244 research outputs found
Condromatosis sinovial en localizaciones atípicas
La condromatosis sinovial es una metaplasia cartilaginosa del tejido sinovial de las articulaciones. Es
una enfermedad de etiología desconocida y poco frecuente. Puede definirse como un proceso benigno sinovial caracterizado
por la formación de nódulos cartilaginosos (cuerpos libres intraarticulares). Afecta principalmente a grandes
articulaciones sinoviales, siendo la sintomatología predominante dolor e inflamación articular. El diagnóstico de presunción
se basa en el estudio radiológico de la articulación. El tratamiento de elección es la extirpación completa de
los cuerpos libres y de la sinovial afecta. Presentamos dos casos clínicos de CS situadas en localizaciones poco frecuentes:
a nivel esternoclavicular y en la articulación temporomandibular, con la particularidad de esta última de presentar
extensión a base de cráneo. Realizamos asimismo una revisión de los datos bibliográficos existentes sobre la CS.Synovial chondromatosis is a cartilaginous metaplasia of the synovial tissue of joints. It is an uncommon
disease whose etiology is unknown. This benign synovial process involves the formation of cartilaginous nodules
(loose bodies) in the synovium and within the articular space. Synovial chondromatosis mainly affects large synovial
joints and the main symptoms are pain and swelling. Diagnosis can be made by panoramic radiograph, computed
tomography scan and magnetic resonance imaging of the joint. The main treatment includes complete removal of
the loose bodies in conjunction with excision of the affected synovium. We report two cases of synovial chondromatosis
located in an uncommon regions: in the esternoclavicular joint and in the temporomandibular joint. We also
make a literature review about synovial chondromatosis
Accidental displacement of a dental implant into the sublingual space: a case report
Dental implant surgery is continuously expanding. In fact, every day more and more surgeons are choosing dental
implants for allowing great results in the field of oral rehabilitation. However, these procedures are not exempt
from complications. This report presents the case of a 66 years old man underwent implant surgery by a specialized
dentist. No problems were reported during implant placement. Despite this, three months later, it was displaced into
the sublingual space at the time of uncovering. Against this backdrop, the patient was referred to an expert maxillofacial
surgeon. Next day, the implant was removed using an intraoral approach to reach the sublingual space.
According with our knowledge, there are no cases reported in the literature that describe this complication
Posttraumatic carotid-cavernous fistula: pathogenetic mechanisms, diagnostic management and proper treatment. A case report
Carotid-cavernous fistulas are an uncommon diseases characterized by abnormal communications between arteries
and veins located in the cavernous sinus. According with Barrow´s classification they could be divided in two
groups: direct and indirect. The typical symptoms showed by theses pathologies are: pulsating exophthalmos and
orbital blow. The present study describes a case of direct posttraumatic carotid-cavernous fistula in a 26 years old
man. Furthermore, we present the images that we used to make the diagnosis.
In this light, we decided to treat this case with endovascular approach after considering several therapeutic options. The
aim of the present report is twofold. First, we examine the importance of the proper management of the direct posttraumatic
carotid-cavernous fistula. Second, we describe this rare syndrome with the goal of proposing suitable treatments
Traumatic arteriovenous fistula as consequence of TMJ arthroscopic surgery: a case report
The ocurrence of a traumatic arteriovenous fistula after arthroscopic surgery of TMJ represents an extremely rare
event. Specifically, this uncommon complication has been described only in a few case reports. In this light, the
most frequent symptoms showed by this disease are thrills, bruits, pulsatile tinnitus, and an expansible vascular
mass. Importantly, the severity of these symptoms is also dependent on the vessels involved. With regard to the
management, is important to note that the vessel ligation with surgery as well as vessel emolization with endovascular
procedures have been shown to be effective in the treatment of these cases. In view of that, the present study
describes a case of superficial temporal arteriovenous fistula that arose as a postoperative complication of a bilateral
arthroscopic eminoplasty of TMJ. The aim of the present report is to characterize this rare syndrome with the goal
of proposing suitable treatments
Jaw osteonecrosis management around a dental implant inserted 2 years before starting treatment with zoledronic acid
Bisphosphonates (BP) are a type of drug known to inhibit bone resorption through complex interventions. Their
primary mechanism of action is aimed at the cellular level, inhibiting osteoclast activity and so bone resorption.
BPs are widely used, with many patients receiving continuous treatment for years. But it is well known that these
drugs can produce osteonecrosis of the jaw (ONJ). Zoledronic acid (ZA) is an intravenous BP used in the treatment
and prophylaxis of bone disease in patients with malignant tumors with bone implication. ZA is the most potent BP
in clinical development.
This report describes the case of a 62-year-old woman with breast cancer antecedents which relapsed, who had
received a maxillary dental implant two years before the start of therapy with zoledronic acid. She later developed
osteonecrosis of the jaw (ONJ), which began in the peri-implant area, and was treated for stage 3 ONJ by sub-total
maxillectom
Centrality dependence of charged particle production at large transverse momentum in Pb-Pb collisions at TeV
The inclusive transverse momentum () distributions of primary
charged particles are measured in the pseudo-rapidity range as a
function of event centrality in Pb-Pb collisions at
TeV with ALICE at the LHC. The data are presented in the range
GeV/ for nine centrality intervals from 70-80% to 0-5%.
