549 research outputs found
Noise-Driven Phenotypic Heterogeneity with Finite Correlation Time in Clonal Populations
- Author
- A Arkin
- A d’Onofrio
- A Hernandez-Machado
- A Sigal
- AP Feinberg
- APL Newton
- ARA Anderson
- Ben D. MacArthur
- CH Waddington
- CP Calderón
- D Diego
- D Dingli
- D Hart
- D Li
- D Nevozhay
- D Shultz
- DT Gillespie
- DT Gillespie
- E Kim
- E Ozbudak
- Eun-Jin Kim
- GC Buehrlng
- H Hasegawa
- H Helaine
- H McAdams
- H Weedon-Fekjar
- J Yokota
- JCM Mombach
- John J. Skinner
- John Reinitz
- L Whitesell
- M Siegal
- Marsha Rich Rosner
- NX Wang
- P Royston
- R Honeycutt
- S Levy
- S Sahoo
- SA Frank
- SL Spencer
- T Bose
- UnJin Lee
- Y Loewenstein
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 23/07/2015
- Field of study
There has been increasing awareness in the wider biological community of the role of clonal phenotypic heterogeneity in playing key roles in phenomena such as cellular bet-hedging and decision making, as in the case of the phage-λ lysis/lysogeny and B. Subtilis competence/vegetative pathways. Here, we report on the effect of stochasticity in growth rate, cellular memory/intermittency, and its relation to phenotypic heterogeneity. We first present a linear stochastic differential model with finite auto-correlation time, where a randomly fluctuating growth rate with a negative average is shown to result in exponential growth for sufficiently large fluctuations in growth rate. We then present a non-linear stochastic self-regulation model where the loss of coherent self-regulation and an increase in noise can induce a shift from bounded to unbounded growth. An important consequence of these models is that while the average change in phenotype may not differ for various parameter sets, the variance of the resulting distributions may considerably change. This demonstrates the necessity of understanding the influence of variance and heterogeneity within seemingly identical clonal populations, while providing a mechanism for varying functional consequences of such heterogeneity. Our results highlight the importance of a paradigm shift from a deterministic to a probabilistic view of clonality in understanding selection as an optimization problem on noise-driven processes, resulting in a wide range of biological implications, from robustness to environmental stress to the development of drug resistance
Towards the reconstruction of integrated genome-scale models of metabolism and gene expression
- Author
- A Brazma
- A Mortazavi
- A Santos-Zavaleta
- AS Blazier
- BJ Schmidt
- C Colijn
- C Willson
- CJ Lloyd
- D Eckweiler
- D Lee
- D Machado
- DL Nelson
- DS Johnson
- DT Banos
- E Motamedian
- H Lodish
- JD Orth
- JJ Faith
- JP Faria
- JP Faria
- JP Faria
- L Marmiesse
- M Moretto
- MN Price
- MW Covert
- N Kolesnikov
- N Sierro
- NE Lewis
- PA Jensen
- PA Jensen
- PS Novichkov
- PS Novichkov
- RA Young
- RJP Berlo van
- S Chandrasekaran
- T Barrett
- T Shlomi
- U Nagalakshmi
- VE Velculescu
- VR Iyer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
The reconstruction of integrated genome-scale models of metabolism and gene expression has been a challenge for a while now. In fact, various methods that allow integrating reconstructions of Transcriptional Regulatory Networks, gene expression data or both into Genome-Scale Metabolic Models have been proposed. Several of these methods are surveyed in this article, which allowed identifying their strengths and weaknesses concerning the reconstruction of integrated models for multiple prokaryotic organisms. Additionally, the main resources of regulatory information were also surveyed, as the existence of novel sources of regulatory information and gene expression data may contribute for the improvement of methodologies referred herein.This study was supported by the Portuguese Foundation for Science andTechnology (FCT) under the scope of the strategic funding of UID/BIO/04469/2019 unit andBioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European RegionalDevelopment Fund under the scope of Norte2020-Programa Operacional Regional do Norte. Fernando Cruz holds a doctoral fellowship (SFRH/BD/139198/2018) funded by the FCT. The authors thank project SHIKIFACTORY100 - Modular cell factories for the production of 100 compounds from the shikimate pathway (814408) funded by the European Commission.info:eu-repo/semantics/publishedVersio
Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdel Khalek S
