CP asymmetries in B0 decays in the left-right model

We study time dependent CP asymmetries in B^0_{d,s} decays in the left-right model with spontaneous breakdown of CP. Due to the new contributions to B^0-\bar B^0 mixing the CP asymmetries can be substantially modified. Moreover, there can be significant new contributions to the $B$-meson decay amplitudes from the magnetic penguins. Most promising for detection of the new physics in the planned $B$ factories is that the CP asymmetries in the decays B--> J/\psi K_S and B--> \phi K_S which are supposed to be equal in the standard model can differ significantly in this class of models independently of the results in the measurements of B--> X_s \gamma.Comment: Revised version, to appear in PR

CP-Violating Asymmetries in Charmless Non-Leptonic Decays B→PP,PV,VVB \to PP, PV, VV in the Factorization Approach

We present estimates of the direct (in decay amplitudes) and indirect (mixing- induced) CP-violating asymmetries in the non-leptonic charmless two-body decay rates for $B \to PP$, $B \to PV$ and $B \to VV$ decays and their charged conjugates, where P(V) is a light pseudoscalar (vector) meson. These estimates are based on a generalized factorization approach making use of next-to-leading order perturbative QCD contributions which generate the required strong phases. No soft final state interactions are included. We study the dependence of the asymmetries on a number of input parameters and show that there are at least two (possibly three) classes of decays in which the asymmetries are parametrically stable in this approach. The decay modes of particular interest are: \optbar{B^0} \to \pi^+ \pi^-, \optbar{B^0} \to K_S^0 \pi^0, \optbar{B^0} \to K_S^0 \eta^\prime, \optbar{B^0} \to K_S^0 \eta and \optbar{B^0} \to \rho^+ \rho^-. Likewise, the CP-violating asymmetry in the decays \optbar{B^0} \to K_S^0 h^0 with $h^0=\pi^0,K_S^0, \eta,\eta^\prime$ is found to be parametrically stable and large. Measurements of these asymmetries will lead to a determination of the phases $\sin 2\alpha$ and $\sin 2 \beta$ and we work out the relationships in these modes in the present theoretical framework. We also show the extent of the so-called "penguin pollution" in the rate asymmetry $A_{CP}(\pi^+ \pi^-)$ and of the "tree shadow" in the asymmetry $A_{CP}(K_S^0\eta^\prime)$ which will effect the determination of $\sin 2 \alpha$ and $\sin 2 \beta$ from the respective measurements. CP-violating asymmetries in $B^\pm \to \pi^\pm \eta^\prime$, $B^\pm \to K^{*\pm} \eta$, $B^\pm \to K^{*\pm} \eta^\prime$ and $B^\pm \to K^{*\pm}\rho^0$ are potentially interesting and are studied here.Comment: 42 pages (LaTex) including 19 figures, requires epsfig.sty; submitted to Phys. Rev.

SUSY GUTs contributions and model independent extractions of CP phases

We consider the origin of new phases in supersymmetric grand unification model, and show how significant new contributions arise from the gluino mediated diagram. We then present a more general model independent analysis of various modes of B-decays suggested previously for measurement of the CKM phases and point out what they really measure. It is in principle possible to separate out all the phases.Comment: 13 pages (Latex), 2 PS figures, a few remarks are added and a typo is corrected. To appear in Phys. Rev. Let

Incidence of erythropoietin antibody-mediated pure red cell aplasia: the Prospective Immunogenicity Surveillance Registry (PRIMS)

Background: Subcutaneous administration of Eprex(®) (epoetin alfa) in patients with chronic kidney disease (CKD) was contraindicated in the European Union between 2002 and 2006 after increased reports of anti-erythropoietin antibody-mediated pure red cell aplasia (PRCA). The Prospective Immunogenicity Surveillance Registry (PRIMS) was conducted to estimate the incidence of antibody-mediated PRCA with subcutaneous administration of a new coated-stopper syringe presentation of Eprex(®) and to compare this with the PRCA incidence with subcutaneous NeoRecormon(®) (epoetin beta) and Aranesp(®) (darbepoetin alfa). Methods: PRIMS was a multicentre, multinational, non-interventional, parallel-group, immunogenicity surveillance registry. Adults with CKD receiving or about to initiate subcutaneous Eprex(®), NeoRecormon(®) or Aranesp(®) for anaemia were enrolled and followed for up to 3 years. Unexplained loss or lack of effect (LOE), including suspected PRCA, was reported, with antibody testing for confirmation of PRCA. Results: Of the 15 333 patients enrolled, 5948 received Eprex(®) (8377 patient-years) and 9356 received NeoRecormon(®)/Aranesp(®) (14 286 patient-years). No treatment data were available for 29 patients. Among 23 patients with LOE, five cases of PRCA were confirmed (Eprex(®), n = 3; NeoRecormon(®), n = 1; Aranesp(®), n = 1). Based on exposed time, PRCA incidence was 35.8/100 000 patient-years (95% CI 7.4-104.7) for Eprex(®) versus 14.0/100 000 patient-years (95% CI 1.7-50.6) for NeoRecormon(®)/Aranesp(®). The incidence of PRCA with Eprex(®) was not significantly different versus comparator ESAs (rate ratio: 2.56; 95% CI 0.43-15.31). An analysis based on observed time produced similar findings. Conclusion: This large, prospective registry demonstrates that PRCA is rare with subcutaneous administration of either the new coated-stopper syringe presentation of Eprex(®), or NeoRecormon(®) or Aranesp(®).This study was funded by Janssen, Pharmaceutical Companies of Johnson & Johnson

