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Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

Author: Aawsaj Y.
Abad Gurumeta A.
Abad-Motos A.
Abate E.
Abatini C.
Abbadessa F.
Abbas A. M.
Abbassi-Ghadi N.
Abbott D.
Abbott T.
Abd Elazeem H. A. S.
Abdalla M.
Abdallah M.
Abdel Al S.
Abdel Jalil R.
Abdeldayem H.
Abdelkader Salama I.
Abdelkarem M. M.
Abdelkarim M.
Abdelmajeed A.
Abdelrahman A.
Abdelrahman S.
Abdelsamed A.
Abdou M.
Abdulkareem A.
Abdulwahed E.
Abdur-Rahman L.
Abel M. K.
Abellan M.
Aboelkassem Ibrahim A.
Abosamak N. E.
Abou Chaar M. K.
Abou-Khalil J.
Abouassi A.
Aboulkassem H.
Abreu Da Silva A.
Abu J.
Abu Za'nouneh F. J.
Abu-Nayla I.
Abubakar A.
Acebes Garcia F.
Achalandabaso Boira M.
Acher A.
Acrich E.
Adamina M.
Adamoli L.
Addae-Boateng E.
Aderombi A.
Adeyeye A.
Adiamah A.
Adishesh M.
Agapov M.
Aggarwal A.
Aghayeva A.
Agilinko J.
Agnes A.
Agostini C.
Agoston P.
Agrawal A.
Agresta F.
Aguado H.
Aguilar Gonzalez M.
Aguzzoli L.
Ahad S.
Ahmadi N.
Ahmeidat A.
Ahn J. H.
Aiken T.
Aime A.
Ajlan A.
Akalin M.
Akaydin E.
Akeel N.
Akgor U.
Akhtar M. A.
Akhter Rahman M. M.
Akilli H.
Akin E.
Akkour K.
Akmenkalne L.
Al Abdallah M.
Al Awwad S.
Al Habes H.
Al Maadany F. S.
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Al-Habsi R.
Al-Ishaq Z.
Al-Khayal K.
Al-Masri M.
Al-Mohammad A.
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AL-Sayed M.
Al-Tamimi Y.
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Publication venue: J Clin Oncol
Publication date: 01/01/2020
Field of study

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

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Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

Author: Aawsaj Y.
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Abad-Motos A.
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Whelan P.
Whisker L.
Whitehall E.
Whitmore H.
Wilkin R.
Wilkins A.
Williams G.
Williams J.
Williams K.
Williams M. A.
Williams T.
Williamson K.
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Winter S.
Wolfer S.
Wong M. P. K.
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Wong W. J.
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Wustrack R.
Xenaki S.
Xu M. J.
Xyda S. E.
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Yahaya A. S.
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Yassin N.
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Yetkin G.
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Yildirim A.
Yildiz A.
Ying Y.
Yip V.
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Youssef A.
Youssef M.
Yuksel E.
Yurttas C.
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Zafar S. N.
Zakai D.
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Zakaria Z.
Zambelli M. F.
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Zani S.
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Zapardiel I.
Zarabini A. G.
Zatecky J.
Zegarac M.
Zelic M.
Zeller N.
Zengin A. K.
Zerbib P.
Zervas K.
Zese M.
Zhang H.
Zivanovic M.
Zivkovic M.
Zizzo M.
Zografos C.
Zonta S.
Zorrilla Ortuzar J.
Zourntou S.
Zouzoulas D.
Zubaidi A.
Zullo A.
Publication venue: 'American Society of Clinical Oncology (ASCO)'
Publication date: 01/01/2021
Field of study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Archivio istituzionale della Ricerca - Università degli Studi di Parma