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
- Abolins M
- Abouzeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akesson TP
- Akimoto G
- Akimov AV
- Alam MA
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Allbrooke BM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso F
- Altheimer A
- Alvarez Gonzalez B
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Anduaga XS
- Angelidakis S
- Anger P
- Angerami A
- Anghinolfi F
- Anisenkov A
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoki M
- Aperio Bella L
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Arce AT
- Arfaoui S
- Arguin JF
- Argyropoulos S
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnal V
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Ask S
- Asman B
- Asquith L
- Assamagan K
- Astalos R
- Astbury A
- Atkinson M
- ATLAS Collaboration The
- Auerbach B
- Auge E
- Augsten K
- Aurousseau M
- Avolio G
- Axen D
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Backes M
- Backhaus M
- Backus Mayes J
- Badescu E
- Bagnaia P
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker OK
- Baker S
- Balek P
- Balli F
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barak L
- Baranov SP
- Barber T
- Barberio EL
- Barberis D
- Barbero M
- Bardin DY
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro Guimarães da Costa J
- Barreiro F
- Bartoldus R
- Barton AE
- Bartsch V
- Basye A
- Bates RL
- Batkova L
- Batley JR
- Battaglia A
- Battistin M
- Bauer F
- Bawa HS
- Beale S
- Beau T
- Beauchemin PH
- Beccherle R
- Bechtle P
- Beck HP
- Becker K
- Becker S
- Beckingham M
- Becks KH
- Beddall A
- Beddall AJ
- Bedikian S
- Bednyakov VA
- Bee CP
- Beemster LJ
- Beermann TA
- Begel M
- Behar Harpaz S
- Belanger-Champagne C
- Bell PJ
- Bell WH
- Bella G
- Bellagamba L
- Bellomo M
- Belloni A
- Beloborodova O
- Belotskiy K
- Beltramello O
- Benary O
- Benchekroun D
- Bendtz K
- Benekos N
- Benhammou Y
- Benhar Noccioli E
- Benitez Garcia JA
- Benjamin DP
- Benoit M
- Bensinger JR
- Benslama K
- Bentvelsen S
- Berge D
- Bergeaas Kuutmann E
- Berger N
- Berghaus F
- Berglund E
- Beringer J
- Bernat P
- Bernhard R
- Bernius C
- Bernlochner FU
- Berry T
- Bertella C
- Bertin A
- Bertolucci F
- Besana MI
- Besjes GJ
- Besson N
- Bethke S
- Bhimji W
- Bianchi RM
- Bianchini L
- Bianco M
- Biebel O
- Bieniek SP
- Bierwagen K
- Biesiada J
- Biglietti M
- Bilokon H
- Bindi M
- Binet S
- Bingul A
- Bini C
- Biscarat C
- Bittner B
- Black CW
- Black JE
- Black KM
- Blair RE
- Blanchard JB
- Blazek T
- Bloch I
- Blocker C
- Blocki J
- Blum W
- Blumenschein U
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
- Bocci A
- Boddy CR
- Boehler M
- Boek J
- Boek TT
- Boelaert N
- Bogaerts JA
- Bogdanchikov A
- Bogouch A
- Bohm C
- Bohm J
- Boisvert V
- Bold T
- Boldea V
- Bolnet NM
- Bomben M
- Bona M
- Boonekamp M
- Bordoni S
- Borer C
- Borisov A
- Borissov G
- Borjanovic I
- Borri M
- Borroni S
- Bortfeldt J
- Bortolotto V
- Bos K
- Boscherini D
- Bosman M
- Boterenbrood H
- Bouchami J
- Boudreau J
- Bouhova-Thacker EV
- Boumediene D
- Bourdarios C
- Bousson N
- Boutouil S
- Boveia A
- Boyd J
- Boyko IR
- Bozovic-Jelisavcic I
- Bracinik J
- Branchini P
- Brandt A
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- Bratzler U
- Brau B
- Brau JE
- Braun HM
- Brazzale SF
- Brelier B
- Bremer J
- Brendlinger K
- Brenner R
- Bressler S
- Bristow TM
- Britton D
- Brochu FM
- Brock I
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- Brooijmans G
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- Bruckman de Renstrom PA
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- Bruneliere R
- Brunet S
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- Bryngemark L
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- Buat Q
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- Buchholz P
- Buckingham RM
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- Burckhart H
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- Buttar CM
- Butterworth JM
- Buttinger W
- Byszewski M
- Büscher V
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- Caforio D
- Cakir O
- Calafiura P
- Calderini G
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- Caloi R
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- Caminal Armadans R
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- Cantrill R
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- Capriotti D
