Effect of phase fluctuation and dephasing on the dynamics of entanglement generation in a correlated emission laser

A detailed study of the effects of phase fluctuation and dephasing on the dynamics of the entanglement generated from a coherently pumped correlated emission laser is presented. It is found that the time evolution of the entanglement is significantly reliant on the phase fluctuation and dephasing, particularly, at early stages of the lasing process. In the absence of external driving radiation, the degree of entanglement and intensity turns out to attain a maximum value just before starting to exhibit oscillation which dies at longer time scale. However, in case the driving mechanism is on, the oscillatory nature disappears due to the additional induced coherent superposition and the degree of entanglement would be larger at steady state. Moreover, the degree of entanglement as predicted by the logarithmic negativity and the Duan-Giedke-Cirac-Zoller criteria exhibits a similar nature when there is no driving radiation, although such a trend is eroded with increasing strength of the pumping radiation at longer time scale. The other important aspect of the phase fluctuation and dephasing is the possibility of relaxing the time at which the maximum entanglement is detected.Comment: 10 pages, 10 figure

Foot ulcers associated with external trauma among people with diabetes: An integrative review of the origin of trauma and outcomes

Background Foot ulcers are common among people with diabetes. These ulcers are caused by a number of factors including trauma. To date, research findings on the origin of external trauma and the outcome of foot ulcers resulting from an external trauma have not been summarised. Objective To examine the origin of external trauma that contribute to the development of foot ulcers among people with diabetes and the outcome of such ulcers. Design An integrative review. Settings Hospital/community. Participants Patients with diabetes and foot ulcer. Method The Joanna Briggs framework was used to underpin this integrative review. Six different databases (CINAHL +, Medline, SCOPUS, Embase, ProQuest and Web of Science databases) were searched systematically to find research publications reporting traumas that contributed to foot ulcers sustained by people with diabetes. The search was limited to articles published in English. The search revealed 3193 articles that were filtered to 78 articles to be assessed at the full-text level and 45 articles were subsequently included. Quality appraisal was conducted independently by two reviewers, using the Joanna Briggs Institute (JBI) Critical Appraisal tools. Data were extracted into a form developed for the purpose of this review. Narrative synthesis was used to manage the extracted verbatim details on the origin of external trauma contributing to foot ulcers and the outcomes. Results The origins of external trauma were summarised into two domains and further specified into 16 categories. The identified traumas were mainly minor and originated within the home environment. The most commonly reported origins of external trauma were puncture wounds, ill-fitting shoes and self-care practices that caused foot ulcers. Twenty-seven studies reported outcomes following the development of an ulcer. Twenty-two studies reported amputation as an outcome and mortality was reported in 10 studies. It was not clear whether these outcomes were directly related to the foot ulcer or related to other diabetes-related complications. Conclusions The majority of ulcers occurred in the home environment and were preventable in nature. The assessment of an individual\u27s local context, particularly the home and actions to reduce risk is a priority. The extent of the risks related to external trauma need to be more widely communicated through clinical guidelines and training opportunities for frontline staff. Tweetable abstract The main origins of external foot trauma among people with diabetes were puncture wounds, ill-fitting footwear and self-care practices

The reported external traumas among people with diabetes-related foot ulcers and their outcomes: A systematic review of case reports

The objective of this systematic review was to collate evidence published in case reports on the reported origins of external traumas that contribute to the development of diabetic foot ulcers and their outcomes. The review also aimed to suggest reporting criteria for external traumas contributing to the development of diabetic foot ulcers. The search strategy led to the identification of 1224 articles across six electronic databases. Additional articles were also sourced from other electronic platforms (Google scholar) and the reference lists of the included case reports. Ninety-four articles met the inclusion criteria and were published between 1989 and 2020. The included case reports were independently assessed for methodological quality using a Joanna Briggs Institute (JBI) checklist. Following the verbatim extraction of data, the JBI three steps approach to “meta-aggregation” for managing qualitative data was used to synthesise the data on external traumas that contributed to the development of foot ulcers along with the reported outcome. Information on the included case report characteristics was also extracted. The case reports included 155 patients. Average age was 57.2 years with a range from 17 to 86 years. External traumas were mainly experienced in the domestic setting and were categorised into two main categories, mechanical trauma (n = 87, 60%) or burns (n = 58, 40%). The most frequently reported origins of external trauma were contact with a hot surface, animal bites, friction, and puncture wounds. Although healing was the most frequent outcome, a prolonged time was recorded for the ulcers to heal highlighting the importance of prevention. Prevention might not eradicate origins of external trauma 100%, showing the importance of patient and/or family role in monitoring domestic risks, early detection of ulcer and seeking immediate professional care. Foot ulcers need to be reported against standardised criteria considering local characteristics of the ulcer and the individual\u27s general profile

Clinical utility of a coronary heart disease risk prediction gene score in UK healthy middle aged men and in the Pakistani population