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

Author: 14 | COVIDSurg COllabOratIVe Tzovaras G. (General University Hospital of Larissa)
Aawsaj Y.
Abad Gurumeta A.
Abad-Motos A.
Abate E.
Abbott D.
Abdalla M.
Abdeldayem H.
Abdelkader Salama I.
Abdelkarim M.
Abdur-Rahman L.
Abel M. K.
Aboelkassem Ibrahim A.
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Abreu da Silva A.
Abubakar A.
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Acher A.
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Adamina M.
Aderombi A.
Adeyeye A.
Adiamah A.
Afonso J.
Agapov M.
Agnes A.
Agostini C.
Agresta F.
Aguado H. (Hellín Hospital)
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Al Awwad S.
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Aldokali N.
Alemanno G.
Alfieri S.
Alghamdi M.
Alhamed A.
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Ali M.
Ali S.
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Alma Mater Studiorum University of Bologna)
Almeida A. C.
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Alnumani T. (King Fahad 16 | COVIDSurg COllabOratIVe General Hospital)
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Cervellera M.
Cervera I.
Chan E.
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Charalabopoulos A.
Chase T.
Chatzikomnitsa P.
Chavarrias N.
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Chebaro A.
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Chern H.
Chessa A.
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Chia Z.
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Clinical Centre of Serbia)
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Collera P.
Colletti G.
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Colombo F.
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Correa Bonito A.
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Corte Real J.
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Costanzi A.
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Cotoia A.
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Coughlin P.
COVIDSurg COllabOratIVe | 15 Violante T. (IRCCS Azienda Ospedaliero – Universitaria di Bologna
Cozza V.
Creavin B.
Crichton A.
Cristian D.
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Crugnale A. S.
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Cullivan O.
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Cunha C.
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Cunningham R. M.
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Cvetkovic A.
Dainius E.
Daliya P.
Daly A.
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Day A. (East Surrey Hospital)
De Andres Olabarria U.
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De Lacy F. B.
De Manzoni Garberini A. (Ospedale Civile Spirito Santo)
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De Palma G. D.
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De Troia A.
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del Valle E.
Delgado Búrdalo L.
Delimpalta C.
Dellaportas D.
Delrio P.
Demir H.
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Demyttenaere S.
Denet C.
Depalma N.
Department of Biomedical Sciences
Derksen T.
Desio M.
Deus A. C.
Devezas V.
Devine M.
Di Bella A.
Di Candido F.
Di Franco G.
Di Giuseppe M.
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Diaz Del Gobbo R.
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Divya G S.
Dixon J.
Diéguez B.
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Domínguez I.
Donati D.
Doyle A.
Duchalais E. (Nantes University Hospital). Germany: Bork U.
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Durán Ballesteros M.
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Esteban Agustí E.
Etchill E.
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Fernandes U.
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Fleming C.
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Fonseca F. (Instituto Português de Oncologia de Lisboa Francisco Gentil)
Fonsi G. B.
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Foo C. C. (Queen Mary Hospital). Hungary: Banky B.
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Gemmill E.
General Surgery Department)
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Ghanbari A.
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Government Medical College). Ireland: Aremu M.
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Health Affairs
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Kilinc G.
Killeen S.
King Abdullah International Medical Research Center
Kirmizi Y.
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Kota Kinabalu
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Kulle C. B. (Koç University Medical School)
Kutkevičius J.
Kyriacou H.
Köken H.
Königsrainer A.
Küçük I. F.
La Regina D.
La Torre F.
Labib P.
Lacy A. M.
Ladd M. R.
Laface L.
Laforest A.
Laharwal A.
Lakkis Z. Manfredelli S. (CHU Besançon)
Lala A. K.
Lalou L.
Lapolla P.
Larentzakis A.
Larkin J. O.
Latinčić S.
Lauretta A.
Lauscher J. C.
Lawday S. Lyons A. (Southmead Hospital)
Le Roy B.
Lecolle K.
Ledesma F. S.
Lee M.
Leece)
Leede E.
Lenzi E.
Leon R.
Lewis-Lloyd C.
Li Z.
Liakakos T.
Liao C. C. L.
Lim M.
Lima da Silva C.
Lima M. J.
Linari C.
Litta F.
Litvina Y.
Lizzi V.
Loch F. N.
Lomonosov Moscow State University). Saudi Arabia: Alshahrani M.
Long C.
Longhi M.
Lopes L.
Lopez F.
Lora- Cumplido P. Sosa M. V. (Hospital de Cabueñes)
Lorenzon L.
Losada M. (Hospital Universitario del Sureste)
Lott N.
Loubani M.
Loutzidou L. (George Papanikolaou General Hospital of Thessaloniki)
Lowery A.
Lozano Lominchar P.
Lucchini S. M. (Sanatorio Allende). Australia: Cecire J.
Luglio G.
Lunghi E. G.
Lynch N.
Lázaro A.
Löffler M. W.
Löfgren N.
M. elghazaly S.
MacCabe T.
MacDonald L.
Machado D.
Machado N.
Madonini M.
Maffioli A. (Ospedale Luigi Sacco Milano)
Magee C. Powell S. (Wirral University Teaching Hospital)
Magowan D.
Mahendran V. (Worcestershire Royal Hospital)
Mahmood M.
Mahmoud Ali F. (Newcastle Upon Tyne Hospitals NHS Foundation Trust. )
Maida P.
Majbar A. M.
Majkowska A.
Mak T. W. C.
Malapati H.
Malcolm F. L.
Malgras B. (Hia Begin)
Malibary N.
Mall J. (KRH Nordstadt-Siloah Hospitals)
Maltinti G.
Manatakis D. K.
Mancini S.
Manku B.
Manso M. I.
Manson J.
Mantoglu B. (Sakarya University Faculty of Medicine)
Manu N.
Maqueda González R.
Marano A.
Marcos-Santos P.
Margalit A.
Mari G.
Marialva J.
Mariani N. M.
Marie-Macron L. (Centre Hospitalier Avignon)
Marino Cosentino L.
Marino M. V.
Markaryan D.
Markovic I.
Markovic V.
Maroli A.
Marques R.
Marqueta De Salas M.
Marra A. A.
Marra E.
Marte G.
Martin E.
Martin-Perez E. (Hospital Universitario de la Princesa)
Martinez German A.
Martins D.
Martins dos Santos G.
Martins Jordão D.
Martins R.
Martín L.
Martín-Arévalo J.
Martínez Chicote C.
Martínez-Hurtado E.
Martínez-Pinedo C.
Martínez-Pérez P.
Marx W. (SUNY Upstate University Hospital)
Marzi F.
Marçal A.
Marín H.
Massey L.
Massie E.
Massobrio A.
Mastoridis S.
Math S.
Matić S.
Matos Costa P. (Hospital Garcia de Orta)
Matute M.
Maté P.
Maw A.
McAleer J.
McAree B.
McCanny A.
McCluney S.
McCormick P.
McDermott F.
McElhinney K.
McEwen R. (University College London Hospital)
McGivern K.
McIntyre J.
McKevitt K.
McLarty N.
McNicol F.
Mehigan B. J.
Mehraj A.
Meima-van Praag E. M.
Memon A. S.
Memos N.
Mendes F. (Centro Hospitalar Cova da Beira)
Mendes J. R.
Mendoza-Moreno F.
Meneghini S.
Menoufia University). Finland: Kauppila J. H.
Mercado M. Á.
Metwalli M.
Michalopoulos N.
Michalski C.
Michel M.
Migliore M.
Mignot G.
Miguel T.
Mihanovic J.
Mihmanli M.
Miladinov M.
Milan)
Milano)
Milanović M.
Mills S.
Milne K.
Mingoli A.
Minicozzi A.
Ministry of National Guard
Minto G.
Mir I.
Mirabella A.
Miranda P.
Mitchell D.
Mithany R.
Mitrofan C. G.
Miu V.
Mochet S. Usai A. (Ospedale Regionale Umberto Parini)
Mohamed Sidek A. S.
Mohammad Z.
Mohammed M. M.
Mohan H.
Mohd Yunus M. F.
Mohsine R.
Mondovì)
Mongelli F. (Ente Ospedaliero Cantonale)
Montelatici M.
Monteleone M. (San Leopoldo Mandic)
Montella M. T.
Montori G.
Mora-Guzmán I. (Hospital Santa Bárbara)
Morais H.
Moras L.
Morelli L.
Morgan R.
Moritani K. (National Cancer Center Hospital). Jordan: Al Abdallah M.
Moro-Valdezate D.
Morris A.
Morsi A.
Mosley F. (Bradford Royal Infirmary)
Moss J.
Moura F.
Mourad M.
Muguerza J. M.
Muiesan P.
Mukherjee S.
Mulligan C.
Muratore A.
Murphy C.
Mustafa A. (Gateshead Health NHS Foundation Trust)
Mutter D.
Muzamil J.
Muñoz Camarena J. M.
Muñoz-Atienza V.
Nafees Ahmed R.
Nageh M. A.
Nahm C. (Leeds Teaching Hospitals Trust)
Nally D.
Nassa H.
Nassif M.
Natale J.
Navaratne L.
Nazir S.
Neary P. C.
Neary P. M.
Neely D. (Antrim Area Hospital – Northern Health and Social Care Trust)
Nel D.
Nelli T.
Neri J.
Nespoli L. C. Tamini N. (Ospedale San Gerardo)
Nessim C.
Newman T.
Newton C. (University Hospitals Bristol NHS Foundation Trust)
Newton K.
Ng H. J. (Dumfries and Galloway Royal Infirmary)
Ng S. S. M. (Prince of Wales Hospital)
Ng V.
Ng V. (Medway Hospital)
Nikaj H. (Azienda Ospedaliero Universitaria Maggiore della Carità)
Nikolic S.
Nitschke C.
Nogueira O.
Nogueiro J.
Nogués A.
Nolan G. J.
Norcini C. (San Giovanni di Dio)
Nordberg M.
Nouh T.
Novello S.
Nowak K. Reinhard T. (Romed Klinikum Rosenheim)
Ntziovara A. M.
Nunes Coelho M.
Nunez-Garcia B.
Nuñez del Barrio H.
Obeidat K. (King Abdullah University Hospital)
Oguttu B. (Kampala International University Teaching Hospital). UK: Agilinko J.
Olasehinde O.
Oliva Mompean F.
Oliveira A.
Olivier J. (Weston General Hospital)
Olivieri M.
Olson K. A.
Onos L.
Oosterlinck W.
Oosterling S. (Spaarne Gasthuis)
Opocher E.
Ortega Vázquez I.
Ortiz de Solórzano Aurusa F. J.
Osman N. (Alexandria Medical Research Institute)
Osorio A.
Otero A.
Ovejero Merino E.
Owen H.
Owens P.
Oyende O.
Ozben V.
Ozgediz D.
Ozmen B. B. (Acibadem Atakent Hospital)
O’Brien H.
O’Brien S.
O’Malley S.
O’Riordan J. M.
O’Shea M.
Pacheco Sánchez D.
Padilla-Valverde D.
Padmore G.
Pagano G.
Palagi S.
Palmeri M.
Panahi P.
Papaconstantinou I.
Papatheodorou P.
Paquette N.
Parasyris S.
Parello A.
Parente A.
Parini S.
Parise P.
Parkin E. (Royal Preston Hospital)
Parkins K.
Parlanti D.
Parmar C.
Parra Baños P. A.
Parray F.
Parreira R. (Hospital do Divino Espírito Santo)
Parseliunas A.
Parwaiz I.
Pascale IRCCS)
Pascale IRCCS)
Paspaliari D.
Passot G. (Hopital Lyon Sud)
Patel K.
Patel M.
Patel P.
Patil S.
Patrone R. (HPB Surgical Oncology Unit – Istituto Nazionale Tumori Fondazione
Patrício B.
Pattyn P. (Az Delta)
Pavlov M.
Pedrazzani C.
Peirce C. (University Hospital Limerick)
Pejnovic L.
Pejovic I.
Pellegrino L.
Pellino G. (Vall d’Hebron University Hospital). Sri Lanka: Arulanantham A.
Peluso C.
Peralta Ferreira M.
Pereca J. (University Hospital Ayr)
Pereira A.
Pereira C.
Pereira R.
Pereira Rodrigues A.
Perez D.
Perez Gonzalez M.
Pergolini I. Reim D. (Klinikum Rechts der Isar TUM School of Medicine)
Perivoliotis K.
Peros G. (Kantonsspital Winterthur). Turkey: Aghayeva A.
Perotto L. O.
Perra T.
Persiani R.
Pertile D.
Petrillo A.
Petropoulos K.
Peyroteo M.
Pezzuto A. P.
Peña Ros E.
Phan D. Townend D. (Lismore Base Hospital)
Phillips E.
Picardo A. L.
Pickett L. (Connolly Hospital Blanchardstown)
Picón Rodríguez R.
Pieniowski E. (Stockholm South General Hospital)
Piessen G.
Pieve Emanuele (Mi))
Pina S.
Pinto J. Tojal A. (Centro Hospitalar Tondela-Viseu)
Pipitone Federico N. S. (Edoardo Agnelli)
Pisani Ceretti A. (ASST Santi Paolo E. Carlo)
Pisanu A.
Pizarro M. J.
Pizzini P. (Ospedale Maggiore di Lodi)
Pla Marti V. (Hospital Clínico Universitario de Valencia)
Poch C.
Pockney P. (John Hunter Hospital)
Podda M. (Cagliari University Hospital)
Poggioli G.
Polydorou A.
Popoola A. (University of Ilorin Teaching Hospital). Pakistan: Jamal A.
Porcu A.
Portinari M.
Posadas-Trujillo O. E.
Posma-Bouman L. (Slingeland Ziekenhuis)
Potter R. (Royal Bournemouth Hospital)
Pourcher G.
Pozotou I.
Praetorius C.
Prando D.
Presl J.
Price C.
Prieto Calvo M.
Prieto Nieto M. I.
Pronk A. J. M.
Prosperi P.
Provozina A. (Immanuel Kant Baltic Federal University
Pruvot F. R.
Pérez Sánchez M. A.
Pérez-Saborido B.
Qasem A. (Al- Basheer Hospital)
Qatora M. S.
Quante M.
Qureshi A.
Raby-Smith W.
Rai . L (Dr Ruth K. M. Pfau Civil Hospital)
Rajaretnam N. (Royal Devon and Exeter Hospital)
Rakvin I. (Zadar General Hospital). Cyprus: Frantzeskou K.
Ramachandran A. (Tunbridge Wells Hospital)
Ramamoorthy 18 | COVIDSurg COllabOratIVe R.
Ramcharan S.
Ramesh P.
Ramirez Faraco M.
Ramos Bonilla A.
Ramos-Martín P.
Ramwell A.
Rapaport S.
Rashid A. (SMHS Hospital
Rashid M. M.
Rattizzato S.
Ratto C.
Ravindrakumar S.
Ravindran S.
Rayamajhi S. (Groote Schuur Hospital). Spain: Paniagua García Señorans M.
Raymond T.
Razafindrahita J. B.
Redfern J.
Rega D.
Regional Clinical Hospital)
Reilly J.
Revez T.
Rey Valcarcel C.
Reynolds I. S.
Ribeiro A.
Ribeiro C. G.
Ribeiro R.
Ribeiro V. I.
Ribolla M. (Ospedale Guglielmo da Saliceto Piacenza)
Rice D.
Richards T.
Ridgway P. F.
Righini E. (Azienda Unità Sanitaria Locale di Ferrara
Riley C.
Rimonda R.
Ringressi M. N.
Ripollés-Melchor J.
Risaliti M.
Rizzi A. (ASST Sette Laghi-Varese)
Robinson A.
Rodimov S.
Rodrigo V. S. D. (District General Hospital Chilaw)
Rodriguez J. L.
Rodríguez Gómez L. (Severo Ochoa University Hospital)
Rogers L. (Derriford Hospital)
Rojo López J. A.
Romano M.
Romero de Diego A.
Ronellenfitsch U. (University Hospital Halle (Saale))
Rooney S.
Rosa F.
Rose J.
Roslani A. C. (University Malaya Medical Centre). Mexico: Buerba G. A.
Rossi S.
Rottoli M.
Roy Mahapatra S.
Royle T.
Rozzano (Mi) and Humanitas University
Rubio-Perez I.
Ruivo A.
Ruiz Escobar A. (Infanta Leonor University Hospital)
Ruiz Soriano M.
Ruiz-Marín M.
Russ J.
Rutegård M. (Umea University Hospital). Switzerland: Arigoni M.
Rutherford D.
Ruzzenente A.
Ryan M. (University Hospital Waterford/University College Cork). Italy: Macina S. (ASST Mantua)
Ryan É. (University Hospital Galway)
Ryska O. (Royal Lancaster Infirmary)
Río Lafuente F. D.
Saad M. M.
Saafan T.
Saavedra J.
Sabah)
Sabratha)
Sabry A.
Saeed S.
Saez Carlin P.
Sagar J.
Sagnotta A. (Ospedale San Filippo Neri)
Sahin I. (Acibadem Altunizade Hospital)
Sahnan K. (Northwick Park Hospital)
Salazar A.
Saleem A.
Salem H.
Salgado-Nesme N.
Salimoğlu S.
Salindera S.
Sallam I.
Samih A.
Samir Abdelaal A.
Samison L. H. (Joseph Ravoahangy Andrianavalona Hospital). Malaysia: Hamdan K. H.
Samkari A.
Sammarco G.
Sammour T. (Royal Adelaide Hospital)
Sampaio da Nóvoa Gomes Miguel I. I. (Centro Hospitalar Universitário do Algarve – Unidade de Portimão)
Sampietro G. M. (Ospedale di Rho – ASST Rhodense)
San Francisco (UCSF))
Sanchez Cabezudo Noguera F.
Sanchez Gonzalez J.
Sanchez Jimenez R.
Sanchez-Pelaez D. (Hospital General Universitario de Ciudad Real)
Sancho-Muriel J. (Hospital Universitario Y Politécnico la Fe)
Sanchon L.
Sanli A. N.
Santanach C.
Santarrufina Martinez S.
Santero-Ramirez M. S.
Santos P. M. D. D.
Santos R.
Santos-Sousa H.
Sanz Larrainzar A.
Sanz Ortega G.
Sanz-Lopez R.
Sapienza P.
Sapre D.
Saraiva P.
Sarantitis I.
Sarigul M.
Sarin A.
Sarjanoja E. (Länsi-Pohja Central Hospital)
Sarma D. R.
Sarre C. (Instituto Nacional de Ciencias Médicas y Nutrición ‘Salvador Zubirán’). Morocco: Amrani L.
Sartarelli L.
Sarveswaran J.
Sasapu K. (Diana Princess of Wales Hospital Grimsby)
Sasia D.
Saudí S. (Hospital Universitario Miguel Servet)
Sauvain M. (Pourtales Neuchatel Hospital)
Sauvat F. (CHU Réunion). Romania: Bezede C.
Savković N.
Sayyed R. (Patel Hospital)
Scabini S.
Scalabre A. (Chu Saint Etienne)
Scanu A. M. (Cliniche San Pietro
Schiavo M. (Ospedale Vittorio Emanuele III – Carate Brianza)
Schiergens T.
Schineis C. (Charité University Medicine
Schizas D.
Schlesinger N.
Schwartz P.
Scott L. (Pinderfields Hospital)
Scotton G. (St Moritz Hospital)
Scrima O.
Sechenov Medical State University)
Seebah K.
Seeliger B. (Strasbourg University Hospitals/IHU-Strasbourg)
Seguin-Givelet A.
Sehgal T.
Selmani J.
Semina E. (Moscow Research and Educational Center
Senossi O.
Serevina O. L.
Serralta de Colsa D. (Infanta Sofía University Hospital)
Serrano González J. (Hospital Universitario de Torrejón de Ardoz)
Serrano-Navidad M.
Sert İ.
Seymour Z. (Ysbyty Gwynedd). USA: Haynes A.
Sganga G. (Fondazione Policlinico Universitario Agostino Gemelli IRCCS)
Sgrò A.
Shah J. (North Manchester General Hospital)
Shah S. (The Whittington Hospital)
Shah Z. A.
Shaikh I.
Shaikh S.
Sharabiany S. (Amsterdam UMC
Sharma P. (Aberdeen Royal Infirmary)
Shehata S.
Shenfine A. (Northumbria NHS Hospital Trust)
Shenit K. (Alexandria Main University Hospital)
Sheridan K.
Sherief M.
Sherif A. (Misr Cancer Center)
Sherif A. E. (National Liver Institute
Sherif G. (National Cancer Institute)
Shokuhi P.
Shortland T.
Sian T.
Sibilla M. G.
Sidiropoulos T.
Silva M.
Silva N.
Silva R.
Silveira Nunes I.
Simões J. (Centro Hospitalar e Universitário de Coimbra)
Singh A.
Singh S. (Queen’s Hospital Romford)
Skrovina M.
Smith C.
Smith H. (Bispebjerg Hospital). Egypt: Al Sayed M.
Smith L.
Smith. J (St James’s Hospital)
Soares A. P.
Soh J. Y.
Sohrabi C.
Solari F.
Soriero D. (IRCCS Ospedale Policlinico San Martino)
Sorrentino L. (Fondazione IRCCS Istituto Nazionale dei Tumori
Sorribas Grifell M.
Soto Montesinos C. (Fundació Althaia – Xarxa Assistencial Universitària de Manresa)
Souadka A. (Institut National d’Oncologie
Soulikia K.
Sousa Fernandes M. (Hospital Beatriz Angelo)
Sousa R. (Centro Hospitalar Universitário Lisboa Central)
Sousa S.
Spagni G.
Spampinato M. G. (Vito Fazzi
Spartalis E.
Spencer N.
Spiezio G. (Colorectal Surgical Oncology Unit – Istituto Nazionale Tumori Fondazione
Spinelli A. (Humanitas Clinical and Research Center IRCCS
Sreedharan L.
Sriram R. K.
Srishankar S. (Teaching Hospital Anuradhapura). Sudan Ali Adil A. K. (Al-Rajhi). COVIDSurg COllabOratIVe | 17 Sweden: Älgå A.
St John S.
Stafford J. (George Eliot Hospital)
Stavrinidou O.
Steele C. (Sheffield Teaching Hospital NHS Foundation Trust)
Steidle C.
Steinke J.
Stevens K.
Stevenson J. (The Ottawa Hospital). Croatia: Bačić G.
Stevic D.
Stewart K. E.
Stylianides N. (Manchester Royal Infirmary)
Stylianidis G. (Evaggelismos General Hospital)
Subhi M. T. (Alkhadra Hospital)
Subocius A.
Subramaniam S. (Queen Elizabeth Hospital and Universiti Malaysia Sabah
Sundaram Venkatesan G. (Glan Clwyd Hospital)
Suszták N. (Szent Borbála Kórház). India: Bhat G. A.
Sutherland A. (Coffs Harbour Health Campus)
Swinson B. (Royal Brisbane and Women’s Hospital). Austria: Messner F.
Syed W. A. S.
Syllaios A.
Szatmary P.
Szubota I. (Hospital and Oncological Centre Novy Jicin). Denmark: Ebbehøj A. L.
Sánchez del Pueblo C.
Sánchez Fuentes N.
Sánchez- Pernaute A.
Sánchez- Rubio M.
Sánchez-García S.
Taddei A.
Tadic B.
Taibi A. (Chu Limoges)
Talal El-Abur I.
Talwar R. (Luton and Dunstable University Hospital)
Tammaro P.
Tan J. A.
Tan X. S.
Tanal M.
Tang A. M.
Tanzanu M.
Tartaglia D. (Azienda Ospedaliero Universitaria Pisana)
Tasis N. (Athens Naval and Veterans Hospital)
Tatar O. C.
Tavares F.
Tayeh S. (Homerton University Hospital)
Tebala G. D.
Teixeira J. (Centro Hospitalar Universitário do Algarve – Unidade de Faro)
Teixeira M. (Centro Hospitalar do Tamega e Sousa)
Tejero- Pintor F. J. (Hospital Universitario Río Hortega)
Testa V. (Santa Croce E. Carle Hospital
Tewari N. (University Hospitals Coventry and Warwickshire NHS Trusts)
Tezas S. (Furness General Hospital)
Thaha M.
Thanapal M. R. (Hospital Kuala Lumpur)
Theodosopoulos T.
Theophilidou E. (Royal Derby Hospital)
Thian A.
Thomas A. (Royal Liverpool University Hospital)
Thompson D. (Morriston Hospital Swansea)
Thornhill M. (Dell Seton Medical Center at the University of Texas)
Thrumurthy S. (Epsom and St Helier University Hospitals NHS Trust)
Thulasiraman S. V.
Timbrell S.
Tirloni L.
Titu S. (Prof. Dr. Ion Chiricuta Institute of Oncology). Russia: Garmanova T.
Tonini V. (S. Orsola-Malpighi Hospital)
Torres A. (Hospital Clínico de Madrid)
Torres Arcos C.
Townson A.
Trabulsi N. (King Abdulaziz University Hospital)
Travaglio E. (Regina Montis Regalis Hospital
Tribillon E. (Institut Mutualiste Montsouris)
Troncoso Pereira P. (Hospital Mateu Orfila)
Tropeano F. P. (Federico II University Hospital)
Trujillo Díaz J.
Tsai L.
Tsarkov P.
Tsiamalou I.
Tsiaoussis I.
TU Dresden)
Tucci R. (Azienda Ospedaliera Universitaria Careggi)
Tufo A. (Ospedale del Mare)
Tugmen C.
Tulina I. (Clinic of Coloproctology and Minimally Invasive Surgery
Tuncer K.
Turnbull A. (Victoria Hospital Kirkcaldy)
Turrado-Rodriguez V.
Turri G. (Azienda Ospedaliera Universitaria Integrata di Verona)
Tweedle E. (Addenbrooke’s Hospital)
Ugarte-Sierra B. (Hospital Universitario de Galdakao)
Uludağ S. S.
Umair M.
Universiti Sains Malaysia)
University of Amsterdam)
Università di Ferrara)
Université Mohammed V Rabat). Netherlands: Hompes R.
Uras C. (Acibadem Maslak Hospital)
Urbani A. (Azienda Ospedaliero Universitaria San’anna)
Urbieta A. (Hospital Universitario la Paz)
Uslu G.
Utkan N. Z.
Uyanik M. S. (Samsun Training and Research Hospital)
Uzunoglu F. G. (University Medical Center Hamburg–Eppendorf). Greece: Antonakis P.
Vaccarella G. (Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello)
Valbuena Jabares V. (Marqués de Valdecilla University Hospital)
Valdes- Hernandez J. (Hospital Universitario Virgen Macarena)
Valero Soriano M. (Hospital General Reina Sofía)
Valle Rubio A. (Getafe University Hospital)
Valverde S. (Hospital Clinic Barcelona)
Van den Eynde J.
Van den Eynde R. (Uz Leuven). Bulgaria: Sokolov M. (University Hospital Alexandrovska). Canada: Boutros M.
Varma M. (University of California
Vasljević J.
Vassiliu P. (Attikon University General Hospital)
Vaz Pereira R.
Vaz S. (Centro Hospitalar e Universitário de São João)
Velchuru V.
Velickovic D. (Clinic for Digestive Surgery
Velidedeoglu M.
Venn M. (Royal London Hospital)
Venskutonis D. (Lithuanian University of Health Sciences Kaunas Clinical Hospital). Madagascar: Rasoaherinomenjanahary F.
Vera Mansilla C. (Hospital Universitario Principe de Asturias)
Verberne C. (John Radcliffe Hospital)
Vergari R. (Ospedali Riuniti di Ancona)
Vernon L. (Cork University Hospital)
Vervoort D.
Vescio G. (University ‘Magna Graecia’ of Catanzaro)
Vezakis A. (Aretaieion Hospital)
Videira J. F. (IPO Porto). Réunion: Kassir R.
Vieira B. (Centro Hospitalar de Trás-Os-Montes e Alto Douro
Vieira Caroço T. (IPO Coimbra)
Vieira Paiva Lopes A. C. (Hospital de Torres Vedras – Centro Hospitalar do Oeste)
Vignali A. (San Raffaele Scientific Institute
Vigorita V. (Álvaro Cunqueiro Hospital)
Vijayan D. (Queen Elizabeth Hospital Birmingham)
Villalabeitia Ateca I. (Hospital Universitario Cruces)
Vimalachandran D. (Countess of Chester Hospital)
Viswanath Y. K. S. (James Cook University Hospital)
Vitali A. (Ospedale San Giovanni di Dio)
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Publication venue: 'Wiley'
Publication date: 01/01/2020
Field of study

