¿Es ético sacrificar animales con fines docentes? Visión de estudiantes y docentes universitarios

El sacrificio de animales con fines docentes despierta una creciente resistencia por parte de los alumnos y de lasociedad, a pesar que parece esencial para muchos objetivos docentes especialmente en carreras cuyo desempeño profesionalincluye el manejo de animales. En este manuscrito se presenta el análisis de alumnos de la carrera de Licenciaturaen Bioquímica de la USACH, y algunos docentes, sobre la eutanasia de roedores de laboratorio en sus cursos. Hubo acuerdounánime en la obligación ética de agotar los recursos antes de recurrir al sacrificio de animales, y que su manipulacióndebe hacerse por personas competentes y nunca por estudiantes de pregrado inexpertos y sin conocimientos en el temadel bienestar animal. El manuscrito presenta argumentos para limitar el uso de animales en la docencia de esta carrera.Palabras claves: Bioética, bienestar animal, docencia, derechos animales, estudiante

Chemical behavior of the Dwarf Irregular Galaxy NGC 6822. Its PN and HII region abundances

We aim to derive the chemical behavior of a significant sample of PNe and HII regions in the irregular galaxy NGC 6822 The selected objects are distributed in different zones of the galaxy. Due to the faintness of PNe and HII regions in NGC 6822, to gather spectroscopic data with large telescopes is necessary. We obtained a well suited sample of spectra by employing VLT-FORS 2 and Gemini-GMOS spectrographs. Ionic and total abundances are calculated for the objects where electron temperatures can be determined through the detection of [OIII] \lambda 4363 or/and [NII] \lambda 5755 lines. A "simple" chemical evolution model has been developed and the observed data are used to compute a model for NGC 6822 in order to infer a preliminary chemical history in this galaxy. Confident determinations of He, O, N, Ne, S and Ar abundances were derived for a sample of 11 PNe and one HII region. We confirm that the present ISM is chemically homogeneous, at least in the central 2 kpc of the galaxy, showing a value 12+log O/H = 8.06$\pm$0.04. From the abundance pattern of PNe, we identified two populations: a group of young PNe with abundances similar to HII regions and a group of older objects with abundances a factor of two lower. A couple of extreme Type I PNe were found. No third dredge-up O enrichement was detected in PNe of this galaxy. The abundance determinations allow us to discuss the chemical behavior of the present and past ISM in NGC 6822. Our preliminary chemical evolution model predicts that an important gas-mass lost occurred during the first 5.3 Gyr, that no star higher than 40 M$_\odot$ was formed, and that 1% of all 3-15 M$_\odot$ stars became binary systems progenitors to SNIa.Comment: 15 pages, 3 figures and 4 tables. A&A, Accepted 13/06/200

Cerebral Microdialysate Metabolite Monitoring using Mid-infrared Spectroscopy.

Funder: Wellcome TrustThe brains of patients suffering from traumatic brain-injury (TBI) undergo dynamic chemical changes in the days following the initial trauma. Accurate and timely monitoring of these changes is of paramount importance for improved patient outcome. Conventional brain-chemistry monitoring is performed off-line by collecting and manually transferring microdialysis samples to an enzymatic colorimetric bedside analyzer every hour, which detects and quantifies the molecules of interest. However, off-line, hourly monitoring means that any subhourly neurochemical changes, which may be detrimental to patients, go unseen and thus untreated. Mid-infrared (mid-IR) spectroscopy allows rapid, reagent-free, molecular fingerprinting of liquid samples, and can be easily integrated with microfluidics. We used mid-IR transmission spectroscopy to analyze glucose, lactate, and pyruvate, three relevant brain metabolites, in the extracellular brain fluid of two TBI patients, sampled via microdialysis. Detection limits of 0.5, 0.2, and 0.1 mM were achieved for pure glucose, lactate, and pyruvate, respectively, in perfusion fluid using an external cavity-quantum cascade laser (EC-QCL) system with an integrated transmission flow-cell. Microdialysates were collected hourly, then pooled (3-4 h), and measured consecutively using the standard ISCUSflex analyzer and the EC-QCL system. There was a strong correlation between the compound concentrations obtained using the conventional bedside analyzer and the acquired mid-IR absorbance spectra, where a partial-least-squares regression model was implemented to compute concentrations. This study demonstrates the potential utility of mid-IR spectroscopy for continuous, automated, reagent-free, and online monitoring of the dynamic chemical changes in TBI patients, allowing a more timely response to adverse brain metabolism and consequently improving patient outcomes

Understanding Rejection between First-and-Second-Grade Elementary Students through Reasons Expressed by Rejecters

