Experimental research into the effect of some operation factors and rock properties on the rate of penetration

Purpose. The purpose of this research is to investigate the effect of weight on bit (WOB), rotary speed (RPM), and some rock properties on the rate of penetration (ROP). Methods. Four types of rock were collected from different sites in the south of Egypt (Aswan sandstone, Isawya limestone, Assiut limestone, and Minya marble). These tested samples were drilled by diamond core bit using a fixed laboratory diamond drilling machine under conditions (400 and 1200 rpm), and loads from 12 to 220 kg. WOB, ROP, torque (T) and specific energy (SE) were continuously observed during the drilling trials. The effect of these factors on ROP were examined. Water is used as a flushing and cooling medium. Findings. The effect of some operation factors on the penetration rate regarding mineral composition and different rock type was evaluated and the general equation was carried out to predict the suitable operation factor which gives the best penetration Rate. Originality. The effect of some operation factors on the penetration rate regarding mineral composition and different rock type was evaluated and the general equation was carried out to predict the suitable operation factor which gives the best penetration Rate. Practical implications. The Results demonstrated that ROP was inversely proportional to compressive strength (CS), tensile strength (TS), and density. It was also found that Aswan sandstone, Isawya limestone, Assiut limestone, and Minya marble have CS 111.94 MPa, 131.22 MPa, 125.0 MPa, and 502.5 MPa respectively. Was established that ROP was directly proportional to porosity. Increasing ROP in case of Aswan sandstone is associated with increase in porosity – 23.158%, and in case of Assiut limestone and Isawya limestone ROP is also associated with an increase in porosity – 19.9% and 17.93% respectively. Decreasing ROP in case of Minya marble is associated with decrease in porosity – 2.314%. So, we concluded that marble has lower ROP due to its higher CS, TS, and density and lower porosity than other tested rocks.Мета. Вивчення впливу комплексу основних експлуатаційних параметрів і ряду фізико-механічних властивостей порід на швидкість буріння в умовах різних родовищ Південного Єгипту. Методика. Були відібрані 4 типи порід з різних районів на півдні Єгипту (Асуанської піщаник, вапняк Ісав, Ассіутскій вапняк і мармур Міньї). Експериментальні зразки отримано на стаціонарній лабораторній буровій установці з алмазним долотом при швидкостях обертання 400 і 1200 об/хв та при навантаженнях від 12 до 220 кг. Під час експериментів постійно вимірювалися навантаження на долото, частота обертання, крутний момент на долоті й питома енергія, а також досліджувався вплив цих факторів на швидкість буріння. Як розчин для промивання і охолоджуючий агент використовувалася вода. Результати. Встановлено залежності швидкості буріння від навантаження на долото, питомої енергії та частоти обертання і питомої енергії. Виявлено, що для всіх чотирьох типів породи швидкість буріння збільшується з ростом навантаження на долото, в той час як питома енергія зменшується з ростом швидкості буріння. Розроблено ефективний спосіб прогнозування продуктивності бурової установки. Встановлено, що швидкість буріння