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Archivio della ricerca- Università di Roma La Sapienza

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

Author: Abdallah J
Abdul Ghani R
Abdul Kadir K
Abdullah R
Abejuela Z
Abouglila K
Abraham O
Abrahamsen I
Abraira Munoz Ld
Abramowitz M
Abusnana S
Accini Mendoza Jl
Acosta I
Agafyina A
Agarwal R
Agarwal Rajiv
Aggarwal N
Agra J
Ahmed F
Ahuad Guerrero Ra
Aiello J
Ainsworth P
Aizenberg D
Akiyama H
Akright L
Akyea-Djamson A
Al-Karadsheh A
Alamartine E
Alappan R
Albisu Jp
Ali N
Ali Z
Alicic R
Allison Dc
Alvarez Garcia P
Alvarisqueta A
Alves da Costa Fa
Amerena J
Amigo A
Amodeo C
Andreeva V
Andreotti Turatti La
Angelescu Lm
Angelova A
Anghel V
Antic S
Aoki H
Aquitania G
Arauz-Pacheco C
Arcos E
Arfeen S
Arif A
Aronson R
Arutchelvam V
Arvind M
Asano A
Asmarats Mercadal L
Atray N
August P
Avendano J
Avram Ri
Awad A
Babikova J
Badat A
Bajaj H
Baker J
Bakris G
Bakris George
Barbarash O
Barna O
Barnard M
Barnhill P
Barranco E
Barrera C
Barrios C
Bartaskova D
Bartolacci I
Barton P
Barysheva O
Beacom M
Behara V
Bellary S
Belo D
Belobradkova J
Bentley-Lewis R
Benusova O
Berenguer R
Berli Ma
Bermudez L
Bernardo M
Bhushan Rs
Bijata-Bronisz R
Bilyk Sd
Bin Shudim Ss
Biscoveanu M
Bompoint Severine
Bonadonna R
Bordonava A
Borot S
Botsyurko V
Bowman-Stroud C
Brandon D
Breedt J
Bregman R
Brenner Barry M
Brenner Bm
Brusco O
Buganova I
Bull Scott
Burst V
Busch R
Busegeanu Mm
Calella P
Camelo Sanches Fc
Canaan Y
Canani Lh
Cannon Christopher P
Cannon Cp
Cantero Mc
Capuano George
Caringal C
Cariou B
Cartasegna Lr
Castellino P
Cercos E
Cereto Castro F
Ceriello A
Chacra Ar
Chae Dw
Chang Ct
Chang T
Chapin L
Charytan David M
Charytan Dm
Che Yusof Md
Cheifetz A
Chen E
Chen N
Chen Q
Cherney D 3rd
Chertow G
Cheung Nw
Chilito A
Chiovato L
Chizhov D
Cho Ym
Chouinard G
Christensen T
Christiano C
Christofides E
Chu Pei-Ling
Chuang Lm
Chuateco C
Cif A
Cigarran Guldris S
Coffee L
Cohen K
Cohen R
Cohen S
Cohen-Stein D
Coloma Gc
Colombo H
Comia Rs
Commendatore V
Conway J
Cook C
Correa Rotter Jr
Cosma D
Cournoyer S
Coyne D
Crisan C
Cruz Jb
Csecsei G
Csiky B
Cuadrado J
Culak J
Cuneo Ca
Cunha Borges Jl
Cunha V\ueancio Sa
Cusumano Am
D'Avila D
da Silva Franco Rj
Daboul N
Danos P
Daroza G
Darwish R
Daswani A
David C
Davies E
Davies M
Davies S
Dawson A
De Brouwer K
de Carvalho Contieri Fl
De Cosmo S
De Nicola L
De Serres S
de Souza Portes E
de Souza P
de Zeeuw D
de Zeeuw Dick
Deak L
Deboni Lm
Deck K
Deepak D
Delos Santos L
Demian Ld
Derosa G
Desouza C
Destree M
Dev D
Dhillon M
Di Carlo A
Di Cianni G
Diaz Escalante T
Diaz Ruiz Jea
Dimitrov S
Distiller L
Distiller L
Djordjevic M
Dobronravov V
Dohnalova L
Dominquez Lopez M
Douthat Wg
Dran Rd
Drasnar T
Dreval A
Droste C
Dua S
Dub\ue9 F
Dudar I
Dudas M
Dussol B
Dzupina A
Dzuponova J
Eder F
Edwards Robert
Edwin Fm
Egido de Los Rios J
El Kossi M
El-Shahawy M
Elosegui Am
English P
Enriquez Sosa Fe
Ervin J
Esquenazi A
Evans J
Faghih M
Farias E
Faulmann G
Fauvel Jp
Ferariu Ie
Ferkl R
Fern\ue1ndez Montenegro Ma
Fernandez Fresnedo G
Fernandez Mf
Feuerstein J
Filho Ff
Finkelstein H
Fishbane S
Flores Lozano F
Flota Cervera Lf
Fragale G
Frasc\ue0 G
Fraser D
Fraser I
Frenk Baron P
Fretes Jo
Frias J
Fuiano G
Fulcher G
Fulop P
Fushtey I
G\uf3rriz Jl
Gaglia J
Galan Serrano A
Galindo-Ramos E
Galphin C
Gambaro G
Gan Cl
Gan S
Garcia Ballesteros C
Garcia Ortiz Lh
Garcia I
Garcia Nh
Garibotto G
Gastaldi A
Gaupsiene E
Gelersztein E
Geloneze Neto B
Genadieva V
Genova-Hristova G
George S
Ghazi A
Giorda C
Glenny Ja
Glinkina I
Gnudi L
Godlevska O
Godoy Jorquera Jg
Goldenberg R
Golovchenko O
Gomes M
Gomez Rangel Jd
Gomez O
Gonzalez Colaso Pdc
Gonzalez Martinez Fj
Gonzalez Orellana Ra
Gonzalez A
Gonzalez E
Gonzalez Jp
Gopalakrishnan N
Gorelick P
Gorson D
Gourdy P
Govender R
Govender V
Gowda A
Goycoa C
Goykhman S
Gracious N
Greco B
Greene T
Greene Tom
Greloni Gc
Grineva E
Grubb S
Guinsburg A
Gulati R
Gunstone A
Gupta A
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Gyrina O
Haase Fp
Hadjadj S
Halciakova K
Hall T
Haller H
Halmagyi I
Hammoud J
Hancu N
Handelsman S
Hanif W
Hansraj A
Harcsa E
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Hartman I
Hawley C
Heerspink Hiddo J L
Heerspink Hjl
Henein S
Hermida S
Hernandez Triana E
Herrera Jimenez Le
Hershon K
Hettiarachchi M
Higuera Jd
Hillis G
Hiser D
Holman R
Home P
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Hufert K
Hwang Sj
Ignjatovic J
Iitsuka T
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Irizar Santana Ss
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Jackson A
Jacob R
Jaffer S
Jaime M
Jain D
Jamal A
Januszewicz A
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Jardine M
Jardine Meg J
Jardine Mj
Jeong Ik
Jerwan-Keim R
Jha V
Ji L
Jimenez Florez F
Jimeno C
Jodar Gimeno Je
Johnson A
Johnson D
Joseph F
Joshi M
Juncos Li
Jurgens J
Kaczmarek B
Kajiyama S
Kamenov Z
Kaminska A
Kashine S
Kasner S
Kaupke C
Kawada T
Kazmirchuk A
Keightley G
Keitel E
Keltai K
Kendereski A
Keresztesi S
Kern E
Kerr Saraiva Jf
Keshavamurthy Cb
Khandwala H
Khanna R
Khirmanov V
Khitan Z
Khullar D
Kim S
Kim Sg
Kim Yh
Kiss K
Kissela B
Klein A
Klokocnikova V
Klyver Mi
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Kohara Sk
Koizumi M
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Kolesnyk I
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Komisarenko I
Kong Wy
Kong Y
Kono H
Konyves L
Koppolu D
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Kovesdy C
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Kozloviene D
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Kravchun N
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Krishnan S
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Krynski F
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Latiff G
Laviada Molina H
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Le Meur Y
Lee Bw
Lee J
Lee Ly
Lee Mk
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Leia C
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Levin A
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Nagibovich O
Nam Ms
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Pererva L
Perez Vera M
Perez A
Perez C
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Perkovic V
Perkovic Vlado
Perlman A
Pertseva T
Pesickova S
Peterfai E
Peterka K
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Pichette V
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Rose L
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Wakeling J
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Wang H
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Wassermann A
Watanabe T
Watson E
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Weiner D
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Wheeler D
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Winocour P
Wong Ac
Woo V
Yakov A
Yamada M
Yamada S
Yanagida K
Yanase T
Yang J
Yao C
Yap Ye
Yavin Yshai
Ygpuara Mdl
Yin A
Yoiti Hayashida C
Yoon Kh
Yost L
Young S
Yu X
Yumita W
Yupanqui H
Zaidman Cj
Zalunardo N
Zamarripa Escobedo R
Zanata Petry Tb
Zanella Mt
Zaniewski-Singh M.
Zanoli L
Zaoui P
Zateyshchikova A
Zateyshshikov D
Zaviriukha V
Zemek S
Zhang H
Zhang Hong
Zhao M
Zheng H
Zinman B
Zinman Bernard
Zlova T
Zsom M
Zub L
Zykova T
Publication venue: 'Massachusetts Medical Society'
Publication date: 01/01/2019
Field of study

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m 2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

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Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial

Author: Abbas J
Abbate A
Abdullakutty J
Abhyanakar AD
Aboyans V
Abrantes JAM
Abu-Fadel M
Acevedo M
Adamkova V
Adhyapak S
Agarwal H
Aggarwal R
Aggarwal RK
Aguirre A
Ahmed H
Ahremark U
Ahuad Guerrero RA
Aidar Ayoub JC
Airaksinen JK
Aitken D
Akatova E
Akhter F
Ako J
Akright L
Akyea-Djamson A
Al Joundi T
Al-Windy NYY
Alan D
Alcocer Gamba MA
Alexander JH
Alexander K
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Zuniga JDH
Zurakowski A
Zuran I
Zweiker R
Publication venue: 'Oxford University Press (OUP)'
Publication date: 01/01/2019
Field of study

Aims The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisin–kexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (≥1.8 mmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and results Median follow-up was 2.8 years. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (n = 2) or Type 5 (n = 5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77–0.95; P = 0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77–0.99; P = 0.032) and Type 2 (0.77, 0.61–0.97; P = 0.025), but not Type 4 MI. Conclusion After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.For complete list of authors see http://dx.doi.org/10.1093/eurheartj/ehz299</p

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ScholarBank@NUS

Canagliflozin and Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus and Chronic Kidney Disease in Primary and Secondary Cardiovascular Prevention Groups