Objective: The aim of this research was to obtain the views of young children regarding their reasons for rejecting a peer. Method: To achieve this goal, we conducted a qualitative study in the context of theory building research using an analysis methodology based on Grounded Theory. The collected information was extracted through semi-structured individual interviews from a sample of 853 children aged 6 from 13 urban public schools in Spain. Results: The children provided 3,009 rejection nominations and 2,934 reasons for disliking the rejected peers. Seven reason categories emerged from the analysis. Four categories refer to behaviors of the rejected children that have a cost for individual peers or peer group such as: direct aggression, disturbance of wellbeing, problematic social and school behaviors and dominance behaviors. A further two categories refer to the identities arising from the preferences and choices of rejected and rejecter children and their peers: personal identity expressed through preferences and disliking, and social identity expressed through outgroup prejudices. The ¿no-behavior or no-choice¿ reasons were covered by one category, unfamiliarity. In addition, three context categories were found indicating the participants (interpersonal¿group), the impact (low¿high), and the subjectivity (subjective¿objective) of the reason. Conclusion: This study provides researchers and practitioners with a comprehensive taxonomy of reasons for rejection that contributes to enrich the theoretical knowledge and improve interventions for preventing and reducing peer rejection.Departamento de Educación y Psicología SocialVersión del edito

Civic Participation and Other Interventions That Promote Children\u2019s Tolerance of Migrants

In this chapter, we begin by providing a definition of \u2018tolerance\u2019, illustrating the wide range of attributes associated with the concept in the literature. Second, we identify some key paths through which tolerance can develop at different stages of an individual\u2019s development. Through a literature review, we will track some of the factors that can increase tolerance toward migrants during early and late stages development. Finally, we will conclude by presenting an overview of methodological approaches that practitioners have at their disposal to promote tolerance toward migrants

The relationship between moral judgment and cooperation in children with high-functioning autism.

This study investigated moral judgment in children with high-functioning autism and their cooperation in prisoner's dilemma game with partners of different moralities. Thirty-eight 6- to 12-year-old high-functioning autistic (HFA) children and 31 typically developing (TD) children were recruited. Children were asked to judge story protagonists' morality. After making this moral judgment correctly, they were asked to play with the morally nice and the morally naughty child in a repeated prisoner's dilemma game. Results showed that both HFA and TD children made correct moral judgments, and that HFA children might even have more rigid criteria for what constitutes morally naughty acts. HFA children's cooperation did not differ depending on the morality of the interaction partner, while TD children showed higher cooperation when interacting with the morally nice than the morally naughty child did. Thus, partner's morality did influence TD children's but not HFA children's subsequent cooperation

Equity and Justice in Developmental Science: Discrimination, Social Exclusion, and Intergroup Attitudes

In this article, the authors assert that (a) the topics of equity and justice reflect important areas of developmental science theory and research which have not yet been recognized as central areas of research in child development and developmental science, (b) a concern for social inequalities serves as a common thread binding equity and justice research across different areas in developmental science, and (c) equity and justice research can inform policies and practices that are designed to improve the lives of all children (including those who are members of stigmatized groups) reduce prejudice and bias, and create programs to rectify social inequalities. For this special section of Child Development, the authors provide the context for this research, and highlight the articles in this special section to demonstrate cutting-edge research in developmental science regarding equity and justice. The authors review current research and make recommendations for new lines of inquiry

The role of impulsivity in the aetiology of drug dependence: reward sensitivity versus automaticity

Journal ArticleResearch Support, Non-U.S. Gov'tCopyright © The Author(s) 2011.RATIONALE: Impulsivity has long been known as a risk factor for drug dependence, but the mechanisms underpinning this association are unclear. Impulsivity may confer hypersensitivity to drug reinforcement which establishes higher rates of instrumental drug-seeking and drug-taking behaviour, or may confer a propensity for automatic (non-intentional) control over drug-seeking/taking and thus intransigence to clinical intervention. METHOD: The current study sought to distinguish these two accounts by measuring Barratt Impulsivity and craving to smoke in 100 smokers prior to their completion of an instrumental concurrent choice task for tobacco (to measure the rate of drug-seeking) and an ad libitum smoking test (to measure the rate of drug-taking-number of puffs consumed). RESULTS: The results showed that impulsivity was not associated with higher rates of drug-seeking/taking, but individual differences in smoking uptake and craving were. Rather, nonplanning impulsivity moderated (decreased) the relationship between craving and drug-taking, but not drug-seeking. CONCLUSIONS: These data suggest that whereas the uptake of drug use is mediated by hypervaluation of the drug as an instrumental goal, the orthogonal trait nonplanning impulsivity confers a propensity for automatic control over well-practiced drug-taking behaviour.MR