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- Carminati L
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- Carquin E
- Carrillo-Montoya GD
- Carter AA
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- Carvalho J
- Casadei D
- Casado MP
- Cascella M
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- Castillo Gimenez V
- Castro NF
- Cataldi G
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- Cavasinni V
- Ceradini F
- Cerqueira AS
- Cerri A
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- Cerutti F
- Cetin SA
- Chafaq A
- Chakraborty D
- Chalupkova I
- Chan K
- Chang P
- Chapleau B
- Chapman JD
- Chapman JW
- Charlton DG
- Chavda V
- Chavez Barajas CA
- Cheatham S
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chelstowska MA
- Chen C
- Chen H
- Chen S
- Chen X
- Chen Y
- Cheng Y
- Cheplakov A
- Cherkaoui El Moursli R
- Chernyatin V
- Cheu E
- Cheung SL
- Chevalier L
- Chiefari G
- Chikovani L
- Childers JT
- Chilingarov A
- Chiodini G
- Chisholm AS
- Chislett RT
- Chitan A
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- Choudalakis G
- Chouridou S
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- Zhemchugov A
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- Publication venue
- American Physical Society
- Publication date
- 01/01/2012
- Field of study
Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02 TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1 μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos2Δϕ modulation for all ΣETPb ranges and particle pT
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at s√=8 TeV with the ATLAS detector
- Author
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- Mitsou VA
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- Muanza S
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- Musheghyan H
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- Schorlemmer ALS
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- Schroeder TV
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- Schwanenberger C
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- Selbach KE
- Seliverstov DM
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- Severini H
- Sfiligoj T
- Sforza F
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- Shabalina E
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- Shan LY
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- Sjursen TB
- Skottowe HP
- Skovpen KY
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- Sliwa K
- Smakhtin V
- Smart BH
- Smestad L
- Smirnov SY
- Smirnov Y
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- Smizanska M
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- Starchenko EA
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- Subramaniam R
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- Sun X
- Sundermann JE
- Suruliz K
- Susinno G
- Sutton MR
- Suzuki Y
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- Swedish S
- Swiatlowski M
- Sykora I
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- Ta D
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- Teoh JJ
- Terada S
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- Teuscher RJ
- Therhaag J
- Theveneaux-Pelzer T
- Thomas JP
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- Thompson AS
- Thompson EN
- Thompson PD
- Thompson PD
- Thomsen LA
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- Thong WM
- Thun RP
- Tian F
- Tibbetts MJ
- Tikhomirov VO
- Tikhonov YA
- Timoshenko S
- Tiouchichine E
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- Tsipolitis G
- Tsirintanis N
- Tsiskaridze S
- Tsiskaridze V
- Tskhadadze EG
- Tsukerman II
- Tsulaia V
- Tsuno S
- Tsybychev D
- Tudorache A
- Tudorache V
- Tuna AN
- Tupputi SA
- Turchikhin S
- Turecek D
- Turra R
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- Ueda I
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- Undrus A
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- Ungaro FC
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- Urbaniec D
- Urquijo P
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- Vacavant L
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- Vachon B
- Valencic N
- Valentinetti S
- Valero A
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- Valladolid Gallego E
- Vallecorsa S
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- van der Geer R