Author: Abraham Oomman
Accini Mendoza Jose Luis
Agarwal R
Aggarwal N
Aizenberg D
Akiyama Hitoshi
Alamartine Eric
Albisu Jp
Alvarisqueta A
Amodeo C
Andreeva V
Angelova A
Aoki Hiromi
Arcos Edgar
Aronson R
Asano Akimichi
Avendano Jorge
Bajaj H
Bakris G
Bartaskova Dagmar
Bartolacci I
Barton Petr
Belobradkova Jana
Berli Ma
Bhushan Raju Sree
Bompoint S
Bonadonna Riccardo
Bordonava A
Borot Sophie
Bregman R
Brenner Bm
Bull S
Burst Volker
Calella P
Canani Lh
Cannon Cp
Cantero Mc
Capuano G
Cariou Bertrand
Cartasegna Lr
Casabella Ts
Castellino Pietro
Cercos E
Ceriello Antonio
Chacra Ar
Charytan Dm
Chen Nan
Chen Qinkai
Cherney D
Cheung Nw
Chiovato Luca
Chouinard G
Colaso Pdg
Coloma Gc
Colombo H
Commendatore V
Contieri Fld
Conway J
Cournoyer S
Csecsei Gyongyi
Csiky Botond
Cuadrado J
Cuneo Ca
Cunha Borges Jl
Cusumano Am
D'Avila D
da Costa Faa
Danos Peter
Daroza G
de Almeida Rs
de Brito Cm
De Cosmo Salvatore
de la Fuente Ral
De Nicola Luca
De Serres S
de Souza P
de Zeeuw D
Deak Laszlo
Deboni Lm
Deepak Dewan
Derosa Giuseppe
Di Carlo Alberto
Di Cianni Graziano
Diaz Ruiz Jorge Ernesto Andres
Diego Higuera Juan
Dimitrov S
Dohnalova Lenka
Douthat Wg
Dran Rd
Drasnar Tomas
Droste C
Dube F
Dudas Mihaly
Dussol Bertrand
Edwards R
Edwin Fernando M.
Faghih Markus
Farias E
Faulmann Grit
Fauvel Jean-Pierre
Felicio Js
Ferkl Richard
Fernandez Montenegro Maria Alicia
Fernandez Mf
Finkelstein H
Fragale G
Fraige F
Franco Rjd
Frasca Giovanni
Fraser I
Fretes Jo
Fuiano Giorgio
Gambaro Giovanni
Gan Shenglian
Garcia Ortiz Luis Hernando
Garcia Nh
Garibotto Giacomo
Gastaldi A
Gelersztein E
Genadieva V
Genova-Hristova G
Giorda Carlo
Glenny Ja
Godoy Jorquera Juan Gonzalo
Goldenberg R
Gomes M
Gonzalez Orellana Ronaldo Arturo
Gonzalez Alexander
Gonzalez Jp
Gopalakrishnan Natarajan
Gourdy Pierre
Goycoa C
Gracious Noble
Greene T
Greloni Gc
Guerrero Raa
Guinsburg A
Gupta A
Gupta M
Hachmann Jct
Halciakova Katarina
Haller Hermann
Hansraj Alva
Harcsa Eleonora
Hayashida Cy
Heerspink Hjl
Henein S
Hermida S
Hernandez Triana Eric
Hissa Mn
Hristozov K
Iitsuka Tadashi
Ines Molina de Salazar Dora
Jain Dinesh
Jardine Mj
Jerwan-Keim Reinhold
Johnson D
Juncos Li
Kajiyama Shizuo
Kamenov Z
Kashine Susumu
Kawada Toshio
Keitel E
Keltai Katalin
Keresztesi Sandor
Keshavamurthy C. B.
Khandwala H
Khullar Dinesh
Kiss
Klein Alexandre
Klokocnikova Vera
Klyver Mi
Kodera Takamoto
Kohara Sk
Kong Yaozhong
Kono Hiroshi
Konyves Laszlo
Koundurdjiev A
Kovar Richard
Koyama Kazunori
Kraft F
Krynski F
Kumeda Yasuro
Lanchiotti Pv
Lastuvka Jiri
Le Meur Yannick
Leiter L
Levin A
Levin A
Li Detian
Li Wenge
Li Xuemei
Lin Hongli
Lisboa Hrk
Liu Jian
Lozanov L
Lu Weiping
Lukac Martin
Madore F
Mah Pm
Mahaffey Kw
Major Lajos
Malaver Natalia
Malberti Fabio
Mandreoli Marcora
Manisha Sahay
Mannucci Edoardo
Mao Hong
Marchetta N
Margaritov V
Maxeiner Stephan
Mcmahon A
Medina Farina Marcelo
Mele P
Milagres R
Mileder Margit
Miyauchi Shozo
Mizuyama Kazuyuki
Molnar Marta
Montenegro R
Moreira Diaz Juan Pablo
Mucsi Janos
Muirhead N
Neal B
Neto Bg
Nicholls K
Nicolai S.
Niiya Tetsuji
Nonchev B
Noronha I
Novoa Pa
Oishi Hiroko
Orio Si
Oroszlan Tamas
Orsi Emanuela
Ory Ivan
Ota Satoshi
Otreras F
Oviedo A
Packham D
Panarotto D
Papini Nr
Paragh Gyorgy
Paschen Bjoern
Paul Haase Franklin
Pecoits R
Penfornis Alfred
Pereira Ma
Peringat Jayameena
Perkovic V
Pesickova Satu
Peterfai Eva
Peterka Karel
Petro Gizella
Petry Tbz
Piatti Piermarco
Pichette V
Plassmann Georg
Pollock C
Portes Ed
Prasad Narayan
Proietto J
Pumprla Jiri
Rabasa-Lhoret R
Raduan Ra
Raffaele P
Ramirez Roca Luis Alberto
Ramos Cs
Rangelov R
Ren Yan
Resk Jh
Revesz Katalin
Rista L
Roberts A
Roger S
Rose Ludger
Rosenthal N
Rosero Ricardo
Roussel Ronan
Rychlik Ivan
Saavedra Gajardo Victor
Sabbag Arn
Sakakibara Terue
Sala J
Sanches Fcc
Sanchez Arenales Jose Antonio
Sanchez Polo Jose Vicente
Santoro Domenico
Santos Jc
Saporito W
Saraiva Jfk
Sasso Ferdinando Carlo
Satyanarayana Rao K.
Saudek Frantisek
Saulnier Pierre-Jean
Schiavi Lb
Schuch T
Scotton As
Serviddio Gaetano
Sessa H
Shinkov A.
Song Weihong
Sreedhar Reddy
Sreelatha Melemadathil
Steele A
Stella Andrea
Sudhakar Bhimavarapu
Sun Jiao
Sun Lin
Sun T
Takacs Robert
Takai Masahiko
Tangri N
Temelkova M
Terront Lozano Monica Alexandra
Tesar Vladimir
Thervet Eric
Thome F
Tomonaga Osamu
Torshizi A
Trevisan Roberto
Tsang V
Tsujimoto Mitsuru
Tu Ping
Turatti Laa
Turcios Juarez Erick
Ulla Mr
Valderrama Cometa Luis
Valdez M
Valenzuela Alex
Valis Martin
Vallejos A
Vangel Sandor
Vargas Alonso Ruben Dario
Vasas Szilard
Vejar Margarita
Velichkova E
Vencio Sac
Veronelli Anna Maria
Villarino A
Villegas Ivan
Visco Ve
Vyasam Ramesh Chandra
Wada Takashi
Wakasugi Masakiyo
Wakida Yasushi
Wang Guixia
Wassermann A
Watanabe Takayuki
Weiner Pavel
Wheeler Dc
Woo V
Yakov A
Yamada Masayo
Yamada S
Yanagida Kazuhiro
Yanase Toshihiko
Yang Jinkui
Yavin Y
Yin Aiping
Yu Xueqing
Yumita Wataru
Yupanqui Hernan
Zaidman Cj
Zalunardo Nadia
Zanella Mt
Zanoli Luca
Zaoui Philippe
Zemek Stanislav
Zhang H
Zhao Minghui
Zheng Hongguang
Zinman B
Zsom Marianna
Publication venue: 'Ovid Technologies (Wolters Kluwer Health)'
Publication date: 01/01/2019
Field of study

Background: Canagliflozin reduces the risk of kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, but effects on specific cardiovascular outcomes are uncertain, as are effects in people without previous cardiovascular disease (primary prevention). Methods: In CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation), 4401 participants with type 2 diabetes mellitus and chronic kidney disease were randomly assigned to canagliflozin or placebo on a background of optimized standard of care. Results: Primary prevention participants (n=2181, 49.6%) were younger (61 versus 65 years), were more often female (37% versus 31%), and had shorter duration of diabetes mellitus (15 years versus 16 years) compared with secondary prevention participants (n=2220, 50.4%). Canagliflozin reduced the risk of major cardiovascular events overall (hazard ratio [HR], 0.80 [95% CI, 0.67-0.95]; P=0.01), with consistent reductions in both the primary (HR, 0.68 [95% CI, 0.49-0.94]) and secondary (HR, 0.85 [95% CI, 0.69-1.06]) prevention groups (P for interaction=0.25). Effects were also similar for the components of the composite including cardiovascular death (HR, 0.78 [95% CI, 0.61-1.00]), nonfatal myocardial infarction (HR, 0.81 [95% CI, 0.59-1.10]), and nonfatal stroke (HR, 0.80 [95% CI, 0.56-1.15]). The risk of the primary composite renal outcome and the composite of cardiovascular death or hospitalization for heart failure were also consistently reduced in both the primary and secondary prevention groups (P for interaction >0.5 for each outcome). Conclusions: Canagliflozin significantly reduced major cardiovascular events and kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, including in participants who did not have previous cardiovascular disease