8 Sep 2015: Beaney KE, Cooper JA, Ullah Shahid S, Ahmed W, Qamar R, et al. (2015) Correction: Clinical Utility of a Coronary Heart Disease Risk Prediction Gene Score in UK Healthy Middle Aged Men and in the Pakistani Population. PLOS ONE 10(9): e0139651. https://doi.org/10.1371/journal.pone.0139651© 2015 Beaney et al. Background: Numerous risk prediction algorithms based on conventional risk factors for Coronary Heart Disease (CHD) are available but provide only modest discrimination. The inclusion of genetic information may improve clinical utility. Methods: We tested the use of two gene scores (GS) in the prospective second Northwick Park Heart Study (NPHSII) of 2775 healthy UK men (284 cases), and Pakistani case-control studies from Islamabad/Rawalpindi (321 cases/228 controls) and Lahore (414 cases/219 controls). The 19-SNP GS included SNPs in loci identified by GWAS and candidate gene studies, while the 13-SNP GS only included SNPs in loci identified by the CARDIoGRAMplusC4D consortium. Results: In NPHSII, the mean of both gene scores was higher in those who went on to develop CHD over 13.5 years of follow-up (19-SNP p=0.01, 13-SNP p=7x10-3). In combination with the Framingham algorithm the GSs appeared to show improvement in discrimination (increase in area under the ROC curve, 19-SNP p=0.48, 13-SNP p=0.82) and risk classification (net reclassification improvement (NRI), 19-SNP p=0.28, 13-SNP p=0.42) compared to the Framingham algorithm alone, but these were not statistically significant. When considering only individuals who moved up a risk category with inclusion of the GS, the improvement in risk classification was statistically significant (19-SNP p=0.01, 13-SNP p=0.04). In the Pakistani samples, risk allele frequencies were significantly lower compared to NPHSII for 13/19 SNPs. In the Islamabad study, the mean gene score was higher in cases than controls only for the 13-SNP GS (2.24 v 2.34, p=0.04). There was no association with CHD and either score in the Lahore study. Conclusion: The performance of both GSs showed potential clinical utility in European men but much less utility in subjects from Pakistan, suggesting that a different set of risk loci or SNPs may be required for risk prediction in the South Asian population.KEB is supported by a Medical Research Council CASE award (1270920) with Randox Laboratories. SUS is supported by Higher Education Commisson Pakistan (IRSIP 24 BMS 41). SEH is a British Heart Foundation Professor and he and JAC are supported by the British Heart Foundation (RG008/08) and by the National Institute for Health Research University College London Hospitals Biomedical Research Centre. NPHSII was supported by the British Medical Research Council, the US National Institutes of Health [grant number NHLBI 33014] and Du Pont Pharma, Wilmington Delaware

Renewable estimation and incremental inference in generalized linear models with streaming data sets

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153655/1/rssb12352_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153655/2/rssb12352-sup-0001-Supinfo.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153655/3/rssb12352.pd

GPS-determination of along-strike variation in Cascadia margin kinematics: Implications for relative plate motion, Subduction zone coupling, and permanent deformation

High‐precision GPS geodesy in the Pacific Northwest provides the first synoptic view of the along‐strike variation in Cascadia margin kinematics. These results constrain interfering deformation fields in a region where typical earthquake recurrence intervals are one or more orders of magnitude longer than the decades‐long history of seismic monitoring and where geologic studies are sparse. Interseismic strain accumulation contributes greatly to GPS station velocities along the coast. After correction for a simple elastic dislocation model, important residual motions remain, especially south of the international border. The magnitude of northward forearc motion increases southward from western Washington (3–7 mm/yr) to northern and central Oregon (∼9 mm/yr), consistent with oblique convergence and geologic constraints on permanent deformation. The margin‐parallel strain gradient, concentrated in western Washington across the populated Puget Lowlands, compares in magnitude to shortening across the Los Angeles Basin. Thus crustal faulting also contributes to seismic hazard. Farther south in southern Oregon, north‐westward velocities reflect the influence of Pacific‐North America motion and impingement of the Sierra Nevada block on the Pacific Northwest. In contrast to previous notions, some deformation related to the Eastern California shear zone crosses northernmost California in the vicinity of the Klamath Mountains and feeds out to the Gorda plate margin

Measurement, modelling, and closed-loop control of crystal shape distribution: Literature review and future perspectives

Crystal morphology is known to be of great importance to the end-use properties of crystal products, and to affect down-stream processing such as filtration and drying. However, it has been previously regarded as too challenging to achieve automatic closed-loop control. Previous work has focused on controlling the crystal size distribution, where the size of a crystal is often defined as the diameter of a sphere that has the same volume as the crystal. This paper reviews the new advances in morphological population balance models for modelling and simulating the crystal shape distribution (CShD), measuring and estimating crystal facet growth kinetics, and two- and three-dimensional imaging for on-line characterisation of the crystal morphology and CShD. A framework is presented that integrates the various components to achieve the ultimate objective of model-based closed-loop control of the CShD. The knowledge gaps and challenges that require further research are also identified