High-Resolution Infrared Spectroscopy of the Brown Dwarf Epsilon Indi Ba

We report on the analysis of high-resolution infrared spectra of the newly discovered brown dwarf Epsilon Indi Ba. This is the closest known brown dwarf to the solar system, with a distance of 3.626 pc. Spectra covering the ranges of 2.308-2.317 microns and 1.553-1.559 microns were observed at a spectral resolution of R=50,000 with the Phoenix spectrometer on the Gemini South telescope. The physical paramters of effective temperature and surface gravity are derived by comparison to model spectra calculated from atmospheres computed using unified cloudy models. An accurate projected rotational velocity is also derived.Comment: 9 pages, 3 figures. Astrophysical Journal Letters, in pres

LSST: from Science Drivers to Reference Design and Anticipated Data Products

(Abridged) We describe here the most ambitious survey currently planned in the optical, the Large Synoptic Survey Telescope (LSST). A vast array of science will be enabled by a single wide-deep-fast sky survey, and LSST will have unique survey capability in the faint time domain. The LSST design is driven by four main science themes: probing dark energy and dark matter, taking an inventory of the Solar System, exploring the transient optical sky, and mapping the Milky Way. LSST will be a wide-field ground-based system sited at Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m effective) primary mirror, a 9.6 deg$^2$ field of view, and a 3.2 Gigapixel camera. The standard observing sequence will consist of pairs of 15-second exposures in a given field, with two such visits in each pointing in a given night. With these repeats, the LSST system is capable of imaging about 10,000 square degrees of sky in a single filter in three nights. The typical 5$\sigma$ point-source depth in a single visit in $r$ will be $\sim 24.5$ (AB). The project is in the construction phase and will begin regular survey operations by 2022. The survey area will be contained within 30,000 deg$^2$ with $\delta<+34.5^\circ$, and will be imaged multiple times in six bands, $ugrizy$, covering the wavelength range 320--1050 nm. About 90\% of the observing time will be devoted to a deep-wide-fast survey mode which will uniformly observe a 18,000 deg$^2$ region about 800 times (summed over all six bands) during the anticipated 10 years of operations, and yield a coadded map to $r\sim27.5$. The remaining 10\% of the observing time will be allocated to projects such as a Very Deep and Fast time domain survey. The goal is to make LSST data products, including a relational database of about 32 trillion observations of 40 billion objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures available from https://www.lsst.org/overvie

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas

RNA polymerase III (Pol-III) transcribes tRNAs and other small RNAs essential for protein synthesis and cell growth. Pol-III is deregulated during carcinogenesis; however, its role in vivo has not been studied. To address this issue, we manipulated levels of Brf1, a Pol-III transcription factor that is essential for recruitment of Pol-III holoenzyme at tRNA genes in vivo. Knockout of Brf1 led to embryonic lethality at blastocyst stage. In contrast, heterozygous Brf1 mice were viable, fertile and of a normal size. Conditional deletion of Brf1 in gastrointestinal epithelial tissues, intestine, liver and pancreas, was incompatible with organ homeostasis. Deletion of Brf1 in adult intestine and liver induced apoptosis. However, Brf1 heterozygosity neither had gross effects in these epithelia nor did it modify tumorigenesis in the intestine or pancreas. Overexpression of BRF1 rescued the phenotypes of Brf1 deletion in intestine and liver but was unable to initiate tumorigenesis. Thus, Brf1 and Pol-III activity are absolutely essential for normal homeostasis during development and in adult epithelia. However, Brf1 overexpression or heterozygosity are unable to modify tumorigenesis, suggesting a permissive, but not driving role for Brf1 in the development of epithelial cancers of the pancreas and gut

WSES Guidelines for the management of acute left sided colonic diverticulitis in the emergency setting

Acute left sided colonic diverticulitis is one of the most common clinical conditions encountered by surgeons in acute setting. A World Society of Emergency Surgery (WSES) Consensus Conference on acute diverticulitis was held during the 3rd World Congress of the WSES in Jerusalem, Israel, on July 7th, 2015. During this consensus conference the guidelines for the management of acute left sided colonic diverticulitis in the emergency setting were presented and discussed. This document represents the executive summary of the final guidelines approved by the consensus conference.Peer reviewe

Provenance signature of changing plate boundary conditions along a convergent margin: Detrital Record of Spreading-Ridge and Flat-Slab Subduction Processes, Cenozoic Forearc Basins, Alaska