Archivio istituzionale della ricerca - Università di Genova

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Author: Liza
- AP-HP) Bertrand Dousset (H\uf4pital Cochin
- APHP) Anne Thomin (H\uf4pital Trousseau
- ASST Rhodense) Carlo Corbellin (Ospedale Di Rho
- NYU Winthrop Hospital) Amir H Sohail (NYU Langone Health
- Xarxa Assistencial Universit\ue0ria de Manresa) Pablo Collera Ormazabal (Fundaci\uf3 Althaia
/ Columbia University Medical Center) Miriam Callahan (NewYork-Presbyterian
3 University Hospital) Bridget Egan (Tallaght
4 Lapolla Pierfrancesco
5 Spain: Eduardo E Rubio Susana Henriques (Hospital Garcia de Orta).
6 G\uf3mez Marcos
\u2013 IRCCS Francesca Gaino (Humanitas Clinical and Research Center
\u2013 Italy) 20089 Rozzano (MI)
\uc1ngel Hern\ue1ndez Bartolom\ue9 Miguel
A Aaraj Mahmoud
A Ayeni Funbi
A Bass Gary
A Benson Ruth
A Bozkurt Mehmet
A Breen Kerry
A Breen Kerry
A Breen Kerry
A Callcut Rachael
A Chung Eric
A Coughlin Patrick
A de Gheldere Charles
A De Marchi Joshua
A Elliott Jessie
A Fahey Brian
A Griffiths Ewen
A Griffiths Ewen
A Griffiths Ewen
A Guariglia Claudio
A Hirji Sameer
A Khalefa Mohamed
A Marra (Fondazione Policlinico Universitario Agostino Gemelli) Angelo
A Nguyen (Frankfurt University Hospital Truong
A Olson (Duke University Medical Center) Steven
A Raptis Dimitri
A Rollett Rebecca
A Saeed Samerah
A Salama Hiba
A Salamah Abdulrauf
A Schnitzbauer Andreas
A Schnitzbauer Andreas
A Singh Aminder
A Stevens Kent
A Stylianides Nicholas
A Thaha Mohamed
A Vega (12 de Octubre University Hospital) Viviana
A Vivas Alfredo
A Zappa Marco
Abate Emmanuele
Abdalaziz (Gloucestershire Royal Hospital) Hossam
Abdelkarim Mostafa
Abdou Hossam
Aboelkassem-Ibrahim Ahmad
Abuown Ala
Acebes-Garcia Fernando
Acharya Metesh
Adamina Michel
Addae-Boateng Emmanuel
Adolfo Pisanu (Cagliari University Hospital) Mauro Podda
Aftab Raiyyan
AG Moir John
Agarwal Arnav
AH Ibrahim Mohamed
Aitken (Queen Elizabeth University Hospital) Emma
Al-Azzawi Marwa
Al-Embideen Somya
Al-Sukaini Ahmad
Alakaloko Felix
Alam (Heartlands Hospital) Ruhina
Alameer Ehab
Alderson Derek
Ali Mohamed Ali (Queen Elizabeth Hospital King's Lynn) Inthekab
Aliyeva (Acibadem Mehmet Ali Aydinlar University Zumrud
Aljanadi Firas
Almasri Murad
Alonso Poza (Hospital Universitario del Sureste) Alfredo
Alonso-Ortu\uf1o Paula
Alser Osaid
Alser Osaid
Alser Osaid
Altintoprak (Sakarya University Faculty of Medicine) Fatih
Amalina Che Bakri Nur
Amjad Rabbia
Anania Gabriele
and Westminster Hospital NHS FT and Imperial College London) Chelsea
Andabaka Tatjana
Andrea Pisani Ceretti (ASST Santi Paolo e Carlo) Nicol\uf2 M Mariani
Angelou Dimitrios
Anita Volpe (New York Presbyterian Queens) Stephen Merola
Annamalai Seethalakshmi
Annessi Valerio
Anthoney James
Anuradha R Bhama (Rush University Medical Center) Alfonso Torquati
Anwar Sibtain
Aragon-Chamizo Juan
Ardito Antonella
Arigoni Michele
Armao Teodora
Arminio (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia) Armando
Armstrong Lara
Asaad Peter
Ashcroft James
Ashmore Christopher
Asqalan Ahmad
Asti (IRCCS Policlinico San Donato Emanuele
Aubry Emmanuelle
Aytac Erman
Ayuso-Herrera Esther
Azerbaijan:Elgun Samadov Joana FF Simoes (Chair). 2 Collaborators: (denotes Local Principal Investigator) Algeria: Faraj S Almaadany (\uc9tablissement Hospitalier Sp\ue9cialis\ue9 en Canc\ue9rologie - Centre Pierre-et- Marie-Curie).
B Avellana Rocio
B Catton Andrew
B Fonsi Giovanni
B Hing Caroline
B O'Meara Lindsay
B Schaffer Kathryn
B Yousuf (Tobruk Medical Center) Farhat
B\ue0mbina (Fabrizio Spaziani Hospital Fabrizio
Bailon-Cuadrado (Hospital Universitario R\uedo Hortega) Martin
Baldi Caterina
Baldini Edoardo
Baldo (Ospedale Santa Corona Stefano
Ballabio Michele
Baloyiannis Ioannis
Baltazar Gerard
Bandiera Alessandro
Barlow Emma
Barmasse (Ospedale Regionale Umberto Parini) Roberto
Barmpagianni Christina
Baronio (Policlinico San Pietro) Gianluca
Barra Fabio
Bartholomew's Hospital) St
Bartsch Anne-Marie
Basgaran Amedra
Basha Amr
Bashkirova (North Middlesex University Hospital) Varvara
Bastazza Marco
BB Sullivan (The Royal London Hospital) Tom
Beak Philip
Belcher Elizabeth
Belgium: Gabrielle H van Ramshorst Sevda Jafarova (Leyla Medical Center).
Beltr\ue1n de Heredia Juan
Belvedere Angela
Ben\uedtez-Linero Inmaculada
Benjamin Franklin) Campus
Bergeat Damien
Bernasconi Matteo
Bhalla Ashish
Bhangu Aneel
Bianco Federica
Bisagni Pietro
BJ Borgstein Alexander
Blake (Southport and Formby District General Hospital) Iain
Blanco-Colino Ruth
Blazquez-Martin (Hospital Principe De Asturias) Alma
Boal Matthew
Bologna) Ausl
Bonavina Giulia
Bonavina Luigi
Bond-Smith Giles
Booth (Freeman Hospital) Karen
Borges Filipe
Borghi Felice
Borja De Lacy (Hospital Clinic Barcelona) F
Bourke Grainne
Boyle Emily
Brachini Gioia
Brain Jessie
Brar Amanpreet
Breckles Lisa
Brendan L Skelly (Altnagelvin Area Hospital) Catherine Rossborough
Brianza) Carate
Brixton Genevieve
Bruzzaniti Placido
Bueser Teofila
Burnside Nathan
C Bosanquet David
C Brown (Manchester University NHS Foundation Trust Benjamin
C De Souza Anthony
C Glasbey James
C Glasbey James
C Hopkins James
C Lauscher Johannes
C McIntyre Robert
C Mckay Siobhan
C Neary Paul
C Nugent III William
C Rodriguez-Sanjuan (Marqu\ue9s de Valdecilla University Hospital) Juan
C Roslani April
C Tucker Sarah
C Velmahos (Massachusetts General Hospital) George
C Winter Stuart
Caballero Albert
Cairo University) Mahmoud MA Elfiky (Kasr Alainy Faculty of Medicine
Calcerrada-Alises Enrique
Camacho Fern\ue1ndez-Pacheco (Complejo Hospitalario Universitario Insular-Materno Infantil) Borja
Camarero Enrique
Campagnaro Tommaso
Campanelli Michela
Candiani Massimo
Cannoletta (Royal Brompton Hospital) Marina
Cantalejo-Diaz (Hospital Universitario Miguel Servet) Miguel
Cao Han
Capizzi Vita
Carcano (Ospedale di Circolo Giulio
Carissimi Francesca
Carlini Massimo
Carlos Bernal-Sprekelsen Juan
Carlos Catal\ue1 Bauset (Consorcio Hospital General Universitario) Juan
Carlucci Michele
Carmela Giuffrida Maria
Carmichael Heather
Carrasco Milagros
Carrillo Mariana
Carvello Michele
Casati Massimiliano
Castoro Carlo
Castro Ruiz Carolina
Catalan Vanesa
Catriona R Luney (Nuffield Orthopaedic Centre) Benjamin JF Dean
Cavaleiro Salom\ue9
Cellerino Paola
Center Amsterdam) Cancer
Centinaio (Ospedale Maggiore di Lodi) Giovanna
Cernei Cristina
Cervellera Maurizio
Chakrabortee Sohini
Chamberlain Stephanie
Chan Jeffrey
Chang Grace
Chaudhry Daoud
Chebaro Alexandre
Chen (Jamaica Hospital) David
Chetty Govind
Chia (Royal Derby Hospital) Zoe
Chiappini Ambra
Chiarugi (Azienda Ospedaliero Universitaria Pisana) Massimo
Chidambaram Swathikan
Chiozza Matteo
Cholewa Hanna
Chong (Evelina London Children's Hospital) Clara
Choolani-Bhojwani Ekta
Christian Cotsoglou (ASST Vimercate) Stefano Granieri
Chui Karen
Chung Choyin
Cirillo Bruno
Citterio Davide
Clermidi Pauline
Coccolini Federico
Colletti Gaia
Compagnoni Bruno
Concepci\uf3n-Mart\uedn Vanesa
Confalonieri Marco
Connolly Hannah
Conso Christel
Conti Luigi
Cooper Zara
Corral Javier
Costa Marta
Costanzi Andrea
Cox Daniel
Cozza Valerio
CR Wormald Justin
Croatia: Jakov Mihanovic Nicolas Duchateau (Heilig Hart Ziekenhuis Lier).
CS Clough Ethan
Cuming Tamzin
Cuneo)
Curtis Miles
Cuschieri Joseph
D Baron Ryan
D Bosch Karen
D Brown Oliver
D Bueno-Ca\uf1ones Alejandro
D Cato Liam
D Drake Thomas
D Jenkinson Michael
D Jenkinson Michael
D Liyanage Aloka S
D Pinkney Thomas
D Rajgor Amarkumar
D Stewart Grant
D Tebala Giovanni
D'Agruma Michele
D'Andrea Giancarlo
D\uedaz P\ue9rez David
D\uedaz-Garc\ueda (Hospital Universitario Nuestra Se\uf1ora de Candelaria) Alberto
Da Roit Anna
da Saliceto\u201d Patrizio Capelli (Ospedale \u201cG.
Dare Oliver
Darko Ebenezer
Data Monitoring and Ethics Committee: Deborah S Keller H. Hunt Batjer (University of Texas Southwestern).
Day Andrew
De Andr\ue9s-Asenjo Beatriz
de Medicina Facultad
De Miguel-Ardevines Maria-Carmen
De Nardi Paola
De Simone Veronica
De Toma Giorgio
Deepti Sinha (University College London Hospital) Nicholas Kalavrezos
Dehal (Kaiser Permanente Panorama City Medical Center) Ahmed
Dehart Dustin
Del Giudice Roberto
Delgado-Oliver Eduardo
Denmark: Henry G Smith Bernarda Bakmaz (Zadar General Hospital).
Denning Max
Desai Anant
Desender (Ghent University Hospital) Liesbeth
Dester (ASST Valcamonica Ospedale di Esine) Sara
Di Candido Francesca
Di Chiara Francesco
Di Franco Gregorio
Di Giuseppe (Ente Ospedaliero Cantonale del Canton Ticino) Matteo
Di Saverio Salomone
Di Saverio Salomone
Di Saverio Salomone
Di Saverio Salomone
Diaz-Pe\uf1a Patricia
Dieguez Fernandez Beatriz
Dissemination Committee: Michel Adamina Aneel Bhangu.
Dolores Del Toro M
Domodossola
Doussot Alexandre
Duff Sarah
Dunning Joel
Dunstan Matt
Duque-Mallen Victoria
Dziakova Jana
E Canova Michaela
e Carle Hospital Chiara Peluso (Santa Croce
e Carlo ASST Santi Paolo
E Dawson Brett
E Dickson Kathryn
E Hudson Victoria
E Jenny (Johns Hopkins Hospital) Hillary
E Lewis Sophia
E Nita George
e Oftalmico) Giulio Iacob (Ospedale Fatebenefratelli
E P\ue9rez-S\ue1nchez Luis
E Rice Henry
E Ssentongo Anna
e Universit\ue1rio de Coimbra) Ana C Almeida (Centro Hospitalar
E Xyda Souzana
Edward Fitzgerald J
EF Abbott Tom
EF Abbott Tom
Egan Richard
Egypt: Mohamed El Kassas University of Copenhagen).
El Youzouri Hanan
El-Ali (Queen's Hospital Abess
Elaine YL Leung (The Pan Birmingham Gynaecological Cancer Centre) Sudha Sundar
Elfeki Hossam
Elhadi Muhammed
Eljareh (Aljalaa Hospital) Mohammed
Elkadi Hannah
Elkady Ramy
Elkhafeefi Fatimah
Elmore Ugo
Elmoslemany (The Walton Centre NHS Foundation Trust) Tarek
EM Bouhuwaish Ahmad
EM Brathwaite Collin
Emmerson (North Manchester General Hospital) Oliver
Enemosah Ibrahim
English Camilla
English William
Ereidge Simon
Escartin Jorge
Estaire-Gomez Mercedes
EuroSurg
Evans (Queen Elizabeth the Queen Mother Hospital Margate) Jessica
Exley Rebecca
F Bath Michael
F Cunha Miguel
F Cunha Miguel
F Davis Niall
F Ridgway Paul
Fabbri Nicol\uf3
Falco Giuseppe
Familiari Pietro
Fancellu (Cliniche San Pietro Alessandro
Fanjul G\uf3mez Mar\ueda
Farik Shebani
Farr\ue9 Font Roser
Farrell Tony
Fehervari Matyas
Fell Adam
Fern\ue1ndez- Mart\uednez Mar\ueda
Fern\ue1ndez-Gomez Cruzado (Hospital Urduliz) Laura
Fern\ue1ndez-Mar\uedn Reyes
Fernandez-Camu\uf1as Angel
Ferrara)
Ferrara Francesco
Ferrari Guglielmo
Ferrero Simone
FF Simoes Joana
FF Simoes Joana
Findlay Laura
Fiore Marco
Fiore Marco
Fiori Enrico
FJ Dunne Declan
Flatman Michael
Flindall Ian
Fontana (Vittorio Emanuele Tommaso
Ford (The Robert Jones and Agnes Hunt Orthopaedic Hospital) David
Ford Samuel
Forlani Stefano
Fr\ue9d\ue9ric Bretagnol (H\uf4pital Louis-Mourier - GHU AP-HP. Nord - Universit\ue9 de Paris) David Moszkowicz
France: Zaher Lakkis Mohamed Sherief (MISR Cancer Center/MISR International Hospital).
Francisco de Vitoria Universidad
Francone Elisa
Frattaruolo Colomba
Frio (Institute of Neurological Sciences of Bologna Federico
Frosinone)
G Aoun Salah
G Barranquero Alberto
G Blazer III Dan
G Collins Chris
G Edwards John
G Edwards John
G Morton Dion
G Povey Meical
G Velopulos Catherine
G Wade Ryckie
Gabriel Kinnaman (IU Health Methodist Hospital) Ashley D Meagher
Gagliano Annalisa
Gagliardi Filippo
Gahunia Sukhpreet
Gala Tanzeela
Galfrascoli Elisa
Galimberti Luca
Galindo Jara (Hospital Universitario de Torrej\uf3n Pablo
Gallagher Phoebe
Galleano Raffaele
Gallo Gaetano
Gallo Gaetano
Gallo Gaetano
Galv\ue1n-P\ue9rez Armando
Gamal Amira Ibrahim Sallam
Gammeri Emanuele
Ganau Mario
Garc\ue9s-Garc\ueda Ra\ufal
Garcia Fernandez Andres
Garcia-Conde Delgado Maria
Garulli (Ospedale Infermi di Rimini) Gianluca
Gascon-Ferrer Isabel
Gattolin (Regina Montis Regalis Hospital Andrea
Gaujoux Sebastien
Gentilli Sergio
Georgiades Fanourios
Germany: Carsten Kamphues Didier Ollat (Institut Mutualiste Montsouris).
Gerogiannis (Kingston Hospital NHS Foundation Trust) Ioannis
Ghanbari (Homerton University Hospital) Amir
Ghosh Dhruv
Giacometti Marco
Giblin Anna-Victoria
Gilbert (Surrey and Sussex Healthcare NHS Trust) Catherine
Gim\ue9nez Clara
Giorgakis Emmanouil
Gipponi Manuel
Glen Paul
GlobalPaedSurg GlobalSurg
Goatly Giles
Gobatti (San Carlo Borromeo Hospital Davide
Godbole Chintamani
Gohil Kajal
Gomez-Rosado Juan-Carlos
Gonullu Emre
Gonzalez-De Miguel Melania
Gonzalez-Gonzalez Enrique
Gordini Luca
Gracia Isabel
Gracia-Roche Carlos
Greece: Konstantinos Bouchagier Markus W L\uf6ffler (University Hospital Tu\u308bingen).
Green Susanna
Grivon Manuela
Grove (Department of Colorectal Surgery Thomas
Guaglio Marcello
Guaitoli (Perrino) Eleonora
Guglielmi Alfredo
Guha Soumya
Gustavino (Unit of Obstetrics and Gynecology IRCCS Ospedale Policlinico San Martino Genoa) Claudio
Guti\ue9rrez Samaniego Mar\ueda
H Babu Bheemanakone
H Chowdhury Abeed
H Davidson Giana
H Davidson Giana
H Davidson Giana
H Elfallal Ahmed
H Emile Sameh
H Kirmani Bilal
H Liu Helen
H Murphy Suzanne
H van Ramshorst Gabrielle
H\uf6lzle Frank
Habeeb Amir
Hagger Robert
Hakmi Hazim
Halkias Constantine
Halkias Constantine
Hampton (Rotherham District General Hospital) Matthew
Handa Siddhartha
Haq Iram
Harky (Liverpool Heart and Chest Hospital) Amer
Harries (Morriston Hospital Rhiannon
Harrison Joseph
Hasan Raashad
Hawari Mohammad
Hawkin Paul
Hebblethwaite Bethany
Helier University Hospitals NHS Trust) St
Heritage Emily
Hernandez Garcia Miguel
Hernandez-Juara Pilar
Herrero-Lopez Maria
Hervieux Erik
Heyd Bruno
Higgs Simon
Hitchman (Hull University Teaching Hospitals NHS Trust) Louise
Ho Beatrice
Hogan Aisling
Hospital of Varese University
Hospital Universitario del Henares) Miguel Angel Garcia-Ure\uf1a (Universidad Francisco de Vitoria
Hospital) Atakent
Hospital) Wythenshawe
Hossain Tanvir
Houston Roy
Hurt Libor
HV Byrne Matthew
i Pujol) Alba Zarate (Hospital Germans Trias
I Roxo (Brigham and Women's Hospital) Vanessa
I van Berge Henegouwen (Amsterdam UMC Mark
I Alessandro Di Bartolomeo (Policlinico Umberto
Iannone Immacolata
Ibrahim Sherif
Iovino Domenico
Ireland: Arnold DK Hill Paraskevi Tourountzi (Kavala General Hospital).
Isik Arda
Israel: Oded Zmora Thomas M Aherne (Galway University Hospital).
Italy: Maurizio Zizzo Nadav Kugler (Shamir Medical Center).
J Abbott Sarah
J Baker Olivia
J Baldwin Alexander
J Beamish Andrew
J Carlos William
J Caruana Edward
J Caruana Edward
J Davies Emma
J Diaz Jose
J Doe Matthew
J Eardley Nicola
J Fern\ue1ndez Antonio
J G\uf3mez D\uedaz Carlos
J Hainsworth Alison
J Hall Bria
J Holme Thomas
J Hutchinson Peter
J Hutchinson Peter
J Kalkwarf Kyle
J Lin Daniel
J Lowery Aoife
J McCluney Simon
J Mehigan Brian
J Mills Sarah
J Pachl (Birmingham Children's Hospital) Max
J Rogers Luke
J Ryan \uc9anna
J Scurrah Rachel
J Shackcloth Michael
J Smart Neil
J Steinkamp Pieter
J Tejero-Pintor Francisco
J Thomas Amy
J Torres Antonio
J Warren Oliver
J Warren Oliver
J Williams Katherine
James RW Hall (Stepping Hill Hospital) Claire Hall
James's Hospital) Conor P Barry (St.
Jamil Tahir
Jayaraju (University Hospital of Wales) Ullas
Jenner Edward
JG Chase Thomas
Jha Shane Lester (James Cook University Hospital) Madan
Jimenez-Higuera Elisa
Jimeno Jaime
JM Dunne Naomi
JM Ferguson Henry
Jo\ue3o Lima Maria
Johnstone Jack
Jones Mark
Jordan: Mahmoud Al-Masri Gela).
JS Wall Joshua
Judkins Nicholas
JW Wilkin Richard
K Abou Chaar Mohamad
K Ambler Graeme
K Bankhead-Kendall Brittany
K Bankhead-Kendall Brittany
K Bankhead-Kendall Brittany
K Brown Allison
K Fusai Giuseppe
K Gill Charn
K Kamarajah Sivesh
K Patel Panna
K Ubhi Harmony
K Weerasinghe Chamindri
K\uf6nigsrainer Alfred
Kalidindi Venugopala
Kamal Mona
Kang Chong
Kara Yasin
Karam Edward
Karim Ahmed
Kashora Florence
KC Jonker (University Medical Center Groningen (University of Groningen) Pascal
Kearney (Beaumont Hospital) David
Khajuria Apoorva
Khan Azam
Khan Umul
Khatri Chetan
Kinross James
Kler Aaron
Klimopoulos (Evangelismos General Hospital) Serafeim
