Simulations of COMPASS vertical displacement events with a self-consistent model for halo currents including neutrals and sheath boundary conditions

The understanding of the halo current properties during disruptions is key to design and operate large scale tokamaks in view of the large thermal and electromagnetic loads that they entail. For the first time, we present a fully self-consistent model for halo current simulations including neutral particles and sheath boundary conditions. The model is used to simulate vertical displacement events (VDEs) occurring in the COMPASS tokamak. Recent COMPASS experiments have shown that the parallel halo current density at the plasma-wall interface is limited by the ion saturation current during VDE-induced disruptions. We show that usual magneto-hydrodynamic boundary conditions can lead to the violation of this physical limit and we implement this current density limitation through a boundary condition for the electrostatic potential. Sheath boundary conditions for the density, the heat flux, the parallel velocity and a realistic parameter choice (e.g. Spitzer's resistivity and Spitzer-Harm parallel thermal conductivity) extend present VDE simulations beyond the state of the art. Experimental measurements of the current density, temperature and heat flux profiles at the COMPASS divertor are compared with the results obtained from axisymmetric simulations. Since the ion saturation current density (Jsat) is shown to be essential to determine the halo current profile, parametric scans are performed to study its dependence on different quantities such as the plasma resistivity and the particle and heat diffusion coefficients. In this respect, the plasma resistivity in the halo region broadens significantly the Jsat profile, increasing the halo width at a similar total halo current

XY models with disorder and symmetry-breaking fields in two dimensions

The combined effect of disorder and symmetry-breaking fields on the two-dimensional XY model is examined. The study includes disorder in the interaction among spins in the form of random phase shifts as well as disorder in the local orientation of the field. The phase diagrams are determined and the properties of the various phases and phase transitions are calculated. We use a renormalization group approach in the Coulomb gas representation of the model. Our results differ from those obtained for special cases in previous works. In particular, we find a changed topology of the phase diagram that is composed of phases with long-range order, quasi-long-range order, and short-range order. The discrepancies can be ascribed to a breakdown of the fugacity expansion in the Coulomb gas representation. Implications for physical systems such as planar Josephson junctions and the faceting of crystal surfaces are discussed.Comment: 17 pages Latex with 5 eps figures, change: acknowledgment extende

In vitro Efficacy of a Novel Guanosine-Analog Phosphonate

Actinic keratosis, a frequent carcinoma in situ of non-melanoma skin cancer (NMSC), can transform into life-threatening cutaneous squamous cell carcinoma. Current treatment is limited due to low complete clearance rates and asks for novel therapeutic concepts; the novel purine nucleotide analogue OxBu may be an option. In order to enhance skin penetration, solid lipid nanoparticles (SLN, 136-156 nm) were produced with an OxBu entrapment efficiency of 96.5 ± 0.1%. For improved preclinical evaluation, we combined tissue engineering with clinically used keratin-18 quantification. Three doses of 10-3 mol/l OxBu, dissolved in phosphate-buffered saline as well as loaded to SLN, were effective on reconstructed NMSC. Tumour response and apoptosis induction were evaluated by an increase in caspase-cleaved fragment of keratin-18, caspase-7 activation as well as by reduced expression of matrix metallopeptidase-2 and Ki-67. OxBu efficacy was superior to equimolar 5-fluorouracil solution, and thus the drug should be subjected to the next step in preclinical evaluation

Characterization of ion cyclotron resonance heating in presence of the ITER-like wall in JET

Carbon is not compatible with the long term use required for plasma facing components in future fusion reactors of the tokamak type e.g. from the point of view of erosion and tritium retention.Wand Be were chosen as plasma facing materials for ITER. JET was equipped with beryllium (as opposed to C or C-coated) walls in the shutdown of 2010-2011. To sustain the very high heat loads inevitably falling on it and thus excluding the use of metals with a low melting point such as Be and in spite of the fact that its radiation is significant because of its large Z, a Tungsten (W) orW-coated divertor was simultaneously installed. The recent JET campaign has focused on characterizing high density high temperature operation with this "ITER-like" wall (ILW). One of the questions that needed to be answered is whether the auxiliary heating methods do not lead to unacceptable high levels of impurity influx preventing fusion-relevant operation. This paper briefly reports on two aspects of the present understanding of ion cyclotron resonance heating (ICRH) or radio frequency (RF) heating in presence of the ILW: ICRH-specific impurity influx and heating performance. They are complementing related discussions on heat loads, and on plasmaWcontent and possible sources. A much more extensive study will be published elsewhere