обернено пропорційна міцності на стиск, міцності на розтягнення й щільності, а також змінюється прямо пропорційно пористості. Визначено, що менша швидкість буріння мармуру пов’язана з великими значеннями міцності на стиск, розтяг і щільність, а також з меншою пористістю у порівнянні з іншими досліджуваними породами. Наукова новизна. Встановлено нові закономірності взаємозв’язку експлуатаційних параметрів буріння з урахуванням різного типу породи (пісковик, вапняк, мармур) та її мінерального складу, а також обґрунтовано головну умову експлуатаційного фактору, який забезпечує оптимальну швидкість буріння. Практична значимість. Отримані результати дозволяють вибирати оптимальні параметри і режими буріння в процесі розвідки умов залягання родовищ Південного Єгипту, їх мінерального вмісту та стратиграфічних особливостей. Результати будуть корисними для проектних організацій, наукових інститутів з геології й розвідки, а також гірничих підприємств.Цель. Изучение влияния комплекса основных эксплуатационных параметров и ряда физико-механических свойств пород на скорость бурения в условиях пород различных месторождений Южного Египта. Методика. Были отобраны 4 типа пород из различных районов на юге Египта (Асуанский песчаник, известняк Исавии, Ассиутский известняк и мрамор Миньи). Экспериментальные образцы получены на стационарной лабораторной буровой установке с алмазным долотом при скоростях вращения 400 и 1200 об/мин и при нагрузках от 12 до 220 кг. Во время экспериментов постоянно измерялись нагрузки на долото, частота вращения, крутящий момент на долоте и удельная энергия, а также и исследовалось влияние этих факторов на скорость бурения. В качестве промывочного раствора и охлаждающего агента использовалась вода. Результаты. Установлены зависимости скорости бурения от нагрузки на долото, удельной энергии и частоты вращения и удельной энергии. Выявлено, что для всех четырех типов породы скорость бурения увеличивается с ростом нагрузки на долото, в то время как удельная энергия уменьшается с ростом скорости бурения. Разработан эффективный способ прогнозирования производительности буровой установки. Установлено, что скорость бурения обратно пропорциональна прочности на сжатие, прочности на растяжение и плотности, а также изменяется прямо пропорционально пористости. Определено, что меньшая скорости бурения мрамора связана с большими значениями прочности на сжатие, растяжение и плотности, а также с меньшей пористостью по сравнению с другими исследуемыми породами. Научная новизна. Получены новые закономерности взаимосвязи эксплуатационных параметров бурения с учетом различного типа породы (песчаник, известняк, мрамор) и ее минерального состава, а также обосновано главное условие эксплуатационного фактора, который обеспечивает оптимальную скорость бурения. Практическая значимость. Полученные результаты позволяют выбирать оптимальные параметры и режимы бурения в процессе разведки условий залегания месторождений Южного Египта, их минерального содержание и стратиграфических особенностей. Результаты будут полезными для проектных организаций, научных институтов по геологии и разведке, а также горных предприятий.Our sincere gratitude for Mining and Metallurgical Engineering Dept. Faculty of Engineering, Assiut, Egypt for invaluable assistance to upgrade and guidance to completed this article