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- van der Ster D
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- van Huysduynen LH
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- van Vulpen I
- van Woerden MC
- Vanadia M
- Vandelli W
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- Vermeulen JC
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- Viazlo O
- Vichou I
- Vickey T
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- Virzi J
- Vivarelli I
- Vlachos S
- Vladoiu D
- Vlasak M
- Vogel A
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- Vokac P
- Volpi G
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- von der Schmitt H
- von Radziewski H
- von Toerne E
- Vorobel V
- Vorobev K
- Vos M
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- Vossebeld JH
- Vranjes N
- Vrba V
- Vreeswijk M
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- Vukotic I
- Vykydal Z
- Wagner P
- Wagner W
- Wahlberg H
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- Weingarten J
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- Wells PS
- Wenaus T
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- Wiglesworth C
- Wiik-Fuchs LAM
- Wijeratne PA
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- Wilson JA
- Wingerter-Seez I
- Winklmeier F
- Winter BT
- Wittgen M
- Wittig T
- Wittkowski J
- Wollstadt SJ
- Wolter MW
- Wolters H
- Wong KHY
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wozniak KW
- Wright M
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- Wu SL
- Wu X
- Wu Y
- Wulf E
- Wyatt TR
- Wynne BM
- Xella S
- Xiao M
- Xu D
- Xu L
- Yabsley B
- Yacoob S
- Yamada M
- Yamaguchi H
- Yamaguchi Y
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamauchi K
- Yamazaki Y
- Yan Z
- Yang H
- Yang H
- Yang UK
- Yang Y
- Yanush S
- Yao L
- Yao W-M
- Yasu Y
- Yatsenko E
- Ye J
- Ye S
- Yen AL
- Yildirim E
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJS
- Youssef S
- Yu DR
- Yu J
- Yu J
- Yu JM
- Yuan L
- Yurkewicz A
- Yusuff I
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang X
- Zhang Z
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
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- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1fb−1 of proton–proton collision data at √s = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via t˜→tχ˜01 or t˜→ bχ˜±1 →bW(∗)χ˜01 , where χ˜01 (χ˜±1 ) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of t˜ → tχ˜01 . For a branching fraction of 100%, top squark masses in the range 270–645 GeV are excluded for χ˜01 masses below 30 GeV. For a branching fraction of 50% to either t˜ → tχ˜01 or t˜ → bχ˜±1 , and assuming the χ˜±1 mass to be twice the χ˜01 mass, top squark masses in the range 250–550 GeV are excluded for χ˜01 masses below 60 GeV
Search for high-mass resonances decaying to dilepton final states in pp collisions at s√=7 TeV with the ATLAS detector
- Author
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- Abajyan T
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
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- AbouZeid OS
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- Zhemchugov A
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- Zobernig G
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- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Springer
- Publication date
- 23/11/2012
- Field of study
The ATLAS detector at the Large Hadron Collider is used to search for high-mass resonances decaying to an electron-positron pair or a muon-antimuon pair. The search is sensitive to heavy neutral Z′ gauge bosons, Randall-Sundrum gravitons, Z * bosons, techni-mesons, Kaluza-Klein Z/γ bosons, and bosons predicted by Torsion models. Results are presented based on an analysis of pp collisions at a center-of-mass energy of 7 TeV corresponding to an integrated luminosity of 4.9 fb−1 in the e + e − channel and 5.0 fb−1 in the μ + μ −channel. A Z ′ boson with Standard Model-like couplings is excluded at 95 % confidence level for masses below 2.22 TeV. A Randall-Sundrum graviton with coupling k/MPl=0.1 is excluded at 95 % confidence level for masses below 2.16 TeV. Limits on the other models are also presented, including Technicolor and Minimal Z′ Models
Search for R-parity-violating supersymmetry in events with four or more leptons in sqrt(s) =7 TeV pp collisions with the ATLAS detector
- Author
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- Yamazaki Y
