Antispermatogenic Activity Of Morinda Morindoides Root Bark Extract In Male Wistar Rats

To investigate the effect of the aqueous extract of the root bark of Morinda morindoides (Rubiaceae) on the reproductive activity of male Wistar rats, three groups (A, B and C) of six rats each were treated with 400,800 and 1600 mg/kg/day of Morinda morindoides root bark extract respectively for 28 days while 5mls/kg of distilled water was given to the control group D. At the end of the experimental period, animals were sacrificed and sperm characteristics, histology of the testes and epididymis were assessed. Morinda morindoides root bark extract caused a significant reduction (p<0.05) in sperm motility, a significant dose dependent reduction in the sperm count and a significant (p<0.05) dose dependent increase in morphological abnormalities of the spermatozoa of the treated rats. Histopathological evaluation of the testis and epididymis revealed varying degrees of degeneration and necrosis of the germinal epithelia cell of the seminiferous tubules and spermiostasis. Morinda morindoides root bark extract has significant anti-spermatogenic effects on adult male Wistar rats which could impair reproductive activities in these male Wistar rats. &nbsp

Haemoglobins with multiple reactive sulfhydryl groups: reactions of 5,5'-dithiobis(2-nitrobenzoate) with CysF9[93] and CysH3[125] of guinea pig haemoglobin

Guinea pig haemoglobin has six sulfhydryl groups, one at each of the positions F9[93], G11[104] and H3[125], which appear in pairs. Titration with p-hydroxymercuri(II)- benzoic acid and with 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB) indicate that four of the six sulfhydryls are reactive. The time course of the DTNB reaction is triphasic at pH > 7. The fast phase is about 2 orders of magnitude faster than the intermediate phase and can be clearly separated from it. The intermediate phase, where it exists, is about 3-4 times faster than the slow phase. However, the amplitude of the intermediate phase, which has a maximum of about 15% of the total signal amplitude, becomes negligible as it approaches pH 7, so that the kinetics eventually becomes biphasic. The pH dependence profile of kapp, the apparent second-order rate constant, for the fast phase resembles the titration curve of a diprotic acid. Quantitative analysis indicates that the reactivity of the sulfhydryl group to which this phase may be attributed is linked to two ionizable groups with pKas of 6.4 0.1 and 7.8 0.2. These values are assigned to HisHC3[146] and CysF9[93], respectively. The pH dependence profile of kapp for the slow phase resembles the titration curve of a monoprotic acid. Quantitative analysis indicates that the sulfhydryl group to which this phase may be attributed is linked to a single ionizable group with a pKa of 6.1 0.2. Examination of the structure of guinea pig haemoglobin near the H3[125] position shows that there is a lysine residue, LysA5[8], which is only 4 (0.4 nm) away from CysH3[125]. The presence of this lysine lowers the pKa of CysH3[125] from the normal value for sulfhydryl groups (between 8 and 8.5) to 6.1. (Received July 31, 2001; revised May 1, 2002) (Bulletin of The Chemical Society of Ethiopia: 2002 16 (2): 175-186

On the Effects of Saturation Terms on A SEIR Epidemic Model with Infected and Susceptible Compartments

The importance of the saturation term in an SEIR (Susceptible, Exposed, Infected, and Recovered) epidemic model was examined in this article. To estimate the basic reproduction number (R0), examine the stabilities and run numerical simulations on the model, the next generation matrix, the Lyapunov function and Runge-Kutta techniques were used. The numerical simulation results reveal that, the saturation term has a significant influence in the model’s susceptible and infected compartments. However, as demonstrated by the simulation results, saturation term has a greater influence on vulnerable people than on infected people. As a result, greater sensitization programs through seminars, media, and awareness will be more beneficial to the vulnerable class than the afflicted class during disease eradication

STOCHASTIC MODEL ANALYSIS OF THE IMPACT OF MEDIA CAMPAIGN ON TRANSMISSION OF COVID – 19 EPIDEMIC.

The COVID - 19 pandemic is currently causing authorities and public health officials more concern. The goal of the project is to convert a deterministic model for COVID-19 transmissions to a stochastic model, and then analyze the results to see how media-driven awareness campaigns have an impact on the disease's spread. The dynamic COVID-19 model was converted to a stochastic model, which was then examined. The model includes the following categories: Susceptible (S), Exposed (E), Infected class (I),  Isolated class ( ), Aware class  and Recovered class (R), as well as the Cumulative density of awareness programs by media denoted by   . With the help of MATLAB, the converted model is then numerically solved using the Eula Maruyama approach, allowing the existence and uniqueness of the model to be examined. The implementation of awareness programs has been found to have a significant positive impact on the spread of COVID-19. As the rate of implementation of these programs rises, the population that is exposed to the virus and those who are infected with it declines, and it has been hypothesized that this will eventually cause COVID-19 to become extinct. According to the report, putting awareness campaigns into place can help stop the COVID-19 epidemic from spreading

