The Slippage between Empires: the production of the colonized subject in Taiwan (1920-1945)

Taiwan makes an interesting case in postcolonial studies not only because of its multilayered colonial trajectory but also because of the intricate relationship between the colonial powers. After Japan’s surrender in 1945, Taiwan fell into another “colonial” power – the nationalist party’s rule, which is considered the “re-colonial” period by many scholars. Although the lifting of martial law in 1987 ushered in the so-called “postcolonial period”, the legitimacy of Hoklo-centric Taiwanese cultural nationalism was challenged by aboriginal movements in ...postprin

The contribution of Alu exons to the human proteome.

BackgroundAlu elements are major contributors to lineage-specific new exons in primate and human genomes. Recent studies indicate that some Alu exons have high transcript inclusion levels or tissue-specific splicing profiles, and may play important regulatory roles in modulating mRNA degradation or translational efficiency. However, the contribution of Alu exons to the human proteome remains unclear and controversial. The prevailing view is that exons derived from young repetitive elements, such as Alu elements, are restricted to regulatory functions and have not had adequate evolutionary time to be incorporated into stable, functional proteins.ResultsWe adopt a proteotranscriptomics approach to systematically assess the contribution of Alu exons to the human proteome. Using RNA sequencing, ribosome profiling, and proteomics data from human tissues and cell lines, we provide evidence for the translational activities of Alu exons and the presence of Alu exon derived peptides in human proteins. These Alu exon peptides represent species-specific protein differences between primates and other mammals, and in certain instances between humans and closely related primates. In the case of the RNA editing enzyme ADARB1, which contains an Alu exon peptide in its catalytic domain, RNA sequencing analyses of A-to-I editing demonstrate that both the Alu exon skipping and inclusion isoforms encode active enzymes. The Alu exon derived peptide may fine tune the overall editing activity and, in limited cases, the site selectivity of ADARB1 protein products.ConclusionsOur data indicate that Alu elements have contributed to the acquisition of novel protein sequences during primate and human evolution

Deduced probable HLA-B*40:01:35-associated HLA haplotype (A*24-B*40:01:35-DRB1*11) found in a Taiwanese unrelated hematopoietic bone marrow stem cell donor

AbstractObjectiveHuman leukocyte antigen (HLA)-B*40:01:35 is a low incidence allele in the HLA-B locus. The objective of this study is to report the ethnicity of B*40:01:35 and its deduced probable HLA associated haplotype in a Taiwanese unrelated bone marrow hematopoietic stem cell donor.Materials and methodsA sequence-based typing method was employed to confirm the low incidence allele B*40:01:35. Polymerase chain reaction was performed to amplify exons 2 and 3 of the HLA-A and HLA-B loci and exon 2 of the HLA-DRB1 locus using group-specific primer sets. The amplicons were sequenced using the BigDye Terminator Cycle Sequencing Ready Reaction kit in both directions according to the manufacturer's protocols.ResultsThe DNA sequence of B*40:01:35 is identical to B*40:01:01 in exons 2 and 3, except for residue 324 where C is changed to T (codon 84, TAC→TAT). The nucleotide exchange does not cause amino acid alteration to the protein sequence of B*40:01:01 due to the silent mutation. We deduced the probable HLA haplotype in association with B*40:01:35 in Taiwanese to be A*24-B*40:01:35-DRB1*11.ConclusionInformation on the deduced probable HLA haplotype in association with the low incidence B*40:01:35 allele that we report here is of value for HLA testing laboratories for reference purposes. In addition, it can be used by stem cell transplantation donor search coordinators to determine a strategy for finding compatible donors in unrelated bone marrow donor registries when a patient has this uncommon HLA allele

Advances in Reconfigurable Antenna Systems Facilitated by Innovative Technologies

© 2013 IEEE. Future fifth generation (5G) wireless platforms will require reconfigurable antenna systems to meet their performance requirements in compact, light-weight, and cost-effective packages. Recent advances in reconfigurable radiating and receiving structures have been enabled by a variety of innovative technology solutions. Examples of reconfigurable partially reflective surface antennas, reconfigurable filtennas, reconfigurable Huygens dipole antennas, and reconfigurable feeding network-enabled antennas are presented and discussed. They represent novel classes of frequency, pattern, polarization, and beam-direction reconfigurable systems realized by the innovative combinations of radiating structures and circuit components

A novel low-profile wideband reconfigurable CP antenna array

© Institution of Engineering and Technology.All Rights Reserved. For future wireless communications, cost-effective, low-profile circular polarization (CP) antennas with wide bandwidth and high directivity are highly desirable to increase system capacity and suppress polarization mismatch. In this paper, a wideband circular polarization antenna array integrated with a polarization-independent artificial magnetic conductor (AMC) is reported that meets the demands. First, a wideband CP reconfigurable antenna with a pair of cross-bowtie radiators and a metal ground is presented to achieve a fractional bandwidth of 35.9%. By replacing the metal ground with a polarization-independent AMC ground, the antenna profile is reduced from 0.25λ0 to 0.05λ0 with only a slight bandwidth decrease. A wideband CP reconfigurable 4-element linear array is achieved using four of those elements. It is low profile (0.05 λ0), and has a wide operating bandwidth (21.7%), and a high realized gain (13 dBic)