Kocata\u15f (Kanuni Sultan Suleyman Training and Research Hospital) Ali
Kolias Angelos
Kolias Angelos
Kontovounisios Christos
Kourdouli (Leicester Royal Infirmary) Amar
Krishnan Emily
Kristinsson Sverrir
Kruijff Schelto
KS Viswanath Yirupaiahgari
Kudsk-Iversen S\uf8ren
Kufeji Dorothy
Kulkarni Rugved
Kurihara Hayato
L Biffl Walter
L Coleman Natasha
L Collins Michelle
L Engel (Temple University Hospital) Jamie
L Fowler Amy
L Garcia Galocha Jose
L Hughes Jane
L J\uf6nsson (Bispebjerg Hospital Maria
L Labib Peter
L Marsh (Scripps Memorial Hospital) Christopher
L McKevitt Kevin
L Osorio Alexander
L Romera Jose
L Serevina Olivia
L Venn Mary
L Venn Mary
L Venn Mary
L Wright Franklin
L Young Alastair
L\ue1zaro Andr\ue9
La Torre Filippo
Laface (Ospedale Vittorio Emanuele III Letizia
Lami Mariam
Landaluce-Olavarria Aitor
Laura Hansen 9
Lawani Ismail
Lawday (Southmead Hospital) Samuel
Lawday Samuel
Le Roy Bertrand
Lecco) Asst
Lecolle Katia
Lederhuber Hans
Lederhuber Hans
Leeds)
Leicester)
Leventoglu Sezai
Li Elizabeth
Li Elizabeth
Li Zoe
Libya: Ghadah Z Alkadeeki Hani Al-Najjar (King Hussein Cancer Center).
Liew Ignatius
Ligure (SV) Pietra
Lima Buarque Igor
Lisi Giorgio
Lizzi Vincenzo
Lo Terence
Lombardia) Regione
Lomiento Daniele
Longhi Marco
Lopez Antonanzas (Hospital Clinico San Carlos Leyre
Losada Ruiz Manuel
Lostis Emilie
Lostoridis Eftychios
Loubani Mahmoud
Lowy- Benoliel Alejandro
Lucianetti (Papa Giovanni XXIII Hospital) Alessandro
Luigi MP Marino Cosentino (PO San Filippo Neri - ASL ROMA 1) Andrea Sagnotta
luis Blas Laina Juan
Luke Evans (Norfolk and Norwich University Hospital) Mina MG Youssef
Luke Louis
Lunevicius Raimundas
Luraghi Marco
Lye George
M Alrahawy (Menofiya University Hospital) Mahmoud
M Andreani Stefano
M Ashoush Fouad
M Bajomo Oreoluwa
M Blundell Chris
M Cicerchia Pierfranco
M Connolly Tara
M Diez-Alonso Manuel
M Dur\ue1n-Mu\uf1oz-Cruzado (Hospital Universitario Virgen del Rocio) Virginia
M Emslie Katy
M Harrison Ewen
M Holbrook Charlotte
M Isolani Simone
M Keatley James
M Leite-Moreira Andr\ue9
M Mithany Reda H
M Mohan Helen
M Mohan Helen
M Monteiro Joana
M Morgom (Tripoli Central Hospital) Marwa
M Muguerza Jose
M Nunes Quentin
M Nygaard Rachel
M Omar Aneel Bhangu Omar
M Philp Matthew
M Pollok Joerg
M Rooney Siobhan
M Sampietro Gianluca
M Sewards Joseph
M Tang Alethea
M Trout Isobel
M Walters (Harborview Medical Center Andrew
MA Kaafarani Haytham
MA Kaafarani Haytham
MA Kaafarani Haytham
Maarten van Heinsbergen (VieCuri Medisch Centrum) Joop Konsten
Mabrouk Islam
Macchi Alberto
MacDonald Luisa
Machairas (Royal Free Hospital) Nikolaos
Madonini Marco
Madrid)
Madrid)
Magalh\ue3es Maia Mariana
Magne Augestad Knut
Magowan Drew
Maha H Haqqani (Boston Medical Center) Frederick T Drake
Maisonneuve Emeline
Majkowska Agata
Majkowski (Northern General Hospital Lawrence
Mak (Queen Elizabeth Hospital Birmingham) Jason
Malabarba Stefano
Malerba Michele
Maninder Kalkat 7
Mannan Syed
Manson Joanna
Mansuri Ahmer
Mantoglu (Sakarya University Research and Educational Hospital) Baris
Manu Nichola
Manzoni 56 Via
Maqsood Afnan
Marano Alessandra
Marchbank Adrian
Marcos-Santos Pablo
Marinos Kouris (Buckinghamshire Healthcare NHS Trust) Spyros
Marqueta De Salas Maria
Marrano Enrico
Mart\uedn-Rom\ue1n Lorena
Mart\uednez P\ue9rez Carolina
Mart\uednez-dePaz Fernando
Martel Lozano Saida
Martin (St Mary's Hospital) Guy
Martin Emmeline
Martin Janet
Martin-Albo Lorena
Martine Uittenbogaart (M\ue1xima Medical Center) Wouter KG Leclercq
Martinelli Fabio
Martinez-German Antonio
Martinez-Pinedo Carlos
Martins Ricardo
Marwan Hisham
Marzi Federica
MAS Baig Mirza
Mateos-Sierra (Hospital General Universitario Gregorio Mara\uf1\uf3n) Olga
Mater Studiorum University of Bologna) Alma
Mathieu (CHU Besan\ue7on) Pierre
Matute-Najarro Maria-Soledad
Maw Andrew
Mazingi Dennis
Mazzaferro (Fondazione IRCCS Istituto Nazionale dei Tumori Vincenzo
McCanny (Antrim Area Hospital) Andrew
McKenzie Katherine
McLarty (Northumbria NHS Hospital Trust) Nicola
McPherson Iain
Medina Esther
Mediratta Saniya
Medone Marzia
Mehra (Guy's and St Thomas\u2019 NHS Foundation Trust) Gautam
Mele Simone
Melero-Cort\ue9s Lidia
Melody Baeza (Morales Meseguer University Hospital) Jos\ue9 Aguilar
Mendon\ue7a Ata\uedde Gomes Gustavo
Mendoza-Moreno Fernando
Meneghini Simona
Merate
Mercante Giuseppe
Merdrignac (Rennes University Hospital) Aude
Metallidis Symeon
Michel (Pinderfields Hospital) Martin
Migliore Marco
Milan)
Milan)
Milan)
Miller Douglas
Minaya- Bravo Ana
Minaya-Bravo Ana
Minaya-Bravo Ana
Minaya-Bravo Ana
Mingoli Andrea
Minto Gary
Mirabella Antonello
Misra Nikhil
Mitrasinovic Stefan
Miu Victor
Moawad (Royal Victoria Hospital) Nader
Mochet Sylvie
Modabber Ali
Mohammad Adam
Mohan Midhun
Moliner-S\ue1nchez Carmen
Mondov\uec)
Mongelli Francesco
Monteleone (Ospedale San Leopoldo Mandic Michela
Montuori Mauro
Moore Rachel
Mora-Guzm\ue1n (Hospital Santa B\ue1rbara) Ismael
Morales Dieter
Morales Xavier
Morelli Luca
Morelli Lucia
Morgan Richard
Morris Chris
Mortini Pietro
Mosca Angelo
Moszkowicz David
Moszkowicz David
Motter Dema
Moug Susan
Mukherjee Samrat
Munoz Rivas Ana
Murcia)
N Bence Matthew
N Hopkinson David
N Mashbari Hassan
N Mashbari Hassan
N Mashbari Hassan
N Naumann David
N Rao Jagan
N Townshend David
N\ufa\uf1ez Jordi
Najdy Manhal
Nakas (Glenfield Hospital Apostolos
Namazov Ilgar
Naredla Pradyumna
Nasef Emmhamed
Nassa Heeam
Nath Rahul
Navarro-S\ue1nchez Antonio
Nazarian (Bupa Cromwell Hospital) Scarlet
Neal Bhutiani (University of Louisville Hospital and Norton Hospital) Robert CG Martin
Negri Giampiero
Nehra Deepika
Neil-Dwyer Jason
Nepogodiev Dmitri
Nepogodiev Dmitri
Nepogodiev Dmitri
Neri Jacopo
Netherlands: Suzanne S Gisbertz Mustafa R Bulugma (Zawia Teaching Hospital). Mexico: Fernando Cordera (ABC Medical Center).
Newton (Manchester Royal Infirmary) Katy
Nikaj (Azienda Ospedaliero Universitaria Maggiore della Carit\ue0 Herald
Niquen Milagros
Nobile (Azienda Ospedaliera Universitaria Integrata di Verona) Sara
Nogueiro Jorge
Nogues Pevidal (Royo Villanova) Ana
Novara)
Ntirenganya Faustin
Nugent Michael
O Ademuyiwa Adesoji
O Kavanagh Dara
O Larkin John
Oca\uf1a Juan
of Amsterdam University
of Ferrara) University
of Insubria University
of Milan) University
of Surgeons in Training (ASiT) Association
of Surgery) Department
of Washington) University
Okafor Barbara U.
Okechukwu Valentine
Oliva-Mompean (Hospital Universitario Virgen Macarena) Fernando
Oliveira Ana
OM Abdalla Mutwakil
Omar M Omar
OO Ayorinde John
Osagie-Clouard (Epsom &amp
Osman (Walsall Manor Hospital) Khabab
Ottolina Jessica
Ourieff (Mount Sinai Hospital) Jared
Outani Oumaima
Oyewole Bankole
P Arnaud Alexis
P Arnaud Alexis
P Arnaud Alexis
P Baker Markus
P Belgaumkar Ajay
P Boddy Alexander
P Duffy (Nottingham City Hospital) John
P Evans Jonathan
P Hazelton Joshua
P Jones Andrew
P Jones Robert
P Joyce Doireann
P Kisiel Aaron
P Pezzuto Anna
P Singh Rabindra
P\ue9rez-Gonz\ue1lez Marta
P\ue9rez-Saborido Baltasar
Pacheco-Sanchez David
Padilla-Valverde (Hospital General Universitario De Ciudad Real) David
Pai (Hammersmith Hospital) Madhava
Paiella Salvatore
Paisley (Brighton and Sussex NHS Trust Samuel
Palermo)
Palini Gianmarco
Palmeri Matteo
Parente Alessandro
Parlanti Daniele
Parmar Chetan
Pascual Angela
Pata Francesco
Pata Francesco
Patel Mahul
Pathak Abhijit
Patil Sangram
Pattyn Piet
Peckham- Cooper Adam
Pedram Panahi (University Hospitals Plymouth NHS Trust) Mariam Rela
Pedrazzani Corrado
Pellino Gianluca
Pereira Andr\ue9
Pereira-Neves Ant\uf3nio
Perez-Diaz Md
Perivoliotis (General University Hospital of Larissa) Konstantinos
Perkins Clare
Perotto (CHU Saint Etienne) Ornella
Perra Teresa
Petrone Patrizio
Phenix George
Piacenza)
Picazo Sara
Picon-Rodriguez Rafael
Piloni Martina
Pingarr\uf3n-Mart\uedn Lorena
Pinotti Enrico
Pizzini Paolo
PM de Vries Jean-Paul
Pockney Peter
Podolsky Dina
Poggioli Gilberto
Pompili Cecilia
Pontari Michael
Porcu Alberto
Portugal: Hugo Santos-Sousa Pakistan: Mariyah Anwer (Jinnah postgraduate medical center).
Potter (Royal Bournemouth Hospital) Ryan
Price Claire
Prita Daliya 8
Pruvot (Lille University Hospital) Fran\ue7ois-Ren\ue9
PTSurg ItSURG
Pujol-Muncunill Roger
Puppo Andrea
Q Mehdi (University of Texas Medical Branch) Mohammad
Quante Markus
Quintana-Villamandos Bego\uf1a
Qureshi Ali
R Burke Joshua
R Davidson Brian
R Dixon Jan
R Fretwell Kenneth
R Gujjuri Rohan
R Gujjuri Rohan
R Kowal Mikolaj
R O\u2019Neill John
R Sarma Diwakar
R Spalding Duncan
R Springford Laurie
Rachel Baumber (Royal National Orthopaedic Hospital) James T Parry
Radenkovic Dejan
Rahman Saad (Medway Maritime Hospital) Abdel
Rakvin Ivan
Ramallo-Sol\ueds Irene
Ramcharan Sean
Ramos Diego
Ramos-Bonilla Antonio
Ramos-De la Medina Antonio
Ramzi Joussi
Rathinam Sridhar
Rausa Emanuele
Ravaioli Matteo
Ravindran Sharanya
Raymond (Royal Lancaster Infirmary) Thomas
Razik Aisha
Redfern (Furness General Hospital) Jennifer
Reguera-Rosal Julio
Rey-Biel Juan
Rey-Valcarcel Cristina
RG Sheel Andrea
Ribolla Marta
Richards Tomos
Richmond (University of Maryland Medical Center) Michael
Righini (Ospedale del Delta Erminio
Rio-Gomez Javier
Riuniti Villa Sofia-Cervello Ospedali
Riyat Harjoat
Rizvi Sana
Roberts Keith
Roberts Matthew
Robertson (University Hospitals Coventry and Warwickshire) Stuart
Robertson (University of Arkansas for Medical Sciences) Ronald
Robin-Valle Alvaro
Rochon Melissa
Rojo Mikel
Rolli Luigi
Romano Silvio
Rome)
Romford)
Ross Elizabeth
Ross Howard
Rottoli Matteo
Royal Hospital) Princess
Ruiz (Hospital General Universitario Reina Sof\ueda Miguel
Ruiz- Grande Fernando
Ruiz-Martin (Rey Juan Carlos University Hospital) Irene
Ruiz-Soriano (Hospital Cl\uednico Universitario de Valladolid) Mar\ueda
Ruzzenente Andrea
Ryska Ondrej
S Abdelaal (Alexandria Main University Hospital) Ahmed
S Al Maadany Faraj
S Faria Carlos
S Hammond John
S Hossain Fahad
S Jeyaretna Deva
S Jones Conor
S Khan (Queen Alexandra Hospital) Jim
S Moura Francisco
S Ng-Kamstra Joshua
S Sica Giuseppe
S Tamimy Muhammad
S Wadley Martin
S\ue1nchez- Arteaga Alejandro
SA Taher Ahmed
Saez Carlos
Sahnan Kapil
Sahni Arun
Salim Ali
Salvia Roberto
Sammarco Giuseppe
Sampaio-Alves Mafalda
San Miguel-Mendez Carlos
Sanchez del Pueblo Cristina
Sanchez-Fuentes Maria-Nieves
Sanchez-Pelaez Daniel
Sanchez-Perez Coral
Sanchez-Rubio Maria
Sancho-Muriel Jorge
Sanchon Fructuoso Lorena
Sanders Julie
Santero-Ramirez Maria-Pilar
Santora Thomas
Santoro Antonio
Santos Irene
Sapienza Paolo
Sartarelli (Sant\u2019Orsola Hospital Lodovico
Sarveswaran Janahan
Sasia Diego
Sassari) A. O. U.
Saudemont Alain
Saudi-Moro Sef
Saxena Dolly
Saxena Shobhit
Sayasneh Ahmad
Scalabre Aurelien
Schache Andrew
Schiavina Riccardo
Schineis (Charit\ue9 University Medicine Christian
Schreckenbach Teresa
Scorza Antonella
Scott Lucy
Seegert (ProMedica Toledo Hospital) Sara
Seguin-Givelet Agathe
Senent-Boza Ana
Serrano Gonz\ue1lez Javier
Sette Laghi Asst
Seymour Keith
Shabana Amanda
Shah (The Whittington Hospital) Sujay
Shah Jigar
Shah Karishma
Shah Preena
Shakir Taner
Shalaby (Mansoura University Hospital) Mostafa
Shankar (Oxford University Hospitals NHS Foundation Trust Sushma
Shaw Richard
Sheffield)
Shehata Sameh
Shelley Hwang E.
Shen Ban Vin
Shenfine Amy
Sheridan Kelda
Sherief Ahmed
Sherif Mohamed
Shinkwin Michael
Shu Sebastian
Siaw-Acheampong Kwabena
Sileri (San Raffaele Scientific Institute Pierpaolo
Singh Abhinav
Singh Shailendra
Sinha Sanjay
Siragusa (Policlinico Tor Vergata Hospital Leandro
Sivaprakasam Rajesh
Sivayoganathan Sriharan
SJ Ledesma Frances
Smillie Robert
Smith (Countess of Chester Hospital) Claire
Smith Andrew
Smith Christopher
Sochorova (Royal Liverpool University Hospital) Dana
Society of Coloproctology (ESCP) European
Society of Colorectal Surgery (SICCR) Italian
Soggiu Fiammetta
Sohrabi (St Bartholomew's Hospital) Catrin
Sohrabi (Whipps Cross University Hospital) Catrin
Sohrabi Catrin
Solari (Royal Gwent Hospital) Francesca
Solli Piergiorgio
Soreide Kjetil
Soto Montesinos Cristina
SpainSurg
Spinelli Antonino
Spinelli Antonino
Spoletini (Sant'Eugenio Hospital) Domenico
Spriano Giuseppe
Sravanam Sanskrithi
Ssentongo (Pennsylvania State University) Paddy
Stanger Sophie
Stavroulias Dionisios
Steel (Sunderland Royal Hospital) Ben
Stella Marco
Stewart Robbie
Stringer Sally
Sudan: Osman M Ali Elima P Cagigal- Ortega (Hospital Universitario Severo Ochoa).
Sulen Nina
Sundar Sudha
Sundhu (Aintree University Hospital) Matthew
Surgical Research Collaborative (ISRC) Irish
Suri (University of California Davis Health Avni
Swansea)
Switzerland: Dimitri Christoforidis Ali A Ali karar (Al-rajhi).
Syed Arooj
Szatmary Peter
T Colonna Emily
T Enjuto Diego
T Montella (Azienda Unit\ue0 Sanitaria Locale-IRCCS di Reggio Emilia) Maria
TA Neely David
Tabiri Stephen
Tadross Daniel
Taglietti Lucio
Tansey (Princess Alexandra Hospital) Rosamond
Tartaglia Dario
Tawheed (Endemic Medicine Department Ahmed
Tayeh Salim
Testa Valentina
Tewari Nilanjana
Thoenissen Philipp
Thomas (Worcestershire Acute Hospitals NHS Trust) Kane
Thrush Jessica
Tierney Sean
Tiwari Abhinav
Tobias Teles (Hospital de Cascais - Dr. Jos\ue9 de Almeida) Pedro A Serralheiro
Toledo Enrique
Tonini Valeria
Torkington Jared
Torzilli Guido
Totty Joshua
Tousidonis Manuel
Townend Philip
Townsend Catherine
Trompeter (St George's Hospital) Alex
Trotta Francesco
Truant St\ue9phanie
Trujillo-D\uedaz Jeancarlos
Tsoulfas George
Tsoulfas Georgios
Turco Celia
Turkey: Volkan Ozben Georgios Peros (Kantonsspital Winterthur).
Turrado- Rodriguez Victor
Turri Giulia
Tustin (Cumberland Infirmary) Harry
Tyler Jayne
Tzedakis Stylianos
Tzovaras George
Ullah Ramzan
Unit\ue0 Sanitaria Locale di Ferrara Azienda
United Kingdom: Richard J Davies Alp Yildiz (Yildirim Beyazit University Yenimahalle Training and Research Hospital).
United States: John RT Monson (AdventHealth Orlando) Lavinia Onos (York Teaching Hospitals NHS Trust).
University Hospitals NHS Trust) Nottingham
University of Rome) Sapienza
University) Goethe
University) Helwan
Urban (University of Colorado Hospital) Shane
Urbani (Azienda Ospedaliero Universitaria San'Anna Alessia
Usai Antonella
V Bhavaraju Avi
V Comini Lara
V Feo Carlo
V Marino Marco
V Shaw Abigail
V\ue1zquez- Fern\ue1ndez Andrea
Vaccarella (Azienda Ospedaliera Gianpaolo
Valdes- Hernandez Javier
Valsecchi Luca
Vashisht Rajiv
VCO) Asl
Venkatesan (Glan Clwyd Hospital) Gowtham
Vera-Mansilla Cristina
Vergari (Ospedali Riuniti di Ancona) Roberto
Vescio (University 'Magna Graecia' of Catanzaro) Giuseppina
Vidya Raghavan
Vieira (Centro Hospital Universit\ue1rio S\ue3oJo\ue3o) Paula
Vijay Vardhini
Vimalachandran Dale
Vimalachandran Dale
Violante Tommaso
Vovola Fernanda
Vulliamy Paul
W Endorf (Hennepin Healthcare) Frederick
W Etchill Eric
W L\uf6ffler Markus
W L\uf6ffler Markus
Wall Rosemary
Wallwork Kate
Ward Alex
Warwick (University Hospital Southampton) David
Waseem Saima
Weaver Helen
Wells Fiona
Wen Jiaxin
West Raha
Whitehall Emma
Wild Laura
Wilkins Alex
Williams Gethin
Williams Matthew
Winnand (University Hospital Aachen) Philipp
Wong (Addenbrooke's Hospital) Ken
Worku (Queen\u2019s Medical Centre Dawit
Wright Naomi
WS Ho (Leeds Teaching Hospitals NHS Trust Michael
WT Ngu Albert
y Cajal) Cristina Cerro (Hospital Universitario Ram\uf3n
Y Oo (Department of Cardiothoracic Surgery Aung
y Polit\ue9cnico La Fe) Blas Flor (Hospital Universitario
Y van der Plas Willemijn
Yalamanchili Seema
Yershov (South Warwickshire NHS Foundation Trust) Danylo
Young Richard
Yousra Ahmed (Portsmouth Hospital NHS Trust) Simon Toh
Yurttas Can
Zadegan Frederic
Zafar (Northwick Park Hospital) Noman
Zakaria Rasheed
Zambon Martina
Zanini Nicola
ZE Durst Alexander
Zerbib Philippe
Zonta (Ospedale San Biagio Sandro
Publication venue: 'Elsevier BV'
Publication date: 01/01/2020
Field of study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