The Pb-Pb spectra are presented in terms of the nuclear modification factor
using a pp reference spectrum measured at the same collision
energy. We observe that the suppression of high- particles strongly
depends on event centrality. In central collisions (0-5%) the yield is most
suppressed with at -7 GeV/. Above
GeV/, there is a significant rise in the nuclear modification
factor, which reaches for GeV/. In
peripheral collisions (70-80%), the suppression is weaker with almost independently of . The measured nuclear
modification factors are compared to other measurements and model calculations.Comment: 17 pages, 4 captioned figures, 2 tables, authors from page 12,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/284
Measurement of charm production at central rapidity in proton-proton collisions at TeV
The -differential production cross sections of the prompt (B
feed-down subtracted) charmed mesons D, D, and D in the rapidity
range , and for transverse momentum GeV/, were
measured in proton-proton collisions at TeV with the ALICE
detector at the Large Hadron Collider. The analysis exploited the hadronic
decays DK, DK, DD, and their charge conjugates, and was performed on a
nb event sample collected in 2011 with a
minimum-bias trigger. The total charm production cross section at TeV and at 7 TeV was evaluated by extrapolating to the full phase space
the -differential production cross sections at TeV
and our previous measurements at TeV. The results were compared
to existing measurements and to perturbative-QCD calculations. The fraction of
cdbar D mesons produced in a vector state was also determined.Comment: 20 pages, 5 captioned figures, 4 tables, authors from page 15,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/307
Anisotropic flow of charged hadrons, pions and (anti-)protons measured at high transverse momentum in Pb-Pb collisions at TeV
The elliptic, , triangular, , and quadrangular, , azimuthal
anisotropic flow coefficients are measured for unidentified charged particles,
pions and (anti-)protons in Pb-Pb collisions at TeV
with the ALICE detector at the Large Hadron Collider. Results obtained with the
event plane and four-particle cumulant methods are reported for the
pseudo-rapidity range at different collision centralities and as a
function of transverse momentum, , out to GeV/.
The observed non-zero elliptic and triangular flow depends only weakly on
transverse momentum for GeV/. The small dependence
of the difference between elliptic flow results obtained from the event plane
and four-particle cumulant methods suggests a common origin of flow
fluctuations up to GeV/. The magnitude of the (anti-)proton
elliptic and triangular flow is larger than that of pions out to at least
GeV/ indicating that the particle type dependence persists out
to high .Comment: 16 pages, 5 captioned figures, authors from page 11, published
version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/186
Association of candidate gene polymorphisms with chronic kidney disease : Results of a case-control analysis in the NEFRONA cohort
Chronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease and premature death. Despite classical clinical risk factors for CKD and some genetic risk factors have been identified, the residual risk observed in prediction models is still high. Therefore, new risk factors need to be identified in order to better predict the risk of CKD in the population. Here, we analyzed the genetic association of 79 SNPs of proteins associated with mineral metabolism disturbances with CKD in a cohort that includes 2,445 CKD cases and 559 controls. Genotyping was performed with matrix assisted laser desorption ionization-time of flight mass spectrometry. We used logistic regression models considering different genetic inheritance models to assess the association of the SNPs with the prevalence of CKD, adjusting for known risk factors. Eight SNPs (rs1126616, rs35068180, rs2238135, rs1800247, rs385564, rs4236, rs2248359, and rs1564858) were associated with CKD even after adjusting by sex, age and race. A model containing five of these SNPs (rs1126616, rs35068180, rs1800247, rs4236, and rs2248359), diabetes and hypertension showed better performance than models considering only clinical risk factors, significantly increasing the area under the curve of the model without polymorphisms. Furthermore, one of the SNPs (the rs2248359) showed an interaction with hypertension, being the risk genotype affecting only hypertensive patients. We conclude that 5 SNPs related to proteins implicated in mineral metabolism disturbances (Osteopontin, osteocalcin, matrix gla protein, matrix metalloprotease 3 and 24 hydroxylase) are associated to an increased risk of suffering CKD
Association of a single nucleotide polymorphism combination pattern of the Klotho gene with non-cardiovascular death in patients with chronic kidney disease
Chronic kidney disease (CKD) is associated with an elevated risk of all-cause mortality, with cardiovascular death being extensively investigated. However, non-cardiovascular mortality represents the biggest percentage, showing an evident increase in recent years. Klotho is a gene highly expressed in the kidney, with a clear influence on lifespan. Low levels of Klotho have been linked to CKD progression and adverse outcomes. Single nucleotide polymorphisms (SNPs) of the Klotho gene have been associated with several diseases, but studies investigating the association of Klotho SNPs with noncardiovascular death in CKD populations are lacking. The main aim of this study was to assess whether 11 Klotho SNPs were associated with non-cardiovascular death in a subpopulation of the National Observatory of Atherosclerosis in Nephrology (NEFRONA) study (n ¼ 2185 CKD patients). After 48 months of follow-up, 62 cardiovascular deaths and 108 non-cardiovascular deaths were recorded. We identified a high non-cardiovascular death risk combination of SNPs corresponding to individuals carrying the most frequent allele (G) at rs562020, the rare allele (C) at rs2283368 and homozygotes for the rare allele (G) at rs2320762 (rs562020 GG/AG þ rs2283368 CC/CT þ rs2320762 GG). Among the patients with the three SNPs genotyped (n ¼ 1016), 75 (7.4%) showed this combination. Furthermore, 95 (9.3%) patients showed a low-risk combination carrying all the opposite genotypes (rs562020 AA þ rs2283368 TT þ rs2320762 GT/TT). All the other combinations [n ¼ 846 (83.3%)] were considered as normal risk. Using competing risk regression analysis, we confirmed that the proposed combinations are independently associated with a higher fhazard ratio [HR] 3.28 [confidence interval (CI) 1.51-7.12]g and lower [HR 6 × 10- (95% CI 3.3 × 10--1.1 × 10-)] risk of suffering a non-cardiovascular death in the CKD population of the NEFRONA cohort compared with patients with the normal-risk combination. Determination of three SNPs of the Klotho gene could help in the prediction of non-cardiovascular death in CKD
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