Formulation and evaluation of orally disintegrating clopidogrel tablets

Recent advances in drug delivery systems have aimed to achieve better patient compliance. One of these advances is the formulation of orally disintegrating tablets (ODTs) that dissolve instantaneously, releasing drugs within a few seconds without the need of water. The main objective of this paper was to prepare and develop ODTs of clopidogrel. The ODTs were prepared by direct compression. The effect of three superdisintegrants, namely crospovidone, croscarmellose sodium, and sodium starch glycolate, using three different disintegration times on the dissolution rate was investigated. The prepared tablets were evaluated for hardness, friability, disintegration time and in vitro drug release. Furthermore, the interaction of clopidogrel with the formulation excipients was studied using differential scanning calorimetry (DSC). DSC studies revealed that there were no interactions between the drug and the excipients used. All tablets had hardness values in the range 4.0-5.2 kp and friability lower than 1%. The weight and drug content uniformity of all formulations was within official limits according to BP. In vitro drug release studies of the ODTs showed that more than 90% of the drug was released within ten minutes. A palatability test in human volunteers showed acceptable taste and mouth feel. Thus, the obtained results conclusively demonstrated successful rapid disintegration of the formulated tablets and acceptable palatability.Recentes avanC'os em sistemas de liberaC'C#o de fC!rmacos novos visam C obtenC'C#o de melhor adesC#o do paciente. Um destes avanC'os C) a formulaC'C#o de comprimidos de desintegraC'C#o oral (ODTs), que se dissolvem instantaneamente, liberando o fC!rmaco, em alguns segundos, sem a necessidade de C!gua. O principal objetivo deste trabalho foi preparar e desenvolver ODTs de clopidogrel. Os ODTs foram preparados pelo mC)todo de compressC#o direta. Estudou-se o efeito de vC!rias concentraC'C5es de diferentes agentes de desintegraC'C#o, tais como super-crospovidona, croscarmelose de sC3dio, glicolato de amido de sC3dio no tempo de desintegraC'C#o e velocidade de dissoluC'C#o. Os comprimidos preparados foram avaliados quanto C dureza, C friabilidade, ao tempo de desintegraC'C#o e C liberaC'C#o do fC!rmaco in vitro. AlC)m disso, estudou-se a interaC'C#o de clopidogrel com os excipientes de formulaC'C#o, utilizando calorimetria de varredura diferencial (DSC). Estudos de DSC revelaram nC#o haver interaC'C#o entre o fC!rmaco e os excipientes utilizados. Todos os comprimidos possuC-am dureza na faixa de 4,0-5,2 kp e a friabilidade inferior a 1%. A variaC'C#o de peso e o teor de fC!rmaco de todas as formulaC'C5es mostraram-se dentro do limite oficial, de acordo com a BP. O estudo de liberaC'C#o do fC!rmaco in vitro de comprimidos ODTs mostrou que mais de 90% do fC!rmaco foram liberados em10 minutos. O teste de palatabilidade em voluntC!rios humanos mostrou sabor e sensaC'C#o na boca aceitC!veis. Assim, os resultados obtidos demonstraram, conclusivamente, a rC!pida e bem-sucedida desintegraC'C#o dos comprimidos formulados e a palatabilidade aceitC!vel

LINEARNO PROGRAMIRANJE KAO ALAT ZA PROJEKTIRANJE SIROVINSKE SMJESE U TVORNICI CEMENTA

This study uses linear programming to develop a methodology for selecting the best raw material mix in an ASCOM cement plant in Egypt. In cement factories, this type adheres to Egyptian chemical composition criteria for raw feed (e.g. 82.5% calcium carbonate, 14.08% silica, 2.5% alumina and 0.92% iron oxide). Furthermore, the model is bound by industry-specific characteristics (e.g. lime saturation factor, silica modulus, alumina modulus and loss of ignition). The results reveal that the model is able to accurately reproduce the mixing of high-quality feed with varying constituent percentages. It is also capable of determining the combining limitations of each ingredient. Furthermore, it demonstrates optimality for additive sourcing short-term planning and capping limestone quality to meet changeable component combinations. Additionally, improving the raw mix reduces limestone feed quality from 51 to 50.6%, resulting in the inclusion of extra limestone reserves.Studija prikazuje metodu linearnoga programiranja uporabljenu sa svrhom odabira najbolje sirovinske smjese u tvornici cementa ASCOM (Egipat). Takva smjesa poštuje egipatske standarde kemijskoga sastava sirovine (npr. 82,5 % kalcijeva karbonata, 14,08 % silikata, 2,5 % aluminijeva oksida, 0,92 % željeznoga oksida). Također, model je uvjetovan industrijskim standardima (npr. faktorom zasićenja vapnom, silikatnim i aluminatnim modulom te gubitkom (oksida) žarenjem). Modelom se mogla točno izračunati visokokvalitetna mješavina različitih (postotnih) komponenti te je dokazan kao optimalan za brz izračun raznih aditiva i postizanje najveće kvalitete vapnenačke sirovine uz doziranje ostalih komponenti. Time je udjel vapnenca bilo moguće smanjiti na 50,6 – 51 %, što je otvorilo put eksploataciji dodatnih rezervi te sirovine

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Effect of wet mass on dextromethorphan hydrobromide matrix pellets