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Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

Author: A. A. Tanaka Montoya
A. Abougabal
A. Akcan-Arikan
A. Akcan-Arikan
A. Alkan
A. Alklit
A. Alvarez
A. Amatu
A. Amirian
A. Andreotti
A. Arali
A. Arcadipane
A. Armaganidis
A. Armaganidis
A. Arthur
A. Artigas
A. Artigas
A. Ballin
A. Ballin
A. Barrero-Almodóvar
A. Bartkowska-Sniatkowska
A. Bauer
A. Ben Cheikh
A. Benard
A. Berry
A. Bertomeu-Artecero
A. Betbese-Roig
A. Bienert
A. Bienert
A. Bjärtå
A. Blandino Ortiz
A. Blet
A. Borsuk
A. Borsuk
A. Braschi
A. Bruhn
A. C. Falk
A. C. Jorge
A. C. Jorge
A. C. P. Antonio
A. C. Santos
A. C. Waldenström
A. Calini
A. Campanario Garcia
A. Canabal
A. Cariou
A. Carranza Pinel
A. Ceccato
A. Chaari
A. Chaari
A. Chaari
A. Chan
A. Chao
A. Chao
A. Colombo
A. Colombo
A. Cortina-Gutiérrez
A. Costa
A. Costa
A. D. Waldmann
A. D. Wright
A. De Cassai
A. Demoule
A. DeWan
A. Diamantakis
A. Diamantakis
A. Doronzio
A. Dubin
A. Dubrawski
A. Dyson
A. Dyson
A. Dyson
A. E. Andersson
A. E. K. Jensen
A. El Sakka
A. El-adawy
A. El-Sherif
A. Eladawy
A. Eladawy
A. Eladawy
A. Escoresca-Ortega
A. Escoval
A. Escoval
A. Evdokimov
A. F. Garcia Marin
A. F. Leivas
A. Fernandez-Blanco
A. Fernández-Porcel
A. Fernández-Porcel
A. Fernández-Porcel
A. Fernández-Porcel
A. G. Wojnicka
A. Gabarrus
A. Garcia de Lorenzo y Mateos
A. García-Alcántara
A. García-Alcántara
A. García-Alcántara
A. García-Alcántara
A. García-de la Torre
A. Gazenkampf
A. Giangregorio
A. Gibson
A. Glossop
A. Goffi
A. Gordillo-Brenes
A. Gritsan
A. Guiga
A. Gunther
A. Gutiérrez-Pizarraya
A. H. Elsaka
A. H. Guirgis
A. H. V. Andrade
A. Hartley
A. Hasanin
A. Hasanin
A. Herpain
A. Hollinger
A. Hoogendijk
A. Horton
A. J. Ferguson
A. Jones
A. Jorda
A. K. Reyners
A. K. Reyners
A. Kadioglu
A. Kara
A. Khedher
A. Khedher
A. Khedher
A. Kilembe
A. Kleyman
A. Koch
A. Komaromi
A. Kortgen
A. Krajčová
A. Kuriyama
A. Kuzovlev
A. L. Beam
A. L. Ruíz Aguilar
A. L. Ruíz Aguilar
A. Lenoire
A. Lesmes Serrano
A. Lobo-Civico
A. Lomas
A. Lotfy
A. Loza Vazquez
A. Luciani
A. Luzi
A. M. A. Liberatore
A. M. A. Liberatore
A. M. A. Liberatore
A. M. A. Liberatore
A. M. C. R. P. F. Martins
A. M. C. R. P. F. Martins
A. M. Cavalheiro
A. M. Dell’Anna
A. M. Dondorp
A. M. Doyle
A. M. E. Spoelstra-de Man
A. M. E. Spoelstra-de Man
A. M. Elmenshawy
A. M. Fagerdahl
A. M. Fayed
A. M. López Lago
A. M. Moktar
A. M. Mukhtar
A. M. Pronina
A. M. Pérez Bailón
A. M. Spoelstra-de Man
A. MacKay
A. Mackay
A. Mackay
A. MacKay
A. MacKay
A. Marino
A. Martinez de la Gandara
A. Martins
A. Marulanda
A. Mebazaa
A. Mebazaa
A. Mehl
A. Mehl
A. Mekontso Dessap
A. Mercat
A. Messina
A. Michalsen
A. Michalsen
A. Modler
A. Mohamed Fehmi
A. Mukhtar
A. Mukhtar
A. Mukhtar
A. Mula Gómez
A. Murza
A. Nierhaus
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A. Ojados Muñoz
A. Oldner
A. Ortín Freire
A. Ozcan
A. P. Meert
A. P. Meert
A. Palmaccio
A. Pedraza Montenegro
A. Pereira
A. Perner
A. Perner
A. Perner
A. Pesenti
A. Pesenti
A. Pesenti
A. Petosic
A. Pironet
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A. Pizza
A. Piñol-Tena
A. Puppo-Moreno
A. R. De Gaudio
A. Raafat
A. Reintam Blaser
A. Rhodes
A. Rhodes
A. Richardson
A. Rimmer
A. Rizk
A. Rodriguez
A. Rodriguez
A. Roman
A. Rugerio Cabrera
A. Ruiz-Perea
A. S. Arunkumar
A. Sanaei Dashti
A. Sandgren
A. Sandiumenge
A. Saraste
A. Sari
A. Scaramuzza
A. Schafer
A. Schettler
A. Serpa Neto
A. Shah
A. Shakotko
A. Sigurta
A. Sinclair
A. Stacke
A. Sugiura
A. Sustic
A. T. Dewan
A. T. Mazzeo
A. Taggu
A. Tonilo
A. Topeli
A. Torres
A. Torres
A. Ukere
A. Urbano
A. Valeiras-Valero
A. Vallejo-Baez
A. Vallejo-Báez
A. Vargiolu
A. Vazin
A. Vazin
A. Vazir
A. Vezzani
A. Vishnu
A. Vàzquez
A. Wallin
A. Wilson
A. Wong
A. Yousefipour
A. Z. Fouad
A. Zaghlol
A. Zanella
A. Zapatero
A. Zerman
B. A. McGrath
B. Aisling
B. Ana
B. Balicco
B. Balsera Garrido
B. Balsera Garrido
B. Barbrel
B. Basarık Aydoğan
B. Bein
B. Blackwood
B. Blackwood
B. Bovento
B. Bovento
B. C. Connolly
B. C. L. Lim
B. Cambiaghi
B. Champigneulle
B. Coloma-Gomez
B. Creagh-Brown
B. Erdogdu
B. Ergin
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B. G. Hassen
B. Gelee
B. Huschens
B. Koeneman
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B. Oomen
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B. Plaud
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B. Saugel
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C. C. Hung
C. Cai
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C. Campbell
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C. Canullán
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C. Cilloniz
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C. Corbett
C. de Tymowski
C. Diakaki
C. Doree
C. E. Baldwin
C. E. Kennedy
C. E. Kennedy
C. Ebm
C. F. Lordani
C. Filippini
C. Fleischmann
C. Fortes
C. Fuchs
C. Galban Rodriguez
C. Galban Rodriguez
C. Galbán Rodríguez
C. García-Fuentes
C. Gecele
C. Giolitti
C. Gomez-Gonzalez
C. Gonen
C. Gonen
C. Granja
C. Groves
C. Gutierrez Melón
C. H. Chang
C. H. Chang
C. H. Chang
C. H. Chiang
C. H. Lai
C. H. Wang
C. Hernandez Caballero
C. Hilasque
C. Hällsjö Sander
C. Hällsjö Sander
C. I. Bernal Matilla
C. I. Bernal Matilla
C. I. Olvera Guzman
C. Iaquaniello
C. Ince
C. Ince
C. Ince
C. Ince
C. J. C. Trepte
C. J. Chen
C. J. Hinds
C. J. Hinds
C. J. Trepte
C. J. Wickerts
C. K. Ho
C. Kaymak
C. Kerr
C. Kirakli
C. Knox
C. Kripper
C. König
C. L. Granger
C. Lai
C. Lange
C. Lee
C. Lee
C. M. Chau
C. M. Park
C. M. Radu
C. Maldonado
C. Maldonado Toral
C. Marenghi
C. Martin Lopez
C. Martin Lopez
C. Marzorati
C. Massant
C. Mazo
C. Mudarra-Reche
C. Orford
C. Ori
C. Ori
C. Ori
C. O’Loughlin
C. P. Liu
C. P. Liu
C. Padilla
C. Palazzi
C. Paños-Espinosa
C. Pena Gil
C. Pena Gil
C. Pintado Delgado
C. Qiu
C. R. Behem
C. R. Chung
C. R. L. M. Costa
C. R. L. M. Costa
C. Richard
C. Ritter
C. Rodríguez-Mejías
C. Roger
C. Rueda-Molina
C. Rueda-Molina
C. Rueda-Molina
C. Rueda-Molina
C. Ryan
C. S. Gerrard
C. S. Hartog
C. S. Socolovsky
C. S. Vallone
C. Scheer
C. Svensen
C. Sánchez Ramirez
C. T. Anthon
C. T. Chong
C. T. Chong
C. T. Lee
C. T. Lee
C. Trepte
C. Turrini
C. Villavicencio Lujan
C. Vilà
C. Vilà
C. W. Hong
C. Waldmann
C. Whiteley
C. Wright
C. Wright
C. Wright
C. Wright
C. Y. Hung
C. Y. Hung
C. Y. Hung
C. Y. Liu
C. Zahrte
C. Zöllner
D. A. Dongelmans
D. A. Dongelmans
D. A. M. P. J. Gommers
D. A. M. P. J. Gommers
D. A. Mckim
D. A. Reuter
D. A. Reuter
D. A. Reuter
D. A. Reuter
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D. Antonakaki
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D. F. Christensen
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D. F. Mcauley
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D. H. Kim
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D. J. Levine
D. J. Pennington
D. K. Song
D. Kiers
D. L. Grieco
D. L. J. Moolenaar
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D. Leasa
D. Lockey
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D. McWilliams
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D. Naumann
D. O. Thomas-Rueddel
D. Ong
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D. Overgaard
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D. P. Gund
D. P. Park
D. Padilla
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D. Pogson
D. R. Thickett
D. Rageb
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D. S. Y. Ong
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D. Talmor
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D. Trásy
D. Verboom
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D. W. de Lange
D. Wang
D. Wendt
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D. Z. Roushdy
D. Érces
D. Érces
D. Šímová
E. Aguilar-Alonso
E. Akerman
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E. Black
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E. W. Ades
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Publication venue: 'Springer Science and Business Media LLC'
Publication date: 01/01/2016
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Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