Genetic diversity among Toxoplasma gondii isolates from different hosts and geographical locations revealed by analysis of ROP13 gene sequences

Toxoplasma gondii can infect almost all the warm-blooded animals and human beings, causing serious public health problems and economic losses worldwide. Rhoptry protein 13 (ROP13) plays some roles in the invasion process of T. gondii. In this study, sequence variation in ROP13 gene among 14 T. gondii isolates from different geographical locations and hosts was examined. The ROP13 gene was amplified from individual isolates and sequenced. Results show that the length of the ROP13 sequences was 1203 bp. In total, there were 44 variable nucleotide positions in the ROP13 sequences, and sequence variations were 0.1 to 2.0% among the 14 examined T. gondii isolates, representing higher rate in transversion than in transition. Intra-specific nucleotide variations were mainly at the second codon positions. Phylogenetic analysis of the 14 examined T. gondii isolates indicate that the ROP13 sequence was not a suitable genetic marker to differentiate T. gondii isolates of different genotypes from different hosts and geographical regions. Low variation in ROP13 gene sequence may suggest that ROP13 gene could represent a good vaccine candidate against toxoplasmosis.Key words: Toxoplasma gondii, toxoplasmosis, rhpotry protein 13 (ROP13), sequence variation, phylogenetic analysis

Effect of WeiJia on carbon tetrachloride induced chronic liver injury

Aim: To study the effect of WeiJia on chronic liver injury using carbon tetrachloride (CCl 4) induced liver injury animal model. Methods: Wista r rats weighing 180-220g were randomly divided into three groups: normal control group (Group A), CCl 4 induced liver injury control group (Group B) and CCl 4 induction with WeiJia treatment group (Group C). Each group consisted of 14 rats. Liver damage and fibrosis was induced by subcutaneous injection with 40% CCl 4 in olive oil at 3 mL/kg body weight twice a week for eight weeks for Groups B and C rats whereas olive oil was used for Group A rats. Starting from the third week, Group C rats also received daily intraperitoneal injection of WeiJia at a dose of 1.25 μg/kg body weight. Animals were sacrificed at the fifth week (4 male, 3 female), and eighth week (4 male, 3 female) respectively. Degree of fibrosis were measured and serological markers for liver fibrosis and function including hyaluronic acid (HA), type IV collagen (CIV), γ-glutamyl transferase (γ-GT), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined. Alpha smooth muscle actin (α-SMA) and proliferating cell nuclear antigen (PCNA) immunohistochemistry were also performed. Results: CCl 4 induction led to the damage of liver and development of fibrosis in Group B and Group C rats when compared to Group A rats. The treatment of WeiJia in Group C rats could reduce the fibrosis condition significantly compared to Group B rats. The effect could be observed after three weeks of treatment and was more obvious after eight weeks of treatment. Serum HA, CIV, ALT, AST and γ-GT levels after eight weeks of treatment for Group C rats were 58±22 μg/L (P 0.05) respectively, similar to normal control group (Group A), but significantly different from CCl 4 induced liver injury control group (Group B). An increase in PCNA and decrease in α-SMA expression level was also observed. Conclusion: WeiJia could improve liver function and reduce liver fibrosis which might be through the inhibition of stellate cell activity. © 2006 The WJG Press. All rights reserved.published_or_final_versio

Anxiety and depression in the primary health care clinics and the use of complementary and alternative medicine

Objective: To determine the prevalence of depression and anxiety disorder in the primary care clinics in Kuching city and to examine the usage of complementary and alternative medicine (CAM) among the primary care patients who have psychiatric problems. Design: A cross-sectional survey design was used. Materials and Methods: This is a cross-sectional study of patients attending the primary care clinics. They were given core screening questionnaire, general questions on socio-demographic and questions pertaining to the usage of CAM. Patients who were positively screened for psychiatric problems will be interviewed by one of the researchers using the confirmatory questions. Results: The prevalence of all psychiatric problems in the primary care clinics was 16.6%. The commonest problem was depression at 6.7% prevalence rate followed by anxiety at 5.6%. 46.4% of the patients with psychiatric problems used CAM compared to only 20.8% of those without psychiatric problems. Significantly more patients with psychiatric problems consulted the Chinese temple medium or taking herbal medicine prescription. Conclusion: Depression and anxiety disorder are common psychiatric problems among the primary care clinic attendee and they are more likely to use CAM Anxiety and depression in the primary health care clinics and the use of complementary and alternative medicine. (PDF Download Available). Available from