Assessment of existing steel structures. A guideline for estimation of the remaining fatigue life

In many countries and regions, traffic infrastructure projects suffer from low funding. The budget is tight for new infrastructure building and, thus, the importance of inspection, maintenance and assessment of the existing traffic infrastructure increases. A new fatigue assessment guideline for the estimation of the remaining fatigue life of steel bridges has been written by technical committee 6 from ECCS. It will be a useful tool for the complementation of bridge management systems, used commonly for condition assessment. Design specifications and rules are harmonised throughout Europe. They are under constant development, but there is still a lack of forwarding and concentrating experiences as well as developing rules for the fatigue assessment on existing steel structures. This paper presents a guideline with a proposed fatigue assessment procedure for existing steel structures embedded in information about old materials and nondestructive testing methods for the evaluation of details (ECCS 2004, Assessment of existing steel structures). Particular attention is paid on remedial measures which are proposed for weak details and damages caused by fatigue. The developed fatigue assessment procedure can be applied to existing steel structures under cyclic loading in general, but the guideline concentrates on the existing traffic infrastructure made from old steel, because of the public importance. The proposed procedure summarizes, regroups and arranges the knowledge in the field of assessment on existing steel to be applied by practicing engineers. The procedure is a milestone in knowledge transfer from a state of scientific knowledge to state-of-the-art

Механический метод очистки сточных вод

В статье рассматриваются основные методы очистки сточных вод. Описан механический метод очистки и представлены его особенности. Приведен процесс очистки вод данным методом. The article deals with the basic methods of wastewater treatment. Described mechanical method of cleaning and presents its features. An process water treatment by this method

Beurteilung bestehender Stahltragwerke : Empfehlungen zur Abschätzung der restnutzungsdauer

Assessment of existing steel structures: recommendations for estimation of remaining fatigue life. The growing importance of sustainability affects new markets for the construction industry; the rehabilitation and refurbishment of existing buildings and civil engineering works is getting more and more into the focus of construction activities. This also applies to bridges as well where the quality management comprising the full life of a bridge has a long tradition. For bridges in particular the enormous increase of freight-volume on roads and rails and the growing age of the bridges cause the question, whether the existing structures are still fit for use and whether or not they can be retrofitted and if so how that could be done. For decision making concerning measures for maintenance and refurbishment of a bridge or its substitution by a new bridge the value of the residual service life is very important. Therefore the bridge authorities have been cooperating for a long time to develop appropriate methods for determining the residual safety and service life of existing bridges. Also the International Technical-Scientific Organisations as the ECCS and fip as well as Standard Organisations as ISO and CEN have cared for an international exchange of views and the harmonisation of methods. For steel bridges in particular the Technical Committee 6 – Fatigue – of the ECCS has taken over the task to develop a technical guidance for the assessment of existing steel bridges on the grounds of national experiences and the present state of the art. This guidance has been prepared to serve as a basis for CEN/TC 250 – the CEN-Technical Committee responsible for the structural Eurocodes – for future further development of these Eurocodes to include the assessment and retrofitting of existing structures. The result of the development of ECCS-TC 6 is a technical- scientific report which has been published by the Commission of the EU (DG-Research – Joint Research Centre – JRC) in the frame of a cooperation agreement between the JRC and the ECCS. This report may be used as a technical recommendation as long as the revision of the Eurocodes has not been carried out. This contribution gives the main information from the JRC-ECCS report, that can be downloaded free of charge from the e-bookshop of the Commission

Combined analysis of data from two granddaughter designs: A simple strategy for QTL confirmation and increasing experimental power in dairy cattle

A joint analysis of five paternal half-sib Holstein families that were part of two different granddaughter designs (ADR- or Inra-design) was carried out for five milk production traits and somatic cell score in order to conduct a QTL confirmation study and to increase the experimental power. Data were exchanged in a coded and standardised form. The combined data set (JOINT-design) consisted of on average 231 sires per grandsire. Genetic maps were calculated for 133 markers distributed over nine chromosomes. QTL analyses were performed separately for each design and each trait. The results revealed QTL for milk production on chromosome 14, for milk yield on chromosome 5, and for fat content on chromosome 19 in both the ADR- and the Inra-design (confirmed within this study). Some QTL could only be mapped in either the ADR- or in the Inra-design (not confirmed within this study). Additional QTL previously undetected in the single designs were mapped in the JOINT-design for fat yield (chromosome 19 and 26), protein yield (chromosome 26), protein content (chromosome 5), and somatic cell score (chromosome 2 and 19) with genomewide significance. This study demonstrated the potential benefits of a combined analysis of data from different granddaughter designs

Educational attainment does not influence brain aging.

Education has been related to various advantageous lifetime outcomes. Here, using longitudinal structural MRI data (4,422 observations), we tested the influential hypothesis that higher education translates into slower rates of brain aging. Cross-sectionally, education was modestly associated with regional cortical volume. However, despite marked mean atrophy in the cortex and hippocampus, education did not influence rates of change. The results were replicated across two independent samples. Our findings challenge the view that higher education slows brain aging

Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS

Minimally invasive biomarkers are urgently needed to detect molecular pathology in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Here, we show that plasma extracellular vesicles (EVs) contain quantifiable amounts of TDP-43 and full-length tau, which allow the quantification of 3-repeat (3R) and 4-repeat (4R) tau isoforms. Plasma EV TDP-43 levels and EV 3R/4R tau ratios were determined in a cohort of 704 patients, including 37 genetically and 31 neuropathologically proven cases. Diagnostic groups comprised patients with TDP-43 proteinopathy ALS, 4R tauopathy progressive supranuclear palsy, behavior variant FTD (bvFTD) as a group with either tau or TDP-43 pathology, and healthy controls. EV tau ratios were low in progressive supranuclear palsy and high in bvFTD with tau pathology. EV TDP-43 levels were high in ALS and in bvFTD with TDP-43 pathology. Both markers discriminated between the diagnostic groups with area under the curve values &gt;0.9, and between TDP-43 and tau pathology in bvFTD. Both markers strongly correlated with neurodegeneration, and clinical and neuropsychological markers of disease severity. Findings were replicated in an independent validation cohort of 292 patients including 34 genetically confirmed cases. Taken together, the combination of EV TDP-43 levels and EV 3R/4R tau ratios may aid the molecular diagnosis of FTD, FTD spectrum disorders and ALS, providing a potential biomarker to monitor disease progression and target engagement in clinical trials.</p

Measurement of the charge asymmetry in highly boosted top-quark pair production in √s=8 TeV pp collision data collected by the ATLAS experiment

In the pp→tt process the angular distributions of top and anti-top quarks are expected to present a subtle difference, which could be enhanced by processes not included in the Standard Model. This Letter presents a measurement of the charge asymmetry in events where the top-quark pair is produced with a large invariant mass. The analysis is performed on 20.3 fb-1 of pp collision data at √s=8TeV collected by the ATLAS experiment at the LHC, using reconstruction techniques specifically designed for the decay topology of highly boosted top quarks. The charge asymmetry in a fiducial region with large invariant mass of the top-quark pair (mtt>0.75 TeV) and an absolute rapidity difference of the top and anti-top quark candidates within -2<|yt|-|yt|<2 is measured to be 4.2±3.2%, in agreement with the Standard Model prediction at next-to-leading order. A differential measurement in three tt- mass bins is also presented