Author: A Kaldun Nossuli
Aamir Jamal
Adalbert Schiller
Adam Cheifetz
Adarsh Daswani
Adeera Levin
Adline Ghazi
Adrian Guinsburg
Adriana Cif
Adriana Gabriela Onaca
Adriana Ilavska
Adriana Villarino
Agarwal R.
Agnieszka Starzec
Ahmed Arif
Ahmed Awad
Aiping Yin
Akimichi Asano
Alan Jackson
Alan McMahon
Alan Perlman
Alberto Di Carlo
Alberto Esquenazi
Alejandra Oviedo
Alejandro Valdes Depeda
Aleksandra Kendereski
Alex Valenzuela
Alexander Dreval
Alexander Gonzalez
Alexander Shinkov
Alexander Turchin
Alexandre Klein
Alfonso Soto Gonzalez
Alfred Penfornis
Alfredo Chew Wong
Alfredo Wassermann
Ali Torshizi
Alicia Chilito
Alina Agafyina
Alison Dawson
Alva Hansraj
Amer Al-Karadsheh
Amorin Remus Popa
Amrendra Kumar
Amy Sprague
Ana Limos
Ana Maria Cusumano
Ana Maria Elosegui
Anabella Amigo
Anatoliy Kazmirchuk
Andrea Phillips
Andrea Stella
Andreas Maddux
Andrej Dzupina
Andres Alvarisqueta
Andrew Johnson
Andrew O'Shaughnessy
Andrew Steele
Andrian Yakov
Andrzej Januszewicz
Andrzej Madej
Angelina Angelova
Anibal Gastaldi
Anil Gupta
Anita Bhajan Manocha
Anjanette Tan
Anna Kaminska
Anna Maria Veronelli
Anna Strzelecka
Anna Zateyshchikova
Anselmo Bordonava
Antanas Navickas
Anthony Gunstone
Anthony Roberts
Antonio Ceriello
Antonio Galan Serrano
Antonio Scafuto Scotton
Antonio Terrelonge
Antônio Roberto Chacra
Anupama Gowda
Arjun D Sinha
Armando Perez
Ashot Mkrtumyan
Atanas Koundurdjiev
Augusto Vallejos
Aurelian-Emil Ranetti
Ayim Akyea-Djamson
Aysha Badat
Bakris G.
Baldev Singh
Barbara Greco
Barbara Kaczmarek
Barbara Rewerska
Barry M Brenner
Belia Martin Del Camp Blanco
Bernard Zinman
Bertrand Cariou
Bertrand Dussol
Bhasker Mehta
Bhimavarapu Sudhakar
Björn Paschen
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Botond Csiky
Boyan Nonchev
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Bull S.
Byung-Wan Lee
C B Keshavamurthy
Cannon C. P.
Capuano G.
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Neil Kumar
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Nelson Rodriguez Papini
Nestor Horacio Garcia
Ngai Wah Cheung
Nicolae Hancu
Nicole Li
Nik Nur Fatnoon Nik Ahmad
Nina Patel
Nizar Daboul
Noble Gracious
Nomangesi Ngcakani
Nonna Kravchun
Nora Marchetta
Norman Muirhead
Norsiah Ali
Oleg Legun
Oleg Nagibovich
Oleg Uriasyev
Oleksandr Golovchenko
Oleksandr Samoylov
Oleksii Korzh
Olga Barbarash
Olga Barna
Olga Barysheva
Olga Benusova
Olga Godlevska
Olga Gyrina
Olga Sazonova
Olivert Gomez
Oomman Abraham
Osamu Tomonaga
Oscar Tarsicio Moreno Loza
Osvaldo Brusco
Pablo Antonio Novoa
Pablo Mele
Pablo Raffaele
Pablo Serrano Sanson
Paranthaman Vengadasalam
Patricia Del Carmen Gonzalez Colaso
Patrick English
Patrick Parfrey
Paul Ainsworth
Paul Frenk Baron
Paul Nixon
Paul Noonan
Paul Rheeder
Paulina Virginia Lanchiotti
Pavel Weiner
Peak Mann Mah
Pedro Calella
Pedro de Souza
Pedro Velasquez-Mieyer
Peggy Barnhill
Peggy Lin
Pere Alvarez Garcia
Perkovic V.
Peter Danos
Peter Fulop
Peter Van Buren
Peter Winocour
Petr Barton
Philip Gorelick
Philip Home
Philip Nicol
Philippe Zaoui
Phyllis August
Piermarco Piatti
Pierre Gourdy
Pierre-Jean Saulnier
Pietro Castellino
Pilar Trueba
Ping Tu
Pollock C.
Prasanth Surampudi
Pusadee Suchinda
Qinkai Chen
Rachel Bregman
Radica Alicic
Radu Jacob
Rafael Simo Canonge
Raied Abdullah
Rajendran Alappan
Rajiv Agarwal
Rajiv Ranjan
Raju Sree Bhushan
Rakesh Gulati
Rakhi Khanna
Rallabhandi Sankaram
Raman Purighalla
Ramesh Chandra Vyasam
Ramesh Thimmaiah
Ramon Berenguer
Ramon Moreda
Rangel Rangelov
Rao K Satyanarayana
Ravendran Govender
Ravi Sarin
Reddy Sreedhar
Reginald Parker
Rehan Symonds
Reinhold Jerwan-Keim
Remi Rabasa-Lhoret
Renan Montenegro Junior
Renata Bijata-Bronisz
Rhea Severina Comia
Rhonda Bentley-Lewis
Riad Darwish
Ricardo Alfonso Leon de la Fuente
Ricardo Dario Dran
Ricardo Rosero
Riccardo Bonadonna
Richard Ferkl
Richard Kovar
Richard Lindley
Richard Orozco Castellanos
Richard Solomon
Robert Busch
Robert Cohen
Robert Schreiman
Robert Takacs
Robert Walker
Roberto Abrão Raduan
Roberto Jorge da Silva Franco
Roberto Pecoits Filho
Roberto Pecoits-Filho
Roberto Simões de Almeida
Roberto Trevisan
Rodica-Ioana Avram
Rodolfo Andres Ahuad Guerrero
Rohana Abdul Ghani
Rohit Pankhaniya
Rolando Zamarripa Escobedo
Ronald Goldenberg
Ronald Harris
Ronald Watts
Ronaldo Arturo Gonzalez Orellana
Ronan Roussel
Ronnie Aronson
Rosa Isela Luna Ceballos
Rosângela Milagres
Ruben Dario Vargas Alonso
Rury Holman
Russell Scott
Sacha De Serres
Sahay Manisha
Saiful Shahrizal Bin Shudim
Sailaja Ventrapragada
Salah Abusnana
Salvatore De Cosmo
Sam Henein
Sam Philip
Samuel Cohen
Samuel Mujica Trenche
Samy Hadjadj
Sandor Keresztesi
Sandor Vangel
Sandra Berenice Saaveddra Sanchez
Sanjeev Rastogi
Sara Jaffer
Sarah Olelewe
Satoshi Ota
Satu Pesickova
Scott Kasner
Secundino Cigarran Guldris
Senan Sultan
Serge Cournoyer
Sergei Nedogoda
Sergey Vorobyev
Sergio Saul Irizar Santana
Shahabul Arfeen
Shahnaz Shahinfar
Shang-Jyh Hwang
Shelley Williams
Shenaz Ramtoola
Shenglian Gan
Sherry Sussman
Shizuo Kajiyama
Shozo Miyauchi
Silvia Ines Orio
Silvia Nicolai
Simon Davies
Simon Roger
Simon Young
Sin Gon Kim
Singhan Krishnan
Sini George
Slobodan Antic
Sohan Dua
Sonia Hermida
Soo Kun Lim
Sophie Borot
Souhila Ounadjela
Sreedhar Mandayam
Srikanth Bellary
Stanislav Zemek
Stanislaw Mazur
Stefan Dimitrov
Stephan Maxeiner
Stephen Grubb
Stephen Smith
Steven Fishbane
Stuart Handelsman
Suely Keiko Kohara
Sun Kim
Sun-Hee Park
Sunil Sheth
Susumu Kashine
Svetlana Goykhman
Svitlana D Bilyk
Swee Win Lam
Sylvia Rosas
Sylvia Shaw
Szilard Vasas
Sérgio Alberto Cunha Vêncio
Sérgio Yamada
Tadashi Iitsuka
Takamoto Kodera
Takashi Wada
Takayuki Watanabe
Tamara Malek Marin
Tamas Oroszlan
Tara Chang
Tareq Nassar
Tarissa Beatrice Zanata Petry
Tatiana Koroleva
Tatiana Morugova
Tatiana Raskina
Tatyana Zykova
Te-Lin Hsia
Terue Sakakibara
Tetiana Zlova
Tetsuji Niiya
Tetyana Pertseva
Tiago Schuch
Timothy Hall
Tom Christensen
Tom Greene
Tomas Drasnar
Tomas Smith Casabella
Tonatiu Diaz Escalante
Toshihiko Yanase
Toshio Kawada
Vadym Vizir
Vanassa Ratnasingam
Venessa Tsang
Venkata Behara
Vera Klokocnikova
Vera Krane
Veronica Anghel
Veselka Genadieva
Vesna Popovic-Radinovic
Viacheslav Marasaev
Victor Commendatore
Victor Saavedra Gajardo
Vijayaraman Arutchelvam
Viktor Margaritov
Viktor Zaviriukha
Viktoria Andreeva
Vimladhevi Govender
Vincent Pichette
Vincent Woo
Vira Tseluyko
Virginia Esther Visco
Vivek Sood
Vivekan Jha
Vladimir Dobronravov
Vladimir Khirmanov
Vladimir Tesar
Vlado Perkovic
Volker Burst
Volodymyr Botsyurko
Walter Guillermo Douthat
Walter Pharr
Wasim Hanif
Wataru Yumita
Wayne H-H Sheu
Wayne Turner
Wei Yen Kong
Weihong Song
Weiping Lu
Wendy Lane
Wenge Li
Wheeler D. C.
Wladmir Saporito
Xuemei Li
Xueqing Yu
Yamil Canaan
Yan Ren
Yannick Le Meur
Yaozhong Kong
Yasuro Kumeda
Yasushi Wakida
Yavin Y.
Yeong Hoon Kim
Yevgeniya Svyshchenko
Young Min Cho
Yulia Samoylova
Yung-Chuan Lu
Yuriy Mostovoy
Yuriy Shwartz
Yvette Ethel Yap
Zaynab Abejuela
Zdravko Kamenov
Zeid Khitan
Zhang H.
Zinman B.
Zishan Ali
Zuzana Ochodnicka
Ângela Regina Nazario Sabbag
Publication venue: 'Massachusetts Medical Society'
Publication date: 01/01/2019
Field of study

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Archivio Istituzionale della Ricerca- Università degli Studi di Foggia

Effect of alirocumab on mortality after acute coronary syndromes. An analysis of the ODYSSEY OUTCOMES randomized clinical trial

Author: Abbas J
Abbate A
Abdullakutty J
Abdullkutty J
Abhyanakar AD
Aboyans V
Abrantes JAM
Abu-Fadel M
Acevedo M
Adamkova V
Adamo A
Adhyapak S
Agarwal H
Aggarwal R
Aggarwal RK
Agnetti V
Aguirre A
Ahmed H
Ahremark U
Ahuad Guerrero RA
Aidar Ayoub JC
Airaksinen JK
Aitken D
Akatova E
Akhter F
Ako J
Akright L
Akyea-Djamson A
Al Joundi T
Al-Windy NYY
Alan D
Alcocer Gamba MA
Alexander JH
Alexander K
Alexandru TM
Alexopoulos D
Alings M
Alonso Martin JJ
Alonso Orcajo N
Alsweiler C
Alvarisqueta AF
Alves De Lima AE
Amarasekera S
Amarasena N
Amir O
Amlani M
Amosova E
Amuchastegui M
Anchante Hernandez HA
Andersen D
Andersen K
Andersen R
Anderson J
Ando K
Angel Hominal M
Annam S
Anscombe R
Apostolovic SR
Appel K-F
Arandjelovic A
Araneda G
Arbel Y
Arif I
Armaganijan L
Aroney C
Arroyo JAC
Arstall MA
Asanin MR
Atar S
Athyros V
Auguadro C
Aylward P
Aylward PE
Aylward PE
Azizad MM
Badreddine E
Bagai A
Bagriy A
Bahit MC
Bai F
Balaguer Recena J
Baldari D
Balinovac J
Ball E
Bang LE
Banuru S
Barakovic F
Baranov E
Baranova E
Barbarash OL
Barbato E
Barna OM
Barone-Rochette G
Barr C
Barraud P
Barrucco R
Bartels GL
Bashir R
Basson MMDV
Bastos JM
Bata I
Batushkin V
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Bayram Llamas EA
Bayron C
Beauloye C
Bednarski J
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Benbernou F
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Benecke JLA
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Berli MA
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Berthou C
Berti S
Bezault M
Bhagwat A
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Bhansali P
Bhatt DL
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Bittner VA
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Blok T
Blumberg EDS
Boccara F
Bodanese LC
Boecker D
Bojovski S
Bokarev I
Bokern MJJA
Bonfanti AJC
Bono JOE
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Botia DCL
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Publication venue: 'Ovid Technologies (Wolters Kluwer Health)'
Publication date: 04/01/2019
Field of study

Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. Results: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. In a prespecified analysis of 8242 patients eligible for ≥3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths (P<0.0001 for the associations). Alirocumab reduced total nonfatal cardiovascular events (P<0.001) and thereby may have attenuated the number of cardiovascular and noncardiovascular deaths. A post hoc analysis found that, compared to patients with lower LDL-C, patients with baseline LDL-C ≥100 mg/dL (2.59 mmol/L) had a greater absolute risk of death and a larger mortality benefit from alirocumab (HR, 0.71; 95% CI, 0.56 to 0.90; Pinteraction=0.007). In the alirocumab group, all-cause death declined wit h achieved LDL-C at 4 months of treatment, to a level of approximately 30 mg/dL (adjusted P=0.017 for linear trend). Conclusions: Alirocumab added to intensive statin therapy has the potential to reduce death after acute coronary syndrome, particularly if treatment is maintained for ≥3 years, if baseline LDL-C is ≥100 mg/dL, or if achieved LDL-C is low. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01663402

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