CP Asymmetries in B_s Decays and Spontaneous CP violation

We study possible effects of new physics in CP asymmetries in two-body $B_s$ decays in left-right models with spontaneous CP violation. Considering the contributions of new CP phases to the $B_s$ mixing as well as to the penguin dominated decay amplitudes we show that, with the present constraints, large deviations from the standard model predictions in CP asymmetries are allowed in both cases. Detection of the new physics can be done by measuring non-zero asymmetries which are predicted to vanish in the standard model or by comparing two measurements which are predicted to be equal in the standard model. In particular, we show that the measurement of the CKM angle $\gamma$ in electroweak penguin dominated processes $B_s^0\to\rho^0\eta^{(')}, \rho^0\phi$ can largely be affected by the new physics.Comment: References and discussion added, version to be published in PR

Pulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-Analysis

Rationale: Methylation integrates factors present at birth and modifiable across the lifespan that can influence pulmonary function. Studies are limited in scope and replication. Objectives: To conduct large-scale epigenome-wide meta-analyses of blood DNA methylation and pulmonary function. Methods: Twelve cohorts analyzed associations of methylation at cytosine-phosphate-guanine probes (CpGs), using Illumina 450K or EPIC/850K arrays, with FEV1, FVC, and FEV1/FVC. We performed multiancestry epigenome-wide meta-analyses (total of 17,503 individuals; 14,761 European, 2,549 African, and 193 Hispanic/Latino ancestries) and interpreted results using integrative epigenomics. Measurements and Main Results: We identified 1,267 CpGs (1,042 genes) differentially methylated (false discovery rate, \u3c0.025) in relation to FEV1, FVC, or FEV1/FVC, including 1,240 novel and 73 also related to chronic obstructive pulmonary disease (1,787 cases). We found 294 CpGs unique to European or African ancestry and 395 CpGs unique to never or ever smokers. The majority of significant CpGs correlated with nearby gene expression in blood. Findings were enriched in key regulatory elements for gene function, including accessible chromatin elements, in both blood and lung. Sixty-nine implicated genes are targets of investigational or approved drugs. One example novel gene highlighted by integrative epigenomic and druggable target analysis is TNFRSF4. Mendelian randomization and colocalization analyses suggest that epigenome-wide association study signals capture causal regulatory genomic loci. Conclusions: We identified numerous novel loci differentially methylated in relation to pulmonary function; few were detected in large genome-wide association studies. Integrative analyses highlight functional relevance and potential therapeutic targets. This comprehensive discovery of potentially modifiable, novel lung function loci expands knowledge gained from genetic studies, providing insights into lung pathogenesis

Micromechanical Properties of Injection-Molded Starch–Wood Particle Composites

The micromechanical properties of injection molded starch–wood particle composites were investigated as a function of particle content and humidity conditions. The composite materials were characterized by scanning electron microscopy and X-ray diffraction methods. The microhardness of the composites was shown to increase notably with the concentration of the wood particles. In addition,creep behavior under the indenter and temperature dependence were evaluated in terms of the independent contribution of the starch matrix and the wood microparticles to the hardness value. The influence of drying time on the density and weight uptake of the injection-molded composites was highlighted. The results revealed the role of the mechanism of water evaporation, showing that the dependence of water uptake and temperature was greater for the starch–wood composites than for the pure starch sample. Experiments performed during the drying process at 70°C indicated that the wood in the starch composites did not prevent water loss from the samples.Peer reviewe

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (P-Bonferroni <1.06 x 10(-7)). In additional analyses in 7,278 participants,Peer reviewe

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

Background Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children. Methods We performed meta-analysis of Illumina's HumanMethylation450-array associations between gestational age and cord blood DNA methylation in 3648 newborns from 17 cohorts without common pregnancy complications, induced delivery or caesarean section. We also explored associations of gestational age with DNA methylation measured at 4-18 years in additional pediatric cohorts. Follow-up analyses of DNA methylation and gene expression correlations were performed in cord blood. DNA methylation profiles were also explored in tissues relevant for gestational age health effects: fetal brain and lung. Results We identified 8899 CpGs in cord blood that were associated with gestational age (range 27-42 weeks), at Bonferroni significance, P <1.06 x 10(- 7), of which 3343 were novel. These were annotated to 4966 genes. After restricting findings to at least three significant adjacent CpGs, we identified 1276 CpGs annotated to 325 genes. Results were generally consistent when analyses were restricted to term births. Cord blood findings tended not to persist into childhood and adolescence. Pathway analyses identified enrichment for biological processes critical to embryonic development. Follow-up of identified genes showed correlations between gestational age and DNA methylation levels in fetal brain and lung tissue, as well as correlation with expression levels. Conclusions We identified numerous CpGs differentially methylated in relation to gestational age at birth that appear to reflect fetal developmental processes across tissues. These findings may contribute to understanding mechanisms linking gestational age to health effects.Peer reviewe