Cenozoic strata from forearc basins in southern Alaska record deposition related to two different types of shallow subduction: Paleocene-Eocene spreading-ridge subduction and Oligocene-Recent oceanic plateau subduction. We use detrital zircon geochronology (n = 1368) and clast composition of conglomerate (n = 1068) to reconstruct the upper plate response to these two subduction events as recorded in forearc basin strata and modern river sediment. Following spreading-ridge subduction, the presence of Precambrian and Paleozoic detrital zircon ages in middle Eocene-lower Miocene arc-margin strata and Early Cretaceous ages in lower Miocene accretionary prism-margin strata indicates that sediment was transported to the basin from older terranes in interior Alaska and from the exhumed eastern part of the Cretaceous forearc system, respectively. By middle-late Miocene time, diminished abundances of these populations reflect shallow subduction of an oceanic plateau and associated exhumation that resulted in an overall contraction of the catchment area for the forearc depositional system. In the southern Alaska forearc basin system, upper plate processes associated with subduction of a spreading ridge resulted in an abrupt increase in the diversity of detrital zircon ages that reflect new sediment sources from far inboard regions. The detrital zircon signatures from strata deposited during oceanic plateau subduction record exhumation of the region above the flat slab, with the youngest detrital zircon population reflecting the last period of major arc activity prior to insertion of the flat slab. This study provides a foundation for new tectonic and provenance models of forearc basins that have been modified by shallow subduction processes, and may help to facilitate the use of U-Pb dating of detrital zircons to better understand basins that formed under changing geodynamic plate boundary conditions

Geology, U‐Pb Geochronology, and Hf Isotope Geochemistry Across the Mesozoic Alaska Range Suture Zone (South‐Central Alaska): Implications for Cordilleran Collisional Processes and Tectonic Growth of North America

The Mesozoic Alaska Range suture zone is defined by a transition from oceanic to continental terranes and is part of a 2000-km-long tectonic boundary throughout the northern Cordillera. Surface geologic mapping of the rock types across this suture zone provides critical information about the upper crustal configuration but provides little insight into the sedimentary, igneous, and metamorphic processes that occurred in deeper levels of the collisional zone. To better constrain the timing and mantle-crust sources of collision-related magmatism, we combine U-Pb ages and Hf isotope compositions of detrital zircons from the three main components of the suture zone. U-Pb/Hf data sets from inboard, continental margin samples have Precambrian-Paleozoic ages with epsilon Hf-(t) values ranging between +10 and -20. U-Pb/Hf data sets from the outboard, oceanic terrane samples have Pennsylvanian-Permian detrital zircon ages with epsilon Hf-(t) values between +16 and +10. The U-Pb/Hf data set of detrital zircons from Mesozoic strata that represent intervening sedimentary basin(s) that formed between the continental margin and oceanic terranes record Precambrian-Mesozoic detrital zircon ages with epsilon Hf-(t) values between +14 and -20. Results of the study document four Archean and Proterozoic global crustal magmatic events that are correlated to the tectonic growth of Laurentia. Also, three Phanerozoic magmatic events have been identified that represent more regional tectonic events. This study demonstrates that the combination of U-Pb geochronology and Hf isotope geochemistry applied to detrital zircons is a powerful tool to define sediment provenance in collisional zones and delineate episodes of global and regional magmatism along convergent plate boundaries.6 month embargo; published online: 5 March 2020This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

A thermochronometric view into an ancient landscape: Tectonic setting, development, and inversion of the Paleozoic eastern Paganzo basin, Argentina

In this study, we utilize multiple thermochronometric methods, including apatite and zircon fission track, (U-Th)/He, and zircon U-Pb, to evaluate the cooling history and provenance of sedimentary strata of the late Carboniferous to Late Permian eastern Paganzo basin and adjacent basement rocks (Argentina). The strata in the study area represent a long-lived, composite basin system that is interpreted to have experienced multiple periods of deformation, and to have received sediment from a number of different source terranes. These strata are well exposed in the Sierra de Chepes of west-central Argentina. New thermochronometric data and field observations, together with published data from the surrounding mountains, allow us to reconstruct: (1) the cooling history of the underlying basement rocks and the high-lands surrounding the basin, (2) the thermal history of the source areas that provided sediment to the basin, and (3) the timing of structural inversion of the basin. Our data suggest that parts of the Sierra de Chepes were rapidly exhumed in Late Devonian-Carboniferous times; these exhuming areas supplied sediment to the adjacent basin. In contrast, the overlying red-bed strata originated from a slowly exhuming region located farther east or north of the basin within the Pampean orogenic belt or the Famatinian belt, respectively. Burial by latest Carboniferous and younger strata and an elevated geothermal gradient resulted in heating of the underlying Upper Carboniferous strata and underlying granitoid basement to temperatures between 80 °C and 140 °C. During Triassic time, the eastern Paganzo basin was structurally inverted; this event was marked by rapid cooling and may be related to regional extension and the development of rift basins to the west. The basement and the Upper Paleozoic strata of the eastern Paganzo basin in the study area have remained below 50°C since latest Jurassic-Early Cretaceous times and are characterized by very slow cooling. Results of this study provide a thermochronometric view along an ~330 m.y. path defining the geologic evolution of the eastern Paganzo basin and the upper crust of west-central Argentina. © 2014 Geological Society of America.Fil: Enkelmann, Eva. University of Cincinnati; Estados UnidosFil: Ridgway, Kenneth D.. Purdue University; Estados UnidosFil: Carignano, Claudio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; ArgentinaFil: Linnemann, Ulf. Senckenberg Gesellschaft Für Naturforschung; Alemani