Dextromethorphan hydrobromide (DM) sustained release matrix pellets containing 10% w/w drug were prepared by an extrusion/spheronization technique. The effect of mixing different concentrations of ethyl cellulose (EC), hydroxypropyl methylcellulpse (HPMC K10), and Carbopol 934 with Avicel PH101 on the rheological properties of pellet wet mass was evaluated using mixer torque rheometry (MTR). The prepared pellets were characterized for size, drug content, and in-vitro DM release rate. The results showed that increasing the concentration of the hydrophobic polymer (EC) with Avicel PH101 decreased wet mass consistency, represented by mass mean line torque. Lower binder ratio was required for optimum wet massing, while mixing with swellable polymers (HPMC and Carbopol) caused a noticeable increase in both mean line torque and binder ratio. Combinations of HPMC and Carbopol at higher concentrations resulted in controlled in vitro release of DM from the prepared pellets. Furthermore, mathematical treatment of the in vitro release data of DM from the prepared pellets showed that all formulations except those containing 5% Carbopol plus 5% HPMC (F10) follow first order release. n values of these formulation were in the range of 0.09-0.40, which support an anomalous non-Fickian release

Isolation, Screening and Characterization of L-Glutaminase Producing Bacteria from Brackish Water

L-glutaminase is an important enzyme owing to their applications in pharmaceutical and food industries. In the present study, 142 L-glutaminase-producing bacterial strains were isolated from brackish water samples collected from the Lake Mariout at the North of Egypt. Results revealed that the majority of these strains produced the enzyme intracellularly and only 18 strains produced extracellular enzyme. Based on 16S rRNA gene analysis, the strains were identified as Citrobacter amalonaticus strain GPBW1, Legionella feeleii strain GPBW2, Enterobacter cloacae strain GPBW3, Empedobacter brevis strain GPBW4, Burkholderia plantarii strain GPBW5, Lysobacter antibioticus strain GPBW6, Vibrio parahaemolyticus strain GPBW7, Serratia fonticola strain GPBW8, Yokenella regensburgei strain GPBW9, and Klebsiella oxytoca strain GPBW10. The study highlighted the promising activity of Klebsiella oxytoca strain GPBW10 for L-glutaminase production

Formulation and evaluation of orally disintegrating clopidogrel tablets

ABSTRACT Recent advances in drug delivery systems have aimed to achieve better patient compliance. One of these advances is the formulation of orally disintegrating tablets (ODTs) that dissolve instantaneously, releasing drugs within a few seconds without the need of water. The main objective of this paper was to prepare and develop ODTs of clopidogrel. The ODTs were prepared by direct compression. The effect of three superdisintegrants, namely crospovidone, croscarmellose sodium, and sodium starch glycolate, using three different disintegration times on the dissolution rate was investigated. The prepared tablets were evaluated for hardness, friability, disintegration time and in vitro drug release. Furthermore, the interaction of clopidogrel with the formulation excipients was studied using differential scanning calorimetry (DSC). DSC studies revealed that there were no interactions between the drug and the excipients used. All tablets had hardness values in the range 4.0-5.2 kp and friability lower than 1%. The weight and drug content uniformity of all formulations was within official limits according to BP. In vitro drug release studies of the ODTs showed that more than 90% of the drug was released within ten minutes. A palatability test in human volunteers showed acceptable taste and mouth feel. Thus, the obtained results conclusively demonstrated successful rapid disintegration of the formulated tablets and acceptable palatability

A Fast Galerkin Approach for Solving the Fractional Rayleigh–Stokes Problem via Sixth-Kind Chebyshev Polynomials

Herein, a spectral Galerkin method for solving the fractional Rayleigh–Stokes problem involving a nonlinear source term is analyzed. Two kinds of basis functions that are related to the shifted sixth-kind Chebyshev polynomials are selected and utilized in the numerical treatment of the problem. Some specific integer and fractional derivative formulas are used to introduce our proposed numerical algorithm. Moreover, the stability and convergence accuracy are derived in detail. As a final validation of our theoretical results, we present a few numerical examples