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- Yanush S
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- Zerwas D
- della Porta GZ
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- Zhemchugov A
- Zhong J
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- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Collaboration ATLAS
- Publication venue
- Springer Verlag
- Publication date
- 01/01/2008
- Field of study
A search for new phenomena in final states with four or more leptons (electrons or muons) is presented. The analysis is based on 4.7 fb−1 of s=7TeV proton-proton collisions delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in two signal regions: one that requires moderate values of missing transverse momentum and another that requires large effective mass. The results are interpreted in a simplified model of R-parity-violating supersymmetry in which a 95% CL exclusion region is set for charged wino masses up to 540 GeV. In an R-parity-violating MSUGRA/CMSSM model, values of m 1/2 up to 820 GeV are excluded for 10 < tan β < 40
Escolha de ginecologia e obstetrícia por graduandos da Universidade de Brasília: um estudo de influências numa série histórica
- Author
- Blanchard MH
- Bland CJ
- Borges NJ
- Burack JH
- Dejano T. Sobral
- Dohn H
- Dorsey ER
- Ellsbury KE
- Elmore KO
- Figueiredo JFC
- Fogarty CA
- Garit DL
- Hammoud MM
- Howell DC
- Kassebaum D
- Kolb DA
- Machado MH
- McAlister RP
- Meurer LN
- Miriam da Silva Wanderley
- Petrides KV
- Schnuth RL
- Senf JH
- Sobral DT
- Sobral DT
- Sobral DT
- Tabachnick BG
- Turner G
- Vaidya NA
- Xu G
- Zeldow PB
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
A Genetic Screen for Anchorage-Independent Proliferation in Mammalian Cells Identifies a Membrane-Bound Neuregulin
- Author
- A Citri
- AC Lloyd
- AI McClatchey
- AI McClatchey
- Alison C. Lloyd
- AN Garratt
- AW Lin
- C Birchmeier
- C Taveggia
- CA Cremona
- Catherine A. Cremona
- D Hanahan
- Davide Danovi
- DL Falls
- DT Leicht
- Gisela Machado-da-Silva
- J Zhu
- JA Gomez-Sanchez
- JC Montero
- JM Funes
- JT Jones
- JY Wang
- K Adlkofer
- KA Nave
- Luke A. Noon
- LV Lotti
- M Serrano
- ME Bottazzi
- MR Hansen
- MS Stonecypher
- MS Stonecypher
- Neil A. Hotchin
- NF Mathon
- PJ Mitchell
- PW Frohnert
- RM Esper
- RP Huijbregts
- S Britsch
- S Cockerill
- Simona Parrinello
- SL Carroll
- Sreya Basu
- VH Freedman
- WC Hahn
- WH Ho
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Anchorage-independent proliferation is a hallmark of oncogenic transformation and is thought to be conducive to proliferation of cancer cells away from their site of origin. We have previously reported that primary Schwann cells expressing the SV40 Large T antigen (LT) are not fully transformed in that they maintain a strict requirement for attachment, requiring a further genetic change, such as oncogenic Ras, to gain anchorage-independence. Using the LT-expressing cells, we performed a genetic screen for anchorage-independent proliferation and identified Sensory and Motor Neuron Derived Factor (SMDF), a transmembrane class III isoform of Neuregulin 1. In contrast to oncogenic Ras, SMDF induced enhanced proliferation in normal primary Schwann cells but did not trigger cellular senescence. In cooperation with LT, SMDF drove anchorage-independent proliferation, loss of contact inhibition and tumourigenicity. This transforming ability was shared with membrane-bound class III but not secreted class I isoforms of Neuregulin, indicating a distinct mechanism of action. Importantly, we show that despite being membrane-bound signalling molecules, class III neuregulins transform via a cell intrinsic mechanism, as a result of constitutive, elevated levels of ErbB signalling at high cell density and in anchorage-free conditions. This novel transforming mechanism may provide new targets for cancer therapy
Anatomia da circulação medular
- Author
- Adamkiewicz A
- Adamkiewicz A
- Alexandre Campos Moraes Amato
- Boll DT
- Bowen BC
- Cech P
- Charles YP
- Chiesa R
- Chiesa R
- Czerny M
- Dickman C
- Etz CD
- Fattori R
- Griepp EB
- Griepp RB
- Machado ABM
- Manjila S
- Mauney MC
- Melissano G
- Melissano G
- Milen MT
- Murakami H
- Noedir Antônio Groppo Stolf
- Skalski JH
- Takase K
- Thron AK
- Thron AK
- Thron AK
- Thron AK
- Toole JF
- Valenstein PN
- Yingbin J
- Yoshioka K
- Yoshioka K
- Zeldes A
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
- …