Fernando SEBASTIÁN AGUILAR, Nueva Evangelización. Fe, cultura y política en la España de hoy, Ed. Encuentro, Madrid 1991, 302 pp. [RECENSIÓN]

\u3cp\u3eThe most recent JET campaign has focused on characterizing operation with the «ITER-like» wall. One of the questions that needed to be answered is whether the auxiliary heating methods do not lead to unacceptably high levels of impurity influx, preventing fusion-relevant operation. In view of its high single pass absorption, hydrogen minority fundamental cyclotron heating in a deuterium plasma was chosen as the reference wave heating scheme in the ion cyclotron domain of frequencies. The present paper discusses the plasma behavior as a function of the minority concentration X[H] in L-mode with up to 4MW of RF power. It was found that the tungsten concentration decreases by a factor of 4 when the minority concentration is increased from X[H] ≈ 5% to X[H] % 20% and that it remains at a similar level when X[H] is further increased to 30%; a monotonic decrease in Beryllium emission is simultaneously observed. The radiated power drops by a factor of 2 and reaches a minimum at X[H] ≈ 20%. It is discussed that poor single pass absorption at too high minority concentrations ultimately tailors the avoidance of the RF induced impurity influx. The edge density being different for different minority concentrations, it is argued that the impact ICRH has on the fate of heavy ions is not only a result of core (wave and transport) physics but also of edge dynamics and fueling.\u3c/p\u3

A novel role for RecA under non-stress: promotion of swarming motility in Escherichia coli K-12

BACKGROUND: Bacterial motility is a crucial factor in the colonization of natural environments. Escherichia coli has two flagella-driven motility types: swimming and swarming. Swimming motility consists of individual cell movement in liquid medium or soft semisolid agar, whereas swarming is a coordinated cellular behaviour leading to a collective movement on semisolid surfaces. It is known that swimming motility can be influenced by several types of environmental stress. In nature, environmentally induced DNA damage (e.g. UV irradiation) is one of the most common types of stress. One of the key proteins involved in the response to DNA damage is RecA, a multifunctional protein required for maintaining genome integrity and the generation of genetic variation. RESULTS: The ability of E. coli cells to develop swarming migration on semisolid surfaces was suppressed in the absence of RecA. However, swimming motility was not affected. The swarming defect of a ΔrecA strain was fully complemented by a plasmid-borne recA gene. Although the ΔrecA cells grown on semisolidsurfaces exhibited flagellar production, they also presented impaired individual movement as well as a fully inactive collective swarming migration. Both the comparative analysis of gene expression profiles in wild-type and ΔrecA cells grown on a semisolid surface and the motility of lexA1 [Ind-] mutant cells demonstrated that the RecA effect on swarming does not require induction of the SOS response. By using a RecA-GFP fusion protein we were able to segregate the effect of RecA on swarming from its other functions. This protein fusion failed to regulate the induction of the SOS response, the recombinational DNA repair of UV-treated cells and the genetic recombination, however, it was efficient in rescuing the swarming motility defect of the ΔrecA mutant. The RecA-GFP protein retains a residual ssDNA-dependent ATPase activity but does not perform DNA strand exchange. CONCLUSION: The experimental evidence presented in this work supports a novel role for RecA: the promotion of swarming motility. The defective swarming migration of ΔrecA cells does not appear to be associated with defective flagellar production; rather, it seems to be associated with an abnormal flagellar propulsion function. Our results strongly suggest that the RecA effect on swarming motility does not require an extensive canonical RecA nucleofilament formation. RecA is the first reported cellular factor specifically affecting swarming but not swimming motility in E. coli. The integration of two apparently disconnected biologically important processes, such as the maintenance of genome integrity and motility in a unique protein, may have important evolutive consequences

Spin dynamics in semiconductors

This article reviews the current status of spin dynamics in semiconductors which has achieved a lot of progress in the past years due to the fast growing field of semiconductor spintronics. The primary focus is the theoretical and experimental developments of spin relaxation and dephasing in both spin precession in time domain and spin diffusion and transport in spacial domain. A fully microscopic many-body investigation on spin dynamics based on the kinetic spin Bloch equation approach is reviewed comprehensively.Comment: a review article with 193 pages and 1103 references. To be published in Physics Reports