Household Level Factors Responsible for Gender Poverty Among Cassava Farmers in Odeda Local Government Area of Ogun State

Poverty is multidimensional, enduring and is prevailing not only globally, but also particular cultural, political and economic features of a specific country increasing it. The gulf between haves and have-nots has lingered. Gender disparities, inequality, spatial dimensions, political instability, week institutions and lack of spiritual capital causes the poverty. The objective of this study was to examine the determinants of poverty among cassava producing households by gender of household heads in Odeda local government area of Ogun state. A total of 120 cassava farming household comprising of 76 male headed households and 46 female headed households were interviewed using structured questionnaire, in obtaining information from them. The study revealed that there is a positive relationship between the household size and poverty status for both the female headed households and male headed households and also the age of the household head has a negative relationship with the poverty status of the female household while farm experience and off farm activities were negatively related to the poverty status among the male household. Also, it was found out that neither of the households dominates one another in the poverty analysis. It was concluded that the household size of both the male and female households is an important determinant of poverty status as it was significant to the poverty status of the respondents.&nbsp

Music Appeal in Advertising and Product Recall in Children

This study investigated the possible influence of music appeal in advertising on children's recall of products

EXPLORING FACTORS THAT INFLUENCES THE ADOPTION OF ICT-BASED BUILDING AND CONSTRUCTION INFORMATIC PLATFORMS

Construction industry has witnessed introduction of automation processes in executing construction operations. Introduction of green building concept, building automation, intelligent buildings and all informatics platform. In this study stratified sampling method was used in data collection. The knowledge gap was bridged with the aid of data collated through questionnaires distributed to 950 respondents Population sample 100 residential accommodation was used while sample size of 95 was picked from the population. The study respondents for this research includes facility managers and professionals that have been informed in the use of informatics platform in solving built environment related problems. Existing informatics platforms were explored, level of awareness of the available informatics platform was also explored and later the factors that influences effective adoption of informatics platform in solving problems in building and construction works was presented in this study

Trypanosoma brucei gambiense group 1 is distinguished by a unique amino acid substitution in the HpHb receptor implicated in human serum resistance

Trypanosoma brucei rhodesiense (Tbr) and T. b. gambiense (Tbg), causative agents of Human African Trypanosomiasis (sleeping sickness) in Africa, have evolved alternative mechanisms of resisting the activity of trypanosome lytic factors (TLFs), components of innate immunity in human serum that protect against infection by other African trypanosomes. In Tbr, lytic activity is suppressed by the Tbr-specific serum-resistance associated (SRA) protein. The mechanism in Tbg is less well understood but has been hypothesized to involve altered activity and expression of haptoglobin haemoglobin receptor (HpHbR). HpHbR has been shown to facilitate internalization of TLF-1 in T.b. brucei (Tbb), a member of the T. brucei species complex that is susceptible to human serum. By evaluating the genetic variability of HpHbR in a comprehensive geographical and taxonomic context, we show that a single substitution that replaces leucine with serine at position 210 is conserved in the most widespread form of Tbg (Tbg group 1) and not found in related taxa, which are either human serum susceptible (Tbb) or known to resist lysis via an alternative mechanism (Tbr and Tbg group 2). We hypothesize that this single substitution contributes to reduced uptake of TLF and thus may play a key role in conferring serum resistance to Tbg group 1. In contrast, similarity in HpHbR sequence among isolates of Tbg group 2 and Tbb/Tbr provides further evidence that human serum resistance in Tbg group 2 is likely independent of HpHbR functio

Health workforce and governance: the crisis in Nigeria

Background In Nigeria, several challenges have been reported within the health sector, especially in training, funding, employment, and deployment of the health workforce. We aimed to review recent health workforce crises in the Nigerian health sector to identify key underlying causes and provide recommendations toward preventing and/or managing potential future crises in Nigeria. Methods We conducted a scoping literature search of PubMed to identify studies on health workforce and health governance in Nigeria. A critical analysis, with extended commentary, on recent health workforce crises (2010–2016) and the health system in Nigeria was conducted. Results The Nigerian health system is relatively weak, and there is yet a coordinated response across the country. A number of health workforce crises have been reported in recent times due to several months’ salaries owed, poor welfare, lack of appropriate health facilities and emerging factions among health workers. Poor administration and response across different levels of government have played contributory roles to further internal crises among health workers, with different factions engaged in protracted supremacy challenge. These crises have consequently prevented optimal healthcare delivery to the Nigerian population. Conclusions An encompassing stakeholders’ forum in the Nigerian health sector remain essential. The national health system needs a solid administrative policy foundation that allows coordination of priorities and partnerships in the health workforce and among various stakeholders. It is hoped that this paper may prompt relevant reforms in health workforce and governance in Nigeria toward better health service delivery in the country

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London