B + → J/ψK + channel to be (2.10 ± 0.08 ± 0.24) %, where the first uncertainty is statistical and the second is systematic

Measurement of the Bs0→J/ψKS0B_s^0\to J/\psi K_S^0 branching fraction

The $B_s^0\to J/\psi K_S^0$ branching fraction is measured in a data sample corresponding to 0.41$fb^{-1}$ of integrated luminosity collected with the LHCb detector at the LHC. This channel is sensitive to the penguin contributions affecting the sin2$\beta$ measurement from $B^0\to J/\psi K_S^0$ The time-integrated branching fraction is measured to be $BF(B_s^0\to J/\psi K_S^0)=(1.83\pm0.28)\times10^{-5}$. This is the most precise measurement to date