Comparative economic value estimation of matsutake mushroom and timber production in Swedish Scots pine forest

The economic value of Swedish forests is largely linked to the production of timber and pulp. Non-timber forest products such as berries and wild mushrooms have yet been considered commercially less valuable than what the trees produce. In 1990s, DNA analyses revealed that matsutake (Tricholoma matsutake), the most expensive edible wild mushroom in Japan, did also occur in Sweden. As a result, commercial matsutake picking in Sweden started in 1998 and since then, small scale export of it to Japan have been taken place. The main objective of this study is to estimate the economic value of Swedish matsutake in comparison with that of Scots pine timber production to figure out how matsutake could potentially contribute to forest management. Cost-benefit analysis is applied as a method. Regarding matsutake production, input data for calculating net present value (NPV) is collected from the matsutake sporocarp inventory survey conducted in between 1998-2012 and a questionnaire was sent to the pickers in 2013. Regarding timber production, state compensation payment for habitat protection that reflects the forest estate value is employed for estimating the NPV. The result shows that the economic values of matsutake at Scots pine sites with high sporocarp productivity is about twice as high as the economic outcome of timber production and it implies that the potential economic value production of matsutake sporocarps at high productivity sites may largely exceed the corresponding economic value of the timber production. This study also suggests that further researches on value estimations of recreational and subsistence use of matsutake and also resource tenure right of it are needed to clarify the cons and prons of forest management with consideration of potential matsutake sporocarp production

Microstructure of Oxide Insulator Coating before and after Thermal Cycling Test

Erbium oxide (Er2O3) was shown to be a high potential candidate for tritium permeation barrier and electrical insulator coating for advanced breeding blanket systems such as liquid Li, Li-Pb or molten-salt blankets. Recently, we succeeded to form Er2O3 coating layer on large interior surface area of metal pipe using Metal Organic Chemical Vapor Deposition (MOCVD) process. In this paper, we investigated the microstructure of Er2O3 coating layer on stainless steel 316 (SUS 316) plate before and after heat treatments with hydrogen or argon gases. From the results of TEM observations, we confirmed that Er2O3 coating layer with 700 nm thickness was formed on the SUS 316 plate and this layer was identified to poly-crystal phase because the diffraction fleck which was arranged like a ring was observed in the selected electron diffraction pattern. No macroscopic defects such as crack and peeling in Er2O3 coating layer were observed before and after thermal cycling test. The change of microstructure of the Er2O3 coating layer on before and after heat cycling test was reported

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements