Higher Education Strategy in Responding to the Generative AI Revolution Decolonising the Standard Response and Action Planning Protocols

Background: The Generative Artifical Intelligence (AI) revolution is here, and the availability of resources such as ChatGPT has triggered rapid responses, actions, and strategy to address the implications this has on education in the United Kingdom (UK). ChatGPT and other Generative AI provisions are viewed as both problematic and beneficial by Higher Education Institutes (HEI’s). Alongside HEI’s, Higher Education England (HEE) Technology Enhanced Learning (TEL) forums are just 1 of many additional UK national groups prioritising the discussion, Continual Professional Development (CPD), and strategical approaches to analysing Generative AI, in determining how it should be addressed in education and practice. In terms of standard practice at London South Bank University (LSBU), the planning of projects and research to explore new technology lies predominantly with those deemed as the most “skilled”, “technical” or “aware” of the technology. People who are in specific roles within the institute are expected to “lead” on strategy, and this onus of responsibility often remains with them throughout the process from start to finish. Recognising the imbalance of power and the benefits of privilege this practice could create, a decision was made to explore and propose re-design of the current protocols in place at LSBU. Aim: Demonstrate the inclusion of a Decolonising step at the earliest designing stage of the project, to influence a practice change in how a HEI could respond to major items affecting education and any subsequent action-planning or project designing. Method: 3 academic members of staff, and 3 undergraduate students, of Black, Asian, African or Minority ethnicity, will be recruited. Individual and group sessions will be conducted using Microsoft Teams. Sessions will involve the participants leading on the discussion and development of the project proposal and associated documents being used in the larger study. This will occur between 19th May – 1st June 2023, after which the project proposal will be registered with the LSBU research ethics committee and internal registration system (Haplo). The Decolonising strategy and effects will be appraised by an independent investigator making objective comparisons to a version of the project protocol originally written by the Principal Investigator as a lone researcher. Themes and major highlights to demonstrate these comparisons, will be presented as the outcome for this project. All results and recommendations will be ready for presentation by no later than 15th June 2023. Expected Outcomes: Recommendations based on the outcome could feasibly affect changes in the future strategy for responding to major items requiring adaptation and evolution in education/practices, and potential other general and/or specific response/action-planning protocols, at London South Bank University. Additional information: This project forms part of a larger LSBU Generative AI project to explore a potential solution to the issues surrounding Generative AI in Higher Education

Synthesis, quantum chemical computations and x-ray crystallographic studies of a new complex based of manganese (+II)

The ligand oxime, C7H9N5O2, was Synthesis and characterises with different characterization methods such as 1H NMR and FTIR spectroscopy. The complexation of this ligand with manganese (II) perchlorate yielded pink crystals of formula [Mn (C7H9N5O2)2]2+, 2[ClO4]-, which crystallized in the monoclinic space group P21/n with a = 12.824(3), b=13.799(2), c=15.441(4)Å, β = 100.17(2), and Z = 4. The complex consists of cations (+II) and two perchlorate anions, the cations part existing in a slightly distorted octahedral complex. Computational investigations of manganese (II) complex are done by using the DFTmethod with B3LYP functional in conjunction with the 6-31G(d,p) and lanl2dz basis sets in the gas phase imposing the C1 and C2v symmetries.Keywords: Manganese complex; Crystal structure; DFT method; B3LYP functional; 6-31G(d,p) and (LANL2DZ) basi

Synthesis, crystal structures, hydrogen bonding graph-sets and theoretical studies of nickel (+II) co-ordinations with pyridine-2,6-dicarboxamide oxime

The pyridine-2,6-dicarboxamide oxime, C7H9N5O2, was Synthesis and  characterises with 1H NMR and FTIR spectroscopy . The reaction of this ligand with nickel (II) perchlorate yielded green crystals of formula  [Ni(C<sub>7</sub>H<sub>9</sub>N<sub>5</sub>O<sub>2</sub>)<sub>2</sub>]<sup>2+</sup>,2[ClO<sub>4</sub>]-, which crystallized in the monoclinic space group C2/c with a = 14.915(2), b = 0.895(2), c = 8.205(1) Å, β = 114.69(1), and Z = 4. The complex consists of discrete cations (+II) and one perchlorate anion, the  cations existing in a slightly distorted octahedral  complex with bonding through the heterocyclic and oxime nitrogen atoms. The structure is held together through N-H…O, O-H…O and C-H...O hydrogen bonds occurring  between the coordinated oxime  molecules and the perchlorate counter-ion. Computational investigations of nickel(II) complex are done by using M062X method with 6-31+G(d)(LANL2DZ) basis set in vacuo.Keywords: Oxime complexe; Crystal structure; Hydrogen-bonding graph-set; DFT; M062X method; 6-31+G(d)(LANL2DZ) basis

Marqueurs chromosomiques: à propos d'un cas

Les marqueurs chromosomiques peuvent être définis comme des petits chromosomes de structure anormale présents en addition aux 46 chromosomes humains connus. C'est un groupe hétérogène d'anomalies de structure chromosomique pouvant être avec ou sans conséquence phénotypique. Plusieurs tentatives sont réalisées afin de retrouver une corrélation génotype-phénotype lors de la présence d'un marqueur chromosomique. L'identification du marqueur, son origine et sa structure suit une stratégie bien codifiée actuellement allant d'abord de l'orientation clinique suivie des techniques de cytogénétique conventionnelle (caryotype métaphasique standard, bandes C, NOR) et de cytogénétique moléculaire (M-FISH, CGH, CGH array) puis une détection par des techniques plus ciblées (painting, sondes locus spécifique). Cet ensemble permet une meilleure analyse et correspondance clinico-génétique. Nous rapportons le cas d'un nourrisson présentant une dysmorphie faciale avec un retard psychomoteur dont l'analyse cytogénétique a révélé la présence d'un marqueur chromosomique avec un caryotype métaphasique 47,XX,+mar. A travers cette observation, nous mettons en valeur le rôle de la cytogénétique conventionnelle et moléculaire dans le diagnostic des syndromes dysmorphiques permettant une meilleure prise en charge du patient et un conseil génétique adéquat pour sa familleKey words: Marqueurs chromosomiques, anomalie chromosomique, analyse cytogénétique, dysmorphi

Investigation of Rheological and Geometric Properties Effect on Nonlinear Behaviour of Fluid Viscous Dampers

Global approval of the use of fluid viscous dampers to control the buildings response against dynamic loadings is growing. The idea behind incorporating additional dampers is that they will reduce most of the energy that is transmitted to the building during shaking event. The objective of this work is to identify and enhance the design parameters that control the nonlinear behaviour of fluid viscous damper subjected to sinusoidal excitation. For this, a numerical model of the flow inside the dissipater has been carried out based on finite volume method. A novel approach has been adopted to simulate elastic behaviour of the fluid, taking into account its compressibility by using the Murnaghan equation of state. A comparison between the calculations of the proposed model and the experimental tests was carried out. The model proved to be sufficiently accurate. A fluid flow analysis was then conducted to fully understand the internal mechanism of the damper. A parametric study was then performed by varying aspects such as dimensions, geometric relationships between components and fluid properties in order to better understand their effect on the non-linear behaviour of the device.  The results highlight the relationship between the parameters governing the shear thinning behaviour of the fluid and the non-linearity exponent of the damper. This makes it possible to better control the non-linear behaviour of the device by selecting the appropriate silicone oil and the appropriate geometric dimensions of its components

Elaboration and Characterization of Recycled PP/Clay Nanocomposites

In this paper, the elaboration and characterization of recycled polypropylene/Tunisian clay nanocomposites has been investigated. When recycled, polypropylene polymer is degraded and has poorer mechanical and rheological properties. To overcome this problem, we proposed to incorporate Tunisian clay nanoparticles in recycled polypropylene (rPP) matrix. The incorporation of Tunisian clay was performed in molten state using maleic anhydride grafted polypropylene (PP-g-MA) as compatibilizer. The dispersion of clay in rPP polymer was evaluated by scanning electron microscopy and Fourier transformed infrared spectroscopy. Thus, Tunisian clay was more dispersed in nanocomposites with the increase of Tunisian clay loading. In dead, the incorporation of silicate layers gave rise to a considerable increase of the static viscosity demonstrating the reinforcing effect of Tunisian clay nanofillers on rPP matrix. However, the increasing trend of morphological and rheological properties is lower when the clay content exceeds 5%

Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis.

Poly (ADP-ribose) polymerase 1 (PARP-1) is a constitutive enzyme, the major isoform of the PARP family, which is involved in the regulation of DNA repair, cell death, metabolism, and inflammatory responses. Pharmacological inhibitors of PARP provide significant therapeutic benefits in various preclinical disease models associated with tissue injury and inflammation. However, our understanding the role of PARP activation in the pathophysiology of liver inflammation and fibrosis is limited. In this study we investigated the role of PARP-1 in liver inflammation and fibrosis using acute and chronic models of carbon tetrachloride (CCl4 )-induced liver injury and fibrosis, a model of bile duct ligation (BDL)-induced hepatic fibrosis in vivo, and isolated liver-derived cells ex vivo. Pharmacological inhibition of PARP with structurally distinct inhibitors or genetic deletion of PARP-1 markedly attenuated CCl4 -induced hepatocyte death, inflammation, and fibrosis. Interestingly, the chronic CCl4 -induced liver injury was also characterized by mitochondrial dysfunction and dysregulation of numerous genes involved in metabolism. Most of these pathological changes were attenuated by PARP inhibitors. PARP inhibition not only prevented CCl4 -induced chronic liver inflammation and fibrosis, but was also able to reverse these pathological processes. PARP inhibitors also attenuated the development of BDL-induced hepatic fibrosis in mice. In liver biopsies of subjects with alcoholic or hepatitis B-induced cirrhosis, increased nitrative stress and PARP activation was noted. CONCLUSION: The reactive oxygen/nitrogen species-PARP pathway plays a pathogenetic role in the development of liver inflammation, metabolism, and fibrosis. PARP inhibitors are currently in clinical trials for oncological indications, and the current results indicate that liver inflammation and liver fibrosis may be additional clinical indications where PARP inhibition may be of translational potential

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector

A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13  TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139  fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV

Search for direct stau production in events with two hadronic tau-leptons in root s=13 TeV pp collisions with the ATLAS detector

A search for the direct production of the supersymmetric partners ofτ-leptons (staus) in final stateswith two hadronically decayingτ-leptons is presented. The analysis uses a dataset of pp collisions corresponding to an integrated luminosity of139fb−1, recorded with the ATLAS detector at the LargeHadron Collider at a center-of-mass energy of 13 TeV. No significant deviation from the expected StandardModel background is observed. Limits are derived in scenarios of direct production of stau pairs with eachstau decaying into the stable lightest neutralino and oneτ-lepton in simplified models where the two staumass eigenstates are degenerate. Stau masses from 120 GeV to 390 GeV are excluded at 95% confidencelevel for